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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SEMA4D 10507 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D  9CD100, coll-4, FLJ39737 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24760652   2014Cell line : -

Source : -

Sample Type : CRC tumor and normal tissues

No. of Sample : 86 CRC and 52 normal tissues

Stage : -

ImmunohistochemistryUp-regulation-HIF-1? and Sema4D has the potential to predict the development trend of colorectal carcinoma and prognosis of patients.


Gene Details



NC_000009.11 (91975706..92112906, complement)

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Gene Type protein coding
Gene Family Semaphorins, "CD molecules", "Immunoglobulin superfamily / Immunoglobulin-like domain containing"
Description -  
Chromosome 9
Location 9q22-q31
Start 91975706  
End 92112906  
Strand -  
Gene Sequence

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Length 137201  
OMIM ID 601866   
HGNC ID HGNC:10732   
Unigene ID Hs.494406   
Ensembl ID ENSG00000187764   
PharmGKB ID PA35654   

mRNA Information


mRNA ID ?NM_001142287.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS47991.1



Protein Information


      
Protein IDNP_001135759.1
Protein Namesema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (se
Molecular Wt. (Da)0
Protein Sequence

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Length 862  
Uniprot IDQ96D42
Ensembl Protein ID ENSP00000344844  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation195;-
NGlycosylation419
NGlycosylation74
NGlycosylation77
NGlycosylation49
NGlycosylation379

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
971CD72118NP_001773.1in vitro;in vivo1   111   437   512   882   840   
5364PLXNB13032NP_002664.2in vitro;in vivo11937491   
5788PTPRC1050NP_002829.2in vitro;in vivo112   546   878   955   171   


Pathway Information


      
Pathway Name Pathway ID
Axon guidance hsa04360


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd1125931-501  Sema_4D
cl1569331-501  Sema superfamily
cd05873559-645  Ig_Sema4D_like
cl11960559-645  Ig superfamily
cd1124042-501  Sema_4
cd1123548-501  Sema_semaphorin
cd1126042-501  Sema_4E
cd1126249-500  Sema_4G
pfam0140350-482  Sema
cd1125742-501  Sema_4B
cd1125841-501  Sema_4C
cd0929549-501  Sema
cd1123950-503  Sema_3
cd1125642-501  Sema_4A
cd1126139-499  Sema_4F
smart0063050-474  Sema
cd1124927-503  Sema_3A
cd1123754-503  Sema_1A
cd1125449-503  Sema_3F
cd1125050-503  Sema_3B
cd1125547-503  Sema_3G
cd1125249-503  Sema_3D
cd1125149-503  Sema_3C
cd1125341-503  Sema_3E
cd1124260-471  Sema_6
cd1126954-501  Sema_6D
cd1123850-501  Sema_2A
cd1126661-450  Sema_6A
cd1126442-501  Sema_5B
cd1124142-500  Sema_5
cd1126761-501  Sema_6B
cd1126342-500  Sema_5A
cd1124335-501  Sema_7A
cd1127061-501  Sema_6E
cd1126861-452  Sema_6C
cd1126542-450  Sema_5C
cd04979560-645  Ig_Semaphorin_C
cd09295228-560  Sema
pfam01437503-554  PSI
cl02601503-554  PSI superfamily
smart00423503-554  PSI
cd11272145-538  Sema_plexin_A2
cd05872574-636  Ig_Sema4B_like
cd1123652-337  Sema_plexin_like
cd1124561-450  Sema_plexin_B
cd05871569-645  Ig_Semaphorin_classIII
cd00096572-633  Ig
smart00408569-627  IGc2
smart00410569-634  IG_like
smart00409569-634  IG


Ontology Information


   
HPRD ID5094
Molecular ClassIntegral membrane protein
Molecular FunctionProtein binding (GO:0005515)
Biological ProcessDNA repair (GO:0006281)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO