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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SNAI1 | 6615 | Snail homolog 1 (Drosophila) | 20 | SNA; SNAH; SNAIL; SLUGH2; SNAIL1; dJ710H13.1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19802011 | 2009 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 32 Stage : - | RT-PCR, PCR amplification, Co-culture and conditioned medium assay, Human protein cytokine array. | Up-regulation | - | SNAI1 was expressed in 18 out of 32 tumor samples (56.3%) and ?ve of these patients also showed SNAI1 expression in the NAT (15.6%) but no epression in normal tissue. |
| 19861116 | 2009 | Cell line : SW 480 Source : Department of Gastroenterological Surgery at Osaka University. Sample Type : - No. of Sample : 30 primary CRC samples Stage : TNM Stage I-III | Cell culture and transfection, Immunohistochemistry, real timeRR-PCR, Invasion assay | Up-regulation | - | Snai1 plays a role in CRC invasion through phosphorylation, suggesting a plausible mechanism for overcoming chemoresistance that will lead to the development of effective treatments for CRC. Immunohistochemistry was performed to evaluate the expression of Snai1 protein in 30 primary CRC samples. |
| 21890490 | 2011 | Cell line : SW 480-ADH, SW 480-R (32), SW 620, SW 1417, HCT 116, HT 29, KM 12C, Caco 2, MCF 7, MDA-MB-231, MDA-MB-453, UACC-257, SK-MEL-28 and AGS Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 96 Normal and tumour tissue samples Stage : - | Transfection, Gene silencing, real time RT-PCR, Western blotting and Immunofluorescence, confocal microscopy | Up-regulation | - | Expression of SNAI1 is inversly correlated with JMJD3 ahistone H3 lysine demethylase. Ie low JMJD3 and high SNAI1 expression and poor tumour differentiation |
| 22569829 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | In stage II CRC tissues, Tumor Bud was associated with increased levels of SNAI1 expression as well as high incidence of metachronous lymph node metastasis post-surgical resection. In CD133- SW480 cells, the SNAI1-induced epithelial-mesenchymal transition (EMT) restored the population of CD133 cells and increased tumorigenicity, cell motility/invasiveness and matrix metalloproteinase 2 (MMP2) expression. CD133 and CD133- SW480 cells were used in this study. |
| 23029563 | 2012 | Cell line : - Source : Department of Pathology (University Hospital Dsseldorf). Sample Type : - No. of Sample : CRC 41 and normal colon mucosa10 samples Stage : - | real time RT-PCR, Immunohistochemistry | Up-regulation | - | SNAI1 and Twist1 are already expressed in benign precursor lesions of colorectal cancer and that SNAI1 expression was significantly correlated with lower expression of CDH1.
|
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Snail homologs, Zinc fingers, C2H2-type |
| Description | The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008] | Chromosome | 20 |
| Location | 20q13.2 |
| Start | 49982976 |
| End | 49988886 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 5911 |
| OMIM ID | 604238 |
| HGNC ID | HGNC:11128 |
| Unigene ID | Hs.48029 |
| Ensembl ID | ENSG00000124216 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_005985.3 |
|---|---|
| Exon | join(1..166,849..1376,4897..5911) | mRNA Sequence | Download Select all |
| Length | 1722 |
CDS Information
| Location | join(85..166,849..1376,4897..5081) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS13423.1 |
Protein Information
| Protein ID | NP_005976.2 |
|---|---|
| Protein Name | Snail homolog 1 (Drosophila) |
| Molecular Wt. (Da) | 28952 |
| Protein Sequence | Download Select all |
| Length | 264 |
| Uniprot ID | P98082 |
| Ensembl Protein ID | ENSP00000313391 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 92 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2932 | GSK3B | 5418 | NP_002084.2 | in vivo | 19004823 |
| 10106 | CTDSP2 | 12281 | NP_005721.3 | in vitro;in vivo | 19004823 |
| 10217 | CTDSPL | 12264 | BAA21667.1 | in vitro;in vivo | 19004823 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adherens junction | hsa04520 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam13465 | 195-218 | zf-H2C2_2 |
| cl22375 | 195-218 | zf-H2C2_2 superfamily |
| pfam00096 | 208-230 | zf-C2H2 |
| cl23491 | 208-230 | zf-C2H2 superfamily |
| pfam13465 | 222-247 | zf-H2C2_2 |
| cl22375 | 222-247 | zf-H2C2_2 superfamily |
| COG5048 | 177-253 | COG5048 |
| COG5048 | 182-231 | COG5048 |
Ontology Information
| HPRD ID | 4424 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Receptor signaling complex scaffold activity (GO:0030159) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.