Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ST3GAL6 | 10402 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 3 | ST3GALVI |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23471507 | 2013 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 6 pairs of CRC and adjacent normal mucosa. Stage : - | Microarray | Hypermethylation | - | Through Preliminary validation, there were two genes (St3gal6, Opcml) in thirty top-ranking genes shown hypermethylated. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Sialyltransferases |
| Description | The protein encoded by this gene is a member of the sialyltransferase family. Members of this family are enzymes that transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. This protein has high specificity for neolactotetraosylceramide and neolactohexaosylceramide as glycolipid substrates and may contribute to the formation of selectin ligands and sialyl Lewis X, a carbohydrate important for cell-to-cell recognition and a blood group antigen. Alternative splicing results in multiple transcript variants that encode different protein isoforms. | Chromosome | 3 |
| Location | 3q12.2 |
| Start | 98732236 |
| End | 98797054 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 64819 |
| OMIM ID | 607156 |
| HGNC ID | HGNC:18080 |
| Unigene ID | Hs.148716 |
| Ensembl ID | ENSG00000064225 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001271142.1 |
|---|---|
| Exon | join(1..297,36195..36294,38644..38721,38886..38955, 40578..40681,41685..41748,52710..52805,55801..55987, 56091..56228,59606..59758,61440..63610) | mRNA Sequence | Download Select all |
| Length | 3458 |
CDS Information
| Location | join(629..776,36195..36294,38644..38721,40578..40681, 41685..41748,52710..52805,55801..55987,56091..56228, 59606..59758,61440..61526) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS74968.1 |
Protein Information
| Protein ID | NP_001258074.1 |
|---|---|
| Protein Name | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 |
| Molecular Wt. (Da) | 43340 |
| Protein Sequence | Download Select all |
| Length | 384 |
| Uniprot ID | P08648 |
| Ensembl Protein ID | ENSP00000293379 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Glycosphingolipid biosynthesis - lacto and neolacto series | hsa00601 |
| Metabolic pathways | hsa01100 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00777 | 58-330 | Glyco_transf_29 |
| cl02965 | 58-330 | Glyco_transf_29 superfamily |
Ontology Information
| HPRD ID | 1903 |
|---|---|
| Molecular Class | Enzyme: Sialyltransferase |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165); Cell adhesion (GO:0007155) |
Drug Information
No matching records could be found.