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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
STUB1 10273 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase  16UBOX1, CHIP, SDCCAG7, HSPABP2, NY-CO-7 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24302614   2014Cell line : HCT 116,LS180

Source : ATCC, The University of Western Australia based at St John of God HealthCare, Subiaco.

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : -

Immunohistochemistry,Methylation-specific PCR,Methylated DNA immunoprecipitation,Immunofluorescence,Real-time?PCR,Migration and invasion ?assays,Luciferase reporter assayDown-regulation/Methylation- This study provides functional evidence for CHIP/STUB1 as a potential tumor suppressor in CRC, and CHIP expression may be a marker for stages of CRC.


Gene Details



NC_000016.9 (730115..732768)

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Gene Type protein coding
Gene Family Tetratricopeptide (TTC) repeat domain containing, "U-box domain containing"
Description This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2. [provided by RefSeq, Jun 2014]  
Chromosome 16
Location 16p13.3
Start 730115  
End 732768  
Strand +  
Gene Sequence

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Length 2654  
OMIM ID 607207   
HGNC ID HGNC:11427   
Unigene ID Hs.592081   
Ensembl ID ENSG00000103266   
PharmGKB ID PA36227   

mRNA Information


mRNA ID ?NM_001293197.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS10419.1



Protein Information


      
Protein IDNP_001280126.1
Protein NameSTIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
Molecular Wt. (Da)0
Protein Sequence

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Length 303  
Uniprot IDQ6X4U4
Ensembl Protein ID ENSP00000304930  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation19
SPhosphorylation23
TPhosphorylation276;-
SPhosphorylation273
SPhosphorylation25
TPhosphorylation271

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                            
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
573BAG13292NP_004314.4in vivo11676916   
2064ERBB21281NP_004439.2in vitro;in vivo12574167   
2861GPR373992NP_005293.1in vitro12150907   
2982GUCY1A3768NP_000847.2in vivo17873020   
3297HSF1778NP_005517.1in vitro;in vivo16293251   
3303HSPA1A774NP_005336.3in vitro;in vivo;yeast 2-hybrid1   033   019   215   189   440   
3304HSPA1B6784NP_005337.2in vitro;in vivo;yeast 2-hybrid16275660   
3308HSPA49025NP_002145.3in vivo16293251   
3320HSP90AA1777NP_001017963.2in vitro;in vivo;yeast 2-hybrid1   155   775   011   146   630   000   000   000   000   000   000   000   000   
4087SMAD23221NP_005892.1in vitro14701756   
4088SMAD34380NP_005893.1in vitro14701756   
4137MAPT1142NP_001116538.1in vitro;in vivo16275660   
5684PSMA31463NP_002779.1in vivo11146632   
5710PSMD43386NP_002801.1in vitro11146632   
7046TGFBR11822NP_004603.1in vivo15761153   
7314UBB6771NP_061828.1in vivo11146632   
7321UBE2D14267NP_003329.1in vitro11557750   
55585UBE2Q115601NP_060052.3in vitro;in vivo;yeast 2-hybrid16275660   
85300ATCAY10491NP_149053.1in vitro;in vivo;yeast 2-hybrid16275660   
161582DYX1C110568NP_570722.2in vivo;yeast 2-hybrid15189447   


Pathway Information


            
Pathway Name Pathway ID
Protein processing in endoplasmic reticulum hsa04141
Ubiquitin mediated proteolysis hsa04120


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam04564227-299  U-box
cl17238227-299  RING superfamily
smart00504230-293  Ubox
pfam0051560-90  TPR_1
cl2289760-90  TPR_1 superfamily
smart0002860-90  TPR
pfam0771960-90  TPR_2
pfam1341425-90  TPR_11
pfam1341460-125  TPR_11
pfam1289540-120  Apc3
PLN0308826-126  PLN03088
COG5113219-298  UFD2
pfam1342456-126  TPR_12
TIGR0099021-96  3a0801s09
COG04573-126  TPR
pfam1343266-124  TPR_16
TIGR0291732-127  PEP_TPR_lipo
pfam1343231-93  TPR_16
TIGR0255241-93  LcrH_SycD
pfam1455970-120  TPR_19
TIGR0255241-126  LcrH_SycD
TIGR0291740-127  PEP_TPR_lipo
TIGR0291721-162  PEP_TPR_lipo
TIGR0252141-144  type_IV_pilW
pfam1342440-90  TPR_12
TIGR0099038-126  3a0801s09
COG306341-143  PilF
COG501021-166  TadD
COG045721-126  TPR


Ontology Information


   
HPRD ID9580
Molecular ClassEnzyme: Ligase
Molecular FunctionTranscription regulator activity (GO:0030528)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO