CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
24464786	2014	Cell line : SW 620 Source : - Sample Type : - No. of Sample : - Stage : -	-	Down-regulation	-	Higher IL-23 levels along with lower Socs3 in CRC tissues accounted for more metastatic cases.

Gene Details

NC_000017.10 (76352858..76356160, complement)
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Gene Type	protein coding
Gene Family	suppressor of cytokine signaling 3
Description	This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]
Chromosome	17
Location	17q25.3
Start	76352858
End	76356160
Strand	-
Gene Sequence	>gi\|568815581:c78360079-78356777 Homo sapiens chromosome 17, GRCh38.p2 Primary Assembly GCGGCTCCGACTTGGACTCCCTGCTCCGCTGCTGCCGCTTCGGCCCCGCACGCAGCCAGCCGCCAGCCGC CCGCCCGGCCCAGCTCCCGCCGCGGCCCCTTGCCGCGGTCCCTCTCCTGGTCCCCTCCCGGTTGGTCCGG GGGTGCGCAGGGGGCAGGGCGGGCGCCCAGGGGAAGCTCGAGGGACGCGCGCGCGAAGGCTCCTTTGTGG ACTTCACGGCCGCCAACATCTGGGCGCAGCGCGGGCCACCGCTGGCCGTCTCGCCGCCGCGTCGCCTTGG GGACCCGAGGGGGCTCAGCCCCAAGGACGGAGACTTCGATTCGGGACCAGGTAGGAAGGAGGAGCGCGGC GTGGGGAGGGGTCTCGCTCAGTCCCGGGAGCTTTTCCCGGTTTCCCCTCCCCTTCCCGGGTCATTCCCGG CAGGGAGGTGACGAGGTAGGGGCAGAGCGGATGGAAGCCGGAGATCCCAGGTTCCCGGAATACTCCGGCT GGGGCCTTCGGGCTTCTCCTGTCCCCTCCCTACCCCCGTGCCTCGGGTTTCTCCCTCCGTCCACACCGCC CGGGGCTACTGGACTGAGCGGCGCCCAGGCAGTCCCGGGGGCCCTTCTCCTGCTCCCCACCCGGCCACAC TCCTGGAGACCTAACTTCCGCGCGCGAGTTTCCCACGCTGCGCCCTTGCAGTGCGCGCCTGGGAAGGGGC TGCCCGGGGCCACCCTGCCGGCAGGGGCGGGAGCCGTGCGGGCTCCGTGAGGCGCCTGGATCGGAGCGCG GGCCCAGGAGAGGGCCCCCGGGGCAGTGGGTGCCCCAGTCGCTCGGCGAAGGCAGGGGAGCCGGGGCGGG CCGGGCGCGCTGGAGGGTTCCGGGCACTCAACGCGCTCGCGCCTTCCTCTCCGCAGCCCCCCGGGATGCG GTAGCGGCCGCTGTGCGGAGGCCGCGAAGCAGCTGCAGCCGCCGCCGCGCAGATCCACGCTGGCTCCGTG CGCCATGGTCACCCACAGCAAGTTTCCCGCCGCCGGGATGAGCCGCCCCCTGGACACCAGCCTGCGCCTC AAGACCTTCAGCTCCAAGAGCGAGTACCAGCTGGTGGTGAACGCAGTGCGCAAGCTGCAGGAGAGCGGCT TCTACTGGAGCGCAGTGACCGGCGGCGAGGCGAACCTGCTGCTCAGTGCCGAGCCCGCCGGCACCTTTCT GATCCGCGACAGCTCGGACCAGCGCCACTTCTTCACGCTCAGCGTCAAGACCCAGTCTGGGACCAAGAAC CTGCGCATCCAGTGTGAGGGGGGCAGCTTCTCTCTGCAGAGCGATCCCCGGAGCACGCAGCCCGTGCCCC GCTTCGACTGCGTGCTCAAGCTGGTGCACCACTACATGCCGCCCCCTGGAGCCCCCTCCTTCCCCTCGCC ACCTACTGAACCCTCCTCCGAGGTGCCCGAGCAGCCGTCTGCCCAGCCACTCCCTGGGAGTCCCCCCAGA AGAGCCTATTACATCTACTCCGGGGGCGAGAAGATCCCCCTGGTGTTGAGCCGGCCCCTCTCCTCCAACG TGGCCACTCTTCAGCATCTCTGTCGGAAGACCGTCAACGGCCACCTGGACTCCTATGAGAAAGTCACCCA GCTGCCGGGGCCCATTCGGGAGTTCCTGGACCAGTACGATGCCCCGCTTTAAGGGGTAAAGGGCGCAAAG GGCATGGGTCGGGAGAGGGGACGCAGGCCCCTCTCCTCCGTGGCACATGGCACAAGCACAAGAAGCCAAC CAGGAGAGAGTCCTGTAGCTCTGGGGGGAAAGAGGGCGGACAGGCCCCTCCCTCTGCCCTCTCCCTGCAG AATGTGGCAGGCGGACCTGGAATGTGTTGGAGGGAAGGGGGAGTACCACCTGAGTCTCCAGCTTCTCCGG AGGAGCCAGCTGTCCTGGTGGGACGATAGCAACCACAAGTGGATTCTCCTTCAATTCCTCAGCTTCCCCT CTGCCTCCAAACAGGGGACACTTCGGGAATGCTGAACTAATGAGAACTGCCAGGGAATCTTCAAACTTTC CAACGGAACTTGTTTGCTCTTTGATTTGGTTTAAACCTGAGCTGGTTGTGGAGCCTGGGAAAGGTGGAAG AGAGAGAGGTCCTGAGGGCCCCAGGGCTGCGGGCTGGCGAAGGAAATGGTCACACCCCCCGCCCACCCCA GGCGAGGATCCTGGTGACATGCTCCTCTCCCTGGCTCCGGGGAGAAGGGCTTGGGGTGACCTGAAGGGAA CCATCCTGGTACCCCACATCCTCTCCTCCGGGACAGTCACCGAAAACACAGGTTCCAAAGTCTACCTGGT GCCTGAGAGCCCAGGGCCCTTCCTCCGTTTTAAGGGGGAAGCAACATTTGGAGGGGATGGATGGGCTGGT CAGCTGGTCTCCTTTTCCTACTCATACTATACCTTCCTGTACCTGGGTGGATGGAGCGGGAGGATGGAGG AGACGGGACATCTTTCACCTCAGGCTCCTGGTAGAGAAGACAGGGGATTCTACTCTGTGCCTCCTGACTA TGTCTGGCTAAGAGATTCGCCTTAAATGCTCCCTGTCCCATGGAGAGGGACCCAGCATAGGAAAGCCACA TACTCAGCCTGGATGGGTGGAGAGGCTGAGGGACTCACTGGAGGGCACCAAGCCAGCCCACAGCCAGGGA AGTGGGGAGGGGGGGCGGAAACCCATGCCTCCCAGCTGAGCACTGGGAATGTCAGCCCAGTAAGTATTGG CCAGTCAGGCGCCTCGTGGTCAGAGCAGAGCCACCAGGTCCCACTGCCCCGAGCCCTGCACAGCCCTCCC TCCTGCCTGGGTGGGGGAGGCTGGAGGTCATTGGAGAGGCTGGACTGCTGCCACCCCGGGTGCTCCCGCT CTGCCATAGCACTGATCAGTGACAATTTACAGGAATGTAGCAGCGATGGAATTACCTGGAACAGTTTTTT GTTTTTGTTTTTGTTTTTGTTTTTGTGGGGGGGGGCAACTAAACAAACACAAAGTATTCTGTGTCAGGTA TTGGGCTGGACAGGGCAGTTGTGTGTTGGGGTGGTTTTTTTCTCTATTTTTTTGTTTGTTTCTTGTTTTT TAATAATGTTTACAATCTGCCTCAATCACTCTGTCTTTTATAAAGATTCCACCTCCAGTCCTCTCTCCTC CCCCCTACTCAGGCCCTTGAGGCTATTAGGAGATGCTTGAAGAACTCAACAAAATCCCAATCCAAGTCAA ACTTTGCACATATTTATATTTATATTCAGAAAAGAAACATTTCAGTAATTTATAATAAAGAGCACTATTT TTTAATGAAAAAC Download Select all
Length	3303
OMIM ID	604176
HGNC ID	HGNC:19391
Unigene ID	Hs.527973
Ensembl ID	ENSG00000184557
PharmGKB ID	PA134885765

mRNA Information

mRNA ID	?NM_003955.4
Exon
mRNA Sequence	>gi\|528078360\|ref\|NM_003955.4\| Homo sapiens suppressor of cytokine signaling 3 (SOCS3), mRNA GCGGCTCCGACTTGGACTCCCTGCTCCGCTGCTGCCGCTTCGGCCCCGCACGCAGCCAGCCGCCAGCCGC CCGCCCGGCCCAGCTCCCGCCGCGGCCCCTTGCCGCGGTCCCTCTCCTGGTCCCCTCCCGGTTGGTCCGG GGGTGCGCAGGGGGCAGGGCGGGCGCCCAGGGGAAGCTCGAGGGACGCGCGCGCGAAGGCTCCTTTGTGG ACTTCACGGCCGCCAACATCTGGGCGCAGCGCGGGCCACCGCTGGCCGTCTCGCCGCCGCGTCGCCTTGG GGACCCGAGGGGGCTCAGCCCCAAGGACGGAGACTTCGATTCGGGACCAGCCCCCCGGGATGCGGTAGCG GCCGCTGTGCGGAGGCCGCGAAGCAGCTGCAGCCGCCGCCGCGCAGATCCACGCTGGCTCCGTGCGCCAT GGTCACCCACAGCAAGTTTCCCGCCGCCGGGATGAGCCGCCCCCTGGACACCAGCCTGCGCCTCAAGACC TTCAGCTCCAAGAGCGAGTACCAGCTGGTGGTGAACGCAGTGCGCAAGCTGCAGGAGAGCGGCTTCTACT GGAGCGCAGTGACCGGCGGCGAGGCGAACCTGCTGCTCAGTGCCGAGCCCGCCGGCACCTTTCTGATCCG CGACAGCTCGGACCAGCGCCACTTCTTCACGCTCAGCGTCAAGACCCAGTCTGGGACCAAGAACCTGCGC ATCCAGTGTGAGGGGGGCAGCTTCTCTCTGCAGAGCGATCCCCGGAGCACGCAGCCCGTGCCCCGCTTCG ACTGCGTGCTCAAGCTGGTGCACCACTACATGCCGCCCCCTGGAGCCCCCTCCTTCCCCTCGCCACCTAC TGAACCCTCCTCCGAGGTGCCCGAGCAGCCGTCTGCCCAGCCACTCCCTGGGAGTCCCCCCAGAAGAGCC TATTACATCTACTCCGGGGGCGAGAAGATCCCCCTGGTGTTGAGCCGGCCCCTCTCCTCCAACGTGGCCA CTCTTCAGCATCTCTGTCGGAAGACCGTCAACGGCCACCTGGACTCCTATGAGAAAGTCACCCAGCTGCC GGGGCCCATTCGGGAGTTCCTGGACCAGTACGATGCCCCGCTTTAAGGGGTAAAGGGCGCAAAGGGCATG GGTCGGGAGAGGGGACGCAGGCCCCTCTCCTCCGTGGCACATGGCACAAGCACAAGAAGCCAACCAGGAG AGAGTCCTGTAGCTCTGGGGGGAAAGAGGGCGGACAGGCCCCTCCCTCTGCCCTCTCCCTGCAGAATGTG GCAGGCGGACCTGGAATGTGTTGGAGGGAAGGGGGAGTACCACCTGAGTCTCCAGCTTCTCCGGAGGAGC