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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SLC6A4 6532 solute carrier family 6 (neurotransmitter transporter), member 4  175-HTT, SERT1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22911682   2012Cell line : -

Source : Avalon Peninsula of Newfoundland, new cases (diagnosed at the Health Sciences Centre, Grace General Hospital, St. Clares Mercy Hospital (all in St. Johns), and Carbonear General Hospital)

Sample Type : population based and retrospective study

No. of Sample : -

Stage : TNM Stage I-IV

Selection and Genotyping of Polymorphisms,Linkage Disequilibrium (LD) Map,Demographic and Clinicopathological VariablesPolymorhpism-Genetic variations in the SLC6A4 gene contribute to poor survival in colorectal cancer patients.


Gene Details



NC_000017.10 (28521337..28562986, complement)

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Gene Type protein coding
Gene Family Solute carriers
Description This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]  
Chromosome 17
Location 17q11.2
Start 28521337  
End 28562986  
Strand -  
Gene Sequence

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Length 41650  
OMIM ID 182138   
HGNC ID HGNC:11050   
Unigene ID Hs.29792   
Ensembl ID ENSG00000108576   
PharmGKB ID PA312   

mRNA Information


mRNA ID ?NM_001045.5
Exon join(1..356,13054..13150,13888..14353,17038..17172, 17632..17851,18665..18803,19753..19887,20255..20358, 23102..23229,24545..24657,25323..25454,26727..26826, 28137..28237,32630..32797,37439..41650)  
mRNA Sequence

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Length 6615  



CDS Information


   
Location 577..2469
CDS Sequence

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CCDS ID CCDS11256.1



Protein Information


      
Protein IDNP_001036.1
Protein Namesolute carrier family 6 (neurotransmitter transporter), member 4
Molecular Wt. (Da)61149
Protein Sequence

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Length 630  
Uniprot IDQ8NFH8
Ensembl Protein ID ENSP00000306033  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
811CALR169NP_004334.1in vivo10364189   


Pathway Information


      
Pathway Name Pathway ID
Serotonergic synapse hsa04726


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd1151379-615  SLC6sbd_SERT
cl0045679-615  SLC5-6-like_sbd superfamily
cd1149779-615  SLC6sbd_SERT-like
pfam0020979-598  SNF
cl1197679-598  SNF superfamily
cd1155679-614  SLC6sbd_SERT-like_u1
cd1149679-614  SLC6sbd-TauT-like
cd1151279-626  SLC6sbd_NET
cd1151479-626  SLC6sbd_DAT1
cd1150079-614  SLC6sbd_PROT
cd1150633-614  SLC6sbd_GAT1
cd1151178-614  SLC6sbd_BGT1
cd1032480-554  SLC6sbd
cd1149979-615  SLC6sbd_GlyT2
cd1151079-614  SLC6sbd_TauT
cd1150979-614  SLC6sbd_CT1
cd1150779-614  SLC6sbd_GAT2
cd1033279-596  SLC6sbd-B0AT-like
cd1149878-615  SLC6sbd_GlyT1
cd1150878-614  SLC6sbd_GAT3
cd1150179-614  SLC6sbd_ATB0
cd1151579-595  SLC6sbd_NTT4-like
cd1151778-598  SLC6sbd_B0AT3
cd1152279-595  SLC6sbd_SBAT1
cd1151879-590  SLC6sbd_SIT1
cd1152179-561  SLC6sbd_NTT4
cd1151679-598  SLC6sbd_B0AT1
cd1033479-552  SLC6sbd_u1
cd1155482-536  SLC6sbd_u2
cd1150279-554  SLC6sbd_NTT5
COG073376-559  YocR
cd1033680-553  SLC6sbd_Tyt1-Like
cd1033379-596  LeuT-like_sbd
cd0685787-552  SLC5-6-like_sbd
pfam0349123-64  5HT_transporter
cl0410823-64  5HT_transporter superfamily


Ontology Information


   
HPRD ID9202
Molecular ClassTransport/cargo protein
Molecular FunctionProtein serine/threonine kinase activity (GO:0004674)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P31645DB00176FluvoxamineSmallMoleculeDrug
P31645DB00182AmphetamineSmallMoleculeDrug
P31645DB00191PhentermineSmallMoleculeDrug
P31645DB00193TramadolSmallMoleculeDrug
P31645DB00215CitalopramSmallMoleculeDrug
P31645DB00285VenlafaxineSmallMoleculeDrug
P31645DB00289AtomoxetineSmallMoleculeDrug
P31645DB00321AmitriptylineSmallMoleculeDrug
P31645DB00344ProtriptylineSmallMoleculeDrug
P31645DB00370MirtazapineSmallMoleculeDrug
P31645DB00408LoxapineSmallMoleculeDrug
P31645DB00422MethylphenidateSmallMoleculeDrug
P31645DB00454PethidineSmallMoleculeDrug
P31645DB00458ImipramineSmallMoleculeDrug
P31645DB00472FluoxetineSmallMoleculeDrug
P31645DB00476DuloxetineSmallMoleculeDrug
P31645DB00514DextromethorphanSmallMoleculeDrug
P31645DB00540NortriptylineSmallMoleculeDrug
P31645DB00543AmoxapineSmallMoleculeDrug
P31645DB00579MazindolSmallMoleculeDrug
P31645DB00656TrazodoneSmallMoleculeDrug
P31645DB00661VerapamilSmallMoleculeDrug
P31645DB00715ParoxetineSmallMoleculeDrug
P31645DB00726TrimipramineSmallMoleculeDrug
P31645DB00805MinaprineSmallMoleculeDrug
P31645DB00852PseudoephedrineSmallMoleculeDrug
P31645DB00907CocaineSmallMoleculeDrug
P31645DB00988DopamineSmallMoleculeDrug
P31645DB01104SertralineSmallMoleculeDrug
P31645DB01105SibutramineSmallMoleculeDrug
P31645DB01114ChlorphenamineSmallMoleculeDrug
P31645DB01142DoxepinSmallMoleculeDrug
P31645DB01149NefazodoneSmallMoleculeDrug
P31645DB01151DesipramineSmallMoleculeDrug
P31645DB01175EscitalopramSmallMoleculeDrug
P31645DB01191DexfenfluramineSmallMoleculeDrug
P31645DB01242ClomipramineSmallMoleculeDrug
P31645DB01363EphedraSmallMoleculeDrug
P31645DB01577MethamphetamineSmallMoleculeDrug
P31645DB04896MilnacipranSmallMoleculeDrug
P31645DB06148MianserinSmallMoleculeDrug
P31645DB06204TapentadolSmallMoleculeDrug
P31645DB06700DesvenlafaxineSmallMoleculeDrug
P31645DB06701DexmethylphenidateSmallMoleculeDrug
P31645DB08918LevomilnacipranSmallMoleculeDrug
P31645DB09016ButriptylineSmallMoleculeDrug
P31645DB09068VortioxetineSmallMoleculeDrug
P31645DB00215CitalopramSmallMoleculeDrug
P31645DB06684VilazodoneSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO