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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SHC1 6464 SHC (Src homology 2 domain containing) transforming protein 1  1p66 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22433385   2012Cell line : -

Source : -

Sample Type : CRC Tumor

No. of Sample : 158 tissue samples, 36 NSCLCs, 43 CRCs, and their corresponding control tissues obtained from patients.

Stage : -

qRT-PCRUp-regulation-In NSCLC, the failure of pathways which involve factors such as DAPK1, GADD45A, SHC1, and TP53, in response to short telomeres, could promote tumor progression.


Gene Details



NC_000001.10 (154934774..154946959, complement)

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Gene Type protein coding
Gene Family SH2 domain containing
Description This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]  
Chromosome 1
Location 1q21
Start 154934774  
End 154946959  
Strand -  
Gene Sequence

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Length 12186  
OMIM ID 600560   
HGNC ID HGNC:10840   
Unigene ID Hs.433795   
Ensembl ID ENSG00000160691   
PharmGKB ID PA35746   

mRNA Information


mRNA ID ?NM_001130040.1
Exon complement(11868..>12195)  
mRNA Sequence

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Length 1066  



CDS Information


   
Location 54..710
CDS Sequence

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CCDS ID CCDS1076.1



Protein Information


      
Protein IDNP_001123512.1
Protein NameSHC (Src homology 2 domain containing) transforming protein 1
Molecular Wt. (Da)46474
Protein Sequence

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Length 583  
Uniprot IDQ9UQ84
Ensembl Protein ID ENSP00000311873  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation349
YPhosphorylation350
YPhosphorylation239
YPhosphorylation240
YPhosphorylation349
YPhosphorylation350
YPhosphorylation239
YPhosphorylation240
YDephosphorylation349
YPhosphorylation239
YPhosphorylation240
YPhosphorylation318
YPhosphorylation427
YPhosphorylation318
YPhosphorylation427
YPhosphorylation318
YPhosphorylation427
YPhosphorylation318
SPhosphorylation139
SPhosphorylation29
YPhosphorylation349
YPhosphorylation350
YPhosphorylation427
YPhosphorylation239
YPhosphorylation240
TPhosphorylation145;-
TPhosphorylation35;-
SPhosphorylation426
SPhosphorylation317

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
238ALK104NP_004295.2in vivo9174053   
351APP100NP_000475.1in vitro;in vivo;yeast 2-hybrid118   774   209   045   663   
602BCL3179NP_005169.2in vivo11707390   
613BCR1044NP_004318.3in vitro9209414   
634CEACAM1191NP_001703.2in vitro11694516   
780DDR12678NP_054700.2in vitro;in vivo10783152   
800CALD1251NP_149129.2in vitro10559276   
867CBL1320NP_005179.2in vitro;in vivo10   570   290   862   171   900   000   000   000   000   
919CD2471729NP_932170.1in vivo8656061   
933CD22114NP_001762.2in vitro;in vivo10748054   
975CD818924NP_004347.1in vivo14676841   
1432MAPK142619NP_001306.1in vivo15688026   
1439CSF2RB739NP_000386.1in vitro1   070   482   510   477   720   
1441CSF3R737NP_724781.1in vivo9824671   
1445CSK496NP_004374.1in vitro;in vivo1   204   819   410   037   690   
1605DAG1546NP_004384.3in vivo11724572   
1796DOK14228NP_001372.1in vitro11071635   
1956EGFR579NP_005219.2in vitro;in vivo9   544   989   888   765   310   000   000   000   000   000   000   000   
1969EPHA21494NP_004422.2in vitro;in vivo12400011   
2057EPOR587NP_000112.1in vitro8400282   
2059EPS82563NP_004438.3in vitro;in vivo7791787   
2064ERBB21281NP_004439.2in vitro;in vivo97   105   881   672   904   300   000   000   
2065ERBB31820NP_001973.2in vivo969   485   016   729   043   
2099ESR1589NP_000116.2in vitro;in vivo11773443   
2212FCGR2A906NP_001129691.1in vitro103   827   618   940   017   
2214FCGR3A903NP_000560.5in vitro9378963   
2260FGFR1634NP_000595.1in vitro7514169   
2321FLT11297NP_002010.2in vitro;in vivo;yeast 2-hybrid10749680   
2324FLT4636NP_891555.2in vitro;in vivo767   545   186   627   489   000   000   
2885GRB2150NP_002077.1in vitro;in vivo117   074   057   524   086   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   
2886GRB73311NP_005301.2in vitro;in vivo8940081   
2889RAPGEF12627NP_941372.1in vivo9344843   
3558IL2979NP_000577.2in vitro10662798   
3560IL2RB896NP_000869.1in vitro;in vivo106   020   278   294   403   
3561IL2RG2391NP_000197.1in vitro8643566   
3566IL4R990NP_000409.1in vivo1   065   221   111   714   800   
3667IRS1943NP_005535.1in vitro7499194   
3691ITGB4946NP_000204.3in vitro11044453   
3717JAK2993NP_004963.1in vitro;in vivo75   357   739   126   968   
3791KDR1867NP_002244.1yeast 2-hybrid10749680   
3875KRT181020NP_000215.1in vitro12577067   
4035LRP1138NP_002323.2in vitro;in vivo1   278   926   712   069   750   
4058LTK1052NP_002335.2in vitro9223670   
4067LYN1301NP_002341.1in vitro7650013   
4233MET1280NP_001120972.1in vivo7731718   
4311MME392NP_000893.2in vitro9659899   
4486MST1R2545NP_002438.2in vivo8918464   
4804NGFR1197NP_002498.1in vivo7541035   
4916NTRK31870NP_001012338.1in vitro7657612   
4921DDR21868NP_006173.2in vivo;yeast 2-hybrid11884411   
5058PAK13995AAC24716.1in vitro15688026   
5159PDGFRB1423NP_002600.1in vivo8195171   
5295PIK3R11381NP_852664.1in vitro;in vivo8   662   998   862   171   910   000   000   
5336PLCG22570AAH11772.1in vivo10623845   
5580PRKCD1501NP_006245.2in vivo12024011   
5594MAPK11496NP_002736.3in vitro;in vivo10996427   
5599MAPK83100NP_620637.1in vivo15688026   
5781PTPN111470NP_002825.3in vitro10650943   
5782PTPN122513NP_002826.3in vitro;in vivo;yeast 2-hybrid79   292   141   143   282   900   000   000   000   000   000   000   000   
5979RET1266NP_066124.1in vitro;in vivo81   835   619   047   384   
6654SOS11681NP_005624.2in vitro;in vivo75   205   238   631   299   
6655SOS23149NP_008870.2in vivo10675333   
6667SP11796NP_612482.2in vitro7933095   
6776STAT5A3301NP_003143.2in vitro10996427   
6777STAT5B5037NP_036580.2in vitro10996427   
7006TEC2786NP_003206.2in vitro;in vivo11825908   
7409VAV11284NP_005419.2in vivo15688026   
7535ZAP701495NP_001070.2in vitro;in vivo96   854   048   761   298   700   000   000   000   000   
10241CALCOCO26846NP_005822.1yeast 2-hybrid16189514   
10603SH2B216097NP_066189.3in vitro9233773   
10750GRAP5062NP_006604.1in vitro;in vivo8995379   


Pathway Information


                                                                                          
Pathway Name Pathway ID
Alcoholism hsa05034
Bacterial invasion of epithelial cells hsa05100
Chemokine signaling pathway hsa04062
Chronic myeloid leukemia hsa05220
ErbB signaling pathway hsa04012
Estrogen signaling pathway hsa04915
Focal adhesion hsa04510
Glioma hsa05214
Insulin signaling pathway hsa04910
MicroRNAs in cancer hsa05206
Natural killer cell mediated cytotoxicity hsa04650
Neurotrophin signaling pathway hsa04722
Phospholipase D signaling pathway hsa04072
Prolactin signaling pathway hsa04917
Ras signaling pathway hsa04014


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd01209146-317  PTB_Shc
cl17171146-317  PH-like superfamily
cd09925480-583  SH2_SHC
cl15255480-583  SH2 superfamily
pfam00640162-317  PID
smart00462157-317  PTB
cd10361481-566  SH2_Fps_family
pfam00017488-559  SH2
smart00252486-565  SH2
cd10337481-581  SH2_BCAR3
cd00173487-559  SH2
cd00934160-308  PTB
cd09935486-563  SH2_ABL
cd10346483-568  SH2_SH2B_family
cd09931488-581  SH2_C-SH2_SHP_like
cd10341485-564  SH2_N-SH2_PLC_gamma_like
cd10347488-532  SH2_Nterm_shark_like
cd09937487-561  SH2_csk_like
cd10412487-566  SH2_SH2B3
cd01274148-317  PTB_Anks
cd09945486-579  SH2_SHB_SHD_SHE_SHF_like
cd10348488-560  SH2_Cterm_shark_like
cd01273149-318  PTB_CED-6
cd09933486-523  SH2_Src_family
cd09944484-581  SH2_Grb7_family
cd09943486-575  SH2_Nck_family
cd10411482-568  SH2_SH2B2
cd10352489-562  SH2_a2chimerin_b2chimerin
cd09940482-579  SH2_Vav_family
cd10354487-559  SH2_Cterm_RasGAP
cd09932485-564  SH2_C-SH2_PLC_gamma_like
cd09942482-581  SH2_nSH2_p85_like
cd10410483-569  SH2_SH2B1
cd09941487-563  SH2_Grb2_like
cd10392488-579  SH2_SHF
cd10365484-559  SH2_Src_Src
cd10350486-575  SH2_SH2D4A
cd13161225-309  PTB_TK_HMTK
cd10351487-578  SH2_SH2D4B
cd10409488-580  SH2_Nck2
cd10413484-562  SH2_Grb7
cd09929483-579  SH2_BLNK_SLP-76
cd10408487-579  SH2_Nck1
cd09926488-522  SH2_CRK_like
cd09934488-579  SH2_Tec_family
cd10414484-539  SH2_Grb14
cd10353488-559  SH2_Nterm_RasGAP
cd10356482-557  SH2_ShkA_ShkC
cd10340488-563  SH2_N-SH2_SHP_like
cd10369486-562  SH2_Src_Frk
cd10418484-561  SH2_Src_Fyn_isoform_a_like
cd10349487-559  SH2_SH2D2A_SH2D7
cd10391486-579  SH2_SHE
cd10407485-564  SH2_Vav3
cd10368484-559  SH2_Src_Fyn
cd10367484-561  SH2_Src_Fgr
cd09938487-581  SH2_N-SH2_Zap70_Syk_like
cd10362486-559  SH2_Src_Lck
cd10390486-579  SH2_SHD
cd10406487-564  SH2_Vav2
cd10366484-562  SH2_Src_Yes
cd13157228-314  PTB_tensin-related
cd10405488-564  SH2_Vav1
cd10399486-579  SH2_Tec_Bmx
cd10343485-581  SH2_SHIP
cd10344488-580  SH2_SLAP
cd10401487-568  SH2_C-SH2_Syk_like
cd10419485-561  SH2_Src_Fyn_isoform_b_like
cd10383480-560  SH2_SOCS2
cd10415484-562  SH2_Grb10
cd10397488-568  SH2_Tec_Btk
cd10389488-579  SH2_SHB
cd10417487-559  SH2_SH2D7
cd10355481-554  SH2_DAPP1_BAM32_like
cd10402487-578  SH2_C-SH2_Zap70
cd09930488-532  SH2_cSH2_p85_like
cd09923487-560  SH2_SOCS_family
cd10370486-532  SH2_Src_Src42
cd10342487-522  SH2_SAP1
cd10358486-564  SH2_PTK6_Brk
cd10400489-528  SH2_SAP1a
cd10363486-559  SH2_Src_HCK
cd10360487-559  SH2_Srm
cd01208159-317  PTB_X11
cd09927488-522  SH2_Tensin_like
cd10416482-581  SH2_SH2D2A
cd01268148-288  PTB_Numb
cd10398488-579  SH2_Tec_Txk
cd01269235-308  PTB_TBC1D1_like
cd10396488-562  SH2_Tec_Itk
cd10345487-577  SH2_C-SH2_Zap70_Syk_like


Ontology Information


   
HPRD ID5487
Molecular ClassAdapter molecule
Molecular FunctionG-protein coupled receptor activity (GO:0004930)
Biological ProcessSignal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO