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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26337959 | 2015 | Cell line : HT 29, HCT 116 and DLD 1 Source : Cell Bank of CAS (Shanghai, China). Sample Type : - No. of Sample : - Stage : - | MTT assay,Clonogenic survival assay,Annexin V Flow cytometry, ELISA,Lactate dehydrogenase assay,Western blotting | Up-regulation | - | Targeting of SphK2 by ABC294640 potently inhibits CRC cell growth both in vitro and in vivo, ABC294640 could be developed as a novel therapeutic for the treatment of CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011] | Chromosome | 19 |
| Location | 19q13.33 |
| Start | 49122548 |
| End | 49133974 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 11427 |
| OMIM ID | 607092 |
| HGNC ID | HGNC:18859 |
| Unigene ID | Hs.528006 |
| Ensembl ID | ENSG00000063176 |
| PharmGKB ID | PA38719 |
Protein Information
| Protein ID | NP_001191087.1 |
|---|---|
| Protein Name | sphingosine kinase 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 654 |
| Uniprot ID | Q8IXK2 |
| Ensembl Protein ID | ENSP00000364150 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 389 |
| S | Phosphorylation | 484 |
| S | Phosphorylation | 387 |
| T | Phosphorylation | 404 |
| S | Phosphorylation | 414 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2534 | FYN | 655 | NP_002028.1 | in vivo | 16316995 |
| 4067 | LYN | 1301 | NP_002341.1 | in vivo | 16316995 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Calcium signaling pathway | hsa04020 |
| Fc gamma R-mediated phagocytosis | hsa04666 |
| Metabolic pathways | hsa01100 |
| Sphingolipid metabolism | hsa00600 |
| Sphingolipid signaling pathway | hsa04071 |
| Tuberculosis | hsa05152 |
| VEGF signaling pathway | hsa04370 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00781 | 187-295 | DAGK_cat |
| cl01255 | 187-295 | DAGK_cat superfamily |
| smart00046 | 239-293 | DAGKc |
| PLN02204 | 187-258 | PLN02204 |
| PLN02958 | 187-381 | PLN02958 |
| COG1597 | 187-378 | LCB5 |
| TIGR00147 | 204-286 | TIGR00147 |
| PHA03247 | 355-516 | PHA03247 |
| PRK13337 | 188-287 | PRK13337 |
Ontology Information
| HPRD ID | 13076 |
|---|---|
| Molecular Class | Enzyme: Phosphotransferase |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.