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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25951369 | 2015 | Cell line : HCT116 Source : DACHS study. Sample Type : Population based case control study No. of Sample : Cohort 1 of 128 patients with stage I-III colorectal cancer; cohort 2 included 817 patients with stage I-III colorectal cancer Stage : TNM stage I-III | Immunohistochemistry | Up-regulation | - | Overexpression of SIX1 induces a more mesenchymal-like phenotype in HCT-116 cells and enhances tumor migration. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Homeoboxes / SINE class |
| Description | The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq, Jul 2008] | Chromosome | 14 |
| Location | 14q23.1 |
| Start | 61111417 |
| End | 61116155 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 4739 |
| OMIM ID | 601205 |
| HGNC ID | HGNC:10887 |
| Unigene ID | Hs.633506 |
| Ensembl ID | ENSG00000126778 |
| PharmGKB ID | PA35787 |
mRNA Information
| mRNA ID | ?NM_005982.3 |
|---|---|
| Exon | join(1..808,2861..4739) | mRNA Sequence | Download Select all |
| Length | 2687 |
Protein Information
| Protein ID | NP_005973.1 |
|---|---|
| Protein Name | SIX homeobox 1 |
| Molecular Wt. (Da) | 79874 |
| Protein Sequence | Download Select all |
| Length | 284 |
| Uniprot ID | Q9HBW0 |
| Ensembl Protein ID | ENSP00000384665 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 166 | AES | 2556 | NP_945320.1 | in vitro;yeast 2-hybrid | 12441302 |
| 2139 | EYA2 | 9041 | NP_742111.1 | yeast 2-hybrid | 10906137 |
| 4188 | MDFI | 7280 | NP_005577.1 | yeast 2-hybrid | 16189514 |
| 7088 | TLE1 | 2557 | NP_005068.2 | in vitro;yeast 2-hybrid | 12441302 |
| 11007 | CCDC85B | 16101 | NP_006839.2 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00086 | 129-180 | homeodomain |
| cl00084 | 129-180 | homeodomain superfamily |
| smart00389 | 131-180 | HOX |
| pfam05920 | 142-178 | Homeobox_KN |
| pfam00046 | 130-180 | Homeobox |
| COG5576 | 124-188 | COG5576 |
Ontology Information
| HPRD ID | 4761 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Protein transporter activity (GO:0008565) |
| Biological Process | Regulation of cell cycle (GO:0000074); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.