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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SMC4 10051 structural maintenance of chromosomes 4  3hCAP-C, CAP-C 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25081869   2014Cell line : -

Source : Hokkaido Gastroenterology Hospital.

Sample Type : CRC tumor and normal tissue

No. of Sample : 71

Stage : TNM Stage III - IV

 RT-PCR,Cell culture and transfection assaysUp-regulation- miR-124-5p may target the tumorigenesis gene, SMC4, which suggests that expression levels of miR-124-5p in plasma and FFPE samples.


Gene Details



NC_000003.11 (160117078..160152755)

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Gene Type protein coding
Gene Family Structural maintenance of chromosomes proteins
Description Members of the structural maintenance of chromosomes, or SMC, family (e.g., SMC1A; MIM 300040) are critical for mitotic chromosome condensation in frogs and for DNA repair in mammals.[supplied by OMIM, Nov 2010]  
Chromosome 3
Location 3q26.1
Start 160117078  
End 160152755  
Strand +  
Gene Sequence

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Length 35678  
OMIM ID 605575   
HGNC ID HGNC:14013   
Unigene ID Hs.58992   
Ensembl ID ENSG00000113810   
PharmGKB ID PA37834   

mRNA Information


mRNA ID ?NM_001002800.2
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS3189.1



Protein Information


      
Protein IDNP_001002800.1
Protein Namestructural maintenance of chromosomes 4
Molecular Wt. (Da)0
Protein Sequence

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Length 1288  
Uniprot IDQ9Y6C9
Ensembl Protein ID ENSP00000303222  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation22
SPhosphorylation28
SPhosphorylation41
SPhosphorylation22
SPhosphorylation28
SPhosphorylation41
SPhosphorylation1056
SPhosphorylation1056
SPhosphorylation41;-
SPhosphorylation41;-
SPhosphorylation22;-
SPhosphorylation27;-
SPhosphorylation36;-
SPhosphorylation27;-
SPhosphorylation36;-
SPhosphorylation27;-
SPhosphorylation36;-
SPhosphorylation28;-
TPhosphorylation44;-
TPhosphorylation44;-
SPhosphorylation982
SPhosphorylation982
TPhosphorylation39
SPhosphorylation50
TPhosphorylation39
SPhosphorylation50
KAcetylation1037
KAcetylation1037
KAcetylation381
KAcetylation356
KAcetylation381
KAcetylation679
KAcetylation654
KAcetylation679
TPhosphorylation48
TPhosphorylation48
SPhosphorylation355
SPhosphorylation330
SPhosphorylation355
SPhosphorylation143
SPhosphorylation118
SPhosphorylation143
YPhosphorylation616
YPhosphorylation591
YPhosphorylation616
SPhosphorylation1071
SPhosphorylation1071

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
9918NCAPD26472NP_055680.3in vivo10958694   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0327482-241  ABC_SMC4_euk
cl2145582-241  P-loop_NTPase superfamily
cd032741181-1275  ABC_SMC4_euk
cl214551181-1275  P-loop_NTPase superfamily
smart00968613-727  SMC_hinge
cl05797613-727  SMC_hinge superfamily
cd032391191-1273  ABC_SMC_head
pfam06470612-727  SMC_hinge
cd0327590-242  ABC_SMC1_euk
cd032751180-1267  ABC_SMC1_euk
cd032781186-1265  ABC_SMC_barmotin
cd0323984-167  ABC_SMC_head
cd032271188-1268  ABC_Class2
cd032731185-1271  ABC_SMC2_euk
cd032721186-1265  ABC_SMC3_euk
cd0327884-164  ABC_SMC_barmotin
cd0327384-238  ABC_SMC2_euk
cd0322786-170  ABC_Class2
cd0327284-245  ABC_SMC3_euk
cd002671188-1267  ABC_ATPase
cd032761191-1267  ABC_SMC6_euk
pfam1347690-304  AAA_23
pfam13304108-176  AAA_21
cd03241104-238  ABC_RecN
pfam133041182-1250  AAA_21
pfam13555103-138  AAA_29
cd0324284-128  ABC_RecF
pfam10152Feb-56  DUF2360
cl10849Feb-56  DUF2360 superfamily
cd0327784-151  ABC_SMC5_euk
TIGR02132327-427  phaR_Bmeg
cl11779327-427  phaR_Bmeg superfamily
pfam0246383-1274  SMC_N
COG119682-1278  Smc
TIGR0216984-1265  SMC_prok_A
TIGR0216892-1265  SMC_prok_B
COG0419768-1250  SbcC
COG041983-545  SbcC
TIGR00618773-1207  sbcc
pfam13166770-972  AAA_13
TIGR04523773-1033  Mplasa_alph_rch
PRK0391890-548  PRK03918
pfam04111945-1022  APG6
TIGR04523769-1042  Mplasa_alph_rch
COG4477769-1022  EzrA
COG4372853-1021  COG4372
pfam07111826-1008  HCR
COG4942842-1033  EnvC
PRK02224773-1148  PRK02224
pfam05483285-535  SCP-1
pfam12128783-1134  DUF3584
PRK03918261-548  PRK03918
COG5022770-1192  COG5022
PRK03918793-1004  PRK03918
pfam06008769-987  Laminin_I
COG4372792-1021  COG4372
TIGR01612738-1113  235kDa-fam
pfam12128773-1009  DUF3584
COG4372769-981  COG4372
TIGR00606769-1024  rad50
COG4372886-1132  COG4372
pfam05667785-1001  DUF812
COG1269918-1188  NtpI
TIGR04523329-589  Mplasa_alph_rch
pfam05483694-1039  SCP-1
pfam09726775-964  Macoilin
COG1579283-430  COG1579
PHA02562788-974  46
COG0497104-427  RecN
COG119584-173  RecF
TIGR00618773-1179  sbcc
PRK02224769-1004  PRK02224
COG4942910-1134  EnvC
COG0419769-1155  SbcC
COG11321189-1263  MdlB
pfam05483773-1011  SCP-1
pfam12128274-547  DUF3584
PRK03918853-1129  PRK03918
COG4942773-1004  EnvC
COG4717774-1013  YhaN
COG1579905-1033  COG1579
pfam01576773-1032  Myosin_tail_1
COG110683-129  AAA15
TIGR04320898-970  Surf_Exclu_PgrA
pfam09731826-1009  Mitofilin
pfam04156917-1030  IncA
pfam01576794-1020  Myosin_tail_1
TIGR04523774-1080  Mplasa_alph_rch
PRK03918773-1129  PRK03918
pfam13514764-1026  AAA_27
pfam04012903-1033  PspA_IM30
COG0840774-986  Tar
TIGR00606769-998  rad50
pfam01576774-1008  Myosin_tail_1
pfam13166819-1003  AAA_13
PRK04863770-1013  mukB
COG5185773-1039  HEC1
PRK01156778-1095  PRK01156
pfam13514794-1208  AAA_27
PRK03918270-545  PRK03918
COG4913736-1043  COG4913
COG4477765-1008  EzrA
COG3206761-1003  GumC
TIGR0061184-166  recf
PTZ00108147-500  PTZ00108
PHA02562896-1273  46
pfam10174773-1130  Cast
COG0419849-1134  SbcC
pfam04111885-1022  APG6
TIGR04523277-444  Mplasa_alph_rch
TIGR03319850-971  RNase_Y
PRK01156770-1267  PRK01156
TIGR04211872-967  SH3_and_anchor
TIGR036081186-1265  L_ocin_972_ABC
PRK03918770-1226  PRK03918
pfam05557828-1033  MAD
pfam10174331-1019  Cast
TIGR04320894-1003  Surf_Exclu_PgrA
COG5185810-1040  HEC1
pfam04849788-992  HAP1_N
pfam13514898-1022  AAA_27
PRK12704335-427  PRK12704
TIGR04523274-441  Mplasa_alph_rch
COG4717772-1168  YhaN


Ontology Information


   
HPRD ID12176
Molecular ClassStructural protein
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO