Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SERPINB5 | 5268 | Serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 18 | PI5; maspin |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17352241 | 2007 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : Colorectal adenocarcinoma 119, adjacent adenoma 22, adjacent non-cancerous mucosa 118 and their metastatic foci 67 Stage : TNM Stage I-IV | Tissue microarray, Immunostaining with intermittent microwave irradiation, Microvessel density | Up-regulation | - | Up-regulated maspin expression was involved in colorectal adenoma-adenocarcinoma sequence. Low maspin expression is closely linked to the liver metastasis of CRA possibly through degradation of the extracellular matrix-tenascin to enhance carcinoma cell mobility. |
| 18949363 | 2008 | Cell line : - Source : - Sample Type : Blood specimens No. of Sample : 81 CRC patients and 36 control Stage : - | Nested RT-PCR | Up-regulation | - | SERPINB5 as a specific marker for the detection of circulating tumor cells in CRC patients. If overexpression of SERPINB5 in peripheral blood specimens of CRC patients is of long-term prognostic significance or might be beneficial for therapeutic decisions. |
| 20812987 | 2010 | Cell line : - Source : Nanfang Hospital tumour tissue bank. Sample Type : - No. of Sample : 150 CRC patients Stage : - | 2-D Gel electrophoresis, and mass spectrometry,Western blotting, Immunohistochemistry | Up-regulation | - | This gene differentially expressed in between normal colorectal tissue and colorectal cancer tissue experiment done by 2-D Gel eclectrophotesis |
| 24114705 | 2014 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | 2-D Gel electrophoresis, matrix-associated laser desorption ionisation-mass spectrometry (MALDI-MS), co-immunoprecipitation and confocal microscopy, Western blotting, ELISA | Up-regulation | - | Strong expression of serpin B5 was associated with a worse prognosis in patients with CRC and its expression may correlate with CEA levels in CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Serine (or cysteine) peptidase inhibitors |
| Description | - | Chromosome | 18 |
| Location | 18q21.33 |
| Start | 63476911 |
| End | 63505085 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 28175 |
| OMIM ID | 154790 |
| HGNC ID | HGNC:8949 |
| Unigene ID | Hs.55279 |
| Ensembl ID | ENSG00000206075 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_002639.4 |
|---|---|
| Exon | join(1..135,7512..7686,10036..10173,12437..12554, 16043..16185,22210..22377,26420..28175) | mRNA Sequence | Download Select all |
| Length | 2633 |
CDS Information
| Location | join(7519..7686,10036..10173,12437..12554,16043..16185, 22210..22377,26420..26812) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS32839.1 |
Protein Information
| Protein ID | NP_002630.2 |
|---|---|
| Protein Name | Serpin peptidase inhibitor, clade B (ovalbumin), member 5 |
| Molecular Wt. (Da) | 41969 |
| Protein Sequence | Download Select all |
| Length | 375 |
| Uniprot ID | P08572 |
| Ensembl Protein ID | ENSP00000353654 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 9 |
| T | Phosphorylation | 102 |
| S | Phosphorylation | 106 |
| S | Phosphorylation | 107 |
| T | Phosphorylation | 108 |
| S | Phosphorylation | 135 |
| Y | Phosphorylation | 356 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MicroRNAs in cancer | hsa05206 |
| p53 signaling pathway | hsa04115 |
Structure Information
| PDB ID | 1WZ9 |
|---|---|
| Resolution | 2.1 |
| Method | X-RAY DIFFRACTION |
| Chains | A,B |
| Molecule | Maspin precursor |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd02057 | 4-375 | maspin_like |
| cl00137 | 4-375 | SERPIN superfamily |
| cd02044 | 4-375 | ov-serpin |
| smart00093 | 13-375 | SERPIN |
| cd02058 | 4-375 | PAI-2 |
| pfam00079 | 7-375 | Serpin |
| cd00172 | 7-372 | SERPIN |
| cd02059 | 7-375 | ovalbumin_like |
| cd02056 | 7-371 | alpha-1-antitrypsin_like |
| cd02048 | 11-375 | neuroserpin |
| COG4826 | 7-375 | SERPIN |
| cd02051 | 9-375 | PAI-1_nexin-1 |
| cd02049 | 7-371 | bacterial_SERPIN |
| cd02045 | 4-371 | antithrombin-III_like |
| cd02046 | 8-372 | hsp47 |
| cd02052 | 4-375 | PEDF |
| cd02047 | 4-375 | HCII |
| cd02043 | 27-375 | plant_SERPIN |
| cd02055 | 9-371 | PZI |
| cd02053 | 10-370 | alpha2AP |
| cd02050 | 11-371 | C1_inh |
| cd02054 | 26-375 | angiotensinogen |
| PHA02948 | 4-375 | PHA02948 |
| PHA02660 | 27-375 | PHA02660 |
| cd07268 | 216-284 | Glo_EDI_BRP_like_4 |
| cl14632 | 216-284 | Glo_EDI_BRP_like superfamily |
Ontology Information
| HPRD ID | 366 |
|---|---|
| Molecular Class | Protease inhibitor |
| Molecular Function | Extracellular matrix structural constituent (GO:0005201) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.