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General Information
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20661223 | 2010 | Cell line : - Source : ATCC Sample Type : - No. of Sample : - Stage : - | Western blotting, Real time RT-PCR, Cell Cycle Analysis and Apoptosis determination, Immunostaining | Up-regulation | - | In colon cancer sprouty-2 over-expression enhances the transformed phenotype and its effects are mediated in part by c-Met up-regulation In colon cancer sprouty functions as an oncogene |
| 21099344 | 2011 | Cell line : - Source : Food Industry Research and Development Institute [Hsinchu, Taiwan], American Type Culture Collection Sample Type : CRC tumor and normal tissue No. of Sample : 67 Primary colon adeno-carcinoma tissue and normal-appearing colon mucosa adjacent to carcinoma Stage : TNM Stage I-IV | RT-PCR, Methylation-specific PCR, immunoblotting, Cell proliferation assay, Colony formation assay | Up-regulation | - | Spry2 is downregulated in colon cancer, which is associated with advanced disease. Furthermore, expression of Spry2 inversely correlates with miRNA-21 expression in the clinical samples of colon cancer, suggesting that Spry2 may be negatively regulated by miRNA-21. Overexpression of Spry2 results in reduced proliferation, migration and anchorage-independent growth of colon cancer cells in vitro, which reflects a role of Spry2 in tumor suppression in colon cancer. |
| 21531130 | 2011 | Cell line : - Source : Japanees patients Sample Type : CRC tumor and normal tissue No. of Sample : 113 Stage : TNM Stage I-IV | Peptide Nucleic Acid (PNA)-clamp real-timeRT-PCR TaqMan assay, Gene expression profiles. | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008] | Chromosome | 13 |
| Location | 13q31.1 |
| Start | 80335976 |
| End | 80340951 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 4976 |
| OMIM ID | 602466 |
| HGNC ID | HGNC:11270 |
| Unigene ID | Hs.18676 |
| Ensembl ID | ENSG00000136158 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_005842.2 |
|---|---|
| Exon | join(1..330,3196..4976) | mRNA Sequence | Download Select all |
| Length | 2126 |
Protein Information
| Protein ID | NP_005833.1 |
|---|---|
| Protein Name | Sprouty homolog 2 (Drosophila) |
| Molecular Wt. (Da) | 34557 |
| Protein Sequence | Download Select all |
| Length | 315 |
| Uniprot ID | P19235 |
| Ensembl Protein ID | ENSP00000222139 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 139 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 867 | CBL | 1320 | NP_005179.2 | in vitro;in vivo;yeast 2-hybrid | 11 053 437 122 349 200 000 000 000 000 000 |
| 2885 | GRB2 | 150 | NP_002077.1 | in vitro;in vivo | 124 020 431 094 062 000 000 000 |
| 5359 | PLSCR1 | 8855 | NP_066928.1 | yeast 2-hybrid | 16189514 |
| 9721 | GPRIN2 | 13804 | NP_055511.2 | yeast 2-hybrid | 16189514 |
| 54507 | ADAMTSL4 | 18237 | NP_061905.2 | yeast 2-hybrid | 16189514 |
| 83755 | KRTAP4-12 | 13941 | NP_114060.1 | yeast 2-hybrid | 16189514 |
| 84767 | SPRYD5 | 10282 | NP_116070.2 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MicroRNAs in cancer | hsa05206 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam05210 | 183-294 | Sprouty |
| cl04988 | 183-294 | Sprouty superfamily |
Ontology Information
| HPRD ID | 2767 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Transmembrane receptor protein tyrosine kinase activity (GO:0004714) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.