Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SLPI | 6590 | secretory leukocyte peptidase inhibitor | 20 | HUSI-I, ALK1, ALP, BLPI, HUSI, WAP4, WFDC4 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25441765 | 2014 | Cell line : - Source : - Sample Type : Population based case control study No. of Sample : Colorectal cancer (6 with stage I, 112 with stage II, 132 with stage III and 46 with stage IV Stage : TNM Stage I-IV | Immunohistochemistry | Up-regulation | - | Upregulated SLPI correlates with aggressive pathologic characteristics of colorectal cancer; SLPI could be used as an indicator of progression and metastasis in patients with colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | WAP four-disulfide core domain containing |
| Description | This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. This antimicrobial protein has antibacterial, antifungal and antiviral activity. [provided by RefSeq, Nov 2014] | Chromosome | 20 |
| Location | 20q13.12 |
| Start | 43880880 |
| End | 43883205 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 2326 |
| OMIM ID | 107285 |
| HGNC ID | HGNC:11092 |
| Unigene ID | Hs.517070 |
| Ensembl ID | ENSG00000124107 |
| PharmGKB ID | PA35944 |
mRNA Information
| mRNA ID | ?NM_003064.3 |
|---|---|
| Exon | join(1..106,832..990,1414..1563,2146..2326) | mRNA Sequence | Download Select all |
| Length | 625 |
Protein Information
| Protein ID | NP_003055.1 |
|---|---|
| Protein Name | secretory leukocyte peptidase inhibitor |
| Molecular Wt. (Da) | 29855 |
| Protein Sequence | Download Select all |
| Length | 132 |
| Uniprot ID | O15075 |
| Ensembl Protein ID | ENSP00000255448 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Proteolytic Cleavage | 67 |
| T | Proteolytic Cleavage | 67 |
| T | Proteolytic Cleavage | 67 |
| R | Proteolytic Cleavage | 45 |
| M | Proteolytic Cleavage | 98 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00199 | 80-130 | WAP |
| cl00156 | 80-130 | WAP superfamily |
| smart00217 | 85-130 | WAP |
| pfam00095 | 31-75 | WAP |
| cl00156 | 31-75 | WAP superfamily |
| smart00217 | 31-76 | WAP |
| pfam00095 | 85-129 | WAP |
| cd00199 | 31-76 | WAP |
Ontology Information
| HPRD ID | 5397 |
|---|---|
| Molecular Class | Protease inhibitor |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.