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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19415750 | 2009 | Cell line : - Source : Kyushu University Hospital at Beppu. Sample Type : CRC tumor and normal tissue No. of Sample : 139 patients with colorectal cancer Stage : TNM Stage I-IV | DNA microarray, RT-PCR, Immunohistochemistry. | Up-regulation | - | STC2 may play an important role in the progression of colorectal cancer and may prove useful as a novel prognostic marker and target for molecular treatment of patients with colorectal cancer. |
| 22930170 | 2012 | Cell line : KM 12C, KM 12SM, HT 29 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Microarray analysis,Real time RT-PCR and Flow cytometry | Up-regulation | - | Gene differentially expressed and analysed bye by Microarray. |
| 25234931 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 47 tumor and matched tumor Stage : - | Real time RT- PCR | Up-regulation | - | STC2 can be used as a biomarker to differentiate between tumor borders and margins. STC2 mRNA expression levels were higher in tumor tissues than the control. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq, Jul 2008] | Chromosome | 5 |
| Location | 5q35.1 |
| Start | 173314723 |
| End | 173329503 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 14781 |
| OMIM ID | 603665 |
| HGNC ID | HGNC:11374 |
| Unigene ID | Hs.233160 |
| Ensembl ID | ENSG00000113739 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_003714.2 |
|---|---|
| Exon | join(1..1461,3494..3636,6074..6285,11255..14781) | mRNA Sequence | Download Select all |
| Length | 5361 |
CDS Information
| Location | join(1311..1461,3494..3636,6074..6285,11255..11657) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS4388.1 |
Protein Information
| Protein ID | NP_003705.1 |
|---|---|
| Protein Name | Stanniocalcin 2 |
| Molecular Wt. (Da) | 30655 |
| Protein Sequence | Download Select all |
| Length | 302 |
| Uniprot ID | P14138 |
| Ensembl Protein ID | ENSP00000311854 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 28 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5432 | POLR2C | 15945 | NP_116558.1 | yeast 2-hybrid | 16169070 |
| 8891 | EIF2B3 | 9379 | NP_065098.1 | yeast 2-hybrid | 16169070 |
| 9131 | AIFM1 | 2161 | NP_004199.1 | yeast 2-hybrid | 16169070 |
| 10621 | POLR3F | 15156 | NP_006457.2 | yeast 2-hybrid | 16169070 |
| 23589 | CARHSP1 | 8515 | NP_055131.2 | yeast 2-hybrid | 16169070 |
| 55701 | - | 13335 | NP_060541.3 | yeast 2-hybrid | 16169070 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam03298 | 6-220 | Stanniocalcin |
| cl03991 | 6-220 | Stanniocalcin superfamily |
Ontology Information
| HPRD ID | 561 |
|---|---|
| Molecular Class | Peptide hormone |
| Molecular Function | Translation regulator activity (GO:0045182) |
| Biological Process | Protein metabolism (GO:0019538); Translation (GO:0043037) |
Drug Information
No matching records could be found.