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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SKI 6497 SKI proto-oncogene  1- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
15153332   2004Cell line : -

Source : -

Sample Type : CRC Tumor and normal tissue

No. of Sample : -

Stage : -

Multivariate Cox analysis,Amplification-Amplification of SKI is a negative prognostic marker in early-stage colorectal cancer.


Gene Details



NC_000001.10 (2160134..2241652)

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Gene Type protein coding
Gene Family SKI transcriptional corepressors
Description This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009]  
Chromosome 1
Location 1p36.33
Start 2160134  
End 2241652  
Strand +  
Gene Sequence

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Length 81519  
OMIM ID 164780   
HGNC ID HGNC:10896   
Unigene ID Hs.656507   
Ensembl ID ENSG00000157933   
PharmGKB ID PA35796   

mRNA Information


mRNA ID ?NM_003036.3
Exon join(1..1041,74284..74409,74591..74706,75146..75408, 75599..75891,77326..77556,77883..81519)  
mRNA Sequence

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Length 5707  



CDS Information


   
Location 73..2259
CDS Sequence

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CCDS ID CCDS39.1



Protein Information


      
Protein IDNP_003027.1
Protein NameSKI proto-oncogene
Molecular Wt. (Da)42681
Protein Sequence

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Length 728  
Uniprot IDQ99650
Ensembl Protein ID ENSP00000274276  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation432

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2736GLI21312NP_005261.2yeast 2-hybrid12435627   
5371PML23NP_150241.2in vitro;in vivo11430826   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam08782219-312  c-SKI_SMAD_bind
cl07406219-312  c-SKI_SMAD_bind superfamily
smart01046217-312  c-SKI_SMAD_bind
pfam0243793-192  Ski_Sno
cl0359293-192  Ski_Sno superfamily
PRK11020569-647  PRK11020
cl23284569-647  PRK11020 superfamily
smart00935604-708  OmpH
cl21485604-708  OmpH superfamily
pfam03938604-705  OmpH
cd07613543-605  BAR_Endophilin_A1
cl12013543-605  BAR superfamily
pfam07946555-648  DUF1682
cl20352555-648  DUF1682 superfamily
pfam10473590-708  CENP-F_leu_zip
cl22858590-708  CENP-F_leu_zip superfamily
cd07614543-605  BAR_Endophilin_A2
pfam06386566-709  GvpL_GvpF
cl05733566-709  GvpL_GvpF superfamily
TIGR02473566-708  flagell_FliJ
cl21477566-708  FliJ superfamily
pfam13863596-707  DUF4200
COG1196538-709  Smc
TIGR02168538-709  SMC_prok_B
COG1196538-709  Smc
COG1196538-709  Smc
TIGR02168538-709  SMC_prok_B
TIGR02169538-726  SMC_prok_A
TIGR02169537-710  SMC_prok_A
TIGR02168538-709  SMC_prok_B
TIGR02168573-709  SMC_prok_B
COG1196538-709  Smc
COG1196538-727  Smc
PRK03918539-707  PRK03918
COG1196538-708  Smc
TIGR02168538-727  SMC_prok_B
TIGR02168538-709  SMC_prok_B
TIGR02168538-728  SMC_prok_B
COG0419539-708  SbcC
PRK03918538-709  PRK03918
TIGR02169546-708  SMC_prok_A
COG1196538-727  Smc
PTZ00121473-703  PTZ00121
PTZ00121538-721  PTZ00121
pfam09731564-709  Mitofilin
PRK02224540-709  PRK02224
COG2433565-726  COG2433
TIGR02168538-698  SMC_prok_B
COG1196587-709  Smc
COG0419552-709  SbcC
PRK12704569-708  PRK12704
COG0419538-709  SbcC
pfam01576539-727  Myosin_tail_1
TIGR02169538-709  SMC_prok_A
pfam13868538-708  Trichoplein
COG0419538-709  SbcC
COG4942538-708  EnvC
COG0419538-727  SbcC
PRK03918540-709  PRK03918
pfam04156581-710  IncA
pfam01576537-709  Myosin_tail_1
pfam09726576-708  Macoilin
COG0419538-707  SbcC
COG2268570-725  YqiK
PRK03918556-707  PRK03918
PTZ00121541-708  PTZ00121
pfam04849580-708  HAP1_N
TIGR02169538-707  SMC_prok_A
pfam05483539-708  SCP-1
PRK00409589-722  PRK00409
pfam05276541-723  SH3BP5
pfam12128538-713  DUF3584
PTZ00121556-725  PTZ00121
pfam01442575-711  Apolipoprotein
TIGR02169537-727  SMC_prok_A
TIGR02169599-709  SMC_prok_A
COG1579586-727  COG1579
COG4372565-713  COG4372
PTZ00121543-700  PTZ00121
TIGR02169543-727  SMC_prok_A
pfam13870564-709  DUF4201
pfam13868556-718  Trichoplein
TIGR00618538-708  sbcc
COG0419537-707  SbcC
pfam00769589-728  ERM
pfam02463568-709  SMC_N
COG4477538-707  EzrA
PRK04863556-718  mukB
pfam13851610-706  GAS
PTZ00449318-478  PTZ00449
PTZ00121539-707  PTZ00121
COG1196538-649  Smc
pfam01576541-709  Myosin_tail_1
pfam11600567-695  CAF-1_p150
PRK14951375-483  PRK14951
PRK02224538-719  PRK02224
PRK12472573-694  PRK12472
pfam05483538-709  SCP-1
COG4942540-666  EnvC
PRK03918544-708  PRK03918
COG0419538-709  SbcC
COG1390586-709  NtpE
pfam09728537-709  Taxilin
pfam13514539-726  AAA_27
pfam13868557-708  Trichoplein
PTZ00121574-708  PTZ00121
pfam02463556-716  SMC_N
pfam13851538-709  GAS
PTZ00121555-718  PTZ00121
pfam05701574-707  WEMBL
pfam00529573-709  HlyD
PRK02224538-707  PRK02224
pfam12128538-709  DUF3584
TIGR04523538-709  Mplasa_alph_rch
COG0419541-709  SbcC
pfam12128576-727  DUF3584
pfam05911560-689  DUF869
PRK11637557-662  PRK11637
TIGR00606539-707  rad50
PRK04778537-707  PRK04778
pfam05557570-707  MAD
PRK04863539-695  mukB
pfam13166538-709  AAA_13
pfam01442605-711  Apolipoprotein
pfam05557538-680  MAD
COG1579538-648  COG1579
PTZ00121543-708  PTZ00121
pfam13868539-707  Trichoplein
PRK03992575-625  PRK03992
pfam00038570-709  Filament
TIGR03185545-727  DNA_S_dndD
COG4942561-697  EnvC
COG4717557-709  YhaN
pfam06160537-707  EzrA
TIGR04523538-708  Mplasa_alph_rch
pfam12128537-722  DUF3584
pfam04111592-700  APG6
pfam15450566-709  DUF4631
PRK12284539-694  PRK12284
pfam07227541-709  DUF1423
pfam10147599-709  CR6_interact
pfam01576539-709  Myosin_tail_1
COG4487546-721  COG4487
COG3547579-714  COG3547
TIGR03319573-708  RNase_Y
COG1196597-709  Smc
TIGR03185615-708  DNA_S_dndD


Ontology Information


   
HPRD ID2262
Molecular ClassTranscription factor
Molecular FunctionCalcium ion binding (GO:0005509)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO