Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SFRP4 | 6424 | secreted frizzled-related protein 4 | 7 | frpHE, FRP-4, FRPHE |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19730886 | 2010 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 20 Stage : - | real time RT-PCR,Western blotting,immunohistochemistry | Up-regulation | - | SFRP1 and SFRP4 appear to be candidate markers for colorectal lesions. Unlike SFRP1 as a negative regulator for CRC carcinogenesis, SFRP4 may play quite different biological role in CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Secreted frizzled-related proteins |
| Description | Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008 | Chromosome | 7 |
| Location | 7p14.1 |
| Start | 37945534 |
| End | 37956525 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 10992 |
| OMIM ID | 606570 |
| HGNC ID | HGNC:10778 |
| Unigene ID | Hs.658169 |
| Ensembl ID | ENSG00000106483 |
| PharmGKB ID | PA35694 |
mRNA Information
| mRNA ID | ?NM_003014.3 |
|---|---|
| Exon | join(1..831,2471..2551,2646..2711,4607..4805,7244..7307, 9260..10992) | mRNA Sequence | Download Select all |
| Length | 2974 |
Protein Information
| Protein ID | NP_003005.2 |
|---|---|
| Protein Name | secreted frizzled-related protein 4 |
| Molecular Wt. (Da) | 39456 |
| Protein Sequence | Download Select all |
| Length | 346 |
| Uniprot ID | O95831 |
| Ensembl Protein ID | ENSP00000287295 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07442 | 20-146 | CRD_SFRP4 |
| cl02447 | 20-146 | CRD_FZ superfamily |
| cd07441 | 22-144 | CRD_SFRP3 |
| cd03581 | 188-296 | NTR_Sfrp3_like |
| cl02512 | 188-296 | NTR_like superfamily |
| pfam01392 | 24-137 | Fz |
| smart00063 | 24-139 | FRI |
| cd07456 | 24-129 | CRD_FZ5_like |
| cd07458 | 24-137 | CRD_FZ1_like |
| cd07066 | 24-140 | CRD_FZ |
| cd07460 | 24-133 | CRD_FZ5 |
| cd07463 | 20-149 | CRD_FZ9 |
| cd07457 | 22-129 | CRD_FZ9_like |
| cd07461 | 24-130 | CRD_FZ8 |
| cd07466 | 24-137 | CRD_FZ7 |
| cd07448 | 24-130 | CRD_FZ4 |
| cd07465 | 24-134 | CRD_FZ1 |
| cd07464 | 24-129 | CRD_FZ2 |
| cd07462 | 24-129 | CRD_FZ10 |
| cd07449 | 24-139 | CRD_FZ3 |
| cd07453 | 22-151 | CRD_crescent |
| cd07452 | 31-139 | CRD_sizzled |
| cd07888 | 24-140 | CRD_corin_2 |
| cd07450 | 24-129 | CRD_FZ6 |
| cd07444 | 29-138 | CRD_SFRP5 |
| cd07446 | 20-139 | CRD_SFRP2 |
| cd07443 | 23-138 | CRD_SFRP1 |
| pfam01759 | 194-287 | NTR |
| cd07454 | 24-139 | CRD_LIN_17 |
| cd07447 | 21-139 | CRD_Carboxypeptidase_Z |
| cd07445 | 24-140 | CRD_corin_1 |
| cd07455 | 29-137 | CRD_Collagen_XVIII |
| cd03523 | 196-280 | NTR_like |
| cd07451 | 48-134 | CRD_SMO |
| smart00643 | 189-296 | C345C |
| cd03579 | 197-301 | NTR_netrin-1_like |
Ontology Information
| HPRD ID | 4801 |
|---|---|
| Molecular Class | Secreted polypeptide |
| Molecular Function | Kinase regulator activity (GO:0019207) |
| Biological Process | Regulation of cell cycle (GO:0000074) |
Drug Information
No matching records could be found.