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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16610049 | 2006 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 127 CRC and 40 normal colorectal mucosae Stage : - | Immunohistochemistry , streptavidin-peroxidase (SP) technique | Up-regulation | - | The most predominant SSTR subtype is SSTR1, and the second is SSTR2 or SSTR5. Five SSTR subtypes play different roles in the development of colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Somatostatin receptors |
| Description | Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008] | Chromosome | 17 |
| Location | 17q24 |
| Start | 71161160 |
| End | 71168094 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 6935 |
| OMIM ID | 182452 |
| HGNC ID | HGNC:11331 |
| Unigene ID | Hs.514451 |
| Ensembl ID | - |
| PharmGKB ID | PA36155 |
Protein Information
| Protein ID | NP_001041.1 |
|---|---|
| Protein Name | somatostatin receptor 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 369 |
| Uniprot ID | P61201 |
| Ensembl Protein ID | ENSP00000299259 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2770 | GNAI1 | 756 | NP_002060.4 | in vivo | 7914078 |
| 5295 | PIK3R1 | 1381 | NP_852664.1 | in vitro;in vivo | 16917505 |
| 5777 | PTPN6 | 1475 | NP_536859.1 | in vitro;in vivo | 930 590 511 920 268 |
| 9630 | GNA14 | 5095 | NP_004288.1 | in vitro | 11264236 |
| 22941 | SHANK2 | 4479 | NP_036441.2 | in vitro;in vivo;yeast 2-hybrid | 1 037 341 211 087 990 |
| 50944 | SHANK1 | 5413 | NP_057232.2 | in vitro;in vivo;yeast 2-hybrid | 1 055 186 711 087 990 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| cAMP signaling pathway | hsa04024 |
| Gastric acid secretion | hsa04971 |
| Neuroactive ligand-receptor interaction | hsa04080 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam10320 | 54-327 | 7TM_GPCR_Srsx |
| cl21561 | 54-327 | 7tm_4 superfamily |
| pfam10328 | 51-238 | 7TM_GPCR_Srx |
| pfam00001 | 66-312 | 7tm_1 |
| PHA03087 | 37-337 | PHA03087 |
| PHA02638 | 50-320 | PHA02638 |
| PHA02834 | 43-330 | PHA02834 |
| PHA03235 | 47-323 | PHA03235 |
Ontology Information
| HPRD ID | 5708 |
|---|---|
| Molecular Class | Not Available |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P30874 | DB00104 | Octreotide | SmallMoleculeDrug |
| P30874 | DB04894 | Vapreotide | SmallMoleculeDrug |
| P30874 | DB06663 | Pasireotide | SmallMoleculeDrug |
| P30874 | DB06791 | Lanreotide | SmallMoleculeDrug |