CAGCTGTCCTGGTGGGACGATAGCAACCACAAGTGGATTCTCCTTCAATTCCTCAGCTTCCCCTCTGCCT CCAAACAGGGGACACTTCGGGAATGCTGAACTAATGAGAACTGCCAGGGAATCTTCAAACTTTCCAACGG AACTTGTTTGCTCTTTGATTTGGTTTAAACCTGAGCTGGTTGTGGAGCCTGGGAAAGGTGGAAGAGAGAG AGGTCCTGAGGGCCCCAGGGCTGCGGGCTGGCGAAGGAAATGGTCACACCCCCCGCCCACCCCAGGCGAG GATCCTGGTGACATGCTCCTCTCCCTGGCTCCGGGGAGAAGGGCTTGGGGTGACCTGAAGGGAACCATCC TGGTACCCCACATCCTCTCCTCCGGGACAGTCACCGAAAACACAGGTTCCAAAGTCTACCTGGTGCCTGA GAGCCCAGGGCCCTTCCTCCGTTTTAAGGGGGAAGCAACATTTGGAGGGGATGGATGGGCTGGTCAGCTG GTCTCCTTTTCCTACTCATACTATACCTTCCTGTACCTGGGTGGATGGAGCGGGAGGATGGAGGAGACGG GACATCTTTCACCTCAGGCTCCTGGTAGAGAAGACAGGGGATTCTACTCTGTGCCTCCTGACTATGTCTG GCTAAGAGATTCGCCTTAAATGCTCCCTGTCCCATGGAGAGGGACCCAGCATAGGAAAGCCACATACTCA GCCTGGATGGGTGGAGAGGCTGAGGGACTCACTGGAGGGCACCAAGCCAGCCCACAGCCAGGGAAGTGGG GAGGGGGGGCGGAAACCCATGCCTCCCAGCTGAGCACTGGGAATGTCAGCCCAGTAAGTATTGGCCAGTC AGGCGCCTCGTGGTCAGAGCAGAGCCACCAGGTCCCACTGCCCCGAGCCCTGCACAGCCCTCCCTCCTGC CTGGGTGGGGGAGGCTGGAGGTCATTGGAGAGGCTGGACTGCTGCCACCCCGGGTGCTCCCGCTCTGCCA TAGCACTGATCAGTGACAATTTACAGGAATGTAGCAGCGATGGAATTACCTGGAACAGTTTTTTGTTTTT GTTTTTGTTTTTGTTTTTGTGGGGGGGGGCAACTAAACAAACACAAAGTATTCTGTGTCAGGTATTGGGC TGGACAGGGCAGTTGTGTGTTGGGGTGGTTTTTTTCTCTATTTTTTTGTTTGTTTCTTGTTTTTTAATAA TGTTTACAATCTGCCTCAATCACTCTGTCTTTTATAAAGATTCCACCTCCAGTCCTCTCTCCTCCCCCCT ACTCAGGCCCTTGAGGCTATTAGGAGATGCTTGAAGAACTCAACAAAATCCCAATCCAAGTCAAACTTTG CACATATTTATATTTATATTCAGAAAAGAAACATTTCAGTAATTTATAATAAAGAGCACTATTTTTTAAT GAAAAAC Download Select all
Length

