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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SLC22A18 | 5002 | solute carrier family 22, member 18 | 11 | BWR1A, TSSC5, ITM |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26196590 | 2015 | Cell line : HCT116, HT29,
SW480. Source : ATCC Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Real time RT-PCR,Immunohistochemistry,Transfection of siRNAs,Western blotting,Flow cytometry,Colony formation assay,Soft agar assay | Down-regulation | - | SLC22A18 as a tumor suppressor in colon epithelial cells and propose that SLC22A18 is potentially a marker of diagnostic and prognostic values. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Solute carriers |
| Description | This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Several alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2015] | Chromosome | 11 |
| Location | 11p15.5 |
| Start | 2920951 |
| End | 2946476 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 25526 |
| OMIM ID | 602631 |
| HGNC ID | HGNC:10964 |
| Unigene ID | Hs.50868 |
| Ensembl ID | ENSG00000110628 |
| PharmGKB ID | PA35846 |
mRNA Information
| mRNA ID | NM_001302862.1 |
|---|---|
| Exon | complement(join(2864..2989,3739..4225)) | mRNA Sequence | Download Select all |
| Length | 1916 |
Protein Information
| Protein ID | NP_001289791.1 |
|---|---|
| Protein Name | solute carrier family 22, member 18 |
| Molecular Wt. (Da) | 61501 |
| Protein Sequence | Download Select all |
| Length | 150 |
| Uniprot ID | Q93097 |
| Ensembl Protein ID | ENSP00000358698 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd06174 | 26-415 | MFS |
| cl21472 | 26-415 | MFS superfamily |
| TIGR00880 | 62-179 | 2_A_01_02 |
| cd06174 | 266-417 | MFS |
| cd06174 | 17-181 | MFS |
| pfam07690 | 26-381 | MFS_1 |
| pfam07690 | 243-412 | MFS_1 |
| COG2814 | 3-181 | AraJ |
Ontology Information
| HPRD ID | 6163 |
|---|---|
| Molecular Class | Membrane transport protein |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of cell proliferation (GO:0042127); Regulation of gene expression, epigenetic (GO:0040029); Cell differentiation (GO:0030154); Hemopoiesis (GO:0030097) |
Drug Information
No matching records could be found.