Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SPDEF | 25803 | SAM pointed domain containing ETS transcription factor | 6 | PDEF, bA375E1.3 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23376423 | 2013 | Cell line : HCT116, SW480 Source : - Sample Type : - No. of Sample : - Stage : - | Tissue Microarray, Microarray | Down-regulation | - | SPDEF is a colon tumor suppressor and a candidate therapeutic target for colon adenomas and adenocarcinoma. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] | Chromosome | 6 |
| Location | 6p21.3 |
| Start | 34505579 |
| End | 34524110 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 18532 |
| OMIM ID | 608144 |
| HGNC ID | HGNC:17257 |
| Unigene ID | Hs.485158 |
| Ensembl ID | ENSG00000124664 |
| PharmGKB ID | PA134993886 |
Protein Information
| Protein ID | NP_001239223.1 |
|---|---|
| Protein Name | SAM pointed domain containing ETS transcription factor |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 335 |
| Uniprot ID | Q4G0P3 |
| Ensembl Protein ID | ENSP00000314736 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 367 | AR | 2437 | NP_000035.2 | in vitro;in vivo | 10625666 |
| 4824 | NKX3-1 | 3620 | NP_006158.2 | in vivo;yeast 2-hybrid | 11809674 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd08532 | 134-214 | SAM_PNT-PDEF-like |
| cl15755 | 134-214 | SAM_superfamily superfamily |
| pfam00178 | 248-334 | Ets |
| cl02599 | 248-334 | Ets superfamily |
| smart00413 | 248-334 | ETS |
| smart00251 | 131-212 | SAM_PNT |
| pfam02198 | 131-213 | SAM_PNT |
| cd08203 | 146-211 | SAM_PNT |
| cd08534 | 141-210 | SAM_PNT-GABP-alpha |
| cd08540 | 143-221 | SAM_PNT-ERG |
| cd08535 | 146-203 | SAM_PNT-Tel_Yan |
| cd08531 | 145-206 | SAM_PNT-ERG_FLI-1 |
| cd08536 | 146-203 | SAM_PNT-Mae |
| cd08541 | 143-207 | SAM_PNT-FLI-1 |
| cd08757 | 146-206 | SAM_PNT_ESE |
| cd08542 | 141-208 | SAM_PNT-ETS-1 |
| cd08533 | 144-208 | SAM_PNT-ETS-1,2 |
| cd08543 | 141-207 | SAM_PNT-ETS-2 |
| cd08538 | 135-203 | SAM_PNT-ESE-2-like |
| cd08539 | 147-206 | SAM_PNT-ESE-3-like |
Ontology Information
| HPRD ID | 16288 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Extracellular matrix structural constituent (GO:0005201) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.