CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
SLC2A1	6513	Solute carrier family 2 (facilitated glucose transporter), member 1	1	PED; DYT9; GLUT; DYT17; DYT18; EIG12; GLUT1; HTLVR; GLUT1DS

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
18097579	2005	Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 60 specimens of colorectal adenocarcinoma and 20 specimens of normal colorectal tissues Stage : -	Immunohistochemistry	Up-regulation	-	The overexpressions of Glut1 and HIF-1alpha play important roles in carcinogenesis and progression of colorectal adenocarcinoma, and closely correlate with cell proliferation of colorectal adenocarcinoma. Positive rates of Glut1 and HIF-1alpha were significantly higher in colorectal adenocarcinoma tissues than in normal colorectal tissues .
19619276	2009	Cell line : SW 620, SW 480 Source : - Sample Type : CRC tumor and normal tissue, Blood sample No. of Sample : 10 Stage : -	RT-PCR	Up-regulation	-	GLUT1 has the potential to be employed as a molecular marker to indicate the degree of hypoxia experienced by tumors circulating in the blood of cancer patients. The increased relative expression ratio of GLUT1 mRNA, under hypoxic conditions was higher in SW620 cells than in SW480 cells.
21786248	2011	Cell line : - Source : - Sample Type : CRC tumor and normal tissue, Blood sample No. of Sample : 163 primary tumors together ,36 liver metastases. Stage : TNM Stage I-IV	RT-PCR	Up-regulation	-	Overexpression of GLUT1 in stage I-III CRCs was independently associated with poor prognosis. The expression of GLUT1 in 163 primary tumors together with the corresponding normal mucosa, and 36 liver metastases was examined using real-time PCR. In CRCs, GLUT1 expression was higher in poorly differentiated than in well and moderately differentiated tumors and higher in stage III IV than in stage I II tumors.
22282467	2012	Cell line : - Source : Kyoto University Hospital Sample Type : CRC tumor and normal tissue, Blood sample No. of Sample : 63 CRC patients Stage : -	PET imaging and analysis, Immunohistochemical analysis.	Up-regulation	-	GLUT1 expression in cancer cells was positively correlated with FDG accumulation and KRAS/BRAF status.
22968445	2012	Cell line : - Source : Department of Pathology of Wrocaw Medical University. Sample Type : - No. of Sample : Samples of grade 2 of CRC Stage : -	Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation	Up-regulation	20	-

Gene Details

Chromosome: 1; NC_000001.10 (43391046..43424847, complement)
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Gene Type	protein coding
Gene Family	Solute carriers
Description	This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. Mutations in this gene have been found in a family with paroxysmal exertion-induced dyskinesia. [provided by RefSeq, Apr 2013]
Chromosome	1
Location	1p34.2
Start	42925375
End	42959176
Strand	-
Gene Sequence	>gi\|568815597:c42959176-42925375 Homo sapiens chromosome 1, GRCh38.p2 Primary Assembly TCCACCATTTTGCTAGAGAAGGCCGCGGAGGCTCAGAGAGGTGCGCACACTTGCCCTGAGTCACACAGCG AATGCCCTCCGCGGTCCCAACGCAGAGAGAACGAGCCGATCGGCAGCCTGAGCGAGGCAGTGGTTAGGGG GGGCCCCGGCCCCGGCCACTCCCCTCACCCCCTCCCCGCAGAGCGCCGCCCAGGACAGGCTGGGCCCCAG GCCCCGCCCCGAGGTCCTGCCCACACACCCCTGACACACCGGCGTCGCCAGCCAATGGCCGGGGTCCTAT AAACGCTACGGTCCGCGCGCTCTCTGGCAAGAGGCAAGAGGTAGCAACAGCGAGCGTGCCGGTCGCTAGT CGCGGGTCCCCGAGTGAGCACGCCAGGGAGCAGGAGACCAAACGACGGGGGTCGGAGTCAGAGTCGCAGT GGGAGTCCCCGGACCGGAGCACGAGCCTGAGCGGGAGAGCGCCGCTCGCACGCCCGTCGCCACCCGCGTA CCCGGCGCAGCCAGAGCCACCAGCGCAGCGCTGCCATGGAGCCCAGCAGCAAGGTGAGTCGCGCGCCCGC GGGCCCTCCCGCCAGGAACAAAGGCGCAGACTCCTGCCCGCCTTACGCCGGCCAGGGCCTCCCCCGCCGC CCCGCTGCGCTGTGCGCCCGGGGCGGGCCGCGCGCCTCTCCGAGCCTGGCTCGGTGCGGGTCCCGAGCGC AGCGCCCCGCCGGGCCGCTGGCCGCAGTGGGGATGGGCTTCGGATCTAGCGGGCCGGAGGGCGCCGCGTG CGTAGTTGGCGCCGGCACTGAGCACATGGCCTCCTTCCGGGGGCGCCGCGCCGTCCACGCGGCCCTGCTG GGGCTGGGGACACAGGGCCCGGGAGCGGCACGTCGCACACGACCTCGGCAGCAGCAGCCCAGCCTCGGCC CCTCCCGGTGCGGGGGAGGGGGCCCGAGCGCGGCGCCCATTGGCTGAGCGGGCCGAGCCCCCGGCCCGGC CCCGGCCCCGGCGCGCGGAGGAGTCAGGAGCCGCCCCCGCTCTCCGTCTGCTCCCCTAGCCCGGACGCCC CTGTAGGTGGGCGGCCTGGTGCGAGGTGTCCCACCGGCCTCCCCTACTCCTCCCGCCAGTCCCCCGCGGT GACGAGGCCGAGGCCGAGGGGAGGGCACTTTTCTCCAGGCCCGGGCTCGAACGCGGGGGTTGAGATGAAC CTCCGGTCTCGGAGGCTCTCCTTTGCGAGGAGTGCAGGCCCCAAAGCTTTGGCCCAGTCTCGCGGAGATG TGTTCCGCGGAGGCAGGTTTACCCTCGGGGCCAGGCGGGGAGCGCAACCGGAGGGGCGGGGGATCTGGGG GCCAGGAAAGAGCCCCAGGCTGAAGTCTAGCGGGAAGCGCGCACGCCACGGGGTTGGGGAATGAGGGATG GGGACTCTGGGGACCAACAACTCCCTAGATAGGATTTCTTTTTTTCTGTGTAAGTGGGCTTGTCCTGCAG GGCATCTTTGTAGCGTCCGCAGAGCGATTTCTTTTCAACAAATTGTTTGTGGAGCCCCTCCTGTGTGTAG GGCATTGTTTCTTTCCACCTCCTTTCCTCCCCCTAGTCTACAATATTTTCAAGTCCCCTTTTTCTTTTGA AACGGTCCCTCTTTATCTATTATACTTTGATTTTTCCATCTCGTCAGCTGGGAGGGCACCTGGATGGCCC TTGTTTTCTTAGCTGGGACGCGGGGGTAGCACTGAATTTTGAACTGCCCTTCCTACTGGCTGTGGAGGTG TCCCGCTGAGACTGAGCGGGGTGGCGCTGGGCCGCACCCTCGGCAGGAAAAGGCCTTCCGCCCCACACCT GTTGAATCCATAAATCCAGACGACTTGGTTCACCCTTCCTGGGCCCTCGCTTGAGGTGAGACCCCGGGGA AGTTCCCGGGGAAGGCTCCCAGGATCTTAGGTGAGCCGTAAGGGTGGGATATAACTAAACAAAAGTTCAG TGAGAAGCTCTTCTAGCTAGTGGCAAGGAAGTCCAAATATCTCAGGGCTCTTGCAGGCCACTTAACTTCT GGGCCTCAGTTTTTCCATCTGAAAGAGATCACTTTTGTCACTTCCTCTAGGGAAGGAACTATCTATTCAG CATACTATGCCAGACATGGGTATTTATTTGTTGAGTGGATAAGGGAATACTACGTGGAGACAGAAAAGTG GAGGAGAAAATCAGCAGGTTCTTAGCCAAACTACTTTAAGCGTCACGGACCTTATAGCCCTGCTGGTTAC TCACTAGCCTGGAGCTCAGAGAAGGGAAATAAGTTTGCCAAAGTCACACAGCTAGTAAGTGGTTGAACTG GATTTGAACCCAGGCCCATCAGATTTAATTTCATTTCTGTCTCCACTGTCTCTCTTCACCACAACATTTC TTGAATTTTGGGCAGAAGGGAGAGAGTTTGCCTATCTTCAAAGGTGGCCCCTTGTGCCAGCTGGTTCTAA ATAGTGTAGCAGGTGGGTGCTCTTCATGGAGTGTTCTCCAAGTTTTCCACTGTCTACCTCGTCAGTAATT AATGTTGGAACACCTCTTTCACAGTGGTGTATCTGTATTTTTATTTTTTTATTTTTATTTATTTATTTTT TGAGACGGAGTTTCGCTTTTGTTGCCCAGGCTGGAGTGCAATGGCGCGATCTCAACTCCCTGCAACCTCT GCCTCCCGGGTTCAAGCGTTTCTTCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCATGTGCCACCA CACCCAGCTAATGTTTTTTTTTTTTTTTTTTTTTTTTTTGTAGTTTTAGTAGAGACGGGGTTTCTCCATG TTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGATGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGAT TACAGGCCTGGGATTACAGGCGTGAGCCACCACGCCCGGCTGTATTTTTAAATTCATGCACATGCAGTTT GATACTAACAGATGATATGCCTTCATAAAATAGAAATTTCAAAAGACAGATAGATACAAGACAGCAGTTA TAGTCATTTTCCCCTCCAAATCTTGTGTAGATCATTCCATATACATTCTGGAATAAAGCCCTTCCCTTTG GAGACTGCTGATTTGACCTGCAAGCACAGCCTTTTTGTGCATGATGTTAGAGGCCTGGGGAGGTCATATC GCTTGCCTTTCACACAAGATCTGAAAACCAGGTGTGTCTGGCTCCAAAGCCTTGGTTCTGCTATGTTCCT CTTTGTCTCCTAGGAAATGGGAACTGACTTAACTAACTTCCCCGTGTTCCATTGTGCTCCTCTGTAACTC ACAGTAATGAGCTTAGCTGAATAGGAAGTAGGGGACAGATGGAATCACCTTGCCTACAAGCCAGGGGTTC GCCCACGATCTCTCCTGGGCAGCACGCAAGGGTGAGCCCTGCCCCAGATGTCTCACCCCACCCTTCGTGA AGAACTTGTAACTAGCCTTGCCTATGCCCATCACTCATCACTTTTCTGGCCAGTCTCTACCTTCCAGAAA AGGAAAAATCAGAAATCTGCAGGCTTTCTCAGCCCCTTTGTGGTGCAGACAGCATAGTTTTTTGTTTTTT GTCTTTTTTTGAGACGAGGTCTCACTCTGTCACCCAGGCAAGTATCTTGGCTTACTGCAACCTCTACCTC CCAGGCTCAAGCGATTCTGTCACCTCAGCCTCTTGAGTAGCTGGAACCACAGACATGCGTCACCGTGCCC AGCTAAATTTTTGTATTTTTGGTAGAGACAGGGTTTCGCCATGTTGCCCAGGCTGGTCTCGAACTCTTGA GCTCAGGTGATCCGCCCACTTCAGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCTACCGCACCCGGCC AAACATAGATGTTTGCATATGTGGTTTTGAATCCCAGCTTAGCTTAGTTGCCCAGTTTTCATCATTACAG TGTCTAGGAATTCAGAAAAGAATGTACGTCTCTGTCCCCATAGATGCTCCATAAATATTTCTTGCTTCCT TGGACTCCCATGATGCCTTACCTGGGCTGTGGGTGACTTGTACCTGGGCCTTGGCCTTTATCCAAAAGCT GGCATTCTGGCAGTATGAGCTTTTGGGGAGTCAGGATGCTGGCCCATGGGTATTAAGTCAGGTAAATCAT TAAAGCTCCCACTAACCCATTCTTCCTAGTAGGGGCTTGTTGGGAAGTGAGTAGGCATGGCACATGGGTG AGAGTGCCAGGCCAGGGAGGGTCAGCTCATGTGAGTGCCCTGCGCTGCTTTGGGCTTCTTTGCTTTGCTT TTTTGCCTTAGGCTTCCTGCCTACCTTTCTGAATTTGGGTCACCCTTGGGATAGTTTGAAAGGGACATTC ATGTCCATTAACTCCAAGGGTCCTCACAACTGCCCTGTGATACAAGTTACAGTGACCTCATGGTCCAATA AAAAATGACTTTGCCAAGATCACACACTGAGCCTCCCACCCCAAGACATGCTGCCAGCCTTTCCAGGATG ACATTAGAGGGTGGAAGGAACCCAGAGCAGGAGGGGCCTTCCAGCCATGGCCCAGCCCTCCATTTGACAA ATGGGGAAATTGAGTCCAGAGAAGGGAAGAGATTTGTCCGAGATAAGGCTATCACAAAAGATTTGAGGCG TTCTATGGAGCTGTGTTTTGTTTTGATTTTTGAGACGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCC ATGACACAATCTCAGCTCACCACAACCTTCGCCTCCCAGGTTCTAGTGGTTCTCCTGCCTCAGCCTCCCG AGTAGCTGGGATTACAGGCATGTGCCACCATGCCCGGCTAATTTTTTTGTATTTTTTTTTAGTAGAGATG GGGTTTCTTCATGTTGGTCAAGCTGGTCTCGAACTCCAGACCTCAGGTGATCCGCCCACCTCGGCCTCCC AAAGTGCTGGGATTACAGGTGTGAGCCACCGCGCCTGGCCTAGCTGTGTTTTTTTTTTAAAGATGCTTTC TTCTCCACATGCCTGTCTGTGCCATCCTCCACCCACCCCAAATGAGCAGGAATCCCCAGACACAGGACTT GCCATGCCATAGGAGCCTGAAAGTTGGATTAGACGTAACTTGACAACTGAAACTCTACTGTGAATGGAAA CAAAACACTAGATGTTCCCACTAAACTCTGACCTTGAAGAAGTGGCTTTCCTTGGAGCCTTGGTTTCCTT CTCAGTAAATAGAGACTTGGCTACCCCCAGTGGATGTGGTGAGACTGGCCCCGTGCCCTAAATTAGAGAA GTGGCTATTTTAAGTGGAAAGACCCTTTGTAAGGCCAGTCTGGGTGTACAAATGATGTAAACAGCCCCAA GATGATCCTTGTCTAGTACCGAGCCATCCAGGGATTCGACCCTATTTGCCCCGGAGCTGGGCCAGCCTCA AATCCCCCGTAATCAGCTTGTGACTTCAAGGAGCTCAGCTTTGCCCAGTGCCTCCTGGTCACGGGGTGTC GGCCCAGAGCTCTGCTCAAGTACCAAGGGTACAGCCATCCAGCTCCCTGCTTCCCCAAGACTGGCAAAGC TGGGGAGGCCTGGAACAAAGAGGAAAGTGTGCAGTGTTGGCTTGGGGCCTGCAACCTCACCCCTTCCCCC ACCTCACTCCTGGGCATAAAGGTGATAAAGCCGCTCACTCAGTCTGCAGTCTGGTAACCGACGTCCCCAT GATGGCGGAGGCTGGGAGGCCTCCTGACCAGATTCATGGGCTCAGAGAGGCTGTGTCCAGGCCTGCAGGC CCAGCCCTGGCTACCCTAACAAGCCTCCAATTGTTACCTCTCTCCACGGGAGGGGTGGACTGGAGCCTGA GGCTCTGTCTTCCAGCCACCAGGCCTGGCAGTAGCTGATGCATAAACATTAGGGTTTTGCAGTAACTGAG CAGGGCTCCCAGGCCTTGAACCTGGGCAGAAAGAAGACAGCATCTCCTCTCTTTGTGACCACACTGACTT GCCTCCCTGAGGCTTCTGCACCCTGGAATGGGAGAGAGCTCTTGCCAGGCCTCAGCTGATGGAGCCTTTG GCTACTGAGGCCTCTGCTGGACAGGAAGTCTGCCTATGTCTCCTAGCCCAGTTTATCTCCCCCTGCCCTG GCATTTGGGAGTGGGGAGGAAACGGCTCCATCAGAAACAGCTCTACCATTGGACCTTAGGCCAGCCACAC TTCTTGTTGGAGCTTGTGTCCTCAGCTGTACTGGGGATGAGAGCTAGCTGTCTGGGTCAGCGGCACTGAG GCTCCAGGGGAGCATGTGGTCTGTGCAGCAGGCTTGGGGAGTGCTGAGCAGCACAGATTGGGTTTCATAG CACAGTGGGAGCCCAGACAGGCCAGCTAGCCATAAGCACCTCTGCTGGAGGAAGAGGTGGACTCTCTTGG GCTGGAGGGCCCAGTTCAAGGAAAGAAACAAACAGCTACACTGGGCTCCTTGATCACCCAGCTGTGGCAG TTCTTCTTGAGGACTTCCTGCCCCTAGGTGGGGGCTGCCTTCAGCTCCCTGCTGCGTGTGATAACTTGGG TGTGGCCCTCACAGCTGTGCAGAAGCTATTCCCAGAGGGTTCTGGCCCCAGGTAAACAGATTCTGCTCTG GGCTCGCCTTGCCTCCATCCCACAGCCCTGTGTGCTGTCTGTGGCACAGCCTAGAGCAGCACTGCCTCGT GGCCCTGGCCCTTATGCGGCTGGAGCTGATCCTGAAGTCCAGTGTCCCAGCGGTCATGGCTGGCATCATC ACCATCTACAACCTGGTGATGGAAGTCCTTATCCCCAACTCGCTGATCGACTGCATCAGCCTCTACGGGA ATCTCCTCCAGCCAAGCGCTAGGCTGAGTGTGGGCCTGAGTGGCCCGGCAGCCAGCTATGTCATCAGCAC TGTGGGGGACACAGTGCTGCCTAGAAGCCCGGGCTATTTGTGGGCTTGATCCTGATCCTCATTTTCACTG CATGGTCTCATTCTCTCCACAAAGTAGCCTTTGAGCCCACCAGCCACAGAATGTGATATAAAGATCACCC CTGCTTATTCCAGAATGAACAGCCTGAGACACATATCCCTTCAGTAGTTGGTCTTGTGAATGCAGTGTCC TAGTGCAAATGCCCATCATCTGTTGACCCCATCCTTGCCCCTGCCTGCCCCATGCTGTGGATATCTGGGC CCCCTCATCACCCATCCTGGCCCCCTGACCAGTGAGGATGCCCCCTCCCATCTAGGGTACTCTGCGTCTA AGGATGAATTCCAGTGTAATTTTCTCTCTTCTGTAGGTTTATTTATGGAAGATTGGACCTGTTCATACAT CTGTGGGGCAGCCCTCCATCTCCCAGCTATATAAAGTCTCTAACCACAGTGTTGCATTGTGGGGTTACCA TGTGGTCTGACACTTCCTTGCATGAACTACCCTCACTCCAGCCCTGGACAGTCCAGGGCCTAGCAGGCAG TGTGTGGGGCCTACCAGGTCCTGGCATCCAAGCTGTGTCCAATAAAGTTCTTAGATGTGACTGGAAAAAA AATTGGATTAAAAAAAAGCTTCAGAAGTTACAGAGCCAACTACAGAGAAGCATAATAAATGAAAGAGTGT CTTCTAGTTTTGACAGTTTGGTGTTTACCCTAAAGACTTCTCTTTGTGCATGTGTAGATACATGCCTATA AATAGAATATTTGTGTAGTTGGATCCCACTTTCTGCATAGTTCTTTGCAACCCATTCTGTTCACCAAACC AACCCTTAGAGGTAAATACTGGCAGTGTTTCTCTCTGCACATACAACCAAGTGCCACTATACAAGTTCAC TAACTCCCTGTTCCTTACACAATATGTACATCCTATTGCTTTTTTTCCCCCCTGAACAATCTACCCTGGT ACTCTTCATAACACATACATGTTATGTGAAACACAGATGTGTTTCATTCTTTCCAATAGCTGCATAATAC TTCATTACAGGCATGTCCCACCATGATTAAGAAATAGCAGCCCCATCACCTTCTTCATACCACTCACCAC CTGATGTATTACATGTATTTATTTTCTGCCCCAGCCTTCAACTAACCTATCAAGTTCCATAGGCAGGGAT TTGGTATAGTTTTATCGCTGAATTTCCATTGACTAGAAGAGTGTTGGGAGCATGCATTCAGGCATAATCT TTCCTTAGCAATATCATTTATTCATAGAAGATCCTCTCTTATGGAGAATTAACTGAAGCTTAGAGGAAGA GACTTTTTTTTGAGACGGAGTTTCACTCTTGTTGCCCAAGCTGGAGTGCAATGGCGCGATCTCGGCTCAC TGCAACCTCTGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGTTGGGATTACAGGCG CGCGCCCCCCACGCCCAGCTAATTTTTCGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGTCAGGCT GGTCTTGAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCCAAAGTGCTGGAATTACAGGCGTGA GCCACCATGCCCAGCCAGGAAAGGACTTTTTTAAGGTCACACAAGTGGAGGAGCTGGGACTTAAATGTGT CTGCTGAGAGTGACAGTGAACTTTGCATGTGCCCAATCTTACCAAATTAATGTTCTCTTAGTTGAATTAT TGCCCATCTCACCACCAAATGTGTATCTTCTCAGGGGTGTCAGTTTCCCCAGGGTCCAGATCCTGGCCCC ACACCCACACATGGCCAAGGAGCCATTTACATTTAACATTCCATAATAGGATGCATACCTTTTCGGTTAT TTAGGGAGGATGTGGTTTTGCCTGGAAGGCTTTGAGAATGCTGGGCAGCTAGCTCAGGGGACGTGGGGCT TAAAGCAGAGGCCGATCAACTTTTTTCTAAAGGGCCAGATAGAGCGTAAATATTGTCAGCTTTGTTGGAC ATGTAGTTCTCGGCCTGCCACTCAGCTTTGCTGTTGCAGTACAAAAGCAGCTGTAGACAAATGAGTGTGG CTGTGTTCCAATAAAACTTTATTCATGGTCACTGAAATGTGAATTTAATATAATTCTTACATATCACAAA ATATTAGTCATTGTCTTTTTTTTCTCCCCAGCTACTTAAAAATGTAAAACTCATTCTTAGCTGCCATAGT TTGCCAACTTTGGCTTATAGCAAATGCAGCAAAGTGGCCCAAAGGTTTCTGAGCCTGTGCCCGGGCTGTC TCAGCTCAGAGTGGGCAAGGCTCAGAGAGTTGCTTTTATGGAATTTGACCTACATAGAAAGCACCAGGTA GAAACCTTGTTTCCTTCAGGGACCAGTACCCGGAAACAAGGGGGAGGACCTAAGCAGGAAAGCCATAGAA TTTGGCATCAGAGACCCCCAATTGGAAACTTCCCTGAAGCCTAGAGTCCCCTGGTTCTGCGCTTTTCCCT CTCTCTCATTTCTCATCTGTGAAAAGGGAGTAATCGCTCCCCAAAAGCTTGTTCATGGTGGTTAATCAGA ATGTGTGAGCAGCCTCTGGCAGGGTGCCTCAGCTCGCTGCTGCTGCTGCTGCTAAATGCACCAGCCCCCT CCTCTCAGTTCTACTTTGAAGACTGGCGAGTGCCTTCTGCCTCGAGGGCAACCAGGGGTGTCTGGAGGTT CAGTCATGCAAGGGTCTTGATATCATTGGAAGGCTTAAAGGAAGTGGCTTCAGGAGCACTTAATGCTTGA GGTCACCCTAAGGTCAGGTTTTGGACTGTTAGTCCATCACTCTTCTTTTTTAAAAGGCTTGGCAGGATGG AACCGGTCAGAGGGTAGAATGCCAGGCTAGGAAACCAAACAACTCTAGTCCCAACCCTGGCTTTTGTTTG TATGCTAGGCTGGGCACCTGCCCTCTGACCTCAGGTGCCTCCTGTCAAGTGCCGATGTTACAGCAGTCTG CAATTTCTTGAGCTTCTTTCTTTCTTATTGCAGCCAAAGCTGTCTTATTTTTTTTTCTTTTGAGAGTGTC TCACTCTGTCGCCCAGACTGGAATGCAGTCGTGCAATATCTGCTCACTACAACCTCCGCCTCCCAGGTTA AAGTGATTCTATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTATAGGCATGTGCCACCACACCCCAC TAATTTTTGTACTTTTTTTTTTTTTTTTTGAGACAGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTG GCGCGATCTCAGCTCACTGCAAGCTCTGCCTCCTGGGTTCAAGCCATTCTCCTGCCTCAGCCTCCCGAGT AGCTGGGACTACAGGCATGCGCCACCATGCCGGGCTAATTTTTTTTTTGTATTTTTAGTAGAAACGGGGT TTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCCGCCTTGCCTCCCAAAGTGC TGGGATTACAGGGGTGAGCCACCGTGCCCGGCTCCAACTTTTCTATTTTTAGTAGAGACAGGGTTTTGCT GTGTTGGCCAAGCTGGTCTGGAACTCCTGGCCTTAACCAATCCGCCCGCCTCGGCCTACCAGAGTGCTGG GATTATAGGTGTAAGCCACCGCGCCCAGCCTTGAGGTTCTTTCTTTTAATGCCCAGAAGTTCATTTAAAT GAGTAAGAAACACAACAAAACAAATTAAAAGGGAGCTGTCATGGATTCAGGTAAACCCCTCCCCCACTCC TTTGAGCCGTGGACTAAGCAGTTGGAAAGCCCTGCGTCCCCTGCTTCCCTGCACCTGGGGAACCCATGTG GGATGCTGTGGGAAGAGGACAAGATGGAGCAACATCTGGAGTCTGCCAGCCCTGGGACCCTCCTCTTGCC AGGAATACCCTGCCTCTGAGTAGCAGTAGCCACGTGCCCTTCCTGTGCCAATATAGATTGAGAACCTGCT GCAGGCCAACCCTGGGGCTGGAGCGCAATGCTGACACACTGACATGGGTCAAAAGGCCACAGTGTTTGGC AAGTTATACAATGTGGCCAGGGCCATCTGGCATCCGAGCGTTGGGGGAGAGGTCCTGAATCTTAACACCT CATCCATGGCTTCCTGGGAGAGGGAGGGCTCTTGTGGGTCGTGAGACCCCCAGCGGTGGGATAGGGAGGG TGAGGGGTGGGGACATGAGAAATGCTTCTCTGTGCTGGACCCTGAGCCCAGTTGCTGGCCAAGCTGGGAG GCCATGACTCTCCTAGGAGAGTCAGGATTTGAACTCAGTCTGCCTGACTTCAGAGGTCCTTCCTTGACAG CCCTGTGGGCTTGGAGTGGAGGGTTTTGTGGGGTGCTGTATTTACCTCTCAGAGCTCTGATGTTCCAGCA CTCGTCAGGGGTTTGATAAATGGCTAAGGATGAACACTGGTCTGGCACAACAGATACTCACAGAGCCAGC TTTGCCCAAAAGCCAAATTGAAAAGTGGCAGGTTTCTTTGTTTGGCAATTAGCATGTGCTGTTCCCTACT CTCGTCACTCTGGCTGCAGACACGGTATGACCCAGGTTCCATTCCTTTTTTTTATCTCACTCTGTTGCCG AGGCTGGAGTGAAGTGGCATGATCTTGGCTCACTGCAACTTCTGCCTCCCAGGCTCAGGTGATACAGATG TGTGCCACCATATCCAGCTGTTTTTTTTTTTTTTTTTTTTTTTTTGTGTGTGTGTGTGTGTAATTTTAGT AGAGACCTGGTTTCACCATATTGCCCAGGCAGGTCTTGAACTCCTGAGCTCAAATGATCCGCCCACCTTG GCCTCCCAAAGTTCTGGGATCACCGCGTCCTGCCCCTGGTTCTATTCTTAAGGAGTTCCCAAACTGAGTG GCAGATGGGTAATAAGCTAGAGACTGCAGAGGACATAGCAAGAGCAAAGGCCTGGAAGAGAATGGAATGT TCTAGAAAGTAGTCTCATCCCCAGGGAGTGCTGATGGGCTGCTGGGGATCCCAGACTCTGGGCTGTACAT TGCTCCCCACCAGTAAAAAAGGCTCCCACAAGAAAATCACAAGCTCTATGGGGCTAGTACCCTTCTCTAA GTCATCACCAACTGTTCATCAGCTTGACACCAGAATAAATAAATACACGTTGAGTGAATGGACTTCATTG CCATGTTCCAGTTCTAGCCACTGGCTGGTGGGGGCAGATGGTGCTGAGGCTGCCCGATCGAGGGTAGCTT GCTATTCTTCACCGATCCAGCAAACACTTGTGGAGGGAATTCTGCCAGGCTTCATGATGGATACTGATAG AAAACGTAACAGCAACCCTTTAAGGAAGGAACTTTCATCCCCGTTTTCTAGGTGAGGAAACCAAGGCCCA GAGCAGGGCTGCCTTGTATCCAACTCCAAGGTGAAAGGAGGCAGCTTGCTGCATTTAAACGTGGGTCTGC TTCCAAGCCCAGCAATGATCAAGCCGGCTATAGTGGGCGCAGCAGAGTGGCAGCATGAATCTGAGATTGG TCGCAGTGTCTTGTGCCTACTGAGGAGCAGGGGCCATGTCCCTCCCCCTACACCTAGCACTGAGCCACAC TGAGCACGCTGTTTCTTAATCTGACTGGTCCCCATTTCTTCTCCTTGCACATACTGTTCTGTCCACCTGG AATGTAGCCTTGCCACTGCTTTCCCACTTGGCAGACTCTCTGTGTGTCCTTCACAGCCCAGCTCCAATGT CACCTCCTGGGAACTCATCTTTTTTTGTACCCAGGCAAAACTGGAAATCTTTCCCTCCAGGGTTCTCACA GTGCCTCATACCAGCCCCCTGTTGAAGCCCAGACCACACTAGCCTCTCATCTTCATCTGCCTCCCCACTG CCCCCACCCCACTGTACTGGAAACTCCTTCCTTGGTGTCAGGACTGGGTCCAGTTTCATCCGGGGCCCCA GCTCTACTTAGCATGAGACCTAGAGCATGGGTCACTGGTATTTTAGTCAGTCCTAGTGCAGCAGCTGCCT GGGTGGATGTGGATATGACCCAGGGAGTGGGTAGGCAGGTTTTCTAAAGTCGAGTTTGACCTCGACCTGC TGATGACAAGGTCCAGCGGAGGGGTATGTCCTTGGCCTCCAGCAGCCCCCATTGACAGAGGCTACAGTCG AGCAGCTGCTCAGTGGGGCCCCAGGGATGACTTCAGAGGCTCCAGACCCCTGGAACATCAGATGCAGACC TCAGTAAAACAGGGCCTGTGATAATAGCACTTACCTCACATAGCCAGTGTCATTCACTCATGCTCTACCA ACATAATTTTTGCCAGATCCATGGATCATTTGTATTATTTTCCACTTAATGTTTTTATTTAAATTGCTTT GTTCTAAGTAATATGAAATCACAGGGCTTGTAAAAATTATTTTGAATAGGTGATTCCATTCACACCATTC AGAATTCAAAAAAGTGCCAAAGGCTATAAAATGAAATCTCCCTTTCACCCTGTCCCCAGTCACCCAGGCC CCCCCGGGGTTAGAATGTTACCTTTCTTGTACATTCTTGTTTTTTGTTTTTTGTTTTTTTTTTTTTTTGA GACAGAGTCTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCCATCTCGGCTCACTTCATCTCCCAGATA AAGTGATTCTTGTCCCTCAGCCTCCCAAGTAGTTGGGACTACAGGCACGCACCACCATGCCCAGCTAATT TTTGTATTTTTAGTAGAGACAGGGTTTTGCCATGTTGGCCAGGCTGGTCTCGAACTCCTGGCCTCAAGCT GAGATTATAGATGTGAGCCACCGTGCCTAGCCTCTTGTGCATTCTTTTAAATAGATGTGTATATTCTCCC CCTACCCCCAGCCAATTTTTTTTTTTAACCCAAAAGGTAGCATACAATATACACACTGCTCTGTTTTTGG TTTCGCTTTTGTTTTTTGGGACAGAGTCTCACTCTGTCACCCAGGCTGGAGTGCCATGGGGTGATCACAG CTCACTGCGGCCTCGAACTCCCAGGTTATGTATTCCATTATATCACTATGCCACGTTTTCTTAAATGATA GATTGATGTCACTGCATTGCTTGTTTTTTAATCTATTCTAATGTGTTCCAGAAAAATACAGTATATACTT TGCATCCCATGAGCAAATGCAGGTAATACCGCAGGCAGAAAGCCCAGCACGTGGCGGGCCTAGCAGTCGC TGTTTAGTGAGCCCTCCTGGTGATGCTTAGTGCCTTGCCACAGCCTCTGAATTAGTGTCCACCCTATGAA TTAGGCTTGACCTGGTGTGTCGCTGGGGTCCCCCAGAAATTTGTCAGCTGCTCACTACCCACTCGGAACA ACAGCTCTGGGCCTGAAGGCTCCCCAGAGAATTGAGAGAAGGGAGATTCTGGGGGCAGTGCCAGGACATA CGGGGGGTGGGGGCTGTCTTTCTAGTTGGGCAATGCAGAGGATTTAGAGGGAATGGAGTCCCTGTGGTAT GAGGGAAGCCCCAGCATGTGGAATAAATGTCCAGAGGCAGGCTAAGGGGTCAGGTAGACAGACTAATGGG AAGGAAGGATGCAGCGCACACACAGAGGGGGCTCTGAGCTGCACACTCCTCCTGGGCCGAAGCCTTCTTC CTCTTTCGCAGCCTCTGATGTGAGAGCCTTGGCTTTTGCAGTCGTTGCCCTGACTGACGCTTTCAGAGAA TGAAAAGACCATACTGGGAATATGCCTGGTAACAGCTATGCCCAGGGCTATCTGTGATGATCTTGAAGTA AAGGCTGCTTCTGGGTTCTGTGGAAACCAAGGCCCAGAGACCCACAGCCAGGCCATGGCCAGCTCCACCC ACTTCCAGGGCCCAGCTTGGTATAGTGTGCGTAGTGAATGCCAGTCGTTTCTTTGGCATGCCTCCCGCAG CCCTGTTCTCCCACAATCAGTTAAAGGCCTGCCTAATGTCACATTTCCTGACTTCCTCATTTTTATAGCT GAAAAGAGCACTTTTCTTCAGCAGGGCTGACACCCTGCTGGCCTCTCAGTCACCTGTGGCTAAGCAGGGC TCTTCACCTGCTGGCCTCTGCCCTTCCTGCTGCCTTAGGTCCTCGGCTTCCAATGGACAGAAGCAAACTG CTCTTTTTCTCTCCCATCCCTTTGCCCATTGGAAACACCTTAGCCCCACACTCTTACTCACCTTGTGCAC TTTTCCAAAGTGCATTCCCGCCTAGCATGTCGTCTATGTCCATATAACCTTGGGAGGCTTATGGTTTGGG GATTATTGCCGTGAGGAGCACTGGGTAAGGAGTCCGGAGCCCTGAGCTCTGCTGCAGGCTCCTGAGTGAT CTGGAACTTGCCTCACCCTCTCAGGGCTCAGTTTCCTGCCCTGTGAACAGCAGGAAGGGTAGGGCAAGGT GGGATCACATCTCCAATGTGACAAACGAAGCTGTTGCCATTTTGCTGACAAGCAAATGGAGGATAGGGGA GAGGTGGTACATGGGGGACTTAGCCTGCTGGAATTCACAGAGCAAACAGGCAGATGGGCTGGAATCAGAA GCCAGCGGCTTCAGCTCCAAATCCAGGGTGCTTCTCCTATCTATATCTGTGCTATTCCTACCAAGTAATT TGGGCCCCCTCGCATAGGAGGGCTGGTTCCTGGGCCTCCCAGTCAGAGAGTCTAGAACCACCAGACCCTA GGCATGGCTCCACCAGGGAAATGAGACCCCCAAGAATCCAAAGCCTCTCCCTCTCTGAGACCTGGCTACA GAGAGAGAAGATCATACTTCCCCTCTCTCCCCAGGAAATGGCCCGGCCAGCCCAGTATCTTGAAGTCAGC TAGGCTGGTTTGGGCACCTAAGGTCAGGAATTGGCCAAGTTTCCTGGGAGAAAGACTGGTGTGGTGCCAA GAGTCAGGCAAGATATCTGAACACAGAAACTTGCCAGTCCAGGCCCTGCCCTGTAGTAACCTGCTCCCAG ACACGCCTATAACAGTGTGGTTTGTTTCTCCGCAGAAGCTGACGGGTCGCCTCATGCTGGCCGTGGGAGG AGCAGTGCTTGGCTCCCTGCAGTTTGGCTACAACACTGGAGTCATCAATGCCCCCCAGAAGGTGAGTACT GTGCCATCGTTGGCTTATGGACACCAGCCTGCTCTGTTGCACATCACACATGCCCACAGTCTCACGCCAC CACCTGAATTAGAGTCATTTATATGAACGCACTGTACTGTCTGCCTCTCCAGCCAGTTTTCTGGCCCTGA TCATGTCAGAGACTCTTCTCTTGCTTTGGAATCAGGGTGGCAGAATTCTAGAATCTCAGGTCCCACAGAA TCCTGGGGTCTTGTATAGGCCCTCTTGACCAACCCCCCACCCAACTCAGTCATTTAATAATATGTTTGAT GATATAATAAACTCAAAGCAAAGCTCAATACAATAATGCTGCATTTCCGTGGCATTCTGGGGCTGCAGAG GGTTTTCATGGGCTTGTCTCACTTGATGCTCACTGCAGCACTGTCAGGAGGCAGCAGGCACCACTCCCAG CCTGCAGGTGTGGGAAACGGCCAGAGAGAGGAAACCCGCCCAATATCACCCAGCTAAGTCAGAGACAGAG CTGGTATCCAACACCTGCCTGCCAGGTGGTCCTTGAGCCTGCACTCATACCCATCCACAGGCAGCACACT TCCTTTATTTGTAGGTTGAAACCGCGTCCTCTCCCTGAAGGCCCTGTGGCAGTCAAAGCAGAAATGGCGT CTTGCCCTAGGGAGCCACAGGGGGTGAAGGTCTGTGCTGGCTTCCTCCTCCCTGCCGTGCATCCTAGATC TGTCCTCACTTGTTTACTTGAATGTCAGGATGGGAAGGGACCTAGACCATCTCCTCCAGCCCAGCCTACT TGCATTAAGGAGGAGAGAAGAGGAAAAGGGGGTAGGGGGTAGGAGGCAGGGACAGGAAAGGAAACTGAGC CCTTCCTCTGTACCAGGCATTTTGCTTGTGTTTATGAGATTGGGTGGTGATTTCCATTTTGTAGACCCGG AAACTGAGGCCCAGGCAGATGAAATGGCCGACAGGCCCAAGGTCACAAAGCTATTGAATGCTGGAGTCAG AAGCCAAGCTCTGTTGTTTCCATGGCCTCAGGTTGTCTTCCTAACCAGCTGCCTTGCCCGTTTAAAAATC TGTACCTTCCCAGAGAGGACCAAATGAGAGTGGGCAGTCCTCACGTCAGGACCACATTTCTTGTCCAGAC GGATGGGGCTAGAAAGTGAGTGCAGTGACTCCCAAAGATCAGGGTCCTGTTTGGGGGAACCAGGTAGTGT CTAGAGTTAGCTGGGCTTCTTCCAAATAGGCAGACAGTGGCTATGGGGCCACGCCCGATGCTGAGGAGCA AGTCACCAGGAAGGCTTGGCCTGCTGAGTCATGCTCAGCTGCAGGGGAGGTGACAGGACTTTTCCAAGTT TGCTGGGCATGGAGACCGTGGGCCCATGCTTGGACCAGCCCCAAGCCCTGCATTTGCTAAGTGCTCTTGA CAGCTCTTGCCAAAGTGTGTGCTTCAGAACTGGCTCCCTTTGGGAATCCTTACAGATGGAAAGTCTGTAA GACAGGCTGGGAGGAAACAGAGGGAGGTTGAGCTCTCCACTTGGTTGCACATTGGGGTTTCCAGAACGCC CCCAGATTCTGATTTAATTGGTCTGGGATGCTGTTTGGGCATTCAATTAAAAGCTTCCCAACCAATTCGA ATGTGCAGCCAAGGTTGACAGCTACTGGATTTAATGATGTCTTGACTGTGATCTCATAGTGAGTTAATGA CAGAACTAGGACTCTAAGGCCAGGACAGAGGAGGTGTTTTCCAGAAACAGAACAGGGTTGGGGTGAGCAG GGGGCCTTCAAAGCAAAATGCCCAGAAGACAGAAAGCCTGGCATTCAGTAAAGCGTGAGTAGTTTAGTGT GTCACTAGAGTGAACAGGAGGAGGGGAAAGGTTGGGGAGGTCAACAAGGTAAGGTAGGCAAGAGCCAGAC CACAAAGGGCCTTGTGAGTATGGCACGGCACAGTCAGAAGGGGCGGATGGGCACCAGCACGGGGGCCCAG CTAGGGAGCATGGACTTCAGGATGAGGACAATAGGGACCCACTGCCCAGGGCAGACGTGATCAGACTTGC ATTGTAGGGAAATGACTCAGGCGTCTGGTATGGAGGGGCGGACTTAAGAATGTGAGACTAGAGACGGGAA ACCATCAAGAAAGTTGCCGTTGGACTAGTGACATAAAAGCAAACCCTCAGAGGAAGAATGGACAGGATTT GGTCATCAATTCCGTGCGAGGGCAACAGAGAAGGGTTTAAAAATGGTTTCTAGGTTTCTGGCATGGGTGA TGTGTGGTTTGAAGAAGGAGCAGGTGTGCCAGGAGCTGAGAGGTGGCCGTGGGATGTGCAGGAATGGAGG CGTGGGGTGACACAGCTGGAGATGTGCAGGAGGCACCTGTATGTATGGGTCTGTTTCTTAGACCCAGGCT GGAGAAAAGTTGAGAATTAGTCACTGGTATCCACACAGTGGAGAAAGATCTTCTAGGGAGACTGTGGAAT AAAAAGAGAAATGAAGATTAAGGCCGGGCATGTGGCTCACGCTGTAATCCCAGCACTTTGGGAGGCTGAG GTGGGTGGATCACTTGAGCCCAGGAGTTCAAGACCAGCCTGAGCAACACATCAAGACCTCATCTCAATTT TATAATTAAATAAATAAAAATTAAAAGTAAAAGATCAAGGCCCCAGAGAACAACCCATTGCTAGAAAAAG ACCCTAAGTAGAAGAACAAGAGCTGGTATCTCTAAAACCAGGAGAGGATACCCTCCCAAGACAGAGGGAT AATGTAAGCCATCGAAGGGCCAGGGTATTTGTCTGGTTTGTCCACGGCCGTGTCCTTAGTGCCTAGAACG GTGCCTGTCATAGTAATAGACACTGGTGGATAGTGAGTGGAGGAAGGCCATCGGGTACCCCAGGGGTTGA ACTGGGCAAGCCTCTCCACATTGCTGAATGCAGAAGAGGCGATGGTGGCCTTGTGGCCACTCGGGCTGAC TGGGTGGCACAGCGTGGATAGAAGCCTCACTACGATTGGGTGAAGAGTGAGAGGCAGATGAGAAAGGGTG GAGACGGCTCTTCCAAAAGAGTTGGTGGGAGAGGGAGAAAAGAGGAGGTTTGGAATGATGGTATGGCTAG GAATTTATTTATTTATTTTAATGAAGGTTATTTTTAAACATGTTGGAAGGAATCAGCAGGAGAGGGTGAA GATAAGGAAGTGAGGGCGGAGGTCTTCCAGGAGGGAGGGTGGTGTCGGAGCAGAAGGGAGGGGCTGCCTT TGGCCAGGAGGGACTGAGATACCTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGCTGCCCA GGCCAGAGTACAGTGGCATGATCTTGGCTCACTGCAACCTCCGCTTCCTGGGTTCAAGTGGTTCTCGTGC CTCAGCTTTCCAAGTAGCTGGGCTACTGGTACAGGTGTGTACCACCACGCCCAGCTAATTTTTGTGTTTT TAGTAGAGATGGGGTTTCACCAGGTTGGTGAGGCTGGTCTCAAACTCCTGACCTCAGGCGATCCACCTGC CTTGGCCTCCCAAAGTGCTGGGATTACAGGTATGAGCCACCATGCCCAGCCAGGGACTGAGAGACTTCTG AAGATGTAGACAAATCTGAGATGAACTTCTGTGATCCCCGGGGCCTCCCATCTAATCAGAAATAGGCAAG AGGTTATAACTGTCATGGAATATGGGCAGAACCTCTGACCAGGGCATCACGGGGCTGGTCAGCAGCACAG AGGGCCCAGATGAGCCTGTAAACTGCATTCATAGGACCATGTATGGTCACCTGTCCAAAGGTCACTTCAG GAACCAGCCCCAGCAGACCGAAGCTGGAGATGTGAGTGGCCAGAACTGAGAACGCTGAAATCTAGCGGTG TTTCTTGGGCAAGCACCCAGACACTTGGTCTGTTGACTTTTGTACTTTACAAACACTTCTCACAAGGCTG GCTGTAGTTTTTCCAACCAGGAGCCAGATTAGAAGTGATACATGTAACATGTGAAGAGAGGACAGAAGGA CCCAAGAAGAAGAAATGAAAGTGAGGCTCAGAGCCCATGTGTAGTAACAGGGCAGAGAGACTCCTGTGCC CGCGTAGGCTGAAGGCCTGCCCTAGGGCGACACAGAGATTCCATCTGGCCAACCCTTTCATTCAGCCAGG ACTTCCTGAGCATCCACGCTGTGCCAGATGCGGTCCTAGACAGTAAGGAGAGAGAAGTATAGCTGTGAAC ACAGCAGGCACATGCTGGCCCTCAGGGAGCTGCCTGAGACACAGTCTGAGCCAGGCCCTGTCTCCACAGC AGTGGGAGAGACCCCTTGGAGAAAGCCAGAGTGTCACTAACAGAGGGCTTCAAGGTGCTGTGAGAGCAAA CGGGGCAACTAATGCTGGGGCTGGGGTGACAGGGGAGATTAAAAAAAGGGCTTCACGAAGGACTTGGCAG CCATGCTCGACCTTGAAGGGTTAGTTGACCTCATAGGGCAGGAGGGGCAGGTGTCTGGGCAGTGAGAGGG GCTTCTGCAGAGGTGCAGGGGTGTGAAATGTTCTGCTGATGCGGAATTGCTAACTGCCTGCAGTGGGCAC ACTGACTTCCCTTGTCTGTTTAGAAGAACCTCTCTTAGGAAACAGCATTGGGTTGGCCACAGTTTGCCTA CTCTTGAGAAGAGACTTTGCCCCACAAGTGGTGAGGATGCCAGAAGCTTGTTCTCTTCCATAAAACAGGC CCCAAAGGGCTTCCTCCTGGAAGTGGTTAATTAATCATACTACCTTATATGTTTACAAAGCACCACCCCA TAAATTACCACCTCACAGCAACTCTACAAGGCAGGCGGGGCTGACATCTTCCCCTCTTCTAAATGAGGGA ACTGAAGCCAGATGAGGTATCTGGAGAGTGAGAGGCTGAGCTAGAGGTGGGCTCCAGGCCTTGTGCCTCC CCAGCTCTGCACACTGCCCCTGCCCTGCTGTGAGTGTGACAGGACATTCCTGCCATGCATCCCCTCCTGG AGGAGGAGGACAGAGCAGAAGAGGTGAGCCCAGCCACAGAGGGAGCAGCTAAATGAACCAGGGAATCCTG ACCATCATACTGGGCTCATCCGAGCACTGCCTTTCCCCTCCCCAAATGACTGAGCTGCCAGTAGAGATGA CTGACGGCCACTGAGAAACCATGAAGTCCTGGCCCAAGGGACAGTGTCAGGCATGTCTGAGAATAAGGCA TCCTCAGAATCCAGAGTTTGGGCCAGAAAGGCCTCAGTTGTTTGACAAACAACACTCCTTGTTTGACAAA GGAGGAACCTGGTCTGCAGAGGAGGTGAGGTCTGCCCAGGATGACCCAGCTTGGTGAGTGAAAGAGCTGG AGGCAACACCCGCCTCCCAACCCAAGCCCTGTGTCCCGTCAGGCTGAACTGGGCTTCGTGCTCTAGGCAG CCTCTCCTTCTCTCTCCTATATCCAAAGAGTTCTAGTCCTCTCTCCCCTTCACCCGTCACCACTACCATA AACCCTTACTGCTTACTTATAGCTTGCCCAGGCATTGTTATACATACTCTAGAAATAGTAATTCAGTTGT TCTTCAAAATAACCCCATTAGGCAGACACCATAATTTTCCCTGCTCTATAAGAAACTGGGGCACAGGAAT GTTAAGCAATTAAAGCAAGGACACACAGCTAGTAAGTGGCAAGGCTGCAATGTAACTCCGGGGAGTCTGG CCCTAGTCTGTGCCCTTGACCATTGTGGAAGATGGACACAGTCCCAGATGGGCACCTAAACACCCTTTCA CTCACCTACAACTGCCACCTAGCTGGCAGTGTGTGGTCTCACTTTGGAGCTGAGTCAAGCTCAGTCATGT ACCAACATCTCAGGTTTCCCACACACAGTTGCACAATCTCTTACACCATCACACCCTGTCATATCACATC ACCCCTCAAGCCCTTCAGTTAGATTCATGGCTTGTTGGTCATTTAGTGTCAACTCTGCACCTCCACCACC GTGCTGGGCACCAGCAACATGGATGCATCAGACAGACCATCTCCGTGCTGAGGTTTACTGTACAGGGAGC ACACGGTACCTTACAGTTAGTCTTCTAAAGGCGATGATGGAAATGCGAGCAAGCACAGTGGGAGCAGGGA AGGAAGAGGGAGAGGGTGCTTCGCCCTTAGAGCAGGGTTTCTCAGCTTGGCACTGTGATGTTTCTGCTGG TGTTGTAGAGGCCTGTCCCATGCATTGGAGGATGTTTATCAGCATCCTTGGCTTCTGCCCTCTAGATACC AGTAGCCAGTGTGGCAACCAAAAATGTCTCTGGGCATTGGCAGATGTCCTATGGGGTACCAAAGCCGTCT CTGTTTGAGAACCAGTTGCAGTGGAGTGGGAGGGGTGGTTCTCGGGAGGAAGGCTTTCCAGAGGAGTATC TGTGCATGTTCTGAAAGGTGATTAGGCCCAAGCAAAGGTGTGAGGTGTCTAGGTCGTATGAGGGAGTCAC