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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ST6GAL1 | 6480 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | 3 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23358684 | 2013 | Cell line : HD3,SW948 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Immunochemistry,Gnene Knockdown assay, Transfection | Up-regulation | - | ST6Gal-I promotes tumorigenesis and may serve as a regulator of the stem cell phenotype in both normal and cancer cell populations. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Three transcript variants encoding two different isoforms have been described. [provided by RefSeq, Aug 2009] | Chromosome | 3 |
| Location | 3q27-q28 |
| Start | 186648315 |
| End | 186796341 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 148027 |
| OMIM ID | 109675 |
| HGNC ID | HGNC:10860 |
| Unigene ID | Hs.207459 |
| Ensembl ID | ENSG00000073849 |
| PharmGKB ID | PA35762 |
mRNA Information
| mRNA ID | ?NM_003032.2 |
|---|---|
| Exon | join(1..492,12006..12085,33443..33584,108400..108531, 112312..112968,120907..121004,142507..142605, 143817..143991,145220..148211) | mRNA Sequence | Download Select all |
| Length | 4867 |
Protein Information
| Protein ID | NP_003023.1 |
|---|---|
| Protein Name | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 |
| Molecular Wt. (Da) | 32079 |
| Protein Sequence | Download Select all |
| Length | 406 |
| Uniprot ID | O00559 |
| Ensembl Protein ID | ENSP00000337675 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 391 |
| Y | Phosphorylation | 391 |
| Y | Phosphorylation | 160 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 933 | CD22 | 114 | NP_001762.2 | in vitro | 8702538 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Metabolic pathways | hsa01100 |
| N-Glycan biosynthesis | hsa00510 |
| Other types of O-glycan biosynthesis | hsa00514 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00777 | 159-391 | Glyco_transf_29 |
| cl02965 | 159-391 | Glyco_transf_29 superfamily |
Ontology Information
| HPRD ID | 3446 |
|---|---|
| Molecular Class | Enzyme: Sialyltransferase |
| Molecular Function | Transmembrane receptor activity (GO:0004888) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.