Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SRPX2 | 27286 | sushi-repeat containing protein, X-linked 2 | X | SRPUL |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25737434 | 2015 | Cell line : HCT116, HT29, SW480 Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 88 Stage : - | Immunohistochemistry | Up-regulation | - | Overexpressed SRPX2 exerts an oncogenic role in colorectal cancer. SRPX2 may promote the invasion of colorectal cancer through MMP-2 and MMP-9 modulated by Wnt/?-catenin pathway. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a secreted protein that contains three sushi repeat motifs. The encoded protein may play a role in the development of speech and language centers in the brain. This protein may also be involved in angiogenesis. Mutations in this gene are the cause of bilateral perisylvian polymicrogyria, rolandic epilepsy, speech dyspraxia and mental retardation. [provided by RefSeq, May 2010] | Chromosome | X |
| Location | Xq21.33-q2 |
| Start | 99899163 |
| End | 99926296 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 27134 |
| OMIM ID | 300642 |
| HGNC ID | HGNC:30668 |
| Unigene ID | Hs.306339 |
| Ensembl ID | ENSG00000102359 |
| PharmGKB ID | PA134983994 |
Protein Information
| Protein ID | NP_055282.1 |
|---|---|
| Protein Name | sushi-repeat containing protein, X-linked 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 465 |
| Uniprot ID | Q96P70 |
| Ensembl Protein ID | ENSP00000354742 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1508 | CTSB | 287 | NP_680090.1 | in vitro;in vivo;yeast 2-hybrid | 18718938 |
| 5329 | PLAUR | 1421 | NP_002650.1 | in vitro;in vivo;yeast 2-hybrid | 18718938 |
| 9507 | ADAMTS4 | 4853 | NP_005090.3 | in vitro;in vivo;yeast 2-hybrid | 18718938 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00033 | 264-319 | CCP |
| cl00043 | 264-319 | CCP superfamily |
| cd00033 | 122-177 | CCP |
| cl00043 | 122-177 | CCP superfamily |
| cd00033 | 72-114 | CCP |
| cl00043 | 72-114 | CCP superfamily |
| pfam13778 | 334-454 | DUF4174 |
| cl16390 | 334-454 | DUF4174 superfamily |
| pfam02494 | 177-259 | HYR |
| cl03620 | 177-259 | HYR superfamily |
| smart00032 | 264-319 | CCP |
| pfam00084 | 264-319 | Sushi |
| smart00032 | 122-176 | CCP |
| pfam00084 | 122-176 | Sushi |
| smart00032 | 82-115 | CCP |
| pfam00084 | 72-115 | Sushi |
| PHA02927 | 24-177 | PHA02927 |
| PHA02954 | 82-177 | PHA02954 |
| PHA02927 | 78-319 | PHA02927 |
| PHA02639 | 95-181 | PHA02639 |
| PHA02927 | 262-323 | PHA02927 |
| PHA02639 | 83-176 | PHA02639 |
Ontology Information
| HPRD ID | 5552 |
|---|---|
| Molecular Class | Secreted polypeptide |
| Molecular Function | Ligase activity (GO:0016874) |
| Biological Process | Regulation of cell cycle (GO:0000074) |
Drug Information
No matching records could be found.