TGCGTGTGCCTTGTGAGTCATAGTTGGGGTAGAGGAGACACTTTATTGCAAGAGCTGAGAAGGGCTTCGG GTGTGGCCACGGCAGTGGGATGATTCCTCTGTCTACCGGGAGGCCTGGCCTGGCCTGGCCTTGGTTTGGA GGCTAGCCATGTCAGGGCTGTTCCAGGGAAGCAGCCTGGGTGGTCCAGCCCTCTGCAGGGGGGTTGGGGC CCAGCTCTAGCCCCAACCTGGGCCTCTTCCCCCAGGCCCCAAAGTGAGGCCCCAGGGGACCCAGTGGGCA GGGTTATCTGTCCAGCCCCACCTGGAACATCTGGCTCCAATCTCCCAGCTCACCCTGGGGTGTGGCTGAG AGTTGCTGTGGAGATGAAGGCCCTGGGCTGAGAGCTTGTGGGAAGGGCAGTGTGGGGCCAGCCCCAACTG GAAGACAGGGGCAGGCAAGGAACAGGGGTGAAGGCCAGGCTGAGAGGCTAAGCCGGAGAAGCTGGCCCTT TCCTCCTTGTAACTGGCGCTGAAAGCTTGGCTGGCAGTTTAGCCCCTTCTTCCCCACAATAGCATCCCGT AGAGCACAGGGAGAGTTGAGACCGAGCCTAAACCTGGCCCAGGGATCCCTGCTGGGGATGACCTAACTGA CCTAGTCCTCCTGGGGTAAAGGAATGTCTAGAGGGAAGGATGGTGAGACCAGCCAGAGGTTCCAAAACGC ATACCCCTCCTGGCAGTGGTCTAGAATCCTAGATCAAGGGTTGGCAGGAGGGCCACATCCAGCCAGCAGC CTGTTTTTGTGCAACCCATGAGCTAACAATGGTTTTTACATTTTTACAAGGTTGAGAAAAAAAGAACAAT GAGTGACAGAGGCCATATGTGGCTCACAGACCCTACCTAATGGATTCTAGCTAGCCTTTTACATAAAATG TTTACCCCAGTCCGGCTCTGGAGCACTTTGACTTGCATGCTCCCTACTTACAGGGAACTCACCACCTGTA AGGTGGGCAGCCTCATACCCTGAAGTCTATAAAGCTCTTCCTTCCCCTGAGCTGGAGTCTGGCCCTGGCA CCTCTGCCCTCTGGGGCTACAGAGTGCTGGGTTCCTCTGCCAGGAGCAGCCGAGCAGGGTCTGGAGACTA GCTTTATTCCCTGAGGCAGGCCCGTAGTTCCTTCAGGTTCCTCCTTACTCTTACATTCTTAGGGTAATGA TTTCTGGCAATTTCAAAATGGAAAACCTTGTCCCTAAGGCTCCTCCGAAAGTGGTGACTTCTTTTCTTGA GAGAGCAACAGTGACAGCAGTAACAGCTTACCCATGTGCCAGGCAGTGTTCGCCGCCTCATGCCCCTCTA CAAAGGGGAAGTGAGAAGTTCCTTGGCAGATGGGCAGACATGTAGTCTCACCCACAGTTGCCTCGACTGG CGGGAGGTGGTGTGGGGATTCCCAGGTGTCCTTAGGCTTGGGCAGGCCTCCCCCTCACCCCAGGAGAGCC ACCGGGTGAGGAATAGCTTCGCGTACCAGAAGCCATCCGGTTCAAAGGATCTCAGCTGCCCAGAGTCAAC CTGCTTCTCCAGGGTGGTCTCCATGGTGGGTGTCCTCTAGGCTCAGTGAGGCACCTGGACAGAGATCTGT AGTAGCCCCTCAGCTCTAGGCTGGCCGACACCATGGCAGTCCCCCCAGGAACTAACCAGAACCGCTCCTC CCTCCTCAACACGCTTGCCGCCACCCAGACTCCACAGCTGGGTGAAGAGACTGGGCTGGGAAGGGAGCAG AGAAGCGGGTGGATGGCCGAGCCTGGCACATTTGGTGTGCAGGACTCCGACTGCATTCTGAGGGGTGGTT CACTGTGGGAAATGGGGTCTGACTTTGGTGGATAGGAAGAGTCGGGAGCAGAATCCAGATGAGACCCAGG GCAGGCTGCCTGGGTAGAGAAGTAGGACAGACTCGGAGGCAGAATCGAGAGGACCTGGTGATGGATGGAT GTGGGGTGGTGGCAGCATCAAGTGTTTAAATCCTAAGCTTGGGACGGGCATGTGAGGTGGGAGCGTTCAG AACAGGCACGTGCCAGGTCTCACCTCACACATGACCCAGGGTTGCGGAGGCTGCTGGGAGCCGGCGGGAT TGGGCCTGTGGGATCCTGTCAGGGCATAATAAGTAGACTCTTCTTTCCTGAGGTGCACCCAGACACTTCT AGGGAGGATGTGACCCCAGAGCTTTTCCCCATGTAGGGTTCTTCTCATTCTCCAGCATCCCCCTGCCTTT CCTGGGCCAAGAGTCAGCGTGGAACCCCATACGAATCCCCAGGGAGGAGAGGGCACAGAGCACCGGAACC AGCAGTAGGAATTGGAAAACCAGGCGTGGCTTCTTCCCAGAAATCTCAGGCATCAAGAGGCAGAAACCCA CTCCCCAGCCTCAGCTTGGCCAGGAAGTGCTGCTGTGGGCTGGAGAGGATGGGTCTAGGCCAAGGTGAAC ATGCAGAGAGCTGGCTGCTCACCCTTCCTCCACCCCATAAAGTGGTCTGAGTAACAGAGCAGCTAGGCAG CGTCCAGGAGCCAGCCCTGGACAAGGTTGGGTCCCTTTGACTGTGTGACCACAGGCAGGAGACGTAACTC AGGGTGGAGCTCTGGTCACACCTCACTTACACACAGCCCTCTTGTCAGTTGCCCCAACATCTCAAGAGAT CTTCAAGCTTATTTAGGTAGTTTCAAGCCTTACTTAGCACCTATTTACTCTTTCTTTGTATACAATTCAA ACAAATTCCATTTGCTGACTTCTTGGCAAATTTCAAAAGAGGTGTGGAGAGTTGTACAAGACAAGCCTCT GAACCACAGAGGGTTGGGGGAATACCTTAGAACTATGGAATGCAGAAATTTAGCCATCAGGAGCCAGTCT GCACAGGGACAAACACCTCTCCTTGCCCCTGGAGAGAGCCCCAAGGGCAGACACCATTGCCCTGCAGCCC TGCTTGTAGGTCTGGTTGCTCAGGAGAGCAAAGTGAAATCTCTTCACATTTTCACCCCATAATGGGTCAG GAAAGATTGGACCCTCAGAAGGGCAAGCGCCATTTATCTGGACCGTTCCCATATCCACCCTCATTCAGAG CAGCCTGTTCTTGGTGGAGCCTGATAAACGGGGCATTACCGTTCCCAACCAGTCCTCCTCTGGGGTTAGT TTCGTCCACAGAAGAACACTTTGCATTTTGTTACTCTGTTTTTTGTCAAAATCTGCCTTCTGTCTGCCCC CAGCAGAATCAAGGGGTTCTAAGAGGAGAGCCTAACACCTTTGGTTCGATTCCTCCATTTCCTCACCAGG TATCCCTGGCACTGGCTCTGGGACAGACCATGGTGTGAATCAACTGTCTTCCTCAGGGAAGACAAACTCC TGGAGTCAGGGAAACCTGGATCTCGAAAGGTTTCAGCAATAAGGCCAGGGGTACCTTCCAGGCAGGAGTA GTAGCATCTCAAAGGCGTAGAGGGGTGGGAGATGGTGTGTAGTGAGTGCAAAGGTGTGGTAGGTAGGGAG ATTGGATTGATACCTGGCAGGAGCCCCGATTTTGAGTTACGGGTTGAAGGCTTGGGGAGACTCTGTTAGT GGTCTGCACAGCCTTCAGGCCACCAGTGTGCAGTGGGGTGATTTTAGGGATGATGACACCAAGCACTGTT TCACTGATTCCCTGCAGCACTGTGAAGCAGCTCCTGCTAATGTCTGCACTTTAGAAATGGGGCCATGGAA ACTCACAGATGAAATAACTTGCTCATGGTCACACTGGAAATAAGGGGTGGAGCTAGGACCTGAATTTAGT TGTGTCCAGAATCAGAGTTCAGGTTTCTATTCACTGCCCTGCATGGCGTCCTTGGAACGGACAAGCAGAT CCTTAGGGCTTGCCTCTGCCCTACCAACTGTCCTCGCCCCTTGGAGCCTGGCCTCCATCAGATGCCTGCT GACTTGGGACAGGTTGTGACAGGGCAGGGGAAAAGATGGCTAGAGGCTGAGCACCCACAGCAATGGGAAG GAAGGCACCAGGAGGCAGGCCCAGCATATTTGAATAGGTGGGCATTTCTGGGACTGCAGGCTTTGGTTTG GCAAGTGTGCCTGCCCACACCTTCTTCTTCTGCTAGACCTCAGTGGGTTGGAAGGGATAGGGAGGACCAA CAGCAGTGATGGAGGCTGCAGAGGCTGCATACCGCTGTGTGTGCATGAACCTGTGGCATGCACACACACG GAGGGGTGTTGGGATGGGTTGGGTTCACATGGAATTGAGTTTGAGCTGTAAGTGGTAGGGGATGAGGGGC ATGTGAGTTTGTGACTGGCTAAAGCAGGAATATTTAGATTCTATGAGCACGGGTATGTGTGTGTGATGGT ATACGTGCATAAGAAGCCGTTTCTGGGTAACTAGGGCCTGCACTCTGCTATACGTGTGGCTGGGTGGGTC TGGCCAGTCCCATGGCACTGAGAGTGTGGTGAGTGTGCTCAGGCAGAACGGGTGCTGCCTGCCTACCACA TCCGTGGGAGCTGGCCAGGGTGGGGGCAGGGCTGGTGGGCAGGGCTGCCCTAGGACGGGCGTTTCCAGTT CCTGGAACTGCTTCCTTGTGTGGAACCTTTCCCCATACCTCCTAGCTGGGCCCTTGGGAGAGGGGAGGAG GCCGTGGGTCCTTCAAGGGGGTGCTCGCAGGCCAGACACAAGGGAGCTAGGCCTGGGGAACAGAAAGCCA CAGCGTGAGTCTTTCAAGCACTTCTGAAGGGTGACATGTGTGAGTTTGTCACACCAGGCCCTCAGTGCGG TCAGGGAGTCTGTACTTCCTGGATGGCGGAACCTGTCTGTCAAGCCCTGCTTCCTCCCCAGCAAGGGGTT GGGGGGAGGGCCTGATGGCAGGAGATGGGCCCCTGGGGCTTTGAGACATGGTGAGGAGAAAAGGGGCAAG TGGGAAGACCCTTTTCCTTCTGTATTTCTCTTTTTTTTTTTTTTTTTTTGAGACATAGAGTCTCACTCTG TCACTCAGGCTGAAGTGCAGTGGCACAGTCTTGGCTCACTGCAAACTCCGTGTCCTGGGTTTAAGCAATT CTGCCTTAGCCTCCCGTGTAGCTGGGATTACATGCTTGCGCCACCACGTCCAGCTAATTTTTTTTTTATT TTTAGTAGAGATAGGGTTTCACCATGTTGGTCTGGCTGGTCTCGAACTCCTGATCTCCAGTGATCTGCTT GCCTTGATCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACACCTGGTCTTGTACCTCTCTGTTCT ATGCCTGAACTTCCACCACTGATCACTTGCCATCATCCCAGCAAGTCACACTGAGCCTGTGAAACCACAG GGCACTGGAAACCACACGTTAGGGGAAGTGGGAGAGTTGGCGGGGCTCTCAGATGAACTCCAACCCCTTG TTTCTCGCCTGGGGAAAGTGAGGCCCACAAAAATAGAGGGACTTGGCTCAAGAACATGCAGTGAATCTGT GGCAGAGCCAGGCCCTGGCCCTCTCTTAGGGAGGGGTGCAAGGGGAAAGGAAAAGGAAGACTGGGTCCTG GCCCCTGGCTTGCTCACCCAGGCTGCATCTCCCCCTGCAGGTGATCGAGGAGTTCTACAACCAGACATGG GTCCACCGCTATGGGGAGAGCATCCTGCCCACCACGCTCACCACGCTCTGGTCCCTCTCAGTGGCCATCT TTTCTGTTGGGGGCATGATTGGCTCCTTCTCTGTGGGCCTTTTCGTTAACCGCTTTGGCCGGTAAGTAGG AGAGGTCCTGGCACTGCCCTTGGAGGGCCCATGCCCTCCTGCCCAGGGAGTCCCAGATGGGGTGGGAGGT AGGGGAGACTTATCTGCCTGTTCCAGGGTATTACCTCTGACCCAGCCCCTCGGAGCCCAAGGAATGTGGG CACTGGCCTGACCTGTGACCCCGTCCCCAGGCGGAATTCAATGCTGATGATGAACCTGCTGGCCTTCGTG TCCGCCGTGCTCATGGGCTTCTCGAAACTGGGCAAGTCCTTTGAGATGCTGATCCTGGGCCGCTTCATCA TCGGTGTGTACTGCGGCCTGACCACAGGCTTCGTGCCCATGTATGTGGGTGAAGTGTCACCCACAGCCCT TCGTGGGGCCCTGGGCACCCTGCACCAGCTGGGCATCGTCGTCGGCATCCTCATCGCCCAGGTAAGCTGG GGCAGGATCTACCTGCCTGGCACGGCCCCTGCCCACAGCTTCAGTGGCTCTCGGATCTGTGCCCAGCAGG GCAGAGTTTCTCTTCCGCCCAGCCCCCACAGCCTTGCAGAGGACAACTATGGTACACAGGTCCAGAGAAC ACAGCACCATGGCCTCCCAGTTGACAGCAAGATGACTTGACTCTTCTCAGTCCCTTTCTTCTCACTCTAG GCTTCCAACCACAGGGCCCGCCTTCCCCCAACATGCCGCAGGCTGTTATGCACAGTACCCTCTCTCCAGG AGGCTTCCCCTTCCCTGTCCCCAAAACCCTCTTGTGGCAGAGTAGCAGCCCCCATTCTCTGTGCTGGACA CATCTGTGGCCTTGTCATTTGTCCTCCCAGCAACACTGTGGGGTAGGTCCTACTTTTCCCATGTGACCGA TGAGGAAACTGAGAAACAGGGCTCATGCTAGTGGCAGAGCCTCTAGAACTGGGGCCCTTCCCTGAAGCAG CAGCTGACACAAAGTAGGGAAGGCCACTCTGGCAGGACGGGGTGGGAAAGGGGGTCAGGGCAGAGGCGCT CACGGCCCCTGCTTCCCCCAGGTGTTCGGCCTGGACTCCATCATGGGCAACAAGGACCTGTGGCCCCTGC TGCTGAGCATCATCTTCATCCCGGCCCTGCTGCAGTGCATCGTGCTGCCCTTCTGCCCCGAGAGTCCCCG CTTCCTGCTCATCAACCGCAACGAGGAGAACCGGGCCAAGAGTGGTACGGGCATGGCCCTGCCCTCCTCC CCACTCCCTGAGCCCTGGCCTTCTTCCCACTCTGAGCCACCCTCACCTTCCCTCCGGTCCCCCCAGTGCT AAAGAAGCTGCGCGGGACAGCTGACGTGACCCATGACCTGCAGGAGATGAAGGAAGAGAGTCGGCAGATG ATGCGGGAGAAGAAGGTCACCATCCTGGAGCTGTTCCGCTCCCCCGCCTACCGCCAGCCCATCCTCATCG CTGTGGTGCTGCAGCTGTCCCAGCAGCTGTCTGGCATCAACGCTGTGAGTGCCCCCACCCACCCTTCCTG TGCCCCAGCCAAGCCCTCTGGTCAAGTGTGCATGGTGAACAAGTCCCAAACTTGAAACAACAGATACGCC TCTGCCGAAGAAGTTTCCCTTTAGACCCCAAGCCCGTAAGGTCACTGCAGTGCAGTGTCCCTTCTGCCTG AGTATTTGTCCCCTTCATTCTTTACTCATCCTGGGTCCCACATCCACTGCTACAGAGGCAGGGAAGGGCC ACAATGTCCAGGTAGGCCCCAACAGTTTCTCTTGTCTGGCAGGTCTTCTATTACTCCACGAGCATCTTCG AGAAGGCGGGGGTGCAGCAGCCTGTGTATGCCACCATTGGCTCCGGTATCGTCAACACGGCCTTCACTGT CGTGTCGGTGAGTCTTTGCTTACTGGCCCCCCCAGCCAAACCCCAGGGAGGAGGCAGTGCCATCTTCCCC ACTGGTCTTTGCAGTGCCCTGTGACTTTCTCAGCTCTTGAGGCAAGGCCTCTGGGTGGGTGGGTTCAGAA GGGCACTAGGCAGGGGTGGCACTGACACTGTCTCTGCCCACAGCTGTTTGTGGTGGAGCGAGCAGGCCGG CGGACCCTGCACCTCATAGGCCTCGCTGGCATGGCGGGTTGTGCCATACTCATGACCATCGCGCTAGCAC TGCTGGTGAGTTGCTAGGTTCTGGAGAGTGAGGGATGCGGGAGAGTTTGCCTGGGCTTCATATCCCAAAA TGCCTGTCTCAGCCCCAGGCTGGCAGGCCTTTTGGTGGCTGCATTCTCCCTGGCTGTGGGTCTGACTTTC TGGCTCCTGAAGTTGTCTCCTTCCAAACCACACACATCCTCTCTTGAACTTGCTCCTCCCTGCTTGATGG ATTCTCAGCGCAGCACCTCTGGTCCCAGACCCCAAACTCTCACCTCCTTAAGGAATTGCTTTGCCTAATA TTAACCCTTTCCAATCTTCATCTGTAGCCTCAATTCATCTTCACAGCAACCCCGGGAAGTAGTGCTGTCC TCCCCATAGAGGCGCAGAAACATGCCTTGCCTCATTCAGTTCACACGACTGGAGGTGTAGTTCAGTTCTT CCCATTTTATGGGGGAGGAAGCTTAAGTCCCAGTGAGGTTAGTAACTTGTCAGATAAAGGATGAAGCCAG GAATCAACCTCAGTCCCAGGCCTGTGACTGTGACCGCTGTGCTAACCCTGTGCCTGGCACTCACACACAG GCACTCGTTTATTTAGCCTCTGGGCAAGGAAAGCACCATGACTGTCATTTTACAGCTCAACCTGGGCTTG GAAAGTTTGGTGGTTGCCGAAAGGCCAGACAGGCAGCAAGTGGAAAGCCCATAAATTTTCTACCCTGGCC TCCTCAAGAATGGTTATATGCAGAACCGTATGCTTAGCGCTTACTCTGTGCCAGCCTGAGCTGGGCACCT CACACGCCTTAGAACCTGAATCCACCCCACCCCCAGGAATGTTCTGCATCCTGCCACAGGCGGACTGTGC TGCAGGCACAGACAGGGGACCATGGGGCCTCTTAGCACCGTCCACATGCACACCACATTACCACTCCCAG CGGGTGGACTCAACACTTGCAGCCACCCTGCAGGACTTAAATCATTTTGTTCGGATGAGGAAACTTAGGC CCAATGCTGGATACACAACAAATCCAGGACCATCCCCAGGCTTCCTGCCTTCTCGCATAGCTCTGCTCTG GCCTCTGTAGCTTCTGTTTCCCCTGAGGATCCATCACAACCCAGTCTAACTTTTCCCCCTCTCCGTCATC CTCAACAGGAGCAGCTACCCTGGATGTCCTATCTGAGCATCGTGGCCATCTTTGGCTTTGTGGCCTTCTT TGAAGTGGGTCCTGGCCCCATCCCATGGTTCATCGTGGCTGAACTCTTCAGCCAGGGTCCACGTCCAGCT GCCATTGCCGTTGCAGGCTTCTCCAACTGGACCTCAAATTTCATTGTGGGCATGTGCTTCCAGTATGTGG AGGTGAGAACCCCCACTGTCTCTATACTCACCCGCACGCATGACCCCACAGTGCTGTGCAAAGTGCTGGC CCAGCATTCTCATTAGGAATCATGCTGAGGAGGAAACTGAGGGTAGGAAGCCCAGGTCACATGACCAAGA ATGCTGACCTCAACTCCAGGGTTCTCCCCTTAGCCTTGAATGGTGCTCCTGGAGCCTGTTACATTCTAGG TACAAGCGTGGTCTCAGTTAATTATGATAGCATCCCTGGGTAGGTGGATGTTCCCTTTTCAGCTCAAAGG CCCAAAGGTAAAGTGACTTATCCAAAGTCCTACAGCCAGGATGTAGGGTCATGACTCCAACCAAGTGTGT CTGTGTGTCTTTCAGCAACTGTGTGGTCCCTACGTCTTCATCATCTTCACTGTGCTCCTGGTTCTGTTCT TCATCTTCACCTACTTCAAAGTTCCTGAGACTAAAGGCCGGACCTTCGATGAGATCGCTTCCGGCTTCCG GCAGGGGGGAGCCAGCCAAAGTGACAAGACACCCGAGGAGCTGTTCCATCCCCTGGGGGCTGATTCCCAA GTGTGAGTCGCCCCAGATCACCAGCCCGGCCTGCTCCCAGCAGCCCTAAGGATCTCTCAGGAGCACAGGC AGCTGGATGAGACTTCCAAACCTGACAGATGTCAGCCGAGCCGGGCCTGGGGCTCCTTTCTCCAGCCAGC AATGATGTCCAGAAGAATATTCAGGACTTAACGGCTCCAGGATTTTAACAAAAGCAAGACTGTTGCTCAA ATCTATTCAGACAAGCAACAGGTTTTATAATTTTTTTATTACTGATTTTGTTATTTTTATATCAGCCTGA GTCTCCTGTGCCCACATCCCAGGCTTCACCCTGAATGGTTCCATGCCTGAGGGTGGAGACTAAGCCCTGT CGAGACACTTGCCTTCTTCACCCAGCTAATCTGTAGGGCTGGACCTATGTCCTAAGGACACACTAATCGA ACTATGAACTACAAAGCTTCTATCCCAGGAGGTGGCTATGGCCACCCGTTCTGCTGGCCTGGATCTCCCC ACTCTAGGGGTCAGGCTCCATTAGGATTTGCCCCTTCCCATCTCTTCCTACCCAACCACTCAAATTAATC TTTCTTTACCTGAGACCAGTTGGGAGCACTGGAGTGCAGGGAGGAGAGGGGAAGGGCCAGTCTGGGCTGC CGGGTTCTAGTCTCCTTTGCACTGAGGGCCACACTATTACCATGAGAAGAGGGCCTGTGGGAGCCTGCAA ACTCACTGCTCAAGAAGACATGGAGACTCCTGCCCTGTTGTGTATAGATGCAAGATATTTATATATATTT TTGGTTGTCAATATTAAATACAGACACTAAGTTATAGTATATCTGGACAAGCCAACTTGTAAATACACCA CCTCACTCCTGTTACTTACCTAAACAGATATAAATGGCTGGTTTTTAGAAACATGGTTTTGAAATGCTTG TGGATTGAGGGTAGGAGGTTTGGATGGGAGTGAGACAGAAGTAAGTGGGGTTGCAACCACTGCAACGGCT TAGACTTCGACTCAGGATCCAGTCCCTTACACGTACCTCTCATCAGTGTCCTCTTGCTCAAAAATCTGTT TGATCCCTGTTACCCAGAGAATATATACATTCTTTATCTTGACATTCAAGGCATTTCTATCACATATTTG ATAGTTGGTGTTCAAAAAAACACTAGTTTTGTGCCAGCCGTGATGCTCAGGCTTGAAATGCATTATTTTG AATGTGAAGTAAATACTGTACCTTTATTGGACAGGCTCAAAGAGGTTATGTGCCTGAAGTCGCACAGTGA ATAAGCTAAAACACCTGCTTTTAACAATGGTACCATACAACCACTACTCCATTAACTCCACCCACCTCCT GCACCCCTCCCCACACACACAAAATGAACCACGTTCTTTGTATGGGCCCAATGAGCTGTCAAGCTGCCCT GTGTTCATTTCATTTGGAATTGCCCCCTCTGGTTCCTCTGTATACTACTGCTTCATCTCTAAAGACAGCT CATCCTCCTCCTTCACCCCTGAATTTCCAGAGCACTTCATCTGCTCCTTCATCACAAGTCCAGTTTTCTG CCACTAGTCTGAATTTCATGAGAAGATGCCGATTTGGTTCCTGTGGGTCCTCAGCACTATTCAGTACAGT GCTTGATGCACAGCAGGCACTCAGAAAATACTGGAGGAAATAAAACACCAAAGATATTTGTC Download Select all
Length	33802
OMIM ID	138140
HGNC ID	HGNC:11005
Unigene ID	Hs.473721
Ensembl ID	ENSG00000117394
PharmGKB ID	-

mRNA Information

mRNA ID	NM_006516.2
Exon	join(1..543,15856..15951,27971..28131,28311..28551, 29142..29304,29397..29584,29863..29967,30144..30245, 31369..31572,31936..33802)
mRNA Sequence	>6513 TCCACCATTTTGCTAGAGAAGGCCGCGGAGGCTCAGAGAGGTGCGCACACTTGCCCTGAGTCAC ACAGCGAATGCCCTCCGCGGTCCCAACGCAGAGAGAACGAGCCGATCGGCAGCCTGAGCGAGGC AGTGGTTAGGGGGGGCCCCGGCCCCGGCCACTCCCCTCACCCCCTCCCCGCAGAGCGCCGCCCA GGACAGGCTGGGCCCCAGGCCCCGCCCCGAGGTCCTGCCCACACACCCCTGACACACCGGCGTC GCCAGCCAATGGCCGGGGTCCTATAAACGCTACGGTCCGCGCGCTCTCTGGCAAGAGGCAAGAG GTAGCAACAGCGAGCGTGCCGGTCGCTAGTCGCGGGTCCCCGAGTGAGCACGCCAGGGAGCAGG AGACCAAACGACGGGGGTCGGAGTCAGAGTCGCAGTGGGAGTCCCCGGACCGGAGCACGAGCCT GAGCGGGAGAGCGCCGCTCGCACGCCCGTCGCCACCCGCGTACCCGGCGCAGCCAGAGCCACCA GCGCAGCGCTGCCATGGAGCCCAGCAGCAAGAAGCTGACGGGTCGCCTCATGCTGGCCGTGGGA GGAGCAGTGCTTGGCTCCCTGCAGTTTGGCTACAACACTGGAGTCATCAATGCCCCCCAGAAGG TGATCGAGGAGTTCTACAACCAGACATGGGTCCACCGCTATGGGGAGAGCATCCTGCCCACCAC GCTCACCACGCTCTGGTCCCTCTCAGTGGCCATCTTTTCTGTTGGGGGCATGATTGGCTCCTTC TCTGTGGGCCTTTTCGTTAACCGCTTTGGCCGGCGGAATTCAATGCTGATGATGAACCTGCTGG CCTTCGTGTCCGCCGTGCTCATGGGCTTCTCGAAACTGGGCAAGTCCTTTGAGATGCTGATCCT GGGCCGCTTCATCATCGGTGTGTACTGCGGCCTGACCACAGGCTTCGTGCCCATGTATGTGGGT GAAGTGTCACCCACAGCCCTTCGTGGGGCCCTGGGCACCCTGCACCAGCTGGGCATCGTCGTCG GCATCCTCATCGCCCAGGTGTTCGGCCTGGACTCCATCATGGGCAACAAGGACCTGTGGCCCCT GCTGCTGAGCATCATCTTCATCCCGGCCCTGCTGCAGTGCATCGTGCTGCCCTTCTGCCCCGAG AGTCCCCGCTTCCTGCTCATCAACCGCAACGAGGAGAACCGGGCCAAGAGTGTGCTAAAGAAGC TGCGCGGGACAGCTGACGTGACCCATGACCTGCAGGAGATGAAGGAAGAGAGTCGGCAGATGAT GCGGGAGAAGAAGGTCACCATCCTGGAGCTGTTCCGCTCCCCCGCCTACCGCCAGCCCATCCTC ATCGCTGTGGTGCTGCAGCTGTCCCAGCAGCTGTCTGGCATCAACGCTGTCTTCTATTACTCCA CGAGCATCTTCGAGAAGGCGGGGGTGCAGCAGCCTGTGTATGCCACCATTGGCTCCGGTATCGT CAACACGGCCTTCACTGTCGTGTCGCTGTTTGTGGTGGAGCGAGCAGGCCGGCGGACCCTGCAC CTCATAGGCCTCGCTGGCATGGCGGGTTGTGCCATACTCATGACCATCGCGCTAGCACTGCTGG AGCAGCTACCCTGGATGTCCTATCTGAGCATCGTGGCCATCTTTGGCTTTGTGGCCTTCTTTGA AGTGGGTCCTGGCCCCATCCCATGGTTCATCGTGGCTGAACTCTTCAGCCAGGGTCCACGTCCA GCTGCCATTGCCGTTGCAGGCTTCTCCAACTGGACCTCAAATTTCATTGTGGGCATGTGCTTCC AGTATGTGGAGCAACTGTGTGGTCCCTACGTCTTCATCATCTTCACTGTGCTCCTGGTTCTGTT CTTCATCTTCACCTACTTCAAAGTTCCTGAGACTAAAGGCCGGACCTTCGATGAGATCGCTTCC GGCTTCCGGCAGGGGGGAGCCAGCCAAAGTGACAAGACACCCGAGGAGCTGTTCCATCCCCTGG GGGCTGATTCCCAAGTGTGAGTCGCCCCAGATCACCAGCCCGGCCTGCTCCCAGCAGCCCTAAG GATCTCTCAGGAGCACAGGCAGCTGGATGAGACTTCCAAACCTGACAGATGTCAGCCGAGCCGG GCCTGGGGCTCCTTTCTCCAGCCAGCAATGATGTCCAGAAGAATATTCAGGACTTAACGGCTCC AGGATTTTAACAAAAGCAAGACTGTTGCTCAAATCTATTCAGACAAGCAACAGGTTTTATAATT TTTTTATTACTGATTTTGTTATTTTTATATCAGCCTGAGTCTCCTGTGCCCACATCCCAGGCTT CACCCTGAATGGTTCCATGCCTGAGGGTGGAGACTAAGCCCTGTCGAGACACTTGCCTTCTTCA CCCAGCTAATCTGTAGGGCTGGACCTATGTCCTAAGGACACACTAATCGAACTATGAACTACAA AGCTTCTATCCCAGGAGGTGGCTATGGCCACCCGTTCTGCTGGCCTGGATCTCCCCACTCTAGG GGTCAGGCTCCATTAGGATTTGCCCCTTCCCATCTCTTCCTACCCAACCACTCAAATTAATCTT TCTTTACCTGAGACCAGTTGGGAGCACTGGAGTGCAGGGAGGAGAGGGGAAGGGCCAGTCTGGG CTGCCGGGTTCTAGTCTCCTTTGCACTGAGGGCCACACTATTACCATGAGAAGAGGGCCTGTGG GAGCCTGCAAACTCACTGCTCAAGAAGACATGGAGACTCCTGCCCTGTTGTGTATAGATGCAAG ATATTTATATATATTTTTGGTTGTCAATATTAAATACAGACACTAAGTTATAGTATATCTGGAC AAGCCAACTTGTAAATACACCACCTCACTCCTGTTACTTACCTAAACAGATATAAATGGCTGGT TTTTAGAAACATGGTTTTGAAATGCTTGTGGATTGAGGGTAGGAGGTTTGGATGGGAGTGAGAC AGAAGTAAGTGGGGTTGCAACCACTGCAACGGCTTAGACTTCGACTCAGGATCCAGTCCCTTAC ACGTACCTCTCATCAGTGTCCTCTTGCTCAAAAATCTGTTTGATCCCTGTTACCCAGAGAATAT ATACATTCTTTATCTTGACATTCAAGGCATTTCTATCACATATTTGATAGTTGGTGTTCAAAAA AACACTAGTTTTGTGCCAGCCGTGATGCTCAGGCTTGAAATGCATTATTTTGAATGTGAAGTAA ATACTGTACCTTTATTGGACAGGCTCAAAGAGGTTATGTGCCTGAAGTCGCACAGTGAATAAGC TAAAACACCTGCTTTTAACAATGGTACCATACAACCACTACTCCATTAACTCCACCCACCTCCT GCACCCCTCCCCACACACACAAAATGAACCACGTTCTTTGTATGGGCCCAATGAGCTGTCAAGC TGCCCTGTGTTCATTTCATTTGGAATTGCCCCCTCTGGTTCCTCTGTATACTACTGCTTCATCT CTAAAGACAGCTCATCCTCCTCCTTCACCCCTGAATTTCCAGAGCACTTCATCTGCTCCTTCAT CACAAGTCCAGTTTTCTGCCACTAGTCTGAATTTCATGAGAAGATGCCGATTTGGTTCCTGTGG GTCCTCAGCACTATTCAGTACAGTGCTTGATGCACAGCAGGCACTCAGAAAATACTGGAGGAAA TAAAACACCAAAGATATTTGTCAAAAAAAAAAAAAAAAA Download Select all
Length	3687

CDS Information

Location	join(526..543,15856..15951,27971..28131,28311..28551, 29142..29304,29397..29584,29863..29967,30144..30245, 31369..31572,31936..32136)
CDS Sequence	>gi\|166795298:526-2004 Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 1 (SLC2A1), mRNA ATGGAGCCCAGCAGCAAGAAGCTGACGGGTCGCCTCATGCTGGCCGTGGGAGGAGCAGTGCTTGGCTCCC TGCAGTTTGGCTACAACACTGGAGTCATCAATGCCCCCCAGAAGGTGATCGAGGAGTTCTACAACCAGAC ATGGGTCCACCGCTATGGGGAGAGCATCCTGCCCACCACGCTCACCACGCTCTGGTCCCTCTCAGTGGCC ATCTTTTCTGTTGGGGGCATGATTGGCTCCTTCTCTGTGGGCCTTTTCGTTAACCGCTTTGGCCGGCGGA ATTCAATGCTGATGATGAACCTGCTGGCCTTCGTGTCCGCCGTGCTCATGGGCTTCTCGAAACTGGGCAA GTCCTTTGAGATGCTGATCCTGGGCCGCTTCATCATCGGTGTGTACTGCGGCCTGACCACAGGCTTCGTG CCCATGTATGTGGGTGAAGTGTCACCCACAGCCCTTCGTGGGGCCCTGGGCACCCTGCACCAGCTGGGCA TCGTCGTCGGCATCCTCATCGCCCAGGTGTTCGGCCTGGACTCCATCATGGGCAACAAGGACCTGTGGCC CCTGCTGCTGAGCATCATCTTCATCCCGGCCCTGCTGCAGTGCATCGTGCTGCCCTTCTGCCCCGAGAGT CCCCGCTTCCTGCTCATCAACCGCAACGAGGAGAACCGGGCCAAGAGTGTGCTAAAGAAGCTGCGCGGGA CAGCTGACGTGACCCATGACCTGCAGGAGATGAAGGAAGAGAGTCGGCAGATGATGCGGGAGAAGAAGGT CACCATCCTGGAGCTGTTCCGCTCCCCCGCCTACCGCCAGCCCATCCTCATCGCTGTGGTGCTGCAGCTG TCCCAGCAGCTGTCTGGCATCAACGCTGTCTTCTATTACTCCACGAGCATCTTCGAGAAGGCGGGGGTGC AGCAGCCTGTGTATGCCACCATTGGCTCCGGTATCGTCAACACGGCCTTCACTGTCGTGTCGCTGTTTGT GGTGGAGCGAGCAGGCCGGCGGACCCTGCACCTCATAGGCCTCGCTGGCATGGCGGGTTGTGCCATACTC ATGACCATCGCGCTAGCACTGCTGGAGCAGCTACCCTGGATGTCCTATCTGAGCATCGTGGCCATCTTTG GCTTTGTGGCCTTCTTTGAAGTGGGTCCTGGCCCCATCCCATGGTTCATCGTGGCTGAACTCTTCAGCCA GGGTCCACGTCCAGCTGCCATTGCCGTTGCAGGCTTCTCCAACTGGACCTCAAATTTCATTGTGGGCATG TGCTTCCAGTATGTGGAGCAACTGTGTGGTCCCTACGTCTTCATCATCTTCACTGTGCTCCTGGTTCTGT TCTTCATCTTCACCTACTTCAAAGTTCCTGAGACTAAAGGCCGGACCTTCGATGAGATCGCTTCCGGCTT CCGGCAGGGGGGAGCCAGCCAAAGTGACAAGACACCCGAGGAGCTGTTCCATCCCCTGGGGGCTGATTCC CAAGTGTGA Download Select all
CCDS ID	CCDS477.1

Protein Information

Protein ID	NP_006507.2
Protein Name	Solute carrier family 2 (facilitated glucose transporter), member 1
Molecular Wt. (Da)	53953
Protein Sequence	>6513 MEPSSKKLTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWVHRYGESILPTTLTTL WSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFI IGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNKDLWPLLLSI IFIPALLQCIVLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTHDLQEMKEESRQMMREKK VTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAF TVVSLFVVERAGRRTLHLIGLAGMAGCAILMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPG PIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFT YFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV Download Select all
Length	492
Uniprot ID	P11511
Ensembl Protein ID	ENSP00000260433

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
N	Glycosylation	45
S	Phosphorylation	490;-
S	Phosphorylation	473
S	Phosphorylation	465
T	Phosphorylation	478
S	Phosphorylation	118

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
811	CALR	169	NP_004334.1	in vivo	8662691
821	CANX	252	NP_001737.1	in vivo	8662691
2040	STOM	585	NP_004090.4	in vitro;in vivo	10562431
10980	COPS6	16735	NP_006824.2	yeast 2-hybrid	16169070

Pathway Information

Pathway Name	Pathway ID
Adipocytokine signaling pathway	hsa04920
Bile secretion	hsa04976
Central carbon metabolism in cancer	hsa05230
Glucagon signaling pathway	hsa04922
HIF-1 signaling pathway	hsa04066
HTLV-I infection	hsa05166
Insulin resistance	hsa04931
Insulin secretion	hsa04911
Pathways in cancer	hsa05200
Renal cell carcinoma	hsa05211
Thyroid hormone signaling pathway	hsa04919

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd06174	62-450	MFS
cl21472	62-450	MFS superfamily
TIGR00880	66-206	2_A_01_02
cd06174	66-208	MFS
pfam00083	19-467	Sugar_tr
TIGR00879	19-463	SP
PRK10077	19-463	xylE
TIGR00898	50-462	2A0119
TIGR00883	67-407	2A0106
pfam07690	66-417	MFS_1
TIGR00895	65-245	2A0115
TIGR01299	71-234	synapt_SV2
TIGR00887	73-464	2A0109
TIGR00893	66-449	2A0114
TIGR00891	57-410	2A0112
COG2814	67-176	AraJ
TIGR00891	54-169	2A0112
pfam07690	66-171	MFS_1
COG0477	52-372	ProP
pfam13347	64-147	MFS_2
TIGR00883	57-155	2A0106
pfam13347	245-410	MFS_2

Ontology Information

HPRD ID	3139
Molecular Class	Membrane transport protein
Molecular Function	Receptor signaling complex scaffold activity (GO:0030159)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report

Drug Information

Uniprot ID DrugBank ID Name Type
P11166 DB00292 Etomidate SmallMoleculeDrug

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO