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General Information
- Evidence
- Gene
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26337959 | 2015 | Cell line : HT 29, HCT 116, DLD 1 Source : Cell Bank of CAS (Shanghai, China) Sample Type : - No. of Sample : - Stage : - | MTT assay,Clonogenic survival assay,Annexin V Flow cytometry, ELISA,Western blotting | Up-regulation | - | Targeting of SphK2 by ABC294640 potently inhibits CRC cell growth both in vitro and in vivo, ABC294640 could be developed as a novel therapeutic for the treatment of CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] | Chromosome | 17 |
| Location | 17q25.2 |
| Start | 74372742 |
| End | 74383941 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 11200 |
| OMIM ID | 603730 |
| HGNC ID | HGNC:11240 |
| Unigene ID | Hs.68061 |
| Ensembl ID | - |
| PharmGKB ID | PA36070 |
Protein Information
| Protein ID | NP_001136073.1 |
|---|---|
| Protein Name | sphingosine kinase 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 384 |
| Uniprot ID | Q9ULW2 |
| Ensembl Protein ID | ENSP00000229030 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 207 |
| T | Phosphorylation | 279 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1501 | CTNND2 | 9181 | NP_001323.1 | in vivo;yeast 2-hybrid | 15193146 |
| 1508 | CTSB | 287 | NP_680090.1 | in vitro | 15710602 |
| 2534 | FYN | 655 | NP_002028.1 | in vivo | 16316995 |
| 4067 | LYN | 1301 | NP_002341.1 | in vivo | 16316995 |
| 7186 | TRAF2 | 3538 | NP_066961.2 | in vitro;in vivo | 11777919 |
| 7189 | TRAF6 | 3833 | NP_665802.1 | in vivo | 17124500 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Calcium signaling pathway | hsa04020 |
| Fc gamma R-mediated phagocytosis | hsa04666 |
| Metabolic pathways | hsa01100 |
| Phospholipase D signaling pathway | hsa04072 |
| Sphingolipid metabolism | hsa00600 |
| Sphingolipid signaling pathway | hsa04071 |
| Tuberculosis | hsa05152 |
| VEGF signaling pathway | hsa04370 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00781 | 16-128 | DAGK_cat |
| cl01255 | 16-128 | DAGK_cat superfamily |
| smart00046 | 18-127 | DAGKc |
| PLN02204 | 13-92 | PLN02204 |
| PLN02958 | 11-345 | PLN02958 |
| COG1597 | 16-212 | LCB5 |
| TIGR00147 | 16-120 | TIGR00147 |
| PRK11914 | 16-114 | PRK11914 |
| PRK13057 | 18-121 | PRK13057 |
Ontology Information
| HPRD ID | 2344 |
|---|---|
| Molecular Class | Lipid Kinase |
| Molecular Function | Auxiliary transport protein activity (GO:0015457) |
| Biological Process | Transport (GO:0006810) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q9NYA1 | DB08868 | Fingolimod | SmallMoleculeDrug |