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General Information
- Evidence
- Gene
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19108950 | 2009 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Down-regulation | - | Expression level of SOX7 was frequently down-regulated in human colorectal cancer cell lines and in primary colorectal tumor tissues. |
| 22171135 | 2011 | Cell line : SW480, HEK-293T Source : - Sample Type : - No. of Sample : - Stage : - | MTT assay, real time RT-PCR, Western blotting,Luciferase reporter assay | Up-regulation | - | SOX7 is upregulated by aspirin and is involved in aspirin-mediated growth inhibition of human colorectal cancer SW480 cells. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | SRY (sex determining region Y)-boxes |
| Description | This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway. [provided by RefSeq, Jul 2008] | Chromosome | 8 |
| Location | 8p22 |
| Start | 10581278 |
| End | 10588084 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 6807 |
| OMIM ID | 612202 |
| HGNC ID | HGNC:18196 |
| Unigene ID | Hs.709543 |
| Ensembl ID | ENSG00000171056 |
| PharmGKB ID | PA38307 |
Protein Information
| Protein ID | NP_113627.1 |
|---|---|
| Protein Name | SRY (sex determining region Y)-box 7 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 388 |
| Uniprot ID | Q86UE4 |
| Ensembl Protein ID | ENSP00000338235 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4090 | SMAD5 | 4381 | NP_005894.3 | yeast 2-hybrid | 15231748 |
| 4092 | SMAD7 | 4241 | NP_005895.1 | yeast 2-hybrid | 15231748 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01388 | 44-115 | SOX-TCF_HMG-box |
| cl00082 | 44-115 | HMG-box superfamily |
| pfam12067 | 199-387 | Sox_C_TAD |
| cl13497 | 199-387 | Sox_C_TAD superfamily |
| pfam00505 | 45-113 | HMG_box |
| smart00398 | 44-113 | HMG |
| cd00084 | 45-110 | HMG-box |
| cd01389 | 44-120 | MATA_HMG-box |
| cd01390 | 46-104 | HMGB-UBF_HMG-box |
| PTZ00199 | 46-112 | PTZ00199 |
| pfam09011 | 44-113 | HMG_box_2 |
| COG5648 | 46-102 | NHP6B |
Ontology Information
| HPRD ID | 12387 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Cytokine activity (GO:0005125) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.