Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SLCO1B1 10599 solute carrier organic anion transporter family, member 1B1  12OATP-C, LST-1, OATP1B1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24143213   2013Cell line : -

Source : Chinese prospective multicenter trial (NCT01282658).

Sample Type : CRC tumor and normal tissue

No. of Sample : 137

Stage : TNM Stage IV

Chi-squared test, univariate and multivariable logistic regression model, and receiver operating characteristic analysis ,Kaplan-Meier survival analysisPolymorhpism-Genotype GA/AA of SNP rs2306283 of the gene SLCO1B1 and genotype GG of SNP rs1051266 of the gene SLC19A1 were associated with a higher rapid response rate.


Gene Details



NC_000012.11 (21284128..21392730)

View Larger Image
   
Gene Type protein coding
Gene Family Solute carriers
Description This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009]  
Chromosome 12
Location 12p12
Start 21284128  
End 21392730  
Strand +  
Gene Sequence

   Download   Select all

Length 108603  
OMIM ID 604843   
HGNC ID HGNC:10959   
Unigene ID Hs.449738   
Ensembl ID ENSG00000134538   
PharmGKB ID PA134865839   

mRNA Information


mRNA ID ?NM_006446.4
Exon  
mRNA Sequence

   Download   Select all

Length  



CDS Information


   
Location
CDS Sequence

   Download   Select all

CCDS ID CCDS8685.1



Protein Information


      
Protein IDNP_006437.3
Protein Namesolute carrier organic anion transporter family, member 1B1
Molecular Wt. (Da)0
Protein Sequence

   Download   Select all

Length 691  
Uniprot IDQ8IZL8
Ensembl Protein ID ENSP00000461625  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation293
SPhosphorylation295
SPhosphorylation659
SPhosphorylation663
TPhosphorylation301

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


      
Pathway Name Pathway ID
Bile secretion hsa04976


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd01330455-508  KAZAL_SLC21
cl00097455-508  KAZAL_FS superfamily
cd0617431-427  MFS
cl2147231-427  MFS superfamily
pfam07648465-506  Kazal_2
cd00104465-506  KAZAL_FS
pfam0313727-622  OATP
TIGR008051-649  oat
pfam0769029-438  MFS_1
pfam13347320-427  MFS_2
PRK13296232-332  PRK13296


Ontology Information


   
HPRD ID10647
Molecular ClassMembrane transport protein
Molecular FunctionTranscription regulator activity (GO:0030528)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q9Y6L6DB01045RifampicinSmallMoleculeDrug
Q9Y6L6DB01211ClarithromycinSmallMoleculeDrug
Q9Y6L6DB00091CyclosporineSmallMoleculeDrug
Q9Y6L6DB00175PravastatinSmallMoleculeDrug
Q9Y6L6DB00177ValsartanSmallMoleculeDrug
Q9Y6L6DB00213PantoprazoleSmallMoleculeDrug
Q9Y6L6DB00220NelfinavirSmallMoleculeDrug
Q9Y6L6DB00224IndinavirSmallMoleculeDrug
Q9Y6L6DB00227LovastatinSmallMoleculeDrug
Q9Y6L6DB00275OlmesartanSmallMoleculeDrug
Q9Y6L6DB00279LiothyronineSmallMoleculeDrug
Q9Y6L6DB00286Conjugated EstrogensSmallMoleculeDrug
Q9Y6L6DB00345AminohippurateSmallMoleculeDrug
Q9Y6L6DB00390DigoxinSmallMoleculeDrug
Q9Y6L6DB00412RosiglitazoneSmallMoleculeDrug
Q9Y6L6DB00451LevothyroxineSmallMoleculeDrug
Q9Y6L6DB00503RitonavirSmallMoleculeDrug
Q9Y6L6DB00509DextrothyroxineSmallMoleculeDrug
Q9Y6L6DB00520CaspofunginSmallMoleculeDrug
Q9Y6L6DB00563MethotrexateSmallMoleculeDrug
Q9Y6L6DB00583L-CarnitineSmallMoleculeDrug
Q9Y6L6DB00641SimvastatinSmallMoleculeDrug
Q9Y6L6DB00655EstroneSmallMoleculeDrug
Q9Y6L6DB00661VerapamilSmallMoleculeDrug
Q9Y6L6DB00669SumatriptanSmallMoleculeDrug
Q9Y6L6DB00688Mycophenolate mofetilSmallMoleculeDrug
Q9Y6L6DB00762IrinotecanSmallMoleculeDrug
Q9Y6L6DB00783EstradiolSmallMoleculeDrug
Q9Y6L6DB00859PenicillamineSmallMoleculeDrug
Q9Y6L6DB00877SirolimusSmallMoleculeDrug
Q9Y6L6DB00908QuinidineSmallMoleculeDrug
Q9Y6L6DB00912RepaglinideSmallMoleculeDrug
Q9Y6L6DB00917DinoprostoneSmallMoleculeDrug
Q9Y6L6DB00950FexofenadineSmallMoleculeDrug
Q9Y6L6DB00973EzetimibeSmallMoleculeDrug
Q9Y6L6DB01045RifampicinSmallMoleculeDrug
Q9Y6L6DB01053BenzylpenicillinSmallMoleculeDrug
Q9Y6L6DB01076AtorvastatinSmallMoleculeDrug
Q9Y6L6DB01092OuabainSmallMoleculeDrug
Q9Y6L6DB01095FluvastatinSmallMoleculeDrug
Q9Y6L6DB01098RosuvastatinSmallMoleculeDrug
Q9Y6L6DB01132PioglitazoneSmallMoleculeDrug
Q9Y6L6DB01232SaquinavirSmallMoleculeDrug
Q9Y6L6DB01241GemfibrozilSmallMoleculeDrug
Q9Y6L6DB01393BezafibrateSmallMoleculeDrug
Q9Y6L6DB01583LiotrixSmallMoleculeDrug
Q9Y6L6DB02659Cholic AcidSmallMoleculeDrug
Q9Y6L6DB05239CobimetinibSmallMoleculeDrug
Q9Y6L6DB06151AcetylcysteineSmallMoleculeDrug
Q9Y6L6DB06210EltrombopagSmallMoleculeDrug
Q9Y6L6DB06290SimeprevirSmallMoleculeDrug
Q9Y6L6DB06403AmbrisentanSmallMoleculeDrug
Q9Y6L6DB06589PazopanibSmallMoleculeDrug
Q9Y6L6DB06626AxitinibSmallMoleculeDrug
Q9Y6L6DB06772CabazitaxelSmallMoleculeDrug
Q9Y6L6DB08860PitavastatinSmallMoleculeDrug
Q9Y6L6DB08864RilpivirineSmallMoleculeDrug
Q9Y6L6DB08884GadoxetateSmallMoleculeDrug
Q9Y6L6DB08912DabrafenibSmallMoleculeDrug
Q9Y6L6DB09054IdelalisibSmallMoleculeDrug
Q9Y6L6DB09102DaclatasvirSmallMoleculeDrug
Q9Y6L6DB09272EluxadolineSmallMoleculeDrug
Q9Y6L6DB09292SacubitrilSmallMoleculeDrug
Q9Y6L6DB11362SelexipagSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO