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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21273618 | 2011 | Cell line : - Source : Kanagawa Cancer Center and at the Gastroenterological Center of Yokohama City University Medical Center. Sample Type : CRC tumor and adjacent normal tissue No. of Sample : 202 Stage : - | real time RT-PCR | Up-regulation | - | High expression of the STC1 gene might be a useful predictor of poor postoperative outcome in patients with colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008] | Chromosome | 8 |
| Location | 8p22-p12 |
| Start | 23699434 |
| End | 23712320 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 12887 |
| OMIM ID | 601185 |
| HGNC ID | HGNC:11373 |
| Unigene ID | Hs.25590 |
| Ensembl ID | ENSG00000159167 |
| PharmGKB ID | PA36190 |
mRNA Information
| mRNA ID | ?NM_003155.2 |
|---|---|
| Exon | join(1..402,2424..2566,3277..3488,9768..12887) | mRNA Sequence | Download Select all |
| Length | 3897 |
Protein Information
| Protein ID | NP_003146.1 |
|---|---|
| Protein Name | stanniocalcin 1 |
| Molecular Wt. (Da) | 36698 |
| Protein Sequence | Download Select all |
| Length | 247 |
| Uniprot ID | Q96PU8 |
| Ensembl Protein ID | ENSP00000275262 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam03298 | 1-209 | Stanniocalcin |
| cl03991 | 1-209 | Stanniocalcin superfamily |
Ontology Information
| HPRD ID | 5202 |
|---|---|
| Molecular Class | Calcium binding protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.