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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
STAT6 6778 signal transducer and activator of transcription 6, interleukin-4 induced  12D12S1644, IL-4-STAT 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
18294957   2008Cell line : HT 29

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Flow cytometry,EMSA,real time RT-PCRActivation--

22121102   2013Cell line : HT 29, Caco 2

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

Genotyping Polymorhpism--

16620708   2006Cell line : -

Source : Beijing People�s Hospital .

Sample Type : CRC tumor and normal tissue

No. of Sample : 119

Stage : TNM Stage I-IV

 RT-PCR,flow cytometryUp-regulation-STAT6 signaling pathway inhibits the apoptosis of colon cancer cells by regulation of the Bcl-2 and Bax genes.

20480530   2010Cell line : -

Source : Twin Cities Metropolitan Area, Kaiser Permanente Medical Care Program of Northern California (KPMCP) and a seven-county area of Utah

Sample Type : Population-based case-control study

No. of Sample : Colon cancer 1,555 controls 1,956 and rectal cancer 754 controls 959

Stage : -

ImmunohistochemistryUp-regulation-EZH2 and STAT6 expressions have significant values in distinguishing clinical stages of CRC


Gene Details



NC_000012.11 (57489187..57505196, complement)

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Gene Type protein coding
Gene Family SH2 domain containing
Description The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]  
Chromosome 12
Location 12q13
Start 57489187  
End 57505196  
Strand -  
Gene Sequence

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Length 16010  
OMIM ID 601512   
HGNC ID HGNC:11368   
Unigene ID Hs.524518   
Ensembl ID -   
PharmGKB ID PA339   

mRNA Information


mRNA ID ?NM_001178078.1
Exon join(1..89,510..1052,1856..1993,2320..2476,4426..4515, 8073..8247,12205..12335,12584..12735,13169..13324, 13729..13908,16796..16883,16984..17106,18064..18156, 18695..18901,19856..19950,20047..20177,20632..20787, 21501..21552,21831..21938,22961..24397)  
mRNA Sequence

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Length 4314  



CDS Information


   
Location 643..3027
CDS Sequence

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CCDS ID CCDS53804.1



Protein Information


      
Protein IDNP_001171549.1
Protein Namesignal transducer and activator of transcription 6, interleukin-4 induced
Molecular Wt. (Da)0
Protein Sequence

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Length 847  
Uniprot IDQ9UNQ0
Ensembl Protein ID ENSP00000237612  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation641
SPhosphorylation8

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                            
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1051CEBPB1801NP_005185.2in vitro;in vivo9712049   
1387CREBBP2534NP_004371.2in vitro;in vivo1   157   454   710   454   340   
4790NFKB11238NP_003989.2in vitro;in vivo9584180   
126961HIST2H3C11822NP_066403.2in vitro;in vivo11509556   


Pathway Information


                  
Pathway Name Pathway ID
Hepatitis B hsa05161
Inflammatory bowel disease (IBD) hsa05321
Jak-STAT signaling pathway hsa04630


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd10377517-646  SH2_STAT6
cl15255517-646  SH2 superfamily
pfam14596655-847  STAT6_C
cl20580655-847  STAT6_C superfamily
pfam02864273-527  STAT_bind
cl03748273-527  STAT_bind superfamily
cd09919517-631  SH2_STAT_family
pfam01017124-271  STAT_alpha
cl19923124-271  STAT_alpha superfamily
cd10376517-650  SH2_STAT5
cd10420517-650  SH2_STAT5b
smart009642-115  STAT_int
cl037492-115  STAT_int superfamily
cd10421517-657  SH2_STAT5a
pfam028652-116  STAT_int
cd10374507-632  SH2_STAT3
cd10372517-646  SH2_STAT1
cd10375517-648  SH2_STAT4
cd10373517-630  SH2_STAT2
pfam00017538-616  SH2
smart00252540-620  SH2
cd00173540-612  SH2
cd10356540-597  SH2_ShkA_ShkC
cd10349540-581  SH2_SH2D2A_SH2D7
PHA03378647-785  PHA03378
pfam09770616-756  PAT1
pfam02948643-759  Amelogenin


Ontology Information


   
HPRD ID10401
Molecular ClassTranscription factor
Molecular FunctionGlutathione transferase activity (GO:0004364)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO