Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SLC7A5 | 8140 | Solute carrier family 7 (cationic amino acid transporter, y+ system), member 5  | 16 | E16; CD98; LAT1; 4F2LC; MPE16; hLAT1; D16S469E  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21036745    | 2010 | Cell line : - Source : Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan. Sample Type : - No. of Sample : 44 patients with rectal adenocarcinoma Stage : - | Immunohistochemistry | Up-regulation | - | LAT1 may be a useful predictive marker of response to HCRT in rectal cancer. |
| 22968445    | 2012 | Cell line : - Source : Department of Pathology of Wrocaw Medical University. Sample Type : - No. of Sample : - Stage : - | Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation. | Up-regulation | 17.4 | - |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules,Solute carriers |
| Description | -   | Chromosome | 16 |
| Location | 16q24.3 |
| Start | 131124959   |
| End | 131234670   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 109712   |
| OMIM ID | 600182    |
| HGNC ID | HGNC:11063    |
| Unigene ID | Hs.513797     |
| Ensembl ID | ENSG00000103257    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | XM_005272216.2 |
|---|---|
| Exon | join(1..791,2566..2761,3374..3525,4321..4519,5808..5878, 7638..7701,8148..8251,9940..10046,10982..11048, 14323..14449,15591..15752,19322..19796,21171..21346, 22529..22626,25366..25452,25658..25807,26778..26936, 34425..34528,38033..38215,38912..38997,39103..39186, 49097..49360,50502..50663,53353..53452,62331..62406, 64095..64173,67250..67334,70275..70336,72258..74057, 76689..76759,90254..90410,97820..97972,103202..103373, 105672..105811,107326..107350,108496..109705)   | mRNA Sequence |    Download   Select all |
| Length | 4420   |
CDS Information
| Location | join(624..791,2566..2761,3374..3525,4321..4519,5808..5878, 7638..7701,8148..8251,9940..10046,10982..11048, 14323..14449,15591..15752,19322..19796,21171..21346, 22529..22626,25366..25452,25658..25807,26778..26936, 34425..34528,38033..38215,38912..38997,39103..39186, 49097..49360,50502..50663,53353..53452,62331..62406, 64095..64173,67250..67334,70275..70336,72258..74057, |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | NP_003477.4 |
|---|---|
| Protein Name | Solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 |
| Molecular Wt. (Da) | 54879 |
| Protein Sequence |    Download   Select all |
| Length | 507   |
| Uniprot ID | Q14209 |    
| Ensembl Protein ID | ENSP00000355249   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 35 |
| S | Phosphorylation | 31 |
| T | Phosphorylation | 45 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 6520 |    SLC3A2 |    1148 |    NP_001012679.1 |    in vitro |    982   997   411   311   135    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Central carbon metabolism in cancer |    hsa05230 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| TIGR00911 | 26-506  | 2A0308 |
| pfam13520 | 50-456  | AA_permease_2 |
| COG0531 | 56-478  | PotE |
| TIGR00909 | 46-473  | 2A0306 |
| PRK11357 | 42-474  | frlA |
| TIGR00906 | 42-420  | 2A0303 |
| TIGR00908 | 57-474  | 2A0305 |
| pfam00324 | 58-416  | AA_permease |
| TIGR03813 | 94-448  | put_Glu_GABA_T |
| TIGR00913 | 242-413  | 2A0310 |
| COG0833 | 242-474  | LysP |
| COG1113 | 48-452  | AnsP |
| TIGR00905 | 48-482  | 2A0302 |
| TIGR04298 | 58-454  | his_histam_anti |
| PRK11021 | 265-364  | PRK11021 |
| PRK15238 | 229-345  | PRK15238 |
| PRK11049 | 251-448  | PRK11049 |
Ontology Information
| HPRD ID | 8833 |    
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | Growth factor activity (GO:0008083) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q01650 | DB00279 | Liothyronine | SmallMoleculeDrug |
| Q01650 | DB00451 | Levothyroxine | SmallMoleculeDrug |
| Q01650 | DB00509 | Dextrothyroxine | SmallMoleculeDrug |
| Q01650 | DB01042 | Melphalan | SmallMoleculeDrug |
| Q01650 | DB01235 | Levodopa | SmallMoleculeDrug |
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
