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General Information
- Evidence
- Gene
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25105144 | 2014 | Cell line : SW480,DLD 1 Source : Department of General Surgery at the Affiliated Hospital of Binzhou Medical University Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Immunohistochemistry,Western Blotting,Cell Proliferation Assay,Cell Migration Assay,Cell Invasion Assay | Up-regulation | - | SIRT3 is closely associated with the clinical outcomes of colon cancer. SIRT3 may be considered as a marker for colon cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008] | Chromosome | 11 |
| Location | 11p15.5 |
| Start | 215030 |
| End | 236362 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 21333 |
| OMIM ID | 604481 |
| HGNC ID | HGNC:14931 |
| Unigene ID | Hs.716456 |
| Ensembl ID | ENSG00000142082 |
| PharmGKB ID | PA37936 |
Protein Information
| Protein ID | NP_001017524.1 |
|---|---|
| Protein Name | sirtuin 3 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 399 |
| Uniprot ID | Q9H165 |
| Ensembl Protein ID | ENSP00000338774 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 103 |
| S | Phosphorylation | 118 |
| S | Phosphorylation | 105 |
| S | Phosphorylation | 114 |
| S | Phosphorylation | 101 |
| S | Phosphorylation | 117 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Central carbon metabolism in cancer | hsa05230 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01408 | 138-373 | SIRT1 |
| cl00195 | 138-373 | SIR2 superfamily |
| cd01407 | 138-365 | SIR2-fam |
| PTZ00410 | 121-349 | PTZ00410 |
| cd00296 | 138-365 | SIR2 |
| pfam02146 | 145-326 | SIR2 |
| COG0846 | 126-377 | SIR2 |
| cd01413 | 138-346 | SIR2_Af2 |
| PRK00481 | 125-377 | PRK00481 |
| PRK14138 | 137-344 | PRK14138 |
| cd01411 | 138-346 | SIR2H |
| cd01410 | 139-343 | SIRT7 |
| cd01412 | 138-374 | SIRT5_Af1_CobB |
| PTZ00409 | 123-330 | PTZ00409 |
| cd01409 | 138-324 | SIRT4 |
| PTZ00408 | 135-330 | PTZ00408 |
| PRK05333 | 138-324 | PRK05333 |
| cd01406 | 138-231 | SIR2-like |
Ontology Information
| HPRD ID | 12042 |
|---|---|
| Molecular Class | Enzyme: Deacetylase |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.