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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SOD2 | 6648 | Superoxide dismutase 2, mitochondrial | 6 | IPOB; MNSOD; MVCD6 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19902052 | 2009 | Cell line : - Source : Department of General and Gastroenterological Surgery and Nutrition, the Department of General, Transplantation and Liver Surgery, and in the Department of General and Transplantation Surgery at the Warsaw Medical University. Sample Type : - No. of Sample : - Stage : ANM Stage I-IV | Western Blotting | Unknown | - | Changes of SOD2 activity during CRC development have a distinctly periodic character, that is: it decreases in stage I, followed by an increase in stage II, a decrease in stage III and again an increase in stage IV. The factor that could cause such changes in SOD2 activity might be its product hydrogen peroxide (H2O2), which is able to reversibly inhibit SOD activity via a feedback Mechanism. Changes of protein level and activity of SOD isoenzymes might be an adaptive response to the oxidative stress, which appears during progression of CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] | Chromosome | 6 |
| Location | 6q25.3 |
| Start | 159679116 |
| End | 159693321 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 14206 |
| OMIM ID | 147460 |
| HGNC ID | HGNC:11180 |
| Unigene ID | Hs.487046 |
| Ensembl ID | ENSG00000112096 |
| PharmGKB ID | PA36017 |
mRNA Information
| mRNA ID | NM_001024466.1 |
|---|---|
| Exon | join(1..177,459..661,8289..8468,10684..10848,14024..14206) | mRNA Sequence | Download Select all |
| Length | 918 |
CDS Information
| Location | join(155..177,459..661,8289..8468,10684..10829) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS34564.1 |
Protein Information
| Protein ID | NP_000627.2 |
|---|---|
| Protein Name | Superoxide dismutase 2, mitochondrial |
| Molecular Wt. (Da) | 22204 |
| Protein Sequence | Download Select all |
| Length | 222 |
| Uniprot ID | P08174 |
| Ensembl Protein ID | ENSP00000316333 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Nitration | 217 |
| Y | Nitration | 58 |
| Y | Nitration | 69 |
| Y | Nitration | 217 |
| Y | Nitration | 58 |
| Y | Nitration | 69 |
| Y | Nitration | 178 |
| Y | Nitration | 58 |
| Y | Nitration | 69 |
| K | Acetylation | 68 |
| K | Acetylation | 68 |
| K | Acetylation | 68 |
| K | Acetylation | 130 |
| K | Acetylation | 130 |
| K | Acetylation | 91 |
Enzyme Information
| EC | 1.15.1.1 |
|---|---|
| Name | superoxide dismutase superoxidase dismutase copper-zinc superoxide dismutase Cu-Zn superoxide dismutase ferrisuperoxide dismutase superoxide dismutase I superoxide dismutase II SOD Cu,Zn-SOD Mn-SOD Fe-SOD SODF SODS SOD-1 SOD-2 SOD-3 SOD-4 hemocuprein erythrocuprein cytocuprein cuprein hepatocuprein |
| Class | Oxidoreductases; Acting on superoxide as acceptor; Acting on superoxide as acceptor (only sub-subclass identified to date) |
| Sysname | superoxide:superoxide oxidoreductase |
| Substrate | O2.- [CPD:C00704]; H+ |
| Product | O2 [CPD:C00007]; H2O2 |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 51608 | C7orf20 | 12909 | NP_057033.2 | yeast 2-hybrid | 16169070 |
| 57670 | KIAA1549 | 13873 | NP_001158137.1 | yeast 2-hybrid | 16169070 |
| 79159 | NOL12 | 17537 | NP_077289.1 | yeast 2-hybrid | 16169070 |
| 84064 | HDHD2 | 13640 | NP_115500.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| FoxO signaling pathway | hsa04068 |
| Huntington's disease | hsa05016 |
| Longevity regulating pathway - mammal | hsa04211 |
| Longevity regulating pathway - multiple species | hsa04213 |
| Peroxisome | hsa04146 |
Structure Information
| PDB ID | 1AP5 |
|---|---|
| Resolution | 2.2 |
| Method | X-RAY DIFFRACTION |
| Chains | A,B |
| Molecule | MANGANESE SUPEROXIDE DISMUTASE |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam02777 | 111-217 | Sod_Fe_C |
| cl03708 | 111-217 | Sod_Fe_C superfamily |
| pfam00081 | 25-106 | Sod_Fe_N |
| cl02809 | 25-106 | Sod_Fe_N superfamily |
| COG0605 | 23-222 | SodA |
| PLN02471 | 1-217 | PLN02471 |
| PRK10925 | 26-221 | PRK10925 |
| PRK10543 | 28-219 | PRK10543 |
| PTZ00078 | 29-210 | PTZ00078 |
| PLN02685 | 32-221 | PLN02685 |
| PLN02184 | 32-221 | PLN02184 |
| PLN02622 | 32-219 | PLN02622 |
Ontology Information
| HPRD ID | 391 |
|---|---|
| Molecular Class | Enzyme: Superoxide dismutase |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.