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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
STAT2 6773 signal transducer and activator of transcription 2, 113kDa  12STAT113 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20233899   2010Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

RT-PCR and immunohistochemistry Up-regulation-STAT2 as a novel contributor to colorectal and skin carcinogenesis that may act to increase the gene expression and secretion of proinflammatory mediators, which in turn activate the oncogenic STAT3 signaling pathway.


Gene Details



NC_000012.11 (56735381..56754058, complement)

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Gene Type protein coding
Gene Family SH2 domain containing
Description The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]  
Chromosome 12
Location 12q13.2
Start 56735381  
End 56754058  
Strand -  
Gene Sequence

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Length 18678  
OMIM ID 600556   
HGNC ID HGNC:11363   
Unigene ID Hs.530595   
Ensembl ID -   
PharmGKB ID PA36184   

mRNA Information


mRNA ID ?NM_005419.3
Exon join(1..196,3676..3813,3969..4122,4463..4546,4722..4811, 4903..4978,5391..5476,5640..5788,8804..8962,9064..9156, 9366..9425,9822..9842,10064..10157,10618..10665, 10745..10828,10993..11091,11195..11330,11450..11502, 11631..11725,13299..13435,13630..13812,14051..14108, 16119..16429,16723..18657)  
mRNA Sequence

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Length 4564  



CDS Information


   
Location204..2747
CDS Sequence

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CCDS ID CCDS55836.1



Protein Information


      
Protein IDNP_005410.1
Protein Namesignal transducer and activator of transcription 2, 113kDa
Molecular Wt. (Da)86876
Protein Sequence

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Length 851  
Uniprot IDO60551
Ensembl Protein ID ENSP00000367407  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation690
KAcetylation375
TPhosphorylation542

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                       
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1387CREBBP2534NP_004371.2in vitro;in vivo884   804   810   464   260   
3065HDAC13143NP_004955.2in vitro14645718   
3454IFNAR1126NP_000620.2in vitro;in vivo8   605   876   117   865   460   000   000   
3717JAK2993NP_004963.1in vivo7746328   
6772STAT12777NP_009330.1in vivo104   461   768   621   447   
6778STAT63302NP_003144.3in vitro;in vivo10490982   
7852CXCR41217NP_001008540.1in vivo10506573   
9282MED142172NP_004220.2in vitro;in vivo12509459   
10379IRF9960NP_006075.3in vitro;in vivo9242679   


Pathway Information


                                                
Pathway Name Pathway ID
Chemokine signaling pathway hsa04062
Hepatitis B hsa05161
Hepatitis C hsa05160
Herpes simplex infection hsa05168
Influenza A hsa05164
Jak-STAT signaling pathway hsa04630
Measles hsa05162
Osteoclast differentiation hsa04380


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd10373556-706  SH2_STAT2
cl15255556-706  SH2 superfamily
pfam02864316-566  STAT_bind
cl03748316-566  STAT_bind superfamily
pfam01017139-314  STAT_alpha
cl19923139-314  STAT_alpha superfamily
cd10375556-683  SH2_STAT4
cd10372556-686  SH2_STAT1
cd09919556-680  SH2_STAT_family
smart009642-124  STAT_int
cl037492-124  STAT_int superfamily
cd10374553-699  SH2_STAT3
pfam028652-125  STAT_int
pfam12188783-838  STAT2_C
cl13603783-838  STAT2_C superfamily
cd10377556-681  SH2_STAT6
cd10376556-678  SH2_STAT5
cd10420556-678  SH2_STAT5b
cd10421556-678  SH2_STAT5a
pfam00017577-648  SH2
smart00252578-649  SH2
cd00173579-648  SH2
cd10349579-610  SH2_SH2D2A_SH2D7
cd09935579-629  SH2_ABL
pfam05887729-789  Trypan_PARP
TIGR0216975-283  SMC_prok_A
pfam0154485-232  CorA
COG119683-216  Smc
COG0419110-260  SbcC


Ontology Information


   
HPRD ID4805
Molecular ClassTranscription factor
Molecular FunctionHelicase activity (GO:0004386)
Biological ProcessDNA repair (GO:0006281)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO