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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SLC7A5 8140 Solute carrier family 7 (cationic amino acid transporter, y+ system), member 5  16E16; CD98; LAT1; 4F2LC; MPE16; hLAT1; D16S469E 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21036745   2010Cell line : -

Source : Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.

Sample Type : -

No. of Sample : 44 patients with rectal adenocarcinoma

Stage : -

ImmunohistochemistryUp-regulation-LAT1 may be a useful predictive marker of response to HCRT in rectal cancer.

22968445   2012Cell line : -

Source : Department of Pathology of Wrocaw Medical University.

Sample Type : -

No. of Sample : -

Stage : -

Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation.Up-regulation17.4-


Gene Details



Chromosome: 16; NC_000016.9 (87863629..87903100, complement)

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Gene Type protein coding
Gene Family CD molecules,Solute carriers
Description -  
Chromosome 16
Location 16q24.3
Start 131124959  
End 131234670  
Strand -  
Gene Sequence

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Length 109712  
OMIM ID 600182   
HGNC ID HGNC:11063   
Unigene ID Hs.513797    
Ensembl ID ENSG00000103257   
PharmGKB ID -   

mRNA Information


mRNA ID XM_005272216.2
Exon join(1..791,2566..2761,3374..3525,4321..4519,5808..5878, 7638..7701,8148..8251,9940..10046,10982..11048, 14323..14449,15591..15752,19322..19796,21171..21346, 22529..22626,25366..25452,25658..25807,26778..26936, 34425..34528,38033..38215,38912..38997,39103..39186, 49097..49360,50502..50663,53353..53452,62331..62406, 64095..64173,67250..67334,70275..70336,72258..74057, 76689..76759,90254..90410,97820..97972,103202..103373, 105672..105811,107326..107350,108496..109705)  
mRNA Sequence

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Length 4420  



CDS Information


   
Location join(624..791,2566..2761,3374..3525,4321..4519,5808..5878, 7638..7701,8148..8251,9940..10046,10982..11048, 14323..14449,15591..15752,19322..19796,21171..21346, 22529..22626,25366..25452,25658..25807,26778..26936, 34425..34528,38033..38215,38912..38997,39103..39186, 49097..49360,50502..50663,53353..53452,62331..62406, 64095..64173,67250..67334,70275..70336,72258..74057,
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_003477.4
Protein NameSolute carrier family 7 (cationic amino acid transporter, y+ system), member 5
Molecular Wt. (Da)54879
Protein Sequence

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Length 507  
Uniprot IDQ14209
Ensembl Protein ID ENSP00000355249  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation35
SPhosphorylation31
TPhosphorylation45

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
6520SLC3A21148NP_001012679.1in vitro982   997   411   311   135   


Pathway Information


      
Pathway Name Pathway ID
Central carbon metabolism in cancer hsa05230


Structure Information


No matching records could be found.

Domain Information




ID Location Description
TIGR0091126-506  2A0308
pfam1352050-456  AA_permease_2
COG053156-478  PotE
TIGR0090946-473  2A0306
PRK1135742-474  frlA
TIGR0090642-420  2A0303
TIGR0090857-474  2A0305
pfam0032458-416  AA_permease
TIGR0381394-448  put_Glu_GABA_T
TIGR00913242-413  2A0310
COG0833242-474  LysP
COG111348-452  AnsP
TIGR0090548-482  2A0302
TIGR0429858-454  his_histam_anti
PRK11021265-364  PRK11021
PRK15238229-345  PRK15238
PRK11049251-448  PRK11049


Ontology Information


   
HPRD ID8833
Molecular ClassTransport/cargo protein
Molecular FunctionGrowth factor activity (GO:0008083)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q01650DB00279LiothyronineSmallMoleculeDrug
Q01650DB00451LevothyroxineSmallMoleculeDrug
Q01650DB00509DextrothyroxineSmallMoleculeDrug
Q01650DB01042MelphalanSmallMoleculeDrug
Q01650DB01235LevodopaSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO