Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SDHD | 6392 | succinate dehydrogenase complex, subunit D, integral membrane protein | 11 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 12883710 | 2003 | Cell line : - Source : - Sample Type : GC and CRC tumor No. of Sample : 52 colorectal and 59 gastric cancers Stage : - | LOH analysis, Western blotting | Down-regulation | - | SDHD alterations can affect mitochondrial respiratory chain functions and play a role in colorectal and gastric cancers as a distinct type of tumor suppressor. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Mitochondrial respiratory chain complex / Complex II |
| Description | This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013] | Chromosome | 11 |
| Location | 11q23 |
| Start | 111957548 |
| End | 111966525 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 8978 |
| OMIM ID | 602690 |
| HGNC ID | HGNC:10683 |
| Unigene ID | Hs.356270 |
| Ensembl ID | - |
| PharmGKB ID | PA35608 |
mRNA Information
| mRNA ID | ?NM_001276503.1 |
|---|---|
| Exon | join(1..136,1034..1150,2044..2188,6257..6386,7982..8978) | mRNA Sequence | Download Select all |
| Length | 1525 |
Protein Information
| Protein ID | NP_001263432.1 |
|---|---|
| Protein Name | succinate dehydrogenase complex, subunit D, integral membrane protein |
| Molecular Wt. (Da) | 88251 |
| Protein Sequence | Download Select all |
| Length | 159 |
| Uniprot ID | Q14694 |
| Ensembl Protein ID | ENSP00000219473 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Alzheimer's disease | hsa05010 |
| Carbon metabolism | hsa01200 |
| Citrate cycle (TCA cycle) | hsa00020 |
| Huntington's disease | hsa05016 |
| Metabolic pathways | hsa01100 |
| Non-alcoholic fatty liver disease (NAFLD) | hsa04932 |
| Oxidative phosphorylation | hsa00190 |
| Parkinson's disease | hsa05012 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03496 | 60-158 | SQR_TypeC_CybS |
| cl00881 | 60-158 | SQR_QFR_TM superfamily |
| pfam05328 | 57-158 | CybS |
| cd03493 | 90-141 | SQR_QFR_TM |
Ontology Information
| HPRD ID | 9147 |
|---|---|
| Molecular Class | Enzyme: Dehydrogenase |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| O14521 | DB00139 | Succinic acid | SmallMoleculeDrug |
| O14521 | DB00756 | Hexachlorophene | SmallMoleculeDrug |