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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23850494 | 2013 | Cell line : - Source : Korean Patient Sample Type : Methacarn-fixed GC and CRC tissues No. of Sample : 91 sporadic GCs and 100 CRCs Stage : TNM Stage I-IV | Immunohistochemistry,SSCP, DNA sequencing | Frameshift Mutation | - | Frameshift mutations of SGOL1 and PDS5B and the loss of their expression may be a feature of gastric and colorectal cancers with high microsatellite instability. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714). Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID:25282101). Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence. Pseudogenes of this gene have been found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015] | Chromosome | 3 |
| Location | 3p24.3 |
| Start | 20202085 |
| End | 20227724 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 25640 |
| OMIM ID | 609168 |
| HGNC ID | HGNC:25088 |
| Unigene ID | Hs.105153 |
| Ensembl ID | ENSG00000129810 |
| PharmGKB ID | PA134988556 |
Protein Information
| Protein ID | NP_001012409.1 |
|---|---|
| Protein Name | shugoshin-like 1 (S. pombe) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 561 |
| Uniprot ID | Q8TE60 |
| Ensembl Protein ID | ENSP00000282849 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 256 |
| S | Phosphorylation | 256 |
| T | Phosphorylation | 425 |
| T | Phosphorylation | 433 |
| T | Phosphorylation | 425 |
| T | Phosphorylation | 433 |
| S | Phosphorylation | 238 |
| S | Phosphorylation | 507 |
| S | Phosphorylation | 507 |
| S | Phosphorylation | 255 |
| S | Phosphorylation | 255 |
| S | Phosphorylation | 238 |
| S | Phosphorylation | 199 |
| S | Phosphorylation | 468 |
| S | Phosphorylation | 468 |
| S | Phosphorylation | 216 |
| S | Phosphorylation | 216 |
| S | Phosphorylation | 199 |
| T | Phosphorylation | 429 |
| S | Phosphorylation | 436 |
| T | Phosphorylation | 429 |
| S | Phosphorylation | 436 |
| S | Phosphorylation | 190 |
| S | Phosphorylation | 192 |
| S | Phosphorylation | 459 |
| S | Phosphorylation | 461 |
| S | Phosphorylation | 459 |
| S | Phosphorylation | 461 |
| S | Phosphorylation | 207 |
| S | Phosphorylation | 209 |
| S | Phosphorylation | 207 |
| S | Phosphorylation | 209 |
| S | Phosphorylation | 190 |
| S | Phosphorylation | 192 |
| T | Phosphorylation | 231 |
| T | Phosphorylation | 500 |
| T | Phosphorylation | 500 |
| T | Phosphorylation | 248 |
| T | Phosphorylation | 248 |
| T | Phosphorylation | 231 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2547 | XRCC6 | 1071 | NP_001460.1 | in vivo | 16541024 |
| 4736 | RPL10A | 10199 | NP_009035.3 | in vivo | 16541025 |
| 5515 | PPP2CA | 8912 | NP_002706.1 | in vivo | 16541025 |
| 5516 | PPP2CB | 1487 | NP_004147.1 | in vivo | 1 654 102 416 541 020 |
| 5518 | PPP2R1A | 16184 | NP_055040.2 | in vivo | 1 654 102 416 541 020 |
| 5519 | PPP2R1B | 4384 | NP_859050.1 | in vivo;yeast 2-hybrid | 1 654 102 416 541 020 |
| 5525 | PPP2R5A | 3384 | NP_006234.1 | in vivo | 1 654 102 416 541 020 |
| 5526 | PPP2R5B | 9038 | NP_006235.1 | in vivo | 1 654 102 416 541 020 |
| 5527 | PPP2R5C | 3385 | NP_002710.2 | in vivo | 1 654 102 416 541 020 |
| 5528 | PPP2R5D | 9039 | NP_006236.1 | in vivo;yeast 2-hybrid | 1 654 102 416 541 020 |
| 5529 | PPP2R5E | 9040 | NP_006237.1 | in vivo | 1 654 102 416 541 020 |
| 5591 | PRKDC | 2941 | NP_008835.5 | in vivo | 16541024 |
| 6129 | RPL7 | 5004 | NP_000962.2 | in vivo | 16541025 |
| 6130 | RPL7A | 1712 | NP_000963.1 | in vivo | 16541025 |
| 6158 | RPL28 | 4702 | NP_001129607.1 | in vivo | 16541025 |
| 6176 | RPLP1 | 1611 | NP_000994.1 | in vivo | 16541025 |
| 6418 | SET | 9023 | NP_001116293.1 | in vivo | 16541025 |
| 7520 | XRCC5 | 8935 | NP_066964.1 | in vivo | 16541024 |
| 55379 | LRRC59 | 15181 | NP_060979.2 | in vivo | 16541025 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Oocyte meiosis | hsa04114 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam07558 | 22-67 | Shugoshin_N |
| cl06547 | 22-67 | Shugoshin_N superfamily |
| pfam07557 | 471-496 | Shugoshin_C |
| cl06546 | 471-496 | Shugoshin_C superfamily |
Ontology Information
| HPRD ID | 16505 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.