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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SMURF2 64750 SMAD specific E3 ubiquitin protein ligase 2  17- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22333948   2012Cell line : -

Source : -

Sample Type : CRC tumor and normal tissues

No. of Sample : Mouse model

Stage : -

real time RT-PCRUp-regulation--


Gene Details



NC_000017.10 (62538400..62658386, complement)

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Gene Type protein coding
Gene Family -
Description -  
Chromosome 17
Location 17q22-q23
Start 62538400  
End 62658386  
Strand -  
Gene Sequence

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Length 119987  
OMIM ID 605532   
HGNC ID HGNC:16809   
Unigene ID Hs.515011   
Ensembl ID ENSG00000108854   
PharmGKB ID PA134985524   

mRNA Information


mRNA ID ?NM_022739.3
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS32707.1



Protein Information


      
Protein IDNP_073576.1
Protein NameSMAD specific E3 ubiquitin protein ligase 2
Molecular Wt. (Da)0
Protein Sequence

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Length 748  
Uniprot IDQ9H6X2
Ensembl Protein ID ENSP00000301945  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
394ARHGAP54060NP_001025226.1yeast 2-hybrid15231748   
821CANX252NP_001737.1yeast 2-hybrid15231748   
864RUNX32565AAH13362.1in vivo15138260   
1601DAB23139NP_001334.2yeast 2-hybrid15231748   
4086SMAD13356NP_005891.1in vitro;yeast 2-hybrid110   169   191   523   174   000   000   000   
4087SMAD23221NP_005892.1in vitro;in vivo;yeast 2-hybrid1   101   691   915   231   740   
4088SMAD34380NP_005893.1in vitro;yeast 2-hybrid11016919   
4090SMAD54381NP_005894.3yeast 2-hybrid15231748   
4092SMAD74241NP_005895.1in vitro;in vivo;yeast 2-hybrid111   632   101   523   174   000   000   000   
6233RPS27A1878NP_002945.1in vivo14755250   
6498SKIL1319NP_005405.2in vivo11389444   
6625SNRNP701617NP_003080.2yeast 2-hybrid15231748   
7046TGFBR11822NP_004603.1in vivo1   116   321   014   722   610   
7186TRAF23538NP_066961.2in vitro18671942   
7805LAPTM53280NP_006753.1yeast 2-hybrid15231748   
7980TFPI28962NP_006519.1yeast 2-hybrid15231748   
8175SF3A22877NP_009096.2yeast 2-hybrid15231748   
8310ACOX34552NP_003492.2yeast 2-hybrid15231748   
9306SOCS65491NP_004223.2in vivo15761153   
9993DGCR28999NP_005128.1yeast 2-hybrid15231748   
10628TXNIP5964NP_006463.3yeast 2-hybrid15231748   
23111SPG206170NP_055902.1yeast 2-hybrid15231748   
23172FAM175B13783NP_115558.3yeast 2-hybrid15231748   
29068ZBTB4413692NP_054874.3yeast 2-hybrid15231748   
54778RNF1119318NP_060080.6yeast 2-hybrid15231748   
64746ACBD38432NP_073572.2yeast 2-hybrid15231748   
135932TMEM1398298NP_699176.1yeast 2-hybrid15231748   
144165PRICKLE116341NP_694571.2in vivo19379695   
166336PRICKLE216342NP_942559.1in vivo19379695   
283629TSSK412642NP_777604.2in vivo15761153   
404093CUEDC113098NP_060419.1yeast 2-hybrid15231748   


Pathway Information


                  
Pathway Name Pathway ID
Endocytosis hsa04144
TGF-beta signaling pathway hsa04350
Ubiquitin mediated proteolysis hsa04120


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00078393-745  HECTc
cl00077393-745  HECTc superfamily
cd0838213-137  C2_Smurf-like
cl1460313-137  C2 superfamily
cd00201160-189  WW
cl00157160-189  WW superfamily
cd00201300-330  WW
cl00157300-330  WW superfamily
cd00201254-283  WW
cl00157254-283  WW superfamily
pfam00632443-745  HECT
cd0003014-117  C2
pfam0016814-98  C2
smart0023913-99  C2
cd0404615-140  C2_Calpain
smart00456298-330  WW
smart00456158-189  WW
cd0402113-89  C2_E3_ubiquitin_ligase
pfam00397159-188  WW
cd0839114-121  C2A_C2C_Synaptotagmin_like
cd0404719-89  C2B_Copine
cd0402414-137  C2A_Synaptotagmin-like
cd0402213-132  C2A_MCTP_PRT_plant
pfam00397299-328  WW
cd0867612-116  C2A_Munc13-like
cd0027613-103  C2B_Synaptotagmin
cd0404014-80  C2D_Tricalbin-like
smart00456252-283  WW
cd0403314-63  C2_NEDD4_NEDD4L
cd0404813-97  C2A_Copine
cd0403614-63  C2_cPLA2
cd0403114-63  C2A_RIM1alpha
cd0404316-82  C2_Munc13_fungal
cd0840213-96  C2B_Synaptotagmin-1
cd0402513-97  C2B_RasA1_RasA4
cd0402713-101  C2B_Munc13
cd0837317-99  C2A_Ferlin
pfam00397253-282  WW
cd08375Jul-81  C2_Intersectin
cd04026Dec-80  C2_PKC_alpha_gamma
cd0401714-63  C2D_Ferlin
cd0868513-96  C2_RGS-like
cd0402021-99  C2B_SLP_1-2-3-4
cd0404514-112  C2C_Tricalbin-like
cd0403013-99  C2C_KIAA1228
cd0841013-82  C2B_Synaptotagmin-17
cd0403715-87  C2E_Ferlin
cd0837714-97  C2C_MCTP_PRT
cd04032Jul-80  C2_Perforin
cd0402814-100  C2B_RIM1alpha
cd0867834-95  C2_C21orf25-like
cd0401913-109  C2C_MCTP_PRT_plant
cd0837950-99  C2D_MCTP_PRT_plant
cd0403513-109  C2A_Rabphilin_Doc2
cd0840313-104  C2B_Synaptotagmin-3-5-6-9-10
cd0405232-88  C2B_Tricalbin-like
smart00119420-745  HECTc
COG5021159-745  HUL4
COG5104155-236  PRP40
COG5104257-328  PRP40
COG503814-102  COG5038


Ontology Information


   
HPRD ID16348
Molecular ClassUbiquitin proteasome system protein
Molecular FunctionTranscription regulator activity (GO:0030528)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO