Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SFRP2 | 6423 | Secreted frizzled-related protein 2 | 4 | FRP-2; SARP1; SDF-5 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22703586 | 2012 | Cell line : - Source : Xinhua Hospital, School of Medicine, Shanghai Jiaotong University. Sample Type : CRC tumor and normal tissue No. of Sample : 40 CRC tissues and matched adjacent normal colorectal mucosa Stage : - | real time RT-PCR, TargetScan and miRanda, microarray analysis | Down-regulation | - | SFRP1 expression level is decreased due to Up-regulation of SFRP2 specific micro RNA mir- 21 and mir 29a. |
| 25053594 | 2014 | Cell line : HCT116, SW480 Source : Comprehensive Cancer Center of Case Western Reserve University andUniversity Hospitals of Cleveland Sample Type : - No. of Sample : - Stage : - | Meta-analysis | Hypermethylation | - | SFRP2 hypermethylation is an important biomarker both in noninvasive diagnosis in feces detection and in colon tissue. |
| 18203283 | 2008 | Cell line : - Source : - Sample Type : Solid tissue, stool and serum samples No. of Sample : 169 CRC patients, 63 patients with advanced adenomas, 46 patients with non-adenomatous polyps and 30 normal healthy controls Stage : - | Fluorescence-based real-time PCR (MethyLight) | Hypermethylation | - | Hypermethylation of SFRP2 gene in fecal DNA is a novel molecular biomarker of CRC and carries a high potential for the remote detection of CRC and premalignant lesions as noninvasive screening method. SFRP2 gene was hypermethylated in 91.3% (63/69) CRC, 79.4% (27/34) and 53.8% (14/26) adenoma and hyperplastic polyp tissues, and in 87.0% (60/69), 61.8% (21/34) and 42.3% (11/26) of corresponding fecal samples, respectively. Sample size: 69 patients with sporadic CRC, 60 patients with benign colorectal diseases (34 adenomas and 26 hyperplastic polyps) and 30 macroscopically normal subjects. |
| 15034581 | 2004 | Cell line : - Source : Okayama University Hospital, Japan. Sample Type : - No. of Sample : 222 CRC and 208 Normal colorectal mucosa sample Stage : - | Methylation specific PCR, RT-PCR, Cloning, Reporter assay,Northern blotting,Colony formation assay | Methylation | - | Restoration of SFRP function in colorectal cancer cells attenuates WNT signaling even in the presence of downstream mutations. Epigenetic loss of SFRP function occurs early in colorectal cancer progression and may thus provide constitutive WNT signaling. |
| 21463549 | 2011 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 2,912 samples, including 1,436 patients with CRC, 866 patients with colon adenomas or polyps, and 610 samples with both normal controls Stage : - | Methylation-specific PCR | Methylation | - | Serum SFRP2 methylation status represents a promising, non-invasive marker for CRC detection and staging. Hypermethylated SFRP2 may have prognostic relevance in patients with CRC. |
| 21709714 | 2011 | Cell line : - Source : First Affiliated Hospital of Yangzhou university Sample Type : - No. of Sample : - Stage : - | DNA isolation and Bisulphide modification, combined busulfide restriction analysis assay | Methylation | - | Expansion of CpG methylation in the SFRP2 promoter region during colorectal tumorigenesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Secreted frizzled-related proteins |
| Description | This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008] | Chromosome | 4 |
| Location | 4q31.3 |
| Start | 153780590 |
| End | 153789076 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 8487 |
| OMIM ID | 604157 |
| HGNC ID | HGNC:10777 |
| Unigene ID | Hs.481022 |
| Ensembl ID | ENSG00000145423 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_003013.2 |
|---|---|
| Exon | join(1..743,3133..3213,7322..8487) | mRNA Sequence | Download Select all |
| Length | 2005 |
CDS Information
| Location | join(242..743,3133..3213,7322..7626) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS34082.1 |
Protein Information
| Protein ID | NP_003004.1 |
|---|---|
| Protein Name | Secreted frizzled-related protein 2 |
| Molecular Wt. (Da) | 31492 |
| Protein Sequence | Download Select all |
| Length | 295 |
| Uniprot ID | P11509 |
| Ensembl Protein ID | ENSP00000301141 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 289;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5076 | PAX2 | 1330 | NP_003981.2 | in vitro | 14561758 |
| 7471 | WNT1 | 1276 | NP_005421.1 | in vitro | 10654605 |
| 54361 | WNT4 | 4601 | NP_110388.2 | in vivo | 9853965 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07446 | 36-163 | CRD_SFRP2 |
| cl02447 | 36-163 | CRD_FZ superfamily |
| cd03580 | 169-295 | NTR_Sfrp1_like |
| cl02512 | 169-295 | NTR_like superfamily |
| cd07444 | 36-155 | CRD_SFRP5 |
| smart00063 | 43-154 | FRI |
| cd07453 | 38-177 | CRD_crescent |
| cd07443 | 36-153 | CRD_SFRP1 |
| pfam01392 | 40-153 | Fz |
| cd07066 | 40-154 | CRD_FZ |
| cd07452 | 38-175 | CRD_sizzled |
| cd07448 | 40-150 | CRD_FZ4 |
| cd07457 | 38-153 | CRD_FZ9_like |
| cd07456 | 40-153 | CRD_FZ5_like |
| cd07461 | 36-159 | CRD_FZ8 |
| cd07463 | 40-153 | CRD_FZ9 |
| cd07458 | 40-153 | CRD_FZ1_like |
| cd07460 | 40-153 | CRD_FZ5 |
| cd07462 | 40-153 | CRD_FZ10 |
| cd07466 | 40-160 | CRD_FZ7 |
| cd07465 | 40-163 | CRD_FZ1 |
| cd07464 | 40-147 | CRD_FZ2 |
| cd07449 | 40-147 | CRD_FZ3 |
| cd07454 | 43-153 | CRD_LIN_17 |
| cd07888 | 39-153 | CRD_corin_2 |
| cd07442 | 29-153 | CRD_SFRP4 |
| cd07441 | 38-153 | CRD_SFRP3 |
| pfam01759 | 187-288 | NTR |
| cd07450 | 40-146 | CRD_FZ6 |
| smart00643 | 186-288 | C345C |
| cd07455 | 37-150 | CRD_Collagen_XVIII |
| cd07447 | 46-145 | CRD_Carboxypeptidase_Z |
| cd03523 | 187-272 | NTR_like |
| cd07445 | 87-145 | CRD_corin_1 |
Ontology Information
| HPRD ID | 324 |
|---|---|
| Molecular Class | Secreted polypeptide |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.