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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25059387 | 2014 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | PCR-based microarrays ,siRNA,Luciferase and chromatin immunoprecipitation | Up-regulation | - | Sox4-Cyr61 molecular network, which may control colon cancer cell proliferation and survival. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | SRY (sex determining region Y)-boxes |
| Description | This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. [provided by RefSeq, Jul 2008] | Chromosome | 6 |
| Location | 6p22.3 |
| Start | 21593972 |
| End | 21598850 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 4879 |
| OMIM ID | 184430 |
| HGNC ID | HGNC:11200 |
| Unigene ID | Hs.643910 |
| Ensembl ID | ENSG00000124766 |
| PharmGKB ID | PA36037 |
Protein Information
| Protein ID | NP_003098.1 |
|---|---|
| Protein Name | SRY (sex determining region Y)-box 4 |
| Molecular Wt. (Da) | 81450 |
| Protein Sequence | Download Select all |
| Length | 474 |
| Uniprot ID | Q9UEE5 |
| Ensembl Protein ID | ENSP00000319192 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 307 |
| S | Phosphorylation | 161 |
| S | Phosphorylation | 175 |
| S | Phosphorylation | 185 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 7329 | UBE2I | 9045 | NP_003336.1 | in vitro;in vivo;yeast 2-hybrid | 16631117 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MicroRNAs in cancer | hsa05206 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01388 | 58-129 | SOX-TCF_HMG-box |
| cl00082 | 58-129 | HMG-box superfamily |
| pfam00505 | 59-127 | HMG_box |
| smart00398 | 58-127 | HMG |
| cd01389 | 58-133 | MATA_HMG-box |
| cd00084 | 59-124 | HMG-box |
| cd01390 | 60-118 | HMGB-UBF_HMG-box |
| pfam09011 | 60-127 | HMG_box_2 |
| PTZ00199 | 60-126 | PTZ00199 |
| COG5648 | 60-116 | NHP6B |
Ontology Information
| HPRD ID | 6824 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | G-protein coupled receptor activity (GO:0004930) |
| Biological Process | Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.