CDS Information

Location
CDS Sequence	Download Select all
CCDS ID	CCDS11756.1

Protein Information

Protein ID	NP_003946.3
Protein Name	suppressor of cytokine signaling 3
Molecular Wt. (Da)	0
Protein Sequence	>lcl\|NM_003955.4_prot_NP_003946.3_1 [gene=SOCS3] [protein=suppressor of cytokine signaling 3] [protein_id=NP_003946.3] [location=419..1096] MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLI RDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSFPSPP TEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQL PGPIREFLDQYDAPL Download Select all
Length	225
Uniprot ID	O95166
Ensembl Protein ID	ENSP00000306866

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
K	Ubiquitination	6

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
1436	CSF1R	1269	NP_005202.2	in vivo	12133942
1441	CSF3R	737	NP_724781.1	in vivo	12133942
1956	EGFR	579	NP_005219.2	in vitro;in vivo	12070153
2057	EPOR	587	NP_000112.1	in vitro;in vivo	1 202 789 010 882 720
2690	GHR	2971	NP_000154.1	in vivo	10585430
3480	IGF1R	932	NP_000866.1	in vitro;in vivo	11071852
3572	IL6ST	2824	NP_002175.2	in vitro;in vivo	1 240 376 810 946 280
3643	INSR	975	NP_000199.2	in vitro;yeast 2-hybrid	1 256 033 011 071 850
3667	IRS1	943	NP_005535.1	in vitro;in vivo	12228220
3717	JAK2	993	NP_004963.1	in vitro;in vivo;yeast 2-hybrid	934 484 810 421 843
3953	LEPR	3001	NP_002294.2	in vitro;in vivo	11018044
5532	PPP3CB	235	AAH28049.1	in vitro;in vivo	11970967
5618	PRLR	1457	NP_000940.1	in vivo	11713228
5921	RASA1	745	NP_002881.1	in vitro;in vivo	11331873
6921	TCEB1	2875	NP_005639.1	in vitro;in vivo	10051596
6923	TCEB2	2874	NP_996896.1	in vitro;in vivo	10051596
7852	CXCR4	1217	NP_001008540.1	in vitro;in vivo	12163560
8660	IRS2	2878	NP_003740.2	in vivo	15514089
8835	SOCS2	5490	NP_003868.1	in vitro	16199887

Pathway Information

Pathway Name	Pathway ID
Adipocytokine signaling pathway	hsa04920
Hepatitis C	hsa05160
Herpes simplex infection	hsa05168
Influenza A	hsa05164
Insulin resistance	hsa04931
Insulin signaling pathway	hsa04910
Jak-STAT signaling pathway	hsa04630
Non-alcoholic fatty liver disease (NAFLD)	hsa04932
Osteoclast differentiation	hsa04380
Prolactin signaling pathway	hsa04917
TNF signaling pathway	hsa04668
Type II diabetes mellitus	hsa04930
Ubiquitin mediated proteolysis	hsa04120

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd10384	35-135	SH2_SOCS3
cl15255	35-135	SH2 superfamily
cd03737	184-225	SOCS_SOCS3
cl02533	184-225	SOCS superfamily
cd09923	45-128	SH2_SOCS_family
cd10382	36-131	SH2_SOCS1
cd10718	41-128	SH2_CIS
cd10387	36-128	SH2_SOCS6
cd10383	38-128	SH2_SOCS2
cd10388	35-109	SH2_SOCS7
smart00252	46-128	SH2
cd00173	46-127	SH2
pfam00017	46-127	SH2
cd09942	39-127	SH2_nSH2_p85_like
smart00253	180-221	SOCS
cd03717	184-221	SOCS_SOCS_like
cd10370	55-127	SH2_Src_Src42
cd09943	46-142	SH2_Nck_family
cd09933	58-128	SH2_Src_family
cd09945	45-133	SH2_SHB_SHD_SHE_SHF_like
cd10371	54-127	SH2_Src_Blk
cd10344	55-127	SH2_SLAP
cd10385	47-136	SH2_SOCS4
cd10386	47-108	SH2_SOCS5
cd09931	52-127	SH2_C-SH2_SHP_like
cd10408	46-131	SH2_Nck1
cd10369	55-127	SH2_Src_Frk
cd03587	185-221	SOCS
cd10409	44-131	SH2_Nck2
cd10392	46-133	SH2_SHF
cd10352	55-124	SH2_a2chimerin_b2chimerin
cd10356	35-106	SH2_ShkA_ShkC
cd09929	41-131	SH2_BLNK_SLP-76
cd09932	47-131	SH2_C-SH2_PLC_gamma_like
cd10363	55-127	SH2_Src_HCK
cd10360	46-121	SH2_Srm
cd10365	42-127	SH2_Src_Src
cd10418	55-127	SH2_Src_Fyn_isoform_a_like
smart00969	188-221	SOCS_box
cd10367	55-128	SH2_Src_Fgr
pfam07525	186-218	SOCS_box
cd09937	51-127	SH2_csk_like
cd09926	44-88	SH2_CRK_like
cd10389	46-133	SH2_SHB
cd09940	44-127	SH2_Vav_family
cd10348	46-128	SH2_Cterm_shark_like
cd10354	57-100	SH2_Cterm_RasGAP
cd10351	55-108	SH2_SH2D4B
cd10355	41-104	SH2_DAPP1_BAM32_like
pfam15512	129-163	CAF-1_p60_C

Ontology Information

HPRD ID	2518
Molecular Class	Not Available
Molecular Function	GTPase activity (GO:0003924)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report