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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
STAT5A 6776 signal transducer and activator of transcription 5A  17MGF 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22367509   2012Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

 Cell viability assays, CCK-8 assay, flow cytometriy, Annexin V RFP staining assayDown-regulation-�STAT5a�may serve as a potential new target for CRC treatment.

23733954   2013Cell line : SW1116

Source : -

Sample Type : -

No. of Sample : -

Stage : -

realtimeRT-PCR, Xenograft Assays, Cell Proliferation assay , and Flow Cytometry,Immunostaining, Immunoprecipitation, Western BlottingDown-regulation/Mutation-Down-regulation, somatic mutations, and deletions of STAT5 genes are found in certain human cancers.

21826656   2012Cell line : YAMC,HEK 293T,DLD 1

Source : -

Sample Type : -

No. of Sample : -

Stage : -

ImmunohistochemistryUp-regulation-Colorectal adenocarcinomas showed higher expression of STAT5a/5b than normal colonic mucosa (P?

Gene Details



NC_000017.10 (40439565..40463961)

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Gene Type protein coding
Gene Family SH2 domain containing
Description The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]  
Chromosome 17
Location 17q11.2
Start 40439565  
End 40463961  
Strand +  
Gene Sequence

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Length 24397  
OMIM ID 601511   
HGNC ID HGNC:11366   
Unigene ID Hs.437058   
Ensembl ID ENSG00000126561   
PharmGKB ID PA338   

mRNA Information


mRNA ID ?NM_001288718.1
Exon join(1..89,510..1052,1856..1993,2320..2476,4426..4515, 8073..8247,12205..12335,12584..12735,13169..13324, 13729..13908,16796..16883,16984..17106,18064..18156, 18695..18901,19856..19950,20047..20177,20632..20787, 21501..21552,21831..21938,22961..24397)  
mRNA Sequence

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Length 4314  



CDS Information


   
Location 643..3027
CDS Sequence

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CCDS ID CCDS11424.1



Protein Information


      
Protein IDNP_001275647.1
Protein Namesignal transducer and activator of transcription 5A
Molecular Wt. (Da)89735
Protein Sequence

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Length 794  
Uniprot IDO94761
Ensembl Protein ID  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation726
SPhosphorylation780
YDephosphorylation694
YDephosphorylation694
YPhosphorylation694
YPhosphorylation694
SPhosphorylation193
YPhosphorylation90

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
660BMX2111NP_975010.1in vitro9373245   
672BRCA1218NP_009231.2in vivo12459499   
675BRCA22554NP_000050.2in vivo12459499   
919CD2471729NP_932170.1in vivo9880255   
1051CEBPB1801NP_005185.2in vitro;in vivo11158330   
1234CCR53223NP_000570.1in vivo10037796   
1956EGFR579NP_005219.2in vivo10358079   
2057EPOR587NP_000112.1in vitro;in vivo;yeast 2-hybrid897   723   215   644   415   
2066ERBB42767NP_005226.1in vivo15534001   
2099ESR1589NP_000116.2in vitro;in vivo15304355   
2690GHR2971NP_000154.1in vivo8702683   
2908NR3C1679NP_001019265.1in vitro;in vivo9528750   
3560IL2RB896NP_000869.1in vivo10602027   
3561IL2RG2391NP_000197.1in vivo11418623   
3716JAK1992NP_002218.2in vivo11722592   
3718JAK32547NP_000206.2in vitro;yeast 2-hybrid904   738   210   037   026   
5479PPIB458NP_000933.1in vitro;in vivo11997457   
5515PPP2CA8912NP_002706.1in vitro;in vivo11440634   
5594MAPK11496NP_002736.3in vitro;in vivo1   019   476   210   996   420   
6714SRC1819NP_005408.1in vivo10358079   
6850SYK2514NP_003168.2in vivo10825200   
7010TEK2571NP_000450.2in vivo14726409   
9612NCOR22910NP_006303.3in vitro;in vivo;yeast 2-hybrid11726519   
56952PRTFDC117917NP_064585.1yeast 2-hybrid16189514   


Pathway Information


                                                                  
Pathway Name Pathway ID
Acute myeloid leukemia hsa05221
AGE-RAGE signaling pathway in diabetic complications hsa04933
Chronic myeloid leukemia hsa05220
ErbB signaling pathway hsa04012
Hepatitis B hsa05161
HTLV-I infection hsa05166
Jak-STAT signaling pathway hsa04630
Measles hsa05162
Pathways in cancer hsa05200
Prolactin signaling pathway hsa04917
Viral carcinogenesis hsa05203


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd10421573-712  SH2_STAT5a
cl15255573-712  SH2 superfamily
pfam02864332-583  STAT_bind
cl03748332-583  STAT_bind superfamily
cd10376573-707  SH2_STAT5
cd10420573-712  SH2_STAT5b
pfam01017138-330  STAT_alpha
cl19923138-330  STAT_alpha superfamily
pfam028652-126  STAT_int
cl037492-126  STAT_int superfamily
cd09919573-685  SH2_STAT_family
cd10377573-695  SH2_STAT6
smart009642-125  STAT_int
cd10374563-685  SH2_STAT3
cd10375573-684  SH2_STAT4
cd10372573-699  SH2_STAT1
cd10373573-683  SH2_STAT2
pfam00017589-668  SH2
smart00252596-634  SH2
cd00173596-635  SH2
cd10349596-627  SH2_SH2D2A_SH2D7
cd09940568-634  SH2_Vav_family
cd10417596-627  SH2_SH2D7
cd09923596-623  SH2_SOCS_family
cd10351596-635  SH2_SH2D4B
cd09930587-622  SH2_cSH2_p85_like
TIGR00618141-303  sbcc
COG1196104-330  Smc
TIGR00618103-243  sbcc


Ontology Information


   
HPRD ID4783
Molecular ClassTranscription factor
Molecular FunctionTransporter activity (GO:0005215)
Biological ProcessTransport (GO:0006810)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO