CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
SMAD7	4092	SMAD family member 7	18	CRCS3; MADH7; MADH8

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
23104301	2012	Cell line : - Source : - Sample Type : Case cnotrol study No. of Sample : 1509 CRC cases and 2307 controls Stage : -	TaqMan assay, Logistic regression	Mutation	-	The minor allele (G) of rs4939827, a SMAD7 (18q21) intronic variant, is associated with a lower risk of developing colorectal cancer (CRC) and poorer survival after diagnosis. Individuals with this SMAD7 variant that develop CRC are more probably to have tumors with greater invasiveness and methylation of RUNX3, which potentially contributes to their poorer observed survival.
21102417	2011	Cell line : - Source : University Clinic Schleswig-Holstein, Campus L?beck. Sample Type : - No. of Sample : Adenoma specimens 18 patients without synchronous or subsequent carcinoma and from 23 patients with synchronous carcinoma, as well as 6 related carcinoma samples Stage : TNM Stage I-IV	Multicolor FISH, Immunohistochemistry, Hedley Method	Mutation	-	Smad 7 genomic instability identified.
19395656	2009	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	Genotyping, EMSA	Polymorhpism	-	The colorectal cancer risk at 18q21 is caused by a novel variant altering SMAD7 expression. A novel C to G single nucleotide polymorphism (SNP) at 44,703,563 bp was maximally associated with CRC risk.
21221812	2011	Cell line : - Source : Han Chinese population. Sample Type : - No. of Sample : 641 cases and 1037 controls Stage : -	Genome-wide association.	Polymorhpism	-	SMAD7 has been demonstrated to antagonize TGF-B-mediated fibrosis, carcinogenesis, and inflammation. rs12953717 SNP of Smad7 was strongly associated with the colorectal, gastric, and lung cancers.
21910156	2011	Cell line : - Source : Institute of Cancer Research,The National Study of Colorectal Cancer Genetics (NSCCG) and Royal Marsden Hospital Trust/Institute of Cancer Research Family History and DNA Registry. Sample Type : Case control study No. of Sample : 2532 CRC cases and 2607 healthy Stage : -	Genotyping	Polymorhpism	-	727 cases were genotyped for two GWAS hits in SMAD7 with minor allele frequency > 30%, one with minor allele associated with decreased risk (rs4939827) and one with minor allele associated with increased risk (rs4464148). SMAD7 variants known to be important for CRC risk were associated with disease-specific survival among prediagnostic NSAID users. Case-control study of CRC incidence from 13 counties in Washington State of eligible women, ages 50-74 years.
22580541	2012	Cell line : - Source : Han Chinese population. Sample Type : Case control study No. of Sample : - Stage : -	Cox regression analysis.	Polymorhpism	-	The minor allele in rs4939827 (SMAD7) was associated with reduced overall survival and disease-specific survival. A variant in SMAD7 could affect progression of CRC.
25640388	2015	Cell line : - Source : 13 counties in Washington State Sample Type : - No. of Sample : 727 cases and control Stage : -	Genotyping of SNPsy PCR-RFLP	Polymorhpism	-	Significant association between CRC risk and the rs4464148 AG genotype.
22457752	2012	Cell line : - Source : - Sample Type : Case control study No. of Sample : 2611 CRC case Stage : -	Meta-analysis, TaqMan SNP Genotyping Assay , RT-PCR	Unknown	-	Significant association of the variant rs4939827 with increased risk of colorectal cancer.males were 59.9% among cases compared with 59.1% among controls.
18781153	2008	Cell line : - Source : Iranian individuals Sample Type : Population based case- control study No. of Sample : CRC among 487 Iranian individuals Stage : -	PCR, Immunohistochemistry	Up-regulation	-	Upregulation of smad7 induces hepatic metastasis in colorectal cancer. Overexpression of Smad7 in colon adenocarcinoma (FET) cells induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis.

Gene Details

Chromosome: 18; NC_000018.9 (46446223..46477081, complement)
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Gene Type	protein coding
Gene Family	SMADs
Description	The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Chromosome	18
Location	18q21.1
Start	48919853
End	48950711
Strand	-
Gene Sequence	>gi\|568815580:c48950711-48919853 Homo sapiens chromosome 18, GRCh38.p2 Primary Assembly CGGAGAGCCGCGCAGGGCGCGGGCCGCGCGGGGTGGGGCAGCCGGAGCGCAGGCCCCCGATCCCCGGCGG GCGCCCCCGGGCCCCCGCGCGCGCCCCGGCCTCCGGGAGACTGGCGCATGCCACGGAGCGCCCCTCGGGC CGCCGCCGCTCCTGCCCGGGCCCCTGCTGCTGCTGCTGTCGCCTGCGCCTGCTGCCCCAACTCGGCGCCC GACTTCTTCATGGTGTGCGGAGGTCATGTTCGCTCCTTAGCAGGCAAACGACTTTTCTCCTCGCCTCCTC GCCCCGCATGTTCAGGACCAAACGATCTGCGCTCGTCCGGCGTCTCTGGAGGAGCCGTGCGCCCGGCGGC GAGGACGAGGAGGAGGGCGCAGGGGGAGGTGGAGGAGGAGGCGAGCTGCGGGGAGAAGGGGCGACGGACA GCCGAGCGCATGGGGCCGGTGGCGGCGGCCCGGGCAGGGCTGGATGCTGCCTGGGCAAGGCGGTGCGAGG TGCCAAAGGTCACCACCATCCCCACCCGCCAGCCGCGGGCGCCGGCGCGGCCGGGGGCGCCGAGGCGGAT CTGAAGGCGCTCACGCACTCGGTGCTCAAGAAACTGAAGGAGCGGCAGCTGGAGCTGCTGCTCCAGGCCG TGGAGTCCCGCGGCGGGACGCGCACCGCGTGCCTCCTGCTGCCCGGCCGCCTGGACTGCAGGCTGGGCCC GGGGGCGCCCGCCGGCGCGCAGCCTGCGCAGCCGCCCTCGTCCTACTCGCTCCCCCTCCTGCTGTGCAAA GTGTTCAGGTGGCCGGATCTCAGGCATTCCTCGGAAGTCAAGAGGCTGTGTTGCTGTGAATCTTACGGGA AGATCAACCCCGAGCTGGTGTGCTGCAACCCCCATCACCTTAGCCGACTCTGCGAACTAGGTGAGAAGTT GTCCCCCTACCCCCAACATTTTCCGGAGCGCCAGTGCTGGAAGAAAAGCCCCTAGGGCAGTGCGTTTGTG CAGCCATCCCTCCAGGGGGAGTGTGCATACCCTCCTGGGAGAGTGTGCATACCCTCCTGGGAGAGTGTGC ATACCCTCCTGGGAAGAGACTGGGGGCTGAAAGTAGAGAAGGGACAAGGGGAAACTCAAAGGGCATTCCC TGGGGGTTCCCTTCCAGGTTTTCTCCTGTGTTGCCCCGAAGGGGTCTACGGGCACTGCTCCTGCAGTCTG CGGTTAAAAATTAGACGCCTTCATTTCCGGATCAACAAGGGGGTGCAGAGGGAGGTGGGGGGGTCACGCC TCCCCGCACCCGGAAAGACGTTGAGGTGTGTGGCCGAGTTGGATTTGGTCCAGGCCCGCCAAGGAAGGCT GGGAGAGGCGTGCTATAAAGGCTGGAAGGTCTCCGTATTTACTCCTTTAGTAAATACGGAGAATCACGTC GAACACCAGTGGCCCAGATACTGTCGTGGCCGCGCACCTTTGGAGTTTTGGGGCAAAGAGAGTTGGATGG AAGGCCGAACTGGGTATCTGTCTCCTTTCAACTCTGCCAGCCCCAGGGTGCAGAGGAACAAACAGGCAGG AGAAGTTGGGTGTCCCCTACTTTTTCCTTCCTTCCGCACAGATAAGTCTGTAGATTAGTGGGGCCCCGGC GCCTCAGTGACGTTGTCGCCTCTTACTGCGCTGGGGCCTGGGCTTCTCGGCTGAGACCCTGAAACTCCTT TCCTTTTATCCTCTCAGCTTTCTCCATTCCTTCCTTTACTCTACGTCTCTGTACACAGAGTGTGATGTGA GGGTTCACCCCGGGCGCCCGCAGATCCCCCACGTTCCCCAGCACGCTTGGGATGCATCTCCCGAGTGCGC TAGGAATGGGCAGCCCCGTGTCCCCCGCGCGAGTGCCGAGCGGACCGGCGGGGGCAGAGGTGAATTGCAC GCCTGGGGGGCGGGCCGGGGCGGGGAGCCGAGGTTGCTGGGAGCTGGGTCTGGAGTCCGAGGACGGGGAG GGGGCATGGTCGCCCCCCGCCCTGTGAACTGTGAAGTGCGCGGCTCCGGCCGAGCCGGTGGTTTCCAGCC GGGCCAGCCGAGCGCGGCGGCTGCGGCCGCAGACGTGGAGGAGCGGAGCGCCGAGGCTGGCGCCAGGCGG CCTCTTTTGTTTATCTGACAGCTAAATATCAAGGCAATCACCGCCTCGCGGCCCTGCCTCCAACCCCCAC AGCTAAGACAAACAGTTGGGCTAAAAGAATGCCTCTGTTATCATAAGTTTCTATCTCTCTTCTCATGGCT GGGCCTTTATTTTCTCTTGCTTTTTTAATTTCAGAGTCTCCCCCCCCTCCTTACTCCAGATACCCGATGG ATTTTCTCAAACCAACTGGTGAGTAGATGATTTTTAAAATATCCTGCTTATCTTAAGTTAGAAATAGAGC CTCTAGAACGTGGCTTTTTGTGTGTAGGCAAAGGCTTGGGGAGGTGCTGGGCTTCACGTTGGTTCTAGGT TTCCTCTGTTGGAAGTTTGGTGAATTTTTCTGTTGTGGCTGGGTTTTTTGCTGTTTTTGCAAAGACGTTC CCTTGATATGCTTTACATTTTGTTCCTTTTTCATGTATTTGTGCTGTGTAGCCGGTGGGCTCAGCTTTAA CACGTGGAAGCTTTAGTCCAGAGAGAAGTGTCTTGGGAACCAAATAGGACTGGTTGATGGGGATAACTCG GAGACTTAGTGAGTGCCAGGAGCATCAGTGGGAATAATGGAAAGGGTGATTCGATAGATGGGAAGACGGT TTAAAAAGGTGCAAAGAAGACTTTGGTCTGGAGTAGACACTAGAACTTTTCAGAAGTATAGGCAACAGCC AGTAAAAGGGGGGGGGGGGTAGGTTCCTCCTGCTCCAGTCACCTGCAAGTCAGTCCTCTCCCGGGGTTTT CTCAGTATTCGCCATAGGGACTATCAAAGTTTGAAGCATAGCTCTGCCTGTCTGCTGCTTTGTCACTGGC TGGCATGAAGCCATGGCAGAAGCCCATTTGAGACTGGCACCAGCCCTGTTGTGGTTGTCTGCATTCAACT TCTGGCCGGCAGCAGCACAGGGGTCCATCCTCTGGACATCACAGTGCTGGGGACAGGGTCAGCAAAATGA ACTTGGGGGTGACAACAAGGACAAACCCAAATTCCTGGAGCTCCCTCTTACAGTAGGAGATAGATCTGTT TGCTAAAAGTACAGGTTGTATGTAACCTTGGTTTTTGTGCCTGTATACTGGTGCCTGAAAAAAACATTAA TACTTGGGACATTTTTATTTTGCCAAGGTTCTGGGAGAAGGAAAAGTGAAGGGTTGGGCACCATTTAGCT CCTGGAATTCTGCAAGTCCTTCCGCCTCCTGCGTTTTGGCTGTTGGGCCTTTCCCCCCACTAATTAAAAG TTTTGCTGGGGCGTTGTCATAAATTAAATACTTTAATGAACGTGTAACCGAAGCCCATACTCTGCAGCCA GTCCTCCTGGGACTCTACCAGCTCCCTCAAGTTGGGAAGGCGTTCCTGCTTGCCTGGTGCCGGTCTAATA AGTGGCCCGCAAAGCATGTGATATTTTGCTTTCGATTTACAAAACACCAGATAAATGGTTATTAATAAGG AGATACCCAGCTCTCTGTATTTGTAACAAACGTTAACTGGAATTACCAAGCTCTGTTTTCCTAAAGACTG TAACTTGACTGGGTTTTGGCTTAAAGAATCAAGAATTCTTTTATGAAGTTCATTTTCCAAGGGGCCACCT CTGACCTGTTTTTTTTGTCCTTCCATATTCTTCAAATTTGGAGGTTTTCCTTAAAAGAGAGAGAACAGTG ACCTTAGCCCCAGGGATAAAGACCAGCAGGGGTAAATGTTCCCAGAAACCTCCAAAAACCATAGAAAAGA AAGGCCATGTTCCCTTGGGTTTCCTGCAGAGACACTGGGATAAATCTGTTCTCAGGATTTAAGCAGTCAT TCTGCCAGGCCAGGGCCTCATTTTCGGTGAGTGGAGTGATATATTTATTCATTAGCAAGTGTTGACATTA GGTAGCAAAATGTGTGTAAACAGAGAAGCCACAAAGACAGGAATGTGCCATTTCCAAGGGGGAGAAAAGT TCTCCAGATCAGCCAATAGGAAGTGATTAACCTGCCAATCGGAAACTAAGACAGCTGGTTACTCACCCAA AACGTTTTGTTGAAAATAGAACAAAAAAAGAAATGAGAAAAGGCGCTGCTGTGTAAGAATTTAGCATCAG TAATAGACAAAGCCCCCACGAAGGGAATTGTCCTGCCACATTGGAGGACAGCCAGGTCTGGAGCTGGAGC ACACCCCCCCCGCCCCCCTCACAGGTCTGGGGCTGGTTTTGCCAGCTGCTGTGGCCGGGGGCATTGAGGT CAGACCACAGATGGGCGCTGACCCAGGTCTTCATCCCCATTTTGCGTATGGGAGAATGTTTGGCCCGGGA ATCTACATGGACCATTTACATTCTTCAGTTTCTATGTCCCTTAGGTTGAATTTTTGGTCTTGGGTTACTA GATGAAACAGGCACAAAGTTTTACAGTGGACAACTGTTAAAATCTTAACCAGTTGCACAACTAAAGGAAT ACATCCTGTGAAGTCTCCATCTTAGGAAAAGGTGGTGGGAATGGGGCTGGGGCCTGGTACCCTGCAGCCT TTGGAGACACAGAGGGCTCAAAGCTAGGAACTCCATTTTGCTATAATTTAAGCCACTCCACTCAGCATCT GGGAGGCCTGGACTTTAGACACCTAGGTACTGTGTGGTCCAACCAGGAGAGCCTTCTTTGAAAGAGTGTT CACATGACTGAACCTAGGGGAGGCCAGTTGTGACTTGTGGCTGTCAGAAGTCAGAAAGACACCCCCACCT CCACATCCCACAAGAAGTCAGAATTTGCTGTTTAAAGCTGGATCTCGGGGATAGCTGTGTGGGCTCTGCT TCCCGTGTTTCATTGTATCTGATGGTCTGAAAGGTTTGAGGAATGGCTGGCCTTGGGGGGTTGCTGGGTG AGCTCTTGAGGGACCCAGGTGGCCAGTATCCATGGGCAGATCCAGCCTGCAAATCCAGATCGGAAGTCTG GTGTCTTGACCTGAGATCTGGCACTGCGTTTCTCTCTTAACCGAGGTCCCTCTTAACTTTTCTAGGCCTC TTTTAAAATCAGCATGATGAAAGAGATTAGGTCATTCATTCATTTATTCATTCATTGGTTCAGTCATTCA TTTTACAGGCATGATGATGTGCCTACCTAGAAATTTGAGGATTCCGATGCAGTGCTGTGTTCTTTTTTTT TCCGAGACAGTCTCATTCTGTGCCCAGGCTGGAGTGCAGTGGCCCGATCTCGGCTCACTGCAAGCTCCAC CTCCTGGGTTCACACCATTGTCCTGCCTCAGCCTCCCGAGCAGCTGGGACTACAGGTGCCCGTCACCATG CCCAGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGAGTTAGCCAGGATGGTCTCGATCTCC TGACCTCGTGTGATCTGCCCACCTCTGCTTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCTG GCAGTGCTGTGTTCTTTTATAACCAGGGTTCATTTGAGTTCTGGGTTGGTTGAACTACCTGGGGCAGAGC TGGGACCCTTGGGGTACAGTGGTGAGTAGGGGCTCCTCTGTCTTTAACAGTACTTAGGAAGCTCAGAACG CAGTTGCTGAGACTATCGTGGGACTCCCAGCTCCTTTACCTTGTACTCATTCTCAATAGTTCGCTCCTTG GCTGCTCCCCAGGGTTGGGTTTTCAAAGACTCTGTTGGAGCTGCTCGGAGAAAGGAATGAGTCTTTTTCT CTCGCAGAACCTAGTGCTTACCAAGTGCTTGATAACACTTAGTGTTGCGTGAGTCAGGAGTGGCCTAGAG CTTCTGTCTGCCAGCCAGCCTGGGCTCTGGGGAACAGGCGACACAGGCCTAAGGTGAGACCCTGACTTCA GAGATCTGTCTATGCGGAGCTTTTCTGTGGGTGAGAGATGGAGGTATGGCTCCTTTAACCTTGAGGCCAG TCTGGATGGCCTGGCCACCTCCAGGAAAGAGGGTAGGGACTCCATAGCCTGCCTGGGGAGTGAGAGCCAT GGGATAGGGCTGGACTCTTGGGAATAGCCCAGCTCACTGGGTGGCCCTTTGAGCTAGTCAGTGACGCCTC AGTTTACCTGGCTGCCTATGGAACAGGTATACTTTGCTTCTTCACAGGGGTGGTAGGGAGGCTTAATTAA CGTTTGTAAATCCCTCTTGAGATCAAAGCCACTGCAGAAGGGCAGAGCACCATTTCACAAAAATGCTTGT GGTTGCCTGTGTGGAGCTGGCTTACCTTTGATCTGAGATGGGCTGACACCCTGAATGTGGTCTCAGCTCT GCTCTGAGATGCCCGGCTTTTCCTTTGAAACACACCTTGCCCCTGGGATTCTGCCAGCCAAAGGTGGCGG GGAGTGGCTGTGGATAAGTCATTATGTTTAATGTGGGGGTGTCTTCCATCTGGGAGGAGTGGGTGGAGGA GAGGGTTGAGAAGCCTATCTCTAGAAAATGATGAAGGCCATCAAAATGGTTTAGAAAGTGCAGGGTATAC ACCATTTAACAAGTAACTCCATTTCCTGCCTGCCTCTATTGTTTTCTGTTTGATTAAGTGTATCCTGTAA AACTGTATATTCCTGTTAGGAATTAGACTTTACCCTGATAAAATGAGATTACACACACAGTCTTCTTTCC CCCTACCCACCGCAGCCACCTCACCCCCACGCCTGCCTCCACTTCTGCCCCTCGCCCGCTTAGGAGAGTT CTTGAAAAGTTGTCCTTCCAGCCTTGAGAATGTGGGAGAGGGAGTGACCCTGAGTTAGAGAGAGAAACTT AGCATTAAGAGGGCAGACAGCAGAAACCCAGAGATGGTTTGGGGCTATGTGTAGGCCACTAAAGGATTCC CATGGGCTACTTGCCCGTCTGCTCTTTTTTTTTGGCTTTCCTATTTGCCAGCATGGCCAAGTGGTTCCAA CTGGAAACCCACAGGGACATTGTCCTGGTGGCCTGGGGTAGGAGGCCTGGTGTCTGCACGATCCAACCTG TTGTGTTTGCTGCGGACCTGGGCAGCACCTTTCCTTAGCCGGGCTCTCCGCTAGGACTTCAGGGAGTTTG GCGCTGCCAGTGGTGCATGACAAGCTTACAGGGTCTTGTGTATTTGTGTTTCATGGGACTAATGAGTTGT GGTTCATGGACATTAGGTTTTGCTTTAATTGCTTGGAGGGCGGTTGTGGAGACTGTTTCTCAGCTGGAAT TGTCATTATCCTCATTAACGGTGAGGTCACTGTGCAGAGTACCTGAGGGTGACAGAAGTTGAAGAGAAGT CTAGTTAAGGGCAGATGCAATCTAAAGGTAAAAATCAGTGAGGAAACTCCGAGTGTTGGGTGCCAAATGT TTTATAGGAACTGAGGGCAGAGAGCCTTAGCAGGTCTGGGGTTGCCTGGGAAGGTTTCCAGAGATGAGGG GTTTGGACTAGCCTGGGAGAGGTAGAACATTTCCCCTCCGGCTCGGAGCCTTGCTGAGAATGTTCTCTGT CTTGATCTGGTGGTGGTTACACAGATGTATACATGAGTAACATTCATTGCGTCTACTTGGGATTTTGTAT ACTTTGCTCTACTTAAGTTAGTCCTCAATTAAAAAAGGGGAAAGAAGTCCCGGCAGCCCAACATCAATCT TGAGAATGTTTTCAAGAACTGGGAAACCTGTCTTTAAAAGGATGAAGGCAGAGAGGACATGGGCTCCAAG GAGAGAGCCTTCTGCCCTTGATGAGGGATGACAGAGCAACCAGGGTTGAGAAAGTCCAACCCAAACCTCC TTTGACCTTGGGAACCACCTGGTATCCGTAATGGGGGACTGGTAATGCAAGAGAAATTCCAGCCAGTCTC ATTGAGCCTGACTCGAGTAATGATTAACTGGCTGCCCGGAGCCCAGACGGGTGACAAGGTGCTGTGGTCT GTCTTACGATGGGCAGTGAAGCCTGAGCAGACCATTAATAATCAGCATCAAGGCCGCGAGTCAGCCTTTT GGAATGTGTGGTTTGTCTTTCATGCTGTTTAGAGCGTGCTTAAAGATGGATCTTGGTGTTTTTATTTGTG TATTTATTTCTTTCTCTCCCCTTTTCAAATCCACAGCAGACTGTCCAGATGCTGTGCCTTCCTCCGCTGA AACAGGGGGAACGAATTATCTGGCCCCTGGGGGGCTTTCAGGTAAGATGCTTTCTCTTATTTTCCTGGCA ATTCCAACCTTTTTTGAAATTGCTAAAGACTGGAGGAATGGGGGTGGCCTTCTGCCACCCCAGCTGGTCT GGACTTCATTCTCATTTTTATATGCCTTAAGTTGGATGCATCGGTGGTGACATTGTGGTGCCCTTCAGCT CCTCATCCTGCAGTCCTTTACGCTCTGGACACTGGATCCGTTCCGTGGACGGGGAGACAAGAGCGAGCTG GGGATTGCTTTGGTGTGTGAAGTGTTGCCCGGTTATTTTTAAGCAGCTCCTGGCTTGGGGGGCTTCAGCT TGGTGACTTTGGTGTCATTAACTCATGCATTTGAGCTCTTTTTTTGCTTTTGCTCTTTGCGCATGGGGGA TGTAAAGGGAATGGACCCACCTTTAGGGAACTTGTTGAAGACAGATCCCAAGCATACGATGGGATTTCAG AGTAGATCTGAGGCTTCCCTCCCAAGTTCTGATTCCCAGCCCAGCCTGCTGCAGGATTTTGCAGCACATG TCTGGGGCTGGGAGCACCAGGGTGGGAGCACTGCCAACAGTAGGAGCTGTAATTGTTCCCTAGCGGGGCA GGTTTTCCTCAGGGCTCACAGGTATGCGTGAAGGCCTGGAATGCCAGTGCTGGGGGGTCACGGGGCTGGC TGACAGGCACGGGGTAGCCAGAGCATTGTTGTTCCTGAGGATGCGAAAAGAGGGCAGTACTTAGAGAAAC TCACTGGTTATGTACATGGGACGCATTTCATGTTGTTCTGAAGAAATCCTATTTCTACCTGTTTTTCCAT CCCCACCATGTCATCACTAGATTTTCTAAGAACTGGCTGAAGCAAGAGGGAAAACGACCTTAAAAACAGA AATTCCAGCAGAGTTTTGGGCATTTGGCATTTCCTTGCCTGTAGGATCACGTGGTAGCAGCTCGAATAGA AGCTGTGCCCTGTTGTGGTGTATCCTCTTGTGTGAGGGGCACCCTTTTTTGTGGGGTACCTGCTCTGACT ACTTGGTGGTGTGTCTTCCATGGCTGGCTCAGGCAAAGTTCATTCCCGGACGGCTCCCTCCCCGGCTCTC CTCTTCAGGAACTGAGCTTGCTGAGAACGTCTTTAGGGAGACCCTTGTTTGTTTTCATTTCAATGCAATA TATACTCTGTTATCTGAGACTGAGGGTATTGTTTACTCAAAGCTTCTAATGAGAATTGAGCAGGAAAAAG AGGGACCTAGAGAAGGGAGGGGGCTTCAGGCAGTACGGTGGGAGTGGACAGAGGAGTTGAGGAGGGAGAA AAGGCAGCAGTGTGTGAACTGCATCTTTTCTGCTTTCTAAGGCTGAGAGAGTTCTTGAAAGAAAGAAGGC CAATGAGAGGAAAGGGTCTCAGCAGAATAACACGCTCAGGATGTTGTTAGATGGTTTTATTTTTTAAACC CTGAATGTGCAGGGAGGAGCCCCGGCCCCTCCAAACCACATGAAATAAGCAAGGGAAGTGGCAGCTTTTG AAAGGGTCCTTTCGGAAGGTTTGTCTTCTTGATAACATCTTGTCTGTCTCCCCTGCCGGAGGAAATGACG ACACCAGGCTGAGATACCAGCCTGAGTGCCTCCTCACCCGCCCGTGCCATGTGACCTGTGAAGCCCTCAG GAGATGGGTGGGCTTTTTTTTTTTTTTCTTTTTTGACAAAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCA GTGGCGCGATTTCGGCTCACACAGACGGAGTCTCGCTCTGTCACCAGGCTGGAGTGCAGTGGCCCGATTT CGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGAT TACAGGCATCCACCACTGTGCCCAGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCGCCATGTTGG CCAGGCTGGTCTTGAACTCCTGACCTCGGATGATCCACCCACCCTTTCCTCCCCAAGTGCTGAGATTACA GGTGTGAGCCACTGCGCCTGGCCGATGGGTGGGCTTTTTTTCCCCAAAGCTCTTCCAGTCCTAGAAAGAA ACTGGGGGTAAAACAATCATTAACTCCTTCCCCTCACCCCTCCAGGTAATTGTAGACACAGATATTAATA AGGAGCTGCCAGGAAGAAGCAGTGACTCTCTGAAGGGCAGTGTGGCTTCAGAAGACTGCAGAGAGAAGAG GGGGCCTTCCACATGGCAAGAGCATTTGTTTTGAATTTCAGCTCTTGATTTACTAATTCCAAAGGCTTCA AAGTTTGAGCTCCTTCTTCTTTCCGTTCAGAGTTGGTGCAGTGTATTCATAATGGGCCATGGTGGGGAGG GTACACTGTTTTGGGGGTTGATGTCACCGGCTTGGGGGCGTCTGGAGGGGAGGTGATGGGCACGGAGAAA ACCTAGGGCTGTCCTCTTTGTAGCGAGAATGCCTTCCAAAAGGGAACTTTATTGGCCCCTGTCCAGGGCA GAGAGTTTTGTAAATGGAGAAAGCCCAAACCTCCTCCTTTTCAAGAAGTTGATCGTTCCATGGGGGGTGG CCTGGGTGTGTCTGCCTTGCTGTGGATGAGGCCAGTGACTGGATGTGGCAGGGCTGGATGGGGGAAGGGG CATAGCAGACACTGAGGTTGGGGGGTGGGAGCCTGGCAGCAAGGTGGGGAGCAGTGAAAACTGAGGAGTT TCTCCCTCCTCCTCCTTGAAATAACCTCTCTGAGCCTCTTTCACAGGCCCTGTGTGCTGTTTTCCTTCCT GTCCTGCCCTGGCTGAGAGCGGGCTTAATGAATGGGGCTCAGTTTAGGGTGGGAGGAAGGTCGGCAGCAG GAGCCAGGGCTTGATTCTCTTGGCAAGGGAAGAAGGGAAAGAAAAAACAGCCGAATGTGAAAATGTGGTG CCTCGGAGGTGGGGGTGGGGTGTGCTCAAAGGCCGGTCCTCTCCTGAAATGCAGGGGTGACTCCAAGGCT GGCCCTTCCCTTTCCTGCGCCCTTGCAAACTGCCCGGGAGGAAGGGGAGTGGGCGGGTAGGAGCCCGGGG GCGGGGCTGCTGGCTGCAGGTTGGAATTCCAGCATTGCAGCTTTGTTTTGGGGGGGTGTGGGGGGGTGGG TAGACGACAGGCCTGGTCGTTAGGGACTTGCAGTGAAACACACCCCACCCTTGCAAGTTTCCTCGGTCTG GGAAAATGGGACATTTTTAGAAGGCAGTGACTTGCTTCCAGGAGATTGTACTTTCATTTTTGACAGCTGG CTCTCTGAGACAGATGGATTGCTGGGTGCAAGCTTGTGTGTGTATGCGTGTGTGTGTGTTGTGGGGGTGG GTGTGTGGGTGGGTGGGTTTTGCCGCAGACGTACAGATAGACAATCCCGTGCGCAAACACATGAGAGCGT GCGGATGCCCACAGGCAGGCTCTGGGATAGGGTGGGTCCCTGTCGCTGGGGTGGGTTGATGTCAGGGCGG CCTCTCCAAGAGGTTGTGGACTTGTGGGGTGGAGTTTGTGGATTGATTCTGCTTTGTGATTTGGCAGTCT GTGCCTGACTCTCTGGGATGGGTGTCTTTTGAAAGGCATGCAACTCCAGAACAGGTCCTTGCTGCTGCTT GGACATGGATGTGTCATGGCTCAGGAAGATCACCTGGGAGAGGTCTGATGTAGCTGGGAAGCCTCTAGGC TCAGCTCCGTCGTGGAGATGGAAAGGATTTGCTCCCAGAGCTTTCCGGGGATCACTGGGAATGCAGAGCA TGTGTTGGAAGCTATCATCTTTGCAGCCTCCATCTGGAGTTTCTGTCTGGGGGCTTTCATTTTGCCTGTC TGCTGTCCTGGTTTGAGTGGGTTGAGGGAGCAGCATCTCCCTTGTGAGTTGTAGGTTATTCAGCTGCAGA CTCATCTTCTAGCCTCCTCCTTTATATATGAATGTCTGGAGCTGGCTGGGCCTCAGCCATATGGACCTGC CCAGTTAGGGTAGGGATTGGAAGCCAGCAACCACTTGTAGTTATTTAAACTTCAAAAGAAGTGCTCCCAT GGATCTCAAGGAGGGAGGTAGGAGGCAGTGGAGACAGAAGTGCTCACGTGTCCTGGGAAACTCCATCTCT TGGCTGTGCGAAGTCATGCTTGTTGGAGAGACCCGGCACCATGCCTCCAACCCAAGGGTGGCCAACTCTT TGCTTGAGATTCATATGTGGCTACTAGTCCCCAAGTCTGGGGGATGGGAGCGTCCTTGAGTCAGTATCCA TTCAGCATCCAAGGATGTTTCTGTCTCCTTCTCTTTGATCCTTGCTGGCATCTGTCATAGTCTCAGAGGA GAGCCTTCAAAAATACCTATATAATCTGAAAATGCACCCCTGGCTCAGTCCACAGTTGACTTGGGCTCAA ACCAAGTAGCTTAGGAAACATTGCTCCATCCTGTTTTAAGGAAAGTTAATCAGCTGCACGTGAACAATTA TTCATTGTCTGGCTTGGAATTGTGATCATGAACTGGGAACCTGGGCCTGGGCGCCTGTTGCTCTGCTTTT AAATTAAGTCACCTCCCCCTGCCTGGCTACAAAACAGCTCATGGTTTCACTGAGGTCTCTAATGCCATTG TGGAGTGAGGGCAGGGGGCACAGGTTGAGCTCACAGGCATGTGGGCCTTTCATCCAAATGCTCATGAGCG TGGACTTTGGGGGACTCAGGTGGACAGGTGCTTGTGACCATGAGCAAGCTCCTTCCTTCCCATCCCCTTA GTACCCTGCAGGCCACTGTGAGAAATGACGGCCTAGAACTCAGGGGACACCTTCTGCCTCTCCTTAAACA CCTGCCAACAGGATGAGTCAGGGCTGGGGCGGGCTCACCTGGTGCACACCCACACCCTGGTGAAGACCAG TCCTGGACCCCGCCTCTTCTGCAGTGCCCCAGGTCATGCACTTCCCCCTGGAGAAGGGCTTACTGATAAA ACCCCTTTTGTCCTGGAAAGAATGAGGCAGTCCGGCAGGGGTTAAATACAGGGTGACAGCATTTAAAATC TCTGGAGCAAATTTGGGCTGCTCTGCCGGCCAGACAAGATGGTCTGCTGCCGCCTCACGCATCCTGTCCC CAGGCTGAACTGGGCCAGCAAAGGGAGAGGGCCAGGTGAAGGCCAGGCTTTGGGTGGTGTCACTTTTGGT GACACTGTAGCATGCTGATTGCCCCTCACTTCCTACACACACACACACACACACACACACACACACACAC ACACACATGCCTTTACTTAGCAAAGCCTGACTGTAGCTGCGTAGACTTGTACACCTATGGGACCTCCGTG GCAAGCTCAGAGCCGGTGGAGCAGTGAAAAGGGAGGAAATGCCGAAGAATTCATGATCAAGTTTGGCTTC CTTTGCTTCTTTTTAAAATTTTTTAATGTTTTAATTTTTTTTTTTTTTAATTCGAGATGGAGTTTTGCTC TGTCGCCCAGGCTGGAGTGCAATGGCAGGATCTCGAGTCACTGCAACCTCTGCCTCCTGGATTCAAGGGA CTCTCCTGCCTCAGCCTCTGAGTAGTTGGATTGCAGGCGTGCACCACCACGCCCGGCTAATTTGTGTACT TTTTTGTAGAGAGAGGGTTTTGCCATGTTGGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCGCC CGCCTTGGCCTCCCAAAGTGCTGGGATTCCAGGCATGAGCCACTGCGCCCGGCCTCTTTGCTCCTTTATT ATTGTTGTTACTGTGTCATAATTCCTTGCAGAATTATGATGGCCAGGCTGGTCTTTACTTCCTTCGGTCC AGGCCTTGAACTCGGAGCAGCACTCTCAAAGCAGTTGTCTTCACCTGGCAGAAGAAAAAAAAGGTGTAAA GTGCTGGTTCCTGGACTTGCTCGCACACTAAAATCCCTCGGGATTCAGCTTCCCAGATAACTTTCTTGCT TCTTTGTAGAGACATTTGAGAGAAAACTATTATTAACTATACATGGTCCACTGTTTTGCTTTGCTGTCAT GAATGGGATTGTAAAAGGGACCCATGGGACCGGGTTTCCTTTTGGGACGATGAAAATGTTCTGGAACTGT AGAGTGGTGATGGTTGCACAGTTCACCGAATGTATTCAATGCCATTGGTGGCACATTTTAAGTTATGTGT ATTTTACCACAAGTTTGACCAAAAAATGGCCAGCGGTAGGTTTTAAATACATGTAGATACTTGGATAATC TATAAGGAACAGTGATTGTGGAGAGTAAAATTGGAGAGACTTCTGTTAGTTGCCTAGGACCTGATGATGG TAGACACTTGTTTTGGTGGCAGCCCTGAGGTCACATGGGAAGTACATTGATGGACCAGGGAGCAAGGCTG GTAGCCTGCCTGGGATCTCGTGTGTGTGTGTGTGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT GTGTTTTGAGATGGAGTCTCACTCTGTCACCCTGGCTGGAGGGCAGTGGCGTGATCTCGGCTCACTACAA CCTCCACCTCCTGGGTTCAAGCCATTCTCATGCGTCAGTATCCCTAGCAGCTGGGATTACAGGCGTGCCA CACCATGCCTGGCTAATTTTTTTCTAGTAGAAAGGGCGTTTCACCATGTTGGCCAGACTGGTCTCGAACT CCTAACCTCAAGTGATCCTCCCGACTTAGCCTCCCAAAGTGCTGGGATTATAGGCGTGTACCACCACGCC TGGCCTTCTGCTGTGTGTTACCTGAGCAAGCAGACACATCTGTGCTGATCCTTCGACCTTCCTTTTTTCT TCGTGGGTTCCAGAAATGAGAGACAGGAAAGTTCCCTCTGGTTTGATTCCCGGCCTGACTTTTCTGCTGG GGGAAGTGAATATGCTTGTTCTCACTCTGCGGGGTCCCCCTGGCCTGCCCATCCCAGTGACTGCGAACCA GGATGGTGCCAGGGTTGGCTCCAAAAGCTGGTGATCCAGACCCTTCCTGGGCCCCTGGAGACCCCAGTCC CTGTGATGTCCTTGCCCAAGTTCTAGGGCTGCAGTGGCCGTAGGTGACTGGCCCGGGCACCCTCCCTTTG CGGGAGCCTCGTGAAAGGATACTGTAAGCACAGCCACAGGGAGGTCACCACTGGCCCTACCACCTCTCGC TCGGTATTGAATGGCTAGCCCCAAGCCTGGCTGCCTGCCTACTGTCACACAGAGGCTTCCTCTCCGGGCT ATTTTCAGCGGGAAGATATTATTAACTGCTGAGGCACAGTTCTCAATTTAGTGGTTAACACACCAAGAAA GCAACACTCACCTGATCCCGGCCACTCTACCTAAACCTGTTGGCTCACTTGGGGGACTCGGCTGCCCCCC AGCCTCTCTGTTTCTCTCTGTGGGTTCACCTGGGAGATGTGGGCTTCCACTCCCGTGGAAGGTGCCCCGT GGATTCAGTATCTGCTAGAGAGAGAACCAGGCTTCTTACGAAGCCAACTCTTAAAAGGTGTAGAAAATGA TCGTATTTATACTCTAAGATGGGGACATTTTTTGATAGGGGTGGGCACTGGCTGGGAAAAGGGACTTTCA GCGGTGTTGAGGACAGTTATTTAAAACAGGGTGATAACTTTCACCTTGTAAGTTAACAGGAAATATTGGG ACAAGACAGGAAATTGCATCATCTTTTTTTTTGAGAATAACTCCAGAGAAAAGTGGTTCGTGAAAGGTAG TGGCTGAGAAACGGCTAGCCTGTTTTCTGTTTTGTGTTTTTTTTTTCTTCCCTTCCACTCCCACGAGAAC ATGTAGGCCATTTTCTTTAAGAAAGAGGCTGTTTGAGAACTTTATGTTATTTTTATTATTTAAAAAAATA TTTTACCAGAAGGGTCACCTTCAGTTGAAATGTTAACTGCCGCCTTATTTCCCATTTTACTAAAGAATCT TTCATGACTTTTTCAGCTTCCTTCCCCAAATGGTAAGGCCAAGCAGCTCTTGGCTGGAAGCTAATTTTGG TTTGGCTGGGGAGTCCTCAACACTGAGCCCCACCCAGTGTCATTAGCTCAGTTTTAACTTGCAAAAAAAA GATTGTATTTTTTTTTTTGATGGGGGGTACGTAAGAATTTACTCACGCCTTTAGCCTTTTTACCCACCCC CGGTACTGCCTTCCCCTAACAGAGGCACCTGGCACTTAGCCGCCGGGAACTCAGGGCTGCCTTCGTGTTT TCAAGCCACCGTGTCCCCCTCATCCTGCAGGAGTTCTGTAACTTTCCTGAGACTATTTCTAGGGTGCTAG TGAGGAGTGGAGGGGAAATGGGTCTCGGAGCTGCCCTGGTACAGCTGTGTCCAGTAACGGTGCTGTGCTT TGGAGGAAGGAGTGATATGGTTCACCTAGAAGCATCTCCCAGAGAGGGGGCTTATCACAGCCCTACAGTG GTGCAGATAAGGTCCAGTTCCATTTTTTGTCTCTGGGTTTCTAAATCCCCTCTTTGTTGATGTCATTGTT CTAATGACACAGGGCATGGGACAGTGCCCCGGCCCGTGCTGCCAAGGAGCCGTCTTTAGGACAGAGACCA GAAAGAAAGAGACCTGTGTGTGTGGCTGGCCCGCTCTCCACTCACGCTCACCCCCACCCTCCCAGCTTTT TCCTTAGCGTGCTTTGTTTTGTTTTCATAACACAACAAGGGCCCTGGGGTGTGTAAAAGCATTGTTGAAC ACTTGGTGAGGGCAACTTGTCCAAACAGAGCAGGACGCCAAAGCAGAATGCTGTGGGCAGGTGGTGTGCC CACAGAGGTTGGTGGGCCGGCGCCGGCCTTGGAAACACCTCTCAGTGGCATATGCCGCGGCGGCTGAGTG TGACCTAGCGCAGAACAGGGCTTCCCTCTTGTGTCCTCCGTGGGGAGTCCAGGAGAGGGACTTGGTCCTT CTGGCTGACTCCGTGCTTGGAAGGTGTGCTCCCCTCTCAGGTGGGTTCACATGTGCCTCCCTCTGCCGGG TGTGAAGCTAGGTGGGCCCGCTGCTTTGGAAGAAGCCAGTGTGTCCCTGTGGTTTGTTTATGGAGCAAAT ATGTATTGACACCTATTATGTGCCAGGCTGTGTGCTGTGCAGAGGACCAGTTCCTGGGCTGGGTTAGAAT TAAGAATTGGCAGTTGGAATGGCTTGTCCGAAGGTGATGTTGAATCCATGGGGATGGAGCCGGCGGGAGG GGGGATTGACTAGGAGTTGCCTCTACCTGGAGGCAGGCAGGGGCAGCTTCTGTAGGACAGAGGAGCCTGG TCCCTCCATGAAGCCAGGCCATAGGTGGGGGAGGTGCAGGGTGGGCCCCCTGGGATGGGCCTAGCTCTTG AGTCATCCACTTCTACTTCTGCTTTGGTTGTGTGGTCTGTTGAGAATTGAGATAAAGCAAAGCTTGTGGA TAAACAGAGGTAGGTCTCCCGGGTTTTGGTTCCAGCCCGCCTCCCCACCCCGCTTCTTGCTGATTGTAAG ATGACAGCAGGAAGAACAGGAGCTGTGGTTATAATCCACCCTCCAGACCCTGGTAGTACCTGGGGCACAG CACAGAGTGGAAGTGACCAGCCTAGCGCCAGGCTCCTCAGTGGACCACGGCCAAGGGGTGGGGAAACATC TGGAAAGACAGTATCTAATGTCTTGACAGCCAGAGGAGAAGTGGGATGTTTTCAAAGCCCAGGAGTGACT TTCCCTTTGTAACTCCAGAGGACTTGATTCGCAACGAAGACCATCTGGGGGATGAAGGAAATTCTTGCTT TTTAATTTTAAATCTGAGGGTTAAGCCCGTTTCTGAGGTGTCAGCCCTGTGTGTGAGGCCCTGGCCTGTC TGGGGTTGGGTTTGGATGAAATAATCTAAGATGCAGTTACCAGGGTGTTTCCTTTTCACATTCATCCTTC TCTGTCTGTTCCCCCGGGGCCAACCGATGGCTTCCAAGCTCTGTGGAGTTCACTAATTGAATTACTCTTC TCGCTCCTCCGTGAAGCCCCACCAGGAAGAAAAGGCGGGGAGAGCTGCTTTTGCTGGGGGGTTTGATCAG AGCAGAAAGGGAAGATCTGGTCTCAATTCCAATTTCATCTTGCAAAGTCGGGACTTTCTTTCAGCCAGAA GACAACTCAGATAACCAGGCCAGCGACTGTGTGCTCATTTCAGTATTGCTTTCTTACGTTTTGATCTGCG ACTGTCACTCAACAGGAACAAAAACAATAAGACGCCAAGATATGACTGTGCCGTTGGCAGATTAGCTGTC TGCATTTTCTGGGGTGGCTCACTCGGAGGTTAAATGATTGTCCCTGTCCCCTGTCCCACCTTCCAGTCAC CTCATGAAGCTGTTAAGTGTCTCCTTCCCCTGCAGGCTAAGTGAGGATCATCAAGAGCTGGGCCTGGGGA CCTTGTCAGCCTCACTGCAGCCTCTGAGCCAGCCCTGCCCCACCCCCTCATGAATCAGTAACCAAGAGGG AAAATTAAAAAGTTAGTTATCAGTGTGATCTGAGTGCACCATACCGTTCTTACAAATAGATGGGCCCCAT CTCCTGCTCAGTGGGGGCACAATCAAAACCCTGCTGGGGGGGCTGTTTTCTGGGGAAGAGCCCAGGATCG TGGGGCCTGCAAAAACTCAGAAGCCCCCCCACCTTCCCCCCAGGGTGTCCAGGATGCCCTAGTCCCAGGA GGGGGCTGGGAGAGAATTACAATGTCGGGGCCAGCATCCTCCACTTTCCTGTCACTAGAGGCTGGCCTGC TCTCCTGGGTTGAGGCCGAGTGTCTCAGCCCCTGGCTGGCCACATGGCCTTGCAGGAGCCATTTCTGTGT TCTGGGCCTCAGTTTTCTCATCTGCAAAATAAGGGCTTGGGCTTGGCTGCCAAGTCCCTTCGGTGATCTG TGATCTTTGTCTCTTGGATTTGAGGGGTGTGGGAATGATCCCCCTATTGATGAGATATCCCTATGGAAGC CAAAGACTGCTTCCATTTTAAAATAAAAAGGTTGTAGTTCTTTCTGTCTCTTGGCTCGCAAACTCTTCCA AGTATGGGTGAAAGCTGAGGACTCTGTTCAGAAAAATGCATGCTATACCACAATTTGTATACATCTGCAG GGGGCCGATATCTTTGCTGAAGCCCAGTCCCACCCGTGGAATCCCCAGTTCAGGAAATCTATGCTTATGA GGACTAGTTATGGGGGTGCAAAGGAGAGCCTTAAGAGAGCTGAGGCCTTTTTCTTTTATTGTGGTAAAAT ATACATAAAATATACCATATTAACAATTTTTAAGTGTATAGTTCTGTGGCATTAAGTACATTCATATTGT GCTATTATCCCCACCGTCCACATCCAGAACTTTTTCATCTTCCCTAGCTGAAACTTTGTTCCCATGAAAC ACTAACTTCCCTTCTCCCCTCCCCCAGCACTTGGCACCCACCATTCTTTCTGTCTATGAATTTGCCTCCT CCTCTAGGTACTTCATAGAATAGTGGAATCAGACAGTGTTTGTCCTTTTGTGATCGGCTTATTTCACTTA ACATAATGCCCTCAGGGTTCATCCATACTCTAGCGTATGTCAGAATTTCCTTCTTTTTTAAGGCTGAATA ATATTTTATTGTATGAATATTCCATGTCTGGTTGATTTATTGCTTGATGGACACTTGGCTTGCTTCTACC TTTTGGCTATTGTGAATAATGCTGCTGTGAACATGGATGTGCAAATACCACTGGAGTCGCCGCTTTCAGT TCTTCTGGGTATATACCCAGAGGTGGAATTGCTAAATTACACTGTCATTCTGTGTTTAATTTTTTAAGGC ATCGCCAACGGTAGGGCCTCCTTGACTTGTGCCTCATGTGTCGGCACACACCGATCGCATGCGGTGGGGG AGCCCTACCCACCGGGGTGGGCTTGAGGGCGAATCCTGGGGCAGAGGGAGTGAGAAAGCGGGGAGGGGAC AGTCTGTCCCTGCGCGGTGGGGGAGGGGCAGTGCTGGGCTGCTGCAGTCACCAGCCAGATTGGAGCTCAC ATTTATGGGAGCCCATGTTTATGGGAGGCCTGGAGGCTCTGAAAGGTGGGGCACCCAGCACAGAGCAGCT GGCCGTGTATGTTGGACTCCAGGGCCTTGTGACAGCAGCTTCTGGGTGGGGGACCCTTTCATTCTTCTTT TATTCCCTTGACCTCCTAACTGGAGGTTAGGAGTGGGAGGACCCGCCAGAGGGAGTGGGGGCTTGGGTCT GGGAGGTCCTGGGTGCTTTAGGGGTGAAAGGGCTGGGATGGCTGAACAGTGAGTGTGTCCAAGCGGGAGA GATTAGATTACGGAGGCAGACAGAAGTAATGATTAACTTTTCCAGTCTGCACGCTGTCTCCAGGCTGTCG TACTGTTGTTTTTCCCTCTAAGTACAGTGCGGCCCTGGCCTGGCCAGGCCCTGGTATTGGGTTGTAAAGT GAGAGATGGAATGAGGGCTGGGAGTGCACGGGGAGGGGGGCCAGGGAGGGAGCTCGCAGGAGAAGAAGGA GCTTTTCCATCGGATCCTGCATTGGAATTTATTGGCCGGAATGCAGTAAATGTTCAAAATGCCATCCCAT CCAACAGTTTTCATAATTGTTATGGAACAAGGGGAGCCGGGGGAGGGGAGGAATGAAAAGGACTTTTGTT TCTCACTGTATTTTTCCATGTCTTCGGACAGTTTTCCTACCCTCTAGAAACTGGAGTGGAGTTGGATCTG TGGGGGATAGGGTGGGAGAAGGGTCTGCCTTTGGGTCCTGTGATGCCTTCCAAGGACTAGGGGTCCTGGT AGCCTGGGGCTTTATTAAAACGAGGCCCACAGCAAAAGTAGCTTGGTTTCTTGCACACACAGAGCCCCCC CACCACCTGCAAAACCAGGGAAAAACTGTCCTGTCCTTCTAGGGGTTTTGTCCTTTTGGAAAATTGGCTT AATGATGCAGTGGTTTGTATTAAGATTTTCATGATGCTTTAACGTGTGTGTGTGTGTGTGTGTGTGTGAG TGAGAGAGAGAGAGAGAGAGAAAGAGAGAAAGAGATTGAGAGAGAGAGAGAGAGAATGAATCAGCATTCA GTGCCAGCTGCCCAGTTGGGAATCCAGATAGGGAATTTGGGGAATCTCCTACACTCTCAGGGTGGCAGGT GGGTAGGTGGGTGAGGTAAGAGACTTGACTTGGTAGTTTCTCTTGGACACGACAGACTTTCTGTTCCATG CTTGTCCCAGCCCTTGTGTCTTCCTGGGGGTGCCAGGGTCATGCCCAGAGGGAAGGCAGCTGAGCAGACA ATGCCATGCAGGGCTGAGGGCTTCTGTGCCTGCTAATATGTGAACCCCCTTTCTGAAGAGAGCTGCTCTG AGTTACTTGGGGGGTAACAGTGGGAACCTGGTTGGTGTACCATGGAGGGGAAGTATCTGGAAATTTGAAC TCGAGAAATGATTCGACTGCATGCACACTAAACAGCAGCCAGAGAGGCCCTTTACTGTCAATATTATGAA TGGAGTTGGCTGGGTCGGGAGTCCCCACCCTTCCTCTGAGGCCTCTCTCAGAGGAGCCTGGGCAGAGTGG GCCTCCTCAGACAGCAGTGGCTGCAGGCAGCTGGGTACACGCTGTAATTTGCATGGCTGAATGCTGGGGC ACAGGAAGCCGCGTCAGCCTGACTGGCGAGACAGACAAGAGCTTTTGATTTGTGTGGCTTTCCTCCCCTG CCCCGTGCCACCCTCAATTACATTCTCCATGGCGAGATAAATGCTCTTAGGAGCATTCATCCCCAGGTTG GGGGCTTCAGACTCAGATGCTTGGGGGGTTTTGGGAGGTGGTGTGGGACCAGTTTGGGGAGCCAGGGAGT ACATTTTAGTTCTAGGAATTGATTATTTAACATAATTTGTAAGGACACAGTCACTAATTAGTGTTCTAGA CCAGCAGGATCTGCGAAATATGTAGGCTTGGGAGAGGTGGCAAGGAGGGCGGTGATGGGAGGAGAAACTT CAGGGAACCAAGCCTGGGCAGACAGTGGACGGATGACAGTGATAAAAGAGATCCTCTCTTGGGGGCTCAC CGTCTCTTGAGGGTGATGAATAGTAAGACAGAGTAAAAAGTCATTTCTGACTCTGAAATTAAAGAAAAAA AAAAGTTGGTTTAGAGATGGACACAGCAAAACCTGACTCAAACCTCCTTTCCCTTTTGATTTTATTTTGT TTTATTGTTGCAAATTAAATGCAAAAATGTACCCTGCTCCTCAAAGTGGTTTTCTTACTCTCTGGAAGGT AGTAAAAATAAATGGAACCAGTGTTGTTTAATACTGAGAATCAGAGTCCAGCCAGAGACCATGAAGGCAG AAGGGGGCCCATGGGGCCATCTTCCCTTGTCCCCTTTACATTATTTATGGACAGGTCAAACTGAGACCCT GAGAGGGCAAGCCACTTGGCCAAGGTCACAGAGCAGCTTGCTGGCAAAAAAGCCGTATCACCCCCCACTT CTTGCTGCAGGGGAGTTGCACCCCATGCGCAGCTCTAAAAGCTGGTGCAGCATTTCCAAAGTGTGTTCTG AAGGACACTTTGGAGAGGAACAGTGGGCTTGGTGGCTTTAGAGGCCTGTGTCCACAGCTCACACCAGGCA ATATTCTGGGCTTGAATTGCAGCTCTGCACTTCGGCCAGTGACTTGTGCCTCACCCCTACTACTCCCTTT TTTTAAGATAGGCTGGTGATAGTATGCAGCCTCAGAGGGTTGTCATGAGCCACTTAGAGAACACAGCCTA TGCAAAGTAAATGCTTATTAAGTGTAGGCATTGGCCCAGAACTGTTCTACCATGGGGTGTGGGGATGTGG AGACAATCAGGAAGACTGGTGGGCATTTTCTGAGCGGCTGGAGAACCCAGGAGCCTCAGAGATGAGACCA ACGTGTGTGCAGCACTCTCCACAAGCTGGCCCCAATCACTTTTGCATCAAATTGGTACAGCAACCTTATG AGGCTGGCCTTGGGGGAACCCTGTTTTAGGGATGAGCTGAACTTACCGGGAGGCTGCATGCGAGGTTGGT GTGAAATGCATATCTGGCTTTGTAGCTGGTCGGCTCACCTCTGGGGTTGGCACAGGGGCGGGGGTTCTGC CATGGCTAGAATGCGCTAAGGGGTGGAAACGAAGCCTGCTGGGCCCGGGAACCAGAGAGCAGCCTGGCCT TTGAAGGAGACCCTGTGGCACCCCCTGCCCACCCCCAAGTCCAGCCATCTCACTTCACTGGAGATGCTGC AAAGCATGAAAAAAAAAAAATCCAGTGTTCTCAGGTCAGCCTTCCACCAGCCAGGATTCATCGTCTGATC TGTTTGGGGAGAGAGCATGGGGTGGTGGAGATGGGTTGGGCCCCAGTGTTTTCTGATTAACTCGCAGTTT ACCTGAAACATTTTGGTTTGTTTCCTCCATGAGGAACTCACTCTAAACCCCAGCATTGTCTGTGTTTCCT GAGGAGTCTGAGGGAGCTCTGGGGTCCTATTTCCTCTTTTGGATGAGGCTGTGAGCATGGTGGATTAGAG ACAGCCCCTTAAAGTTAGCCCAGATATCTCAGCAAGTTTTACGCGTCTCTATTTGGGGGAGGGATTCGCC TATTGAAAACAAGAGACCAGCAAGGGTCCTTGTGAATTATGATGGTTTGGCGTGAGAATAGATGGGATGG ATTGGCACTGGAGTCCCCTTTTATCTTAGGCTTGTCCCTGAAGAGGGCTTGTTGATATCAGAACAGCCAA TTTCCTGACAGGGTTGGGAGCAGGGGATGGGTGCTGTTAACCTTTGAGATGTCCGTTGTGGAGGGAGAGA CAGGATGAGGCAACCGTTGGTGGCGCCTGGGTCCTGAGGAGGGAGGACCCTGGACCTGGCGTTAGCGAGG CGTGGTGATGTTTGCGCTCCCAGGTTGCCAGGTGCAAGCTGTCTGTGTCCACATTTCTGCCCTTCATTTG CCCCTGATTGGCACAGGGAGCCTGCAGGAGGCGGCCGTGCCTGCCCAGGCGCCCTTCCTCCCCAACTTCT CCGTCCTCAGCCTTCTGCTCTGCTGGACCATGGAGGAGGGGGCTGATAGGCCCGTGGCCCTGTTGGACTT TGGCAGAGGAATATCACTTCATTATCCAAGTGCCTCACAGAGATGAGAGCCGGTGGAGACCCGTCCTCAC TCGCCTTTGACCCCAGCTCCCGGTACCCTAGCAATTGGGCACATTTAACCGTGGGTCATCAGCTGATGGA GCTCATGTCTTTACTGGCTTTTTTCCCCAAGCTTGCCCTTGTTCCTAAATGGAATCTTGGGGGACCCCCT CCCCACAAGTACGTTCTTTGTGTGTCTGGGCCCAGTCAGGCCCAGATAGCTTCTCTTCCACGCGTGCCCG TGTTCTCATAACCCCATGGCTGTTCTTGGAGCTGCTCTGCCTCTCTGCCCTCTGCCTTCAGGTGGAGAAT GGTATTGTTGAGGCACTGAGCAAGGCCTTTCCCCCCTCCTCCCATTTTTCTTCTTTCTCATCTCCTGACG CCTTCAAATTAAAAATTTAAGAAGGGGTCTGGGTGCGGCGGCTCACGCCTATAATCCCAGCACTTTGGGA GGCTGAGGCTGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCTGTCTC TACTAAAAATACAAAAAATTAGCCAGGCGTGGTGGCGGGTGCCTGTAGTCCCAGCTACTCGGGAGGCTGA GGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAGC CTGGGCGACAGAGCGAGACTCCATCTCAAAAAAAAAAAAGAAAAACATTTAAGAAGGGGAAAATTCCTTG CTTAACCTAAAATGTGGCCTTGAGGCCTGGTCACCCTGTGCCATTGAGACCTGGGGTGTGAGGTTCATTC ACGAGCCTCTGGTCTCCTGGAAGGGTCTGGTCTGTTCATTCATGAGCAGGGTAATTAAATAACTCTTTGT AAGAGTCAGGGAGCTCCTTGCTAAGTGGTCTTCCCCAGTTGGAGCGCAAACACAGGCTGAAGTCCTCTCC TTTCTCAACACCCACCTCCCCCTTCCCTTTAAAGGGAGGATTTTATGCTTTAAGGGAAATGGGGAAGGTT GGGGGGGGGCAACACCTTAAAGGAATTTTAGGCAGATTCAGCATTTTTCTGGTGTTGCTCCAAAAATTCC CCACACTGTAATAAAAAGATACAACTGTGAGCAGGCATCTGATTAGTGAGCTTTTTACAACACAGCTTTT CTTTTGGATGCTTTAAAATGAACACATACTGTTTTAAAACAAGCCCCTGTACAGTTTTCTGGGGAGGGGG AGAAGTTTGTGGAAAATACCGGAAAAGGTTATAAAGCTGAGGGAAATTAACAAAGGACTGTGAGTTTTGC CTTCAGAGGTTAACTATCAGCGAGAGGCCAAGGCTCTTCCTTAGTCCTTGTACTGACTGAACTTCCCAGC CCCTCGACACGTGGCCCGGGAAGTCCCTGGGAGCAAAGCGTCCACACAGACCTTTGTGGGGAGACTCGTG TGGGCTGTGGGCCCGATTCAGGGAACTGTGTTTCTGTGAAGATGAAGCTGAGCATTTCCCAGAAATGAGC CCAAATGGCGGGGAATTCAGGGCAAAGGGGAATCTCTGTAGTGGCAATGGGGGATGTCGTGCGGGGTCCC CAGAAGGTGTGATGTCCACACAAGGGTGTGTGTTCGAGGGGCCTTTGCTGTTGCCGAATGGTTTTGCTGG AAAGCTTGTTTTTTGTGTGTGCTTAGAGATAGTCCCGGCAGGAGGAGACTGGAGCTGTCCTAACGGGAGG ACAGAGGCTGCTGGTGGGGGAGCTGGAGGGGACAGCGAGGGAGGAGCAGGCAGGAGTCTCCCTGCGGTGG GTTAGGGCACCAAATGGACTTCAGGGCCCTTGTTCACACACAGCAGCATTCACGACATCCATGCATTGCA GTTTTTCTGGGCTGGGCCATTAACCTCAGCAGAAAAATGCTTTTTCCAGGGGGTGTCTGGCAGCACATTG CTGGCGGGCTGCACAGATGAAACAGAAACCCACCTGACACTTCCCCGTCCTGCTACAGATCTCAGGCTCC AGTCCCCACCCAGCTTCCTCTGCCCCCAGAGGCCCCCACCCTTGGCAGACAAGGCTTCCACCCCTTGCCT AGGTGGCTGACAGGCCTGGCATGGGGGCACCTCGATCTCAGGTCCATACTCCACTCACTCCCTTGCTCCT CCTCCTCCTCCTCCTGTTGGCCGGTGCCAGGTTTCAGTGGGTCCTGGCTGCATGAAACAAAGCATTGTGA GGCTCTGCTGAGGGTCTCCCACCCACCCTCCCTCCCGCCTCCTTCCCAGCAGCTCCTCGAGTCTTCCTTT CCAGGCCAGGTTTGTTGTCCCGAATTGGGAAAATAAGCAAAAGCTTCTTGTGTTTCAGAACACCCTCCTC CACACCAAAAGGGTGGATGTGCTGTGCCTCCCGGAAGAGGGCTTTCTCCCCCGCTTCACACTTGATGCCA ATGTGTCCTTCCTTCCCTGGGCGTTCAGGTCTTTGGTGTAGCCTTCAGAGCTGAGTTCCCTCAGCAAGAA AGTTCAAAGATTGCCAGCGCTCACAAGTTTATTAGCAGTTGATGGATACTTTGCAGAAACAAGTGAATGC CTGATGAGTCACCTTCTCCCTGTCCCTGTCTTGTTTTCCATATGTTCCAGTACGTATGTGCACACAGAAA CACACATAACACACACTCGTACACACTGACATCATGGACACAGTCTTGCACACGCACATGCACAAGCACT GGACTTCCAAGCTACATGGGGGGTGGTGACCGGCCAGTTTTCTGGTGTTGATTTTTAGTGGGGGTTGGGG GTTGAGGGAAAGGAATGAGACCTCAGTGTCCCCTTTTTGTGGAGCTTTTGGGGCAGGCATTTGGGAAGGC CAGCTTGGGGTGTCTGTAGGGAACCGCTGCTCTGGGTGTGTGTGTCTGTGGCTGCCCCAGCAGGCCGCAG TGTGCACATTTGTATGGCCTTACTGACGGGCACCTCCATCCAACACTGGCTGCTACTTAAAACAACAACA ACAACAACAACAACTGAGTGGAGCCAGTGGGTTCCCAGGTCCTAACACGCCTGTAAAAGTTGGAGCCAGT TAGTGTCCTGGGCTGCCCCAGTTACCCAGCCTGCTGGGGCAGCAGGATGCGGCCCCATCTTCCGCCATGG ACCCCCTGCAGGGTGCAACCCATCATCATTGACTCTGAACCCAGTTACTCCAGAAACACAAAGGCCACAC CAAAACACATCTCACACTCAACCCCTGCTTTGTGCCCCCCAGGTCCCCAAGAGGAGGAGCTGGGGCTGCA GGGAGCGAGGGCAAGGCCCTGACCGACGTGGGGCCCTTCCCCTCTGCTTTTCCCCCTCTGCTGTCCCCAT TTTTGTTAACAAATACAAGACTTCCGGTCTCCACCCTGCTGCCACAAACCACAGCGTTCCTGCAGTCTGG CTGGGCTGGGGAGATTTATGGTCCCAAGTCTGAGGCCTGCCCGCTGGCTCCTACTTAAGGAGGAGTCAGA ATGCCCGCCGCCGGGGCTCCCTTTCCCTCCGTGTGACCCCCCTTTTAAAGTCCTCCAAGTGCCTGTTGAG GAAAATTACCTTACCAGAATCACCCCGGCCCCCAGGCTGCCTGTGGGAAGACTGTGTAGGGAAGCGGGGC GGGGCCTGCAGGGGAGGGATGAGGGCGGAGCAGGGCGCCCTGCAGGCTCCAGATGCTTCTGTGGAAGGAG GGGAGAGAGGGGGCACCCCTGGGGATGGGGGTGCCGGCAGAGAAGGGGAGAAGGGGGACGCATCTATTTG AGACACATAATCTTCTGTCTGGGCTGGAGGAAGCTTTGTTAAGGTAGCCCGGGTTAATACCGGTCTGCAT GTTGTGATTTGGCATTTTGACATGAATTCACCCTTTGTGTACAGGGCTGCTGCTGACACACTGAGACTGT TTTCCTATTAGGAATATAGATGTTTTTGTCCCAAGCCACCCTCATTTTTATTTTTACCAGATAGGTTCCT CATGACCACGGCACTGATTTGAGAGCTGGGTGACAGGCACCCAGAGACCATCGCATAGGTGGTCCCAGAG TCTAGACACCTGGGTTCTAGCTCTGGCTGTGTCATCCCCTGGTACTCCAGCAGCAGGCTTTCTGGGTCCT GGTTTTCTCATCAGGATGACAAGGGGCTGGAGGAGCTGGCCTTCAAGGTTCCATCCAGTTGAAAGATCTG TAACTCCAGGACGTTGCTGAGGCTTTTTGAGGCCCTAAAAGCAGACTACCCAAGCTATTAAGGGTCCCTT TGCATCTGTGCTCTGCAGAGAAGAGGCTTTGTTGGCCAGGTGGGCACAGATGCTGGTGTACTGGACTCCT GATGGGCAGGGGCCTGGAGAGAAGCAGCACCCAGCGCTTCCTATGCTTAAAGAAAGGCAGGGTCCTGGTC AAAGGGCTGTAAGAGCCTGGGCAAGTCCAGGACTAGCCTCACCGCCTCCTTCTTTCTGTCTCGTCCTGAG AGATGAGCTGGTGACTGGGTGCAGTGGGGGGGCGGGTGTCTTCATTCTAGGAGTCACCAATGCCTGTCCC CACTAACCCTCTCTGCCAATGTGTTTTCTAGATTCCCAACTTCTTCTGGAGCCTGGGGATCGGTCACACT GGTGCGTGGTGGCATACTGGGAGGAGAAGACGAGAGTGGGGAGGCTCTACTGTGTCCAGGAGCCCTCTCT GGATATCTTCTATGATCTACCTCAGGGGAATGGCTTTTGCCTCGGACAGCTCAATTCGGACAACAAGAGT CAGCTGGTGCAGAAGGTGCGGAGCAAAATCGGCTGCGGCATCCAGCTGACGCGGGAGGTGGATGGTGTGT GGGTGTACAACCGCAGCAGTTACCCCATCTTCATCAAGTCCGCCACACTGGACAACCCGGACTCCAGGAC GCTGTTGGTACACAAGGTGTTCCCCGGTTTCTCCATCAAGGCTTTCGACTACGAGAAGGCGTACAGCCTG CAGCGGCCCAATGACCACGAGTTTATGCAGCAGCCGTGGACGGGCTTTACCGTGCAGATCAGCTTTGTGA AGGGCTGGGGCCAGTGCTACACCCGCCAGTTCATCAGCAGCTGCCCGTGCTGGCTAGAGGTCATCTTCAA CAGCCGGTAGCCGCGTGCGGAGGGGACAGAGCGTGAGCTGAGCAGGCCACACTTCAAACTACTTTGCTGC TAATATTTTCCTCCTGAGTGCTTGCTTTTCATGCAAACTCTTTGGTCGTTTTTTTTTTGTTTGTTGGTTG GTTTTCTTCTTCTCGTCCTCGTTTGTGTTCTGTTTTGTTTCGCTCTTTGAGAAATAGCTTATGAAAAGAA TTGTTGGGGGTTTTTTTGGAAGAAGGGGCAGGTATGATCGGCAGGACACCCTGATAGGAAGAGGGGAAGC AGAAATCCAAGCACCACCAAACACAGTGTATGAAGGGGGGCGGTCATCATTTCACTTGTCAGGAGTGTGT GTGAGTGTGAGTGTGCGGCTGTGTGTGCACGCGTGTGCAGGAGCGGCAGATGGGGAGACAACGTGCTCTT TGTTTTGTGTCTCTTATGGATGTCCCCAGCAGAGAGGTTTGCAGTCCCAAGCGGTGTCTCTCCTGCCCCT TGGACACGCTCAGTGGGGCAGAGGCAGTACCTGGGCAAGCTGGCGGCTGGGGTCCCAGCAGCTGCCAGGA GCACGGCTCTGTCCCCAGCCTGGGAAAGCCCCTGCCCCTCCTCTCCCTCATCAAGGACACGGGCCTGTCC ACAGGCTTCTGAGCAGCGAGCCTGCTAGTGGCCGAACCAGAACCAATTATTTTCATCCTTGTCTTATTCC CTTCCTGCCAGCCCCTGCCATTGTAGCGTCTTTCTTTTTTGGCCATCTGCTCCTGGATCTCCCTGAGATG GGCTTCCCAAGGGCTGCCGGGGCAGCCCCCTCACAGTATTGCTCACCCAGTGCCCTCTCCCCTCAGCCTC TCCCCTGCCTGCCCTGGTGACATCAGGTTTTTCCCGGACTTAGAAAACCAGCTCAGCACTGCCTGCTCCC ATCCTGTGTGTTAAGCTCTGCTATTAGGCCAGCAAGCGGGGATGTCCCTGGGAGGGACATGCTTAGCAGT CCCCTTCCCTCCAAGAAGGATTTGGTCCGTCATAACCCAAGGTACCATCCTAGGCTGACACCTAACTCTT CTTTCATTTCTTCTACAACTCATACACTCGTATGATACTTCGACACTGTTCTTAGCTCAATGAGCATGTT TAGACTTTAACATAAGCTATTTTTCTAACTACAAAGGTTTAAATGAACAAGAGAAGCATTCTCATTGGAA ATTTAGCATTGTAGTGCTTTGAGAGAGAAAGGACTCCTGAAAAAAAACCTGAGATTTATTAAAGAAAAAA ATGTATTTTATGTTATATATAAATATATTATTACTTGTAAATATAAAGACGTTTTATAAGCATCATTATT TATGTATTGTGCAATGTGTATAAACAAGAAAAATAAAGAAAAGATGCACTTTGCTTTAATATAAATGCAA ATAACAAATGCCAAATTAAAAAAGATAAACACAAGATTGGTGTTTTTTTCTATGGGTGTTATCACCTAGC TGAATGTTTTTCTAAAGGAGTTTATGTTCCATTAAACGATTTTTAAAATGTACACTTGA Download Select all
Length	30859
OMIM ID	602932
HGNC ID	HGNC:6773
Unigene ID	Hs.465087
Ensembl ID	ENSG00000101665
PharmGKB ID	PA30530

mRNA Information

mRNA ID	NM_001190821.1
Exon	join(1..900,2275..2328,8160..8231,28802..30859)
mRNA Sequence	>4092 CGGAGAGCCGCGCAGGGCGCGGGCCGCGCGGGGTGGGGCAGCCGGAGCGCAGGCCCCCGATCCC CGGCGGGCGCCCCCGGGCCCCCGCGCGCGCCCCGGCCTCCGGGAGACTGGCGCATGCCACGGAG CGCCCCTCGGGCCGCCGCCGCTCCTGCCCGGGCCCCTGCTGCTGCTGCTGTCGCCTGCGCCTGC TGCCCCAACTCGGCGCCCGACTTCTTCATGGTGTGCGGAGGTCATGTTCGCTCCTTAGCAGGCA AACGACTTTTCTCCTCGCCTCCTCGCCCCGCATGTTCAGGACCAAACGATCTGCGCTCGTCCGG CGTCTCTGGAGGAGCCGTGCGCCCGGCGGCGAGGACGAGGAGGAGGGCGCAGGGGGAGGTGGAG GAGGAGGCGAGCTGCGGGGAGAAGGGGCGACGGACAGCCGAGCGCATGGGGCCGGTGGCGGCGG CCCGGGCAGGGCTGGATGCTGCCTGGGCAAGGCGGTGCGAGGTGCCAAAGGTCACCACCATCCC CACCCGCCAGCCGCGGGCGCCGGCGCGGCCGGGGGCGCCGAGGCGGATCTGAAGGCGCTCACGC ACTCGGTGCTCAAGAAACTGAAGGAGCGGCAGCTGGAGCTGCTGCTCCAGGCCGTGGAGTCCCG CGGCGGGACGCGCACCGCGTGCCTCCTGCTGCCCGGCCGCCTGGACTGCAGGCTGGGCCCGGGG GCGCCCGCCGGCGCGCAGCCTGCGCAGCCGCCCTCGTCCTACTCGCTCCCCCTCCTGCTGTGCA AAGTGTTCAGGTGGCCGGATCTCAGGCATTCCTCGGAAGTCAAGAGGCTGTGTTGCTGTGAATC TTACGGGAAGATCAACCCCGAGCTGGTGTGCTGCAACCCCCATCACCTTAGCCGACTCTGCGAA CTAGAGTCTCCCCCCCCTCCTTACTCCAGATACCCGATGGATTTTCTCAAACCAACTGACTGTC CAGATGCTGTGCCTTCCTCCGCTGAAACAGGGGGAACGAATTATCTGGCCCCTGGGGGGCTTTC AGATTCCCAACTTCTTCTGGAGCCTGGGGATCGGTCACACTGGTGCGTGGTGGCATACTGGGAG GAGAAGACGAGAGTGGGGAGGCTCTACTGTGTCCAGGAGCCCTCTCTGGATATCTTCTATGATC TACCTCAGGGGAATGGCTTTTGCCTCGGACAGCTCAATTCGGACAACAAGAGTCAGCTGGTGCA GAAGGTGCGGAGCAAAATCGGCTGCGGCATCCAGCTGACGCGGGAGGTGGATGGTGTGTGGGTG TACAACCGCAGCAGTTACCCCATCTTCATCAAGTCCGCCACACTGGACAACCCGGACTCCAGGA CGCTGTTGGTACACAAGGTGTTCCCCGGTTTCTCCATCAAGGCTTTCGACTACGAGAAGGCGTA CAGCCTGCAGCGGCCCAATGACCACGAGTTTATGCAGCAGCCGTGGACGGGCTTTACCGTGCAG ATCAGCTTTGTGAAGGGCTGGGGCCAGTGCTACACCCGCCAGTTCATCAGCAGCTGCCCGTGCT GGCTAGAGGTCATCTTCAACAGCCGGTAGCCGCGTGCGGAGGGGACAGAGCGTGAGCTGAGCAG GCCACACTTCAAACTACTTTGCTGCTAATATTTTCCTCCTGAGTGCTTGCTTTTCATGCAAACT CTTTGGTCGTTTTTTTTTTGTTTGTTGGTTGGTTTTCTTCTTCTCGTCCTCGTTTGTGTTCTGT TTTGTTTCGCTCTTTGAGAAATAGCTTATGAAAAGAATTGTTGGGGGTTTTTTTGGAAGAAGGG GCAGGTATGATCGGCAGGACACCCTGATAGGAAGAGGGGAAGCAGAAATCCAAGCACCACCAAA CACAGTGTATGAAGGGGGGCGGTCATCATTTCACTTGTCAGGAGTGTGTGTGAGTGTGAGTGTG CGGCTGTGTGTGCACGCGTGTGCAGGAGCGGCAGATGGGGAGACAACGTGCTCTTTGTTTTGTG TCTCTTATGGATGTCCCCAGCAGAGAGGTTTGCAGTCCCAAGCGGTGTCTCTCCTGCCCCTTGG ACACGCTCAGTGGGGCAGAGGCAGTACCTGGGCAAGCTGGCGGCTGGGGTCCCAGCAGCTGCCA GGAGCACGGCTCTGTCCCCAGCCTGGGAAAGCCCCTGCCCCTCCTCTCCCTCATCAAGGACACG GGCCTGTCCACAGGCTTCTGAGCAGCGAGCCTGCTAGTGGCCGAACCAGAACCAATTATTTTCA TCCTTGTCTTATTCCCTTCCTGCCAGCCCCTGCCATTGTAGCGTCTTTCTTTTTTGGCCATCTG CTCCTGGATCTCCCTGAGATGGGCTTCCCAAGGGCTGCCGGGGCAGCCCCCTCACAGTATTGCT CACCCAGTGCCCTCTCCCCTCAGCCTCTCCCCTGCCTGCCCTGGTGACATCAGGTTTTTCCCGG ACTTAGAAAACCAGCTCAGCACTGCCTGCTCCCATCCTGTGTGTTAAGCTCTGCTATTAGGCCA GCAAGCGGGGATGTCCCTGGGAGGGACATGCTTAGCAGTCCCCTTCCCTCCAAGAAGGATTTGG TCCGTCATAACCCAAGGTACCATCCTAGGCTGACACCTAACTCTTCTTTCATTTCTTCTACAAC TCATACACTCGTATGATACTTCGACACTGTTCTTAGCTCAATGAGCATGTTTAGACTTTAACAT AAGCTATTTTTCTAACTACAAAGGTTTAAATGAACAAGAGAAGCATTCTCATTGGAAATTTAGC ATTGTAGTGCTTTGAGAGAGAAAGGACTCCTGAAAAAAAACCTGAGATTTATTAAAGAAAAAAA TGTATTTTATGTTATATATAAATATATTATTACTTGTAAATATAAAGACGTTTTATAAGCATCA TTATTTATGTATTGTGCAATGTGTATAAACAAGAAAAATAAAGAAAAGATGCACTTTGCTTTAA TATAAATGCAAATAACAAATGCCAAATTAAAAAAGATAAACACAAGATTGGTGTTTTTTTCTAT GGGTGTTATCACCTAGCTGAATGTTTTTCTAAAGGAGTTTATGTTCCATTAAACGATTTTTAAA ATGTACACTTGAA Download Select all
Length	3085

CDS Information

Location	join(288..900,2275..2328,8160..8231,28802..29340)
CDS Sequence	>gi\|299890804:288-1565 Homo sapiens SMAD family member 7 (SMAD7), transcript variant 2, mRNA ATGTTCAGGACCAAACGATCTGCGCTCGTCCGGCGTCTCTGGAGGAGCCGTGCGCCCGGCGGCGAGGACG AGGAGGAGGGCGCAGGGGGAGGTGGAGGAGGAGGCGAGCTGCGGGGAGAAGGGGCGACGGACAGCCGAGC GCATGGGGCCGGTGGCGGCGGCCCGGGCAGGGCTGGATGCTGCCTGGGCAAGGCGGTGCGAGGTGCCAAA GGTCACCACCATCCCCACCCGCCAGCCGCGGGCGCCGGCGCGGCCGGGGGCGCCGAGGCGGATCTGAAGG CGCTCACGCACTCGGTGCTCAAGAAACTGAAGGAGCGGCAGCTGGAGCTGCTGCTCCAGGCCGTGGAGTC CCGCGGCGGGACGCGCACCGCGTGCCTCCTGCTGCCCGGCCGCCTGGACTGCAGGCTGGGCCCGGGGGCG CCCGCCGGCGCGCAGCCTGCGCAGCCGCCCTCGTCCTACTCGCTCCCCCTCCTGCTGTGCAAAGTGTTCA GGTGGCCGGATCTCAGGCATTCCTCGGAAGTCAAGAGGCTGTGTTGCTGTGAATCTTACGGGAAGATCAA CCCCGAGCTGGTGTGCTGCAACCCCCATCACCTTAGCCGACTCTGCGAACTAGAGTCTCCCCCCCCTCCT TACTCCAGATACCCGATGGATTTTCTCAAACCAACTGACTGTCCAGATGCTGTGCCTTCCTCCGCTGAAA CAGGGGGAACGAATTATCTGGCCCCTGGGGGGCTTTCAGATTCCCAACTTCTTCTGGAGCCTGGGGATCG GTCACACTGGTGCGTGGTGGCATACTGGGAGGAGAAGACGAGAGTGGGGAGGCTCTACTGTGTCCAGGAG CCCTCTCTGGATATCTTCTATGATCTACCTCAGGGGAATGGCTTTTGCCTCGGACAGCTCAATTCGGACA ACAAGAGTCAGCTGGTGCAGAAGGTGCGGAGCAAAATCGGCTGCGGCATCCAGCTGACGCGGGAGGTGGA TGGTGTGTGGGTGTACAACCGCAGCAGTTACCCCATCTTCATCAAGTCCGCCACACTGGACAACCCGGAC TCCAGGACGCTGTTGGTACACAAGGTGTTCCCCGGTTTCTCCATCAAGGCTTTCGACTACGAGAAGGCGT ACAGCCTGCAGCGGCCCAATGACCACGAGTTTATGCAGCAGCCGTGGACGGGCTTTACCGTGCAGATCAG CTTTGTGAAGGGCTGGGGCCAGTGCTACACCCGCCAGTTCATCAGCAGCTGCCCGTGCTGGCTAGAGGTC ATCTTCAACAGCCGGTAG Download Select all
CCDS ID	-

Protein Information

Protein ID	NP_001177750.1
Protein Name	SMAD family member 7
Molecular Wt. (Da)	46224
Protein Sequence	>4092 MFRTKRSALVRRLWRSRAPGGEDEEEGAGGGGGGGELRGEGATDSRAHGAGGGGPGRAGCCLGK AVRGAKGHHHPHPPAAGAGAAGGAEADLKALTHSVLKKLKERQLELLLQAVESRGGTRTACLLL PGRLDCRLGPGAPAGAQPAQPPSSYSLPLLLCKVFRWPDLRHSSEVKRLCCCESYGKINPELVC CNPHHLSRLCELESPPPPYSRYPMDFLKPTDCPDAVPSSAETGGTNYLAPGGLSDSQLLLEPGD RSHWCVVAYWEEKTRVGRLYCVQEPSLDIFYDLPQGNGFCLGQLNSDNKSQLVQKVRSKIGCGI QLTREVDGVWVYNRSSYPIFIKSATLDNPDSRTLLVHKVFPGFSIKAFDYEKAYSLQRPNDHEF MQQPWTGFTVQISFVKGWGQCYTRQFISSCPCWLEVIFNSR Download Select all
Length	425
Uniprot ID	P11802
Ensembl Protein ID	ENSP00000257904

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
K	Acetylation	64
K	Acetylation	70

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
91	ACVR1B	3193	NP_004293.1	in vivo	12023024
1432	MAPK14	2619	NP_001306.1	in vitro;in vivo	12589052
2033	EP300	4078	NP_001420.2	in vitro;in vivo	12408818
4091	SMAD6	4240	NP_005576.3	in vitro;in vivo;yeast 2-hybrid	9256479
4654	MYOD1	1166	NP_002469.2	yeast 2-hybrid	15231748
5606	MAP2K3	3816	NP_659732.1	in vitro;in vivo	12589052
5608	MAP2K6	3155	NP_002749.2	in vivo	12589052
6660	SOX5	18086	NP_008871.3	yeast 2-hybrid	15231748
6885	MAP3K7	4011	NP_663304.1	in vivo	12589052
7046	TGFBR1	1822	NP_004603.1	in vitro;in vivo	921 563 815 148 321
7048	TGFBR2	1823	NP_001020018.1	in vitro;in vivo	11163210
7270	TTF1	2866	NP_031370.2	yeast 2-hybrid	15231748
8458	TTF2	5280	NP_003585.3	yeast 2-hybrid	15231748
9580	SOX13	9205	AAC83687.1	yeast 2-hybrid	15231748
10454	MAP3K7IP1	4012	NP_006107.1	in vivo	11737269
27107	ZBTB11	15690	NP_055230.2	yeast 2-hybrid	15231748
29068	ZBTB44	13692	NP_054874.3	yeast 2-hybrid	15231748
51427	ZNF107	18669	NP_001013768.1	yeast 2-hybrid	15231748
55870	ASH1L	6416	NP_060959.2	yeast 2-hybrid	15231748

Pathway Information

Pathway Name	Pathway ID
Hippo signaling pathway	hsa04390
TGF-beta signaling pathway	hsa04350

Structure Information

PDB ID	2DJY
Resolution	-
Method	solution NMR
Chains	A
Molecule	Smad ubiquitination regulatory factor 2
Model	View

Domain Information

ID	Location	Description
cd10500	254-424	MH2_SMAD_7
cl00056	254-424	MH2 superfamily
cd10494	60-205	MH1_SMAD_7
cl00055	60-205	MH1 superfamily
cd10496	261-424	MH2_I-SMAD
cd10499	256-424	MH2_SMAD_6
pfam03166	259-426	MH2
smart00524	260-424	DWB
cd00050	261-424	MH2
smart00523	89-205	DWA
cd10489	89-205	MH1_SMAD_6_7
pfam03165	92-202	MH1
cd10493	89-205	MH1_SMAD_6
cd00049	89-202	MH1
cd10495	261-421	MH2_R-SMAD
cd10498	260-421	MH2_SMAD_4
cd10985	261-424	MH2_SMAD_2_3
cd10497	260-424	MH2_SMAD_1_5_9
cd10488	98-201	MH1_R-SMAD
cd10492	98-200	MH1_SMAD_4
cd10491	98-201	MH1_SMAD_2_3
cd10490	98-201	MH1_SMAD_1_5_9

Ontology Information

HPRD ID	2867
Molecular Class	Transcription regulatory protein
Molecular Function	Kinase regulator activity (GO:0019207)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO

Mechanism	Mutation
Biomarker	-
Drug Target	-
Biological Process	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism