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General Information
- Evidence
- Gene
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25312940 | 2015 | Cell line : HCT116 and A549 Source : - Sample Type : - No. of Sample : - Stage : - | MTT assay,Colony formation assay,In vitro wound-healing assay,Western blotting,RT-PCR, Annexin V/Propidium iodide staining | Up-regulation | - | Inhibition of SIRT2 using AK-1 would be a beneficial intervention in the treatment of colon cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010] | Chromosome | 19 |
| Location | 19q13 |
| Start | 39369195 |
| End | 39390502 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 21308 |
| OMIM ID | 604480 |
| HGNC ID | HGNC:10886 |
| Unigene ID | Hs.466693 |
| Ensembl ID | ENSG00000068903 |
| PharmGKB ID | PA35786 |
Protein Information
| Protein ID | NP_001180215.1 |
|---|---|
| Protein Name | sirtuin 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 389 |
| Uniprot ID | Q9UNL4 |
| Ensembl Protein ID | ENSP00000343396 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 368;- |
| S | Phosphorylation | 331;- |
| S | Phosphorylation | 46;- |
| T | Phosphorylation | 365 |
| T | Phosphorylation | 328 |
| S | Phosphorylation | 23 |
| S | Phosphorylation | 27 |
| S | Phosphorylation | 25 |
| S | Phosphorylation | 366 |
| S | Phosphorylation | 329 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2648 | KAT2A | 3807 | NP_066564.2 | in vivo | 12887892 |
| 7277 | TUBA4A | 1851 | NP_005991.1 | in vitro;in vivo | 12620231 |
| 8555 | CDC14B | 4615 | NP_201588.1 | in vitro;in vivo | 12697818 |
| 8850 | KAT2B | 6780 | NP_003875.3 | in vivo | 12887892 |
| 10013 | HDAC6 | 2228 | NP_006035.2 | in vivo | 12620231 |
| 11262 | SP140 | 9780 | NP_009168.4 | in vivo | 12887892 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01408 | 77-331 | SIRT1 |
| cl00195 | 77-331 | SIR2 superfamily |
| cd01407 | 77-296 | SIR2-fam |
| cd00296 | 77-295 | SIR2 |
| PTZ00410 | 56-291 | PTZ00410 |
| pfam02146 | 84-268 | SIR2 |
| COG0846 | 77-276 | SIR2 |
| cd01413 | 74-272 | SIR2_Af2 |
| PRK00481 | 77-296 | PRK00481 |
| PRK14138 | 76-285 | PRK14138 |
| cd01411 | 78-288 | SIR2H |
| cd01410 | 78-285 | SIRT7 |
| cd01412 | 77-288 | SIRT5_Af1_CobB |
| cd01409 | 73-266 | SIRT4 |
| PTZ00409 | 55-276 | PTZ00409 |
| PTZ00408 | 75-296 | PTZ00408 |
| PRK05333 | 74-266 | PRK05333 |
| cd01406 | 78-172 | SIR2-like |
Ontology Information
| HPRD ID | 1075 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.