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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SOCS1 8651 Suppressor of cytokine signaling 1  16JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; SOCS-1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
15074307   2004Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 74 colorectal cancer patients

Stage : -

Methylation-specific PCRMethylation-SOCS-1 may act as a tumor suppressor in at least some colorectal cancers and that SOCS-1 methylation may be a particular phenomenon related to a nearly onset of colorectal cancer.polymerase chain reaction (PCR;MSP) for SOCS-1 CpG island in primary tumors.

15793636   2005Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 61 resected primary colorectal cancers

Stage : -

Methylation-specific PCRMethylation-Colorectal cancers without lymph node metastasis frequently exhibited the aberrant methylation of HLTF , SOCS-1 , and CDH13 genes.

Examined the combined methylation status of HLTF, SOCS-1, and CDH13 in 61 resected primary colorectal cancers using methylation-specific polymerase chain reaction.

16717119   2006Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Histopathological and immunohistochemistryMethylation-SOCS1 is a unique antioncogene which prevents chronic inflammation-mediated carcinogenesis by regulation of the IFNgamma/STAT1 pathways.

22121102   2011Cell line : -

Source : -

Sample Type : Population-based case-control studies.

No. of Sample : Colon cancer 1555 cases, 1,956 controls; rectal cancer 754 cases, 959 controls

Stage : -

Population-based case-control studies.Polymorhpism-SOCS1 associated with colorectal cancer survival.

Suppressors of cytokine signaling (SOCS)1 (2 SNPs) associated with risk of colorectal cancer.

Used data from population-based case-control studies (


Gene Details



Chromosome: 16; NC_000016.9 (11348274..11350039, complement)

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Gene Type protein coding
Gene Family Suppressors of cytokine, signaling SH2 domain containing
Description This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]  
Chromosome 16
Location 16p13.13
Start 11254417  
End 11256182  
Strand +  
Gene Sequence

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Length 1766  
OMIM ID 603597   
HGNC ID HGNC:19383   
Unigene ID Hs.50640    
Ensembl ID ENSG00000185338   
PharmGKB ID -   

mRNA Information


mRNA ID NM_003745.1
Exon join(1..104,655..1766  
mRNA Sequence

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Length 1216  



CDS Information


   
Location705..1340
CDS Sequence

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CCDS ID CCDS10546.1



Protein Information


      
Protein IDNP_003736.1
Protein NameSuppressor of cytokine signaling 1
Molecular Wt. (Da)23420
Protein Sequence

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Length 211  
Uniprot IDP25101
Ensembl Protein ID ENSP00000315011  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                    
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1435CSF1388NP_000748.3in vitro;in vivo;yeast 2-hybrid11297560   
1436CSF1R1269NP_005202.2in vitro;in vivo;yeast 2-hybrid1   129   756   010   022   830   
1956EGFR579NP_005219.2in vivo12070153   
2322FLT3635NP_004110.2in vivo10022833   
2534FYN655NP_002028.1in vitro10022833   
2690GHR2971NP_000154.1in vivo10585430   
2885GRB2150NP_002077.1in vivo10022833   
3459IFNGR1127NP_000407.1in vivo15522878   
3480IGF1R932NP_000866.1in vivo;yeast 2-hybrid9727029   
3560IL2RB896NP_000869.1in vivo11133764   
3643INSR975NP_000199.2in vitro;yeast 2-hybrid15169905   
3667IRS1943NP_005535.1in vitro;in vivo1   222   822   011   208   860   
3702ITK1746NP_005537.3in vitro10022833   
3716JAK1992NP_002218.2in vitro11133764   
3717JAK2993NP_004963.1in vitro;in vivo;yeast 2-hybrid11   971   965   100   645   900   000   000   
3718JAK32547NP_000206.2in vitro11133764   
3815KIT1287NP_000213.1in vivo10022833   
4690NCK12740NP_006144.1in vitro10022833   
5295PIK3R11381NP_852664.1in vitro10022833   
6921TCEB12875NP_005639.1in vitro;in vivo10051596   
6923TCEB22874NP_996896.1in vitro;in vivo10051596   
7006TEC2786NP_003206.2in vitro;in vivo;yeast 2-hybrid9341160   
7010TEK2571NP_000450.2yeast 2-hybrid10022833   
7409VAV11284NP_005419.2in vitro;in vivo;yeast 2-hybrid10022833   
7410VAV22694NP_001127870.1in vivo10022833   
7852CXCR41217NP_001008540.1in vivo12163560   
11040PIM22244NP_006866.2in vitro11854514   
114609TIRAP5878AAH32474.1in vivo16415872   


Pathway Information


                                                
Pathway Name Pathway ID
Insulin signaling pathway hsa04910
Jak-STAT signaling pathway hsa04630
MicroRNAs in cancer hsa05206
Osteoclast differentiation hsa04380
Prolactin signaling pathway hsa04917
Toxoplasmosis hsa05145
Type II diabetes mellitus hsa04930
Ubiquitin mediated proteolysis hsa04120


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd1038268-165  SH2_SOCS1
cl1525568-165  SH2 superfamily
cd03735169-211  SOCS_SOCS1
cl02533169-211  SOCS superfamily
cd0992378-155  SH2_SOCS_family
cd1038474-159  SH2_SOCS3
cd1038378-155  SH2_SOCS2
cd1071874-155  SH2_CIS
smart0025277-158  SH2
cd0017379-154  SH2
cd1038868-144  SH2_SOCS7
cd03717170-207  SOCS_SOCS_like
smart00253165-207  SOCS
cd0994078-154  SH2_Vav_family
cd1038778-155  SH2_SOCS6
pfam0001779-154  SH2
cd0993180-154  SH2_C-SH2_SHP_like
cd1039393-154  SH2_RIN1
pfam07525171-205  SOCS_box
cd0994274-154  SH2_nSH2_p85_like
cd1040978-158  SH2_Nck2
cd03587170-207  SOCS
cd1038580-154  SH2_SOCS4
cd1035676-141  SH2_ShkA_ShkC
cd0994175-158  SH2_Grb2_like
cd0994379-158  SH2_Nck_family
cd1033984-154  SH2_RIN_family
cd03718173-204  SOCS_SSB1_4
cd0994578-164  SH2_SHB_SHD_SHE_SHF_like
cd0992675-121  SH2_CRK_like
cd1040788-154  SH2_Vav3
cd1038680-154  SH2_SOCS5
cd1040879-158  SH2_Nck1
cd1034492-154  SH2_SLAP
cd0993072-118  SH2_cSH2_p85_like
cd0993397-154  SH2_Src_family
cd1040579-154  SH2_Vav1
smart00969172-207  SOCS_box
cd1035379-154  SH2_Nterm_RasGAP
cd0992779-158  SH2_Tensin_like
cd1035780-128  SH2_ShkD_ShkE
cd03716169-204  SOCS_ASB_like
cd1039484-154  SH2_RIN2
cd1036398-154  SH2_Src_HCK
cd0993787-154  SH2_csk_like
cd1035573-158  SH2_DAPP1_BAM32_like
cd1034787-154  SH2_Nterm_shark_like


Ontology Information


   
HPRD ID1858
Molecular ClassAdapter molecule
Molecular FunctionReceptor binding (GO:0005102)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO