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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21228115 | 2011 | Cell line : - Source : Bellvitge University Hospital, the Institut Catal� d?Oncolog�a, Barcelona, Hospital Puerta de Hierro (Madrid), and the Hospital of Cabue�es (Gij�n). Sample Type : Serum samples No. of Sample : - Stage : Duke Stage B-D | Phage Microarrays,T7 Phage Display cDNA Library Synthesis and Biopanning,Immunohistochemistry Analysis,ELISA | Up-regulation | - | - |
| 25477293 | 2015 | Cell line : Caco 2, HCT116 Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | SULF1 or SULF2 overexpression contributes to colorectal cancer cell proliferation, migration, and invasion. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] | Chromosome | 8 |
| Location | 8q13.2 |
| Start | 70378859 |
| End | 70573147 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 194289 |
| OMIM ID | 610012 |
| HGNC ID | HGNC:20391 |
| Unigene ID | Hs.409602 |
| Ensembl ID | ENSG00000137573 |
| PharmGKB ID | PA134861022 |
Protein Information
| Protein ID | NP_001121676.1 |
|---|---|
| Protein Name | sulfatase 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 871 |
| Uniprot ID | Q8WVD3 |
| Ensembl Protein ID | ENSP00000257190 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam12548 | 533-680 | DUF3740 |
| cl13923 | 533-680 | DUF3740 superfamily |
| pfam00884 | 43-374 | Sulfatase |
| cl21476 | 43-374 | alkPPc superfamily |
| PRK05434 | 289-387 | PRK05434 |
| COG0696 | 363-388 | GpmI |
| cl21476 | 363-388 | alkPPc superfamily |
| COG3119 | 42-386 | AslA |
| PRK13759 | 42-397 | PRK13759 |
| TIGR03417 | 74-389 | chol_sulfatase |
| COG1368 | 121-376 | MdoB |
| COG3083 | 248-378 | YejM |
Ontology Information
| HPRD ID | 17952 |
|---|---|
| Molecular Class | Enzyme: Sulphatase |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.