Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 7 | PAI |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20491774 | 2010 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | The plasma levels of VCAM-1 and PAI-1 together may be a promising biomarker for predicting post-operative recurrence in patients with colorectal cancer. A multivariate logistic regression analysis revealed that the concentrations of vascular cell adhesion molecule 1 (VCAM-1) and plasminogen activator inhibitor-1 (PAI-1) were significantly higher in the post-operative recurrence group. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Serine (or cysteine) peptidase inhibitors |
| Description | This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. | Chromosome | 7 |
| Location | 7q22.1 |
| Start | 101127089 |
| End | 101139266 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 12178 |
| OMIM ID | 173360 |
| HGNC ID | HGNC:8583 |
| Unigene ID | Hs.414795 |
| Ensembl ID | ENSG00000106366 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_000602.4 |
|---|---|
| Exon | join(1..156,1305..1576,3333..3566,4787..4981,6607..6805, 8406..8506,8627..8713,9913..9996,10317..12178) | mRNA Sequence | Download Select all |
| Length | 3207 |
CDS Information
| Location | join(1306..1576,3333..3566,4787..4981,6607..6805, 8406..8506,8627..8713,9913..9996,10317..10354) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS5711.1 |
Protein Information
| Protein ID | NP_000593.1 |
|---|---|
| Protein Name | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
| Molecular Wt. (Da) | 42769 |
| Protein Sequence | Download Select all |
| Length | 402 |
| Uniprot ID | Q14103 |
| Ensembl Protein ID | ENSP00000313199 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 232 |
| N | Glycosylation | 288 |
| S | Proteolytic Cleavage | 360 |
| V | Proteolytic Cleavage | 364 |
| R | Proteolytic Cleavage | 379 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1991 | ELANE | 554 | NP_001963.1 | in vitro | 7521069 |
| 3488 | IGFBP5 | 901 | NP_000590.1 | in vitro;in vivo | 9202242 |
| 3875 | KRT18 | 1020 | NP_000215.1 | in vitro;yeast 2-hybrid | 15493875 |
| 4035 | LRP1 | 138 | NP_002323.2 | in vitro;in vivo | 15001579 |
| 5004 | ORM1 | 724 | NP_000598.2 | in vitro;yeast 2-hybrid | 11418606 |
| 5340 | PLG | 1417 | NP_000292.1 | in vitro | 11113116 |
| 56893 | UBQLN4 | 5670 | NP_064516.2 | yeast 2-hybrid | 16713569 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| AGE-RAGE signaling pathway in diabetic complications | hsa04933 |
| Chagas disease (American trypanosomiasis) | hsa05142 |
| Complement and coagulation cascades | hsa04610 |
| HIF-1 signaling pathway | hsa04066 |
| Hippo signaling pathway | hsa04390 |
| p53 signaling pathway | hsa04115 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd02051 | 25-402 | PAI-1_nexin-1 |
| cl00137 | 25-402 | SERPIN superfamily |
| smart00093 | 40-402 | SERPIN |
| pfam00079 | 36-402 | Serpin |
| cd00172 | 36-399 | SERPIN |
| cd02048 | 36-402 | neuroserpin |
| cd02049 | 37-399 | bacterial_SERPIN |
| cd02044 | 36-402 | ov-serpin |
| cd02058 | 38-402 | PAI-2 |
| COG4826 | 38-402 | SERPIN |
| cd02056 | 36-399 | alpha-1-antitrypsin_like |
| cd02059 | 37-402 | ovalbumin_like |
| cd02043 | 47-402 | plant_SERPIN |
| cd02055 | 36-399 | PZI |
| cd02045 | 36-399 | antithrombin-III_like |
| cd02057 | 36-402 | maspin_like |
| cd02047 | 34-402 | HCII |
| PHA02948 | 39-402 | PHA02948 |
| cd02052 | 27-402 | PEDF |
| cd02053 | 38-399 | alpha2AP |
| cd02050 | 37-399 | C1_inh |
| cd02054 | 30-402 | angiotensinogen |
| cd02046 | 31-399 | hsp47 |
| PHA02660 | 54-402 | PHA02660 |
Ontology Information
| HPRD ID | 850 |
|---|---|
| Molecular Class | Protease inhibitor |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P05121 | DB00009 | Alteplase | BiotechDrug |
| P05121 | DB00013 | Urokinase | BiotechDrug |
| P05121 | DB00015 | Reteplase | BiotechDrug |
| P05121 | DB00029 | Anistreplase | BiotechDrug |
| P05121 | DB00031 | Tenecteplase | BiotechDrug |
| P05121 | DB00055 | Drotrecogin alfa | BiotechDrug |