Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| STMN1 | 3925 | stathmin 1 | 1 | SMN, OP18, PR22, PP19, PP17, Lag, FLJ32206 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19513025 | 2009 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry,Real Time PCR, CpG island methylation and pyrosequencing | Up-regulation | - | STMN1 overexpression in colorectal cancer is independently associated with improved survival. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] | Chromosome | 1 |
| Location | 1p36.11 |
| Start | 26210670 |
| End | 26233368 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 22699 |
| OMIM ID | 151442 |
| HGNC ID | HGNC:6510 |
| Unigene ID | Hs.209983 |
| Ensembl ID | ENSG00000117632 |
| PharmGKB ID | PA35491 |
mRNA Information
| mRNA ID | NM_001145454.2 |
|---|---|
| Exon | join(376..489,2140..2214,3065..3237,5196..5387, 21009..22692) | mRNA Sequence | Download Select all |
| Length | 2251 |
Protein Information
| Protein ID | NP_001138926.1 |
|---|---|
| Protein Name | stathmin 1 |
| Molecular Wt. (Da) | 58202 |
| Protein Sequence | Download Select all |
| Length | 174 |
| Uniprot ID | Q13207 |
| Ensembl Protein ID | ENSP00000240328 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 16 |
| S | Phosphorylation | 63 |
| S | Phosphorylation | 16 |
| S | Phosphorylation | 16 |
| S | Phosphorylation | 63 |
| S | Phosphorylation | 25 |
| S | Phosphorylation | 38 |
| S | Phosphorylation | 38 |
| S | Phosphorylation | 25 |
| S | Phosphorylation | 38 |
| S | Phosphorylation | 16 |
| S | Phosphorylation | 63 |
| S | Phosphorylation | 16 |
| S | Phosphorylation | 16 |
| S | Phosphorylation | 63 |
| S | Phosphorylation | 25 |
| S | Phosphorylation | 25 |
| S | Phosphorylation | 25 |
| S | Phosphorylation | 25 |
| S | Phosphorylation | 63 |
| S | Phosphorylation | 63 |
| S | Phosphorylation | 25;- |
| S | Phosphorylation | 25;- |
| S | Phosphorylation | 25;- |
| S | Phosphorylation | 38;- |
| S | Phosphorylation | 38;- |
| S | Phosphorylation | 38;- |
| S | Phosphorylation | 63;- |
| S | Phosphorylation | 63;- |
| S | Phosphorylation | 63;- |
| S | Phosphorylation | 16;- |
| S | Phosphorylation | 16;- |
| S | Phosphorylation | 16;- |
| S | Phosphorylation | 28 |
| S | Phosphorylation | 28 |
| S | Phosphorylation | 28 |
| T | Phosphorylation | 146 |
| T | Phosphorylation | 146 |
| T | Phosphorylation | 146 |
| K | Acetylation | 9 |
| K | Acetylation | 9 |
| K | Acetylation | 9 |
| K | Acetylation | 80 |
| K | Acetylation | 80 |
| K | Acetylation | 80 |
| K | Acetylation | 95 |
| K | Acetylation | 95 |
| K | Acetylation | 95 |
| K | Acetylation | 119 |
| K | Acetylation | 119 |
| K | Acetylation | 119 |
| K | Acetylation | 128 |
| K | Acetylation | 128 |
| K | Acetylation | 128 |
| K | Acetylation | 100 |
| K | Acetylation | 100 |
| K | Acetylation | 100 |
| S | Phosphorylation | 46 |
| S | Phosphorylation | 46 |
| S | Phosphorylation | 46 |
| T | Phosphorylation | 102 |
| T | Phosphorylation | 102 |
| T | Phosphorylation | 102 |
| S | Phosphorylation | 31 |
| S | Phosphorylation | 31 |
| S | Phosphorylation | 31 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3309 | HSPA5 | 682 | NP_005338.1 | in vitro;yeast 2-hybrid | 101 974 487 724 523 |
| 6774 | STAT3 | 26 | NP_644805.1 | in vitro;in vivo | 16401721 |
| 56893 | UBQLN4 | 5670 | NP_064516.2 | yeast 2-hybrid | 16713569 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MAPK signaling pathway | hsa04010 |
| MicroRNAs in cancer | hsa05206 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00836 | 4-143 | Stathmin |
| cl02980 | 4-143 | Stathmin superfamily |
| PRK12704 | 50-140 | PRK12704 |
| pfam09726 | 38-139 | Macoilin |
Ontology Information
| HPRD ID | 3373 |
|---|---|
| Molecular Class | Structural protein |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.