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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SLC25A4 291 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4  4T1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21625861   2012Cell line : LoVo, SW480, HT29 and Caco 2

Source : -

Sample Type : -

No. of Sample : -

Stage : -

real time RT-PCRUnknown--


Gene Details



NC_000004.11 (186064417..186071538)

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Gene Type protein coding
Gene Family Solute carriers
Description This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. [provided by RefSeq, Jun 2013]  
Chromosome 4
Location 4q35
Start 186064417  
End 186071538  
Strand +  
Gene Sequence

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Length 7122  
OMIM ID 103220   
HGNC ID HGNC:10990   
Unigene ID Hs.246506   
Ensembl ID ENSG00000151729   
PharmGKB ID PA35866   

mRNA Information


mRNA ID NM_001151.3
Exon join(1..221,1502..1988,2497..2637,3552..7122)  
mRNA Sequence

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Length 4420  



CDS Information


   
Location 111..1007
CDS Sequence

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CCDS ID CCDS34114.1



Protein Information


      
Protein IDNP_001142.2
Protein Namesolute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
Molecular Wt. (Da)32933
Protein Sequence

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Length 298  
Uniprot IDP33993
Ensembl Protein ID ENSP00000307288  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KAcetylation272
KAcetylation96

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                              
Pathway Name Pathway ID
Calcium signaling pathway hsa04020
cGMP-PKG signaling pathway hsa04022
HTLV-I infection hsa05166
Huntington's disease hsa05016
Parkinson's disease hsa05012


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam001537-101  Mito_carr
cl028137-101  Mito_carr superfamily
pfam00153110-206  Mito_carr
cl02813110-206  Mito_carr superfamily
pfam00153222-297  Mito_carr
cl02813222-297  Mito_carr superfamily
PTZ001697-298  PTZ00169
PTZ00168116-238  PTZ00168


Ontology Information


   
HPRD ID406
Molecular ClassTransport/cargo protein
Molecular FunctionReceptor activity (GO:0004872)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P12235DB00171Adenosine triphosphateSmallMoleculeDrug
P12235DB00720ClodronateSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO