Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SERPINC1 | 462 | Serpin peptidase inhibitor, clade C (antithrombin), member 1 | 1 | AT3; AT3D; ATIII; THPH7 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands Sample Type : - No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis. | Unknown | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Serine (or cysteine) peptidase inhibitors |
| Description | The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009] | Chromosome | 1 |
| Location | 1q25.1 |
| Start | 173903800 |
| End | 173917378 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 13579 |
| OMIM ID | 107300 |
| HGNC ID | HGNC:775 |
| Unigene ID | Hs.75599 |
| Ensembl ID | ENSG00000117601 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_005245198.2 |
|---|---|
| Exon | join(38..160,2193..2361,2460..2826,5365..5580,6488..6625, 7437..7827,9865..9929,13314..13579) | mRNA Sequence | Download Select all |
| Length | 1599 |
CDS Information
| Location | join(120..160,2460..2826,5365..5580,6488..6625,7437..7827, 9865..9929,13314..13490) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS1313.1 |
Protein Information
| Protein ID | NP_000479.1 |
|---|---|
| Protein Name | Serpin peptidase inhibitor, clade C (antithrombin), member 1 |
| Molecular Wt. (Da) | 49039 |
| Protein Sequence | Download Select all |
| Length | 464 |
| Uniprot ID | P30556 |
| Ensembl Protein ID | ENSP00000273430 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 128 |
| N | Glycosylation | 167 |
| N | Glycosylation | 187 |
| N | Glycosylation | 224 |
| C | Disulfide Bridge | 279;462 |
| C | Disulfide Bridge | 40;160 |
| C | Disulfide Bridge | 53;127 |
| R | Proteolytic Cleavage | 425 |
| S | Phosphorylation | 68 |
| T | Phosphorylation | 63 |
| S | Phosphorylation | 174 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Complement and coagulation cascades | hsa04610 |
Structure Information
| PDB ID | 1ANT |
|---|---|
| Resolution | 3 |
| Method | X-RAY DIFFRACTION |
| Chains | I,L |
| Molecule | ANTITHROMBIN |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd02045 | 79-458 | antithrombin-III_like |
| cl00137 | 79-458 | SERPIN superfamily |
| smart00093 | 94-461 | SERPIN |
| pfam00079 | 86-461 | Serpin |
| cd00172 | 86-458 | SERPIN |
| cd02059 | 83-461 | ovalbumin_like |
| cd02058 | 83-461 | PAI-2 |
| cd02044 | 83-461 | ov-serpin |
| cd02056 | 86-458 | alpha-1-antitrypsin_like |
| cd02048 | 90-461 | neuroserpin |
| COG4826 | 81-461 | SERPIN |
| cd02049 | 83-458 | bacterial_SERPIN |
| cd02043 | 97-461 | plant_SERPIN |
| cd02051 | 88-461 | PAI-1_nexin-1 |
| cd02047 | 79-461 | HCII |
| cd02057 | 83-461 | maspin_like |
| cd02053 | 83-458 | alpha2AP |
| cd02055 | 82-458 | PZI |
| cd02052 | 82-461 | PEDF |
| cd02046 | 83-458 | hsp47 |
| cd02050 | 90-458 | C1_inh |
| cd02054 | 94-461 | angiotensinogen |
| PHA02948 | 95-461 | PHA02948 |
| PHA02660 | 206-461 | PHA02660 |
Ontology Information
| HPRD ID | 107 |
|---|---|
| Molecular Class | Protease inhibitor |
| Molecular Function | G-protein coupled receptor activity (GO:0004930) |
| Biological Process | Signal transduction (GO:0007165); Regulation of blood pressure (GO:0008217); Homeostasis (GO:0042592) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P01008 | DB00407 | Ardeparin | SmallMoleculeDrug |
| P01008 | DB00569 | Fondaparinux sodium | SmallMoleculeDrug |
| P01008 | DB01109 | Heparin | SmallMoleculeDrug |
| P01008 | DB01225 | Enoxaparin | SmallMoleculeDrug |
| P01008 | DB06271 | Sulodexide | BiotechDrug |
| P01008 | DB06779 | Dalteparin | SmallMoleculeDrug |
| P01008 | DB06822 | Tinzaparin | SmallMoleculeDrug |
| P01008 | DB08813 | Nadroparin | SmallMoleculeDrug |