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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16610049 | 2006 | Cell line : - Source : Second Hospital Affiliated to Fujian Medical University Sample Type : CRC tumor and normal tissue No. of Sample : 127 Stage : - | Immunohistochemistry | Up-regulation | - | SSTR3 and SSTR5 expression decreased with Dukes' stage. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Somatostatin receptors |
| Description | Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.[provided by RefSeq, Feb 2010] | Chromosome | 16 |
| Location | 16p13.3 |
| Start | 1122756 |
| End | 1131454 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 8699 |
| OMIM ID | 182455 |
| HGNC ID | HGNC:11334 |
| Unigene ID | Hs.449840 |
| Ensembl ID | - |
| PharmGKB ID | PA36158 |
Protein Information
| Protein ID | NP_001044.1 |
|---|---|
| Protein Name | somatostatin receptor 5 |
| Molecular Wt. (Da) | 21489 |
| Protein Sequence | Download Select all |
| Length | 364 |
| Uniprot ID | Q9UKN8 |
| Ensembl Protein ID | ENSP00000361219 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1813 | DRD2 | 539 | NP_000786.1 | in vivo | 10753124 |
| 5830 | PEX5 | 2684 | NP_001124495.1 | in vitro;in vivo;yeast 2-hybrid | 16012170 |
| 6751 | SSTR1 | 1673 | NP_001040.1 | in vitro | 10713101 |
| 57120 | GOPC | 6024 | NP_065132.1 | in vitro;in vivo;yeast 2-hybrid | 16012170 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| cAMP signaling pathway | hsa04024 |
| Neuroactive ligand-receptor interaction | hsa04080 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam10320 | 54-319 | 7TM_GPCR_Srsx |
| cl21561 | 54-319 | 7tm_4 superfamily |
| pfam10328 | 58-245 | 7TM_GPCR_Srx |
| pfam00001 | 63-304 | 7tm_1 |
| PHA03087 | 54-329 | PHA03087 |
| PHA02638 | 54-312 | PHA02638 |
| PHA02834 | 54-320 | PHA02834 |
| PHA03235 | 77-364 | PHA03235 |
| PHA03234 | 59-334 | PHA03234 |
Ontology Information
| HPRD ID | 4776 |
|---|---|
| Molecular Class | Not Available |
| Molecular Function | Receptor binding (GO:0005102) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P35346 | DB00104 | Octreotide | SmallMoleculeDrug |
| P35346 | DB04894 | Vapreotide | SmallMoleculeDrug |
| P35346 | DB06663 | Pasireotide | SmallMoleculeDrug |
| P35346 | DB06791 | Lanreotide | SmallMoleculeDrug |