Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SVIL 6840 Supervillin  10- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20089989   2010Cell line : -

Source : VU University Medical Center, Amsterdam, The Netherlands.

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : -

Biochemical isolation to nano-LC-MS/MS analysis Up-regulation--


Gene Details



Chromosome: 10; NC_000010.10 (29746277..30024730, complement)

View Larger Image
   
Gene Type protein coding
Gene Family -
Description This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Two transcript variants encoding different isoforms of supervillin have been described. [provided by RefSeq, Jul 2008]  
Chromosome 10
Location 10p11.2
Start 29457338  
End 29736935  
Strand -  
Gene Sequence

   Download   Select all

Length 279598  
OMIM ID 604126   
HGNC ID HGNC:11480   
Unigene ID Hs.499209   
Ensembl ID ENSG00000197321   
PharmGKB ID -   

mRNA Information


mRNA ID XM_005252570.2
Exon join(1..251,50285..50383,78868..78967,167624..167681, 173644..173735,181828..181885,182002..182153, 185673..186339,200867..200947,203478..204407, 204764..204934,205648..205682,206268..206329, 207092..207231,209880..209975,212221..212464, 212909..213485,214301..214526,224075..224201, 228547..228594,229122..229199,237673..237820, 241755..241844,241936..242022,243545..243722, 245917..246089,248180..248335,249637..249773, 250379..250526,250706..250851,252105..252280, 255208..255352,256123..256399,262947..263098, 265693..265798,266453..266660,269061..269194, 271186..271341,273301..273444,274535..274659, 278347..278502,278603..279598)  
mRNA Sequence

   Download   Select all

Length 8330  



CDS Information


   
Locationjoin(181878..181885,182002..182153,185673..186339, 205648..205682,206268..206329,207092..207231, 212221..212464,212909..213485,214301..214526, 224075..224201,237673..237820,241755..241844, 241936..242022,243545..243722,245917..246089, 248180..248335,249637..249773,250379..250526, 250706..250851,252105..252280,255208..255352, 256123..256399,262947..263
CDS Sequence

   Download   Select all

CCDS ID CCDS7163.1



Protein Information


      
Protein IDNP_003165.2
Protein NameSupervillin
Molecular Wt. (Da)200717
Protein Sequence

   Download   Select all

Length 1788  
Uniprot IDP20711
Ensembl Protein ID ENSP00000350616  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation852
TPhosphorylation426
SPhosphorylation245;-
SPhosphorylation245;-
TPhosphorylation342;-
SPhosphorylation261;-
SPhosphorylation263;-
SPhosphorylation259;-
SPhosphorylation251;-
SPhosphorylation253;-
SPhosphorylation270;-
TPhosphorylation1175;-
TPhosphorylation749;-
SPhosphorylation237;-
SPhosphorylation238;-
SPhosphorylation237;-
SPhosphorylation238;-
TPhosphorylation240;-
TPhosphorylation240;-
SPhosphorylation263;-
SPhosphorylation263;-
SPhosphorylation221;-
SPhosphorylation221;-
TPhosphorylation229;-
TPhosphorylation229;-
SPhosphorylation1322;-
SPhosphorylation896;-
SPhosphorylation50
SPhosphorylation50
SPhosphorylation63
SPhosphorylation65
SPhosphorylation63
SPhosphorylation65
SPhosphorylation66
SPhosphorylation66
SPhosphorylation707
SPhosphorylation313
SPhosphorylation920
SPhosphorylation494
TPhosphorylation1111
SPhosphorylation1120
TPhosphorylation685
SPhosphorylation694
YPhosphorylation1317
YPhosphorylation891
TPhosphorylation657
SPhosphorylation270
SPhosphorylation1904
SPhosphorylation1478
SPhosphorylation319
SPhosphorylation259
YPhosphorylation966
YPhosphorylation540
SPhosphorylation968
SPhosphorylation542
YPhosphorylation850
YPhosphorylation424
SPhosphorylation86
SPhosphorylation86
SPhosphorylation261
SPhosphorylation914
SPhosphorylation488
SPhosphorylation924
SPhosphorylation498
SPhosphorylation938
SPhosphorylation512
TPhosphorylation1910
TPhosphorylation1484
SPhosphorylation872
SPhosphorylation446
TPhosphorylation1828
TPhosphorylation1402

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
60ACTB32NP_001092.1VV12202484   
81ACTN45222NP_004915.2VV12202484   
87ACTN120NP_001123476.1VV12202484   
367AR2437NP_000035.2in vitro;yeast 2-hybrid11792840   
546ATRX2069NP_000480.2Y2H20309963   
699BUB13907NP_004327.1 VV;Y2H20309963   
820CAMP2722NP_004336.2VV12202484   
859CAV33154NP_203123.1VV12711699   
1063CENPF2582NP_057427.3Y2H20309963   
1213CLTC350NP_004850.1VV12202484   
1488CTBP24016NP_073713.2Y2H16880273   
2017CTTN1268NP_005222.2VT;VV19109420   
2040STOM585NP_004090.4VV12202484   
2316FLNA2060NP_001104026.1 VV;Y2H20309963   
2319FLOT2580NP_004466.2VV12202484   
2771GNAI2764NP_002061.1VV12202484   
2783GNB211820NP_005264.2VV12202484   
2801GOLGA23989NP_004477.3Y2H16880273   
3161HMMR2963NP_001136028.1 VV;Y2H20309963   
3309HSPA5682NP_005338.1Y2H16880273   
3320HSP90AA1777NP_001017963.2Y2H20309963   
3801KIFC35171NP_005541.3 VV;Y2H20309963   
3835KIF224445NP_015556.1Y2H20309963   
3875KRT181020NP_000215.1Y2H20309963   
4000LMNA1035CAA27173.1Y2H20309963   
4026LPP2828NP_005569.1Y2H16880273   
4297MLL1162NP_005924.2Y2H20309963   
4627MYH91177NP_002464.1VT17925381   
4628MYH101178NP_005955.1VT;VV17925381   
4638MYLK2952NP_444253.3VT17925381   
4703NEB1196NP_004534.2 VV; Vt;Y2H18639526   
4831NME21132NP_001018146.1Y2H20309963   
4957ODF23601NP_002531.3 VV;Y2H20309963   
5027P2RX73977NP_002553.2in vivo11707406   
6709SPTAN11684NP_001123910.1VV12202484   
6711SPTBN11683NP_003119.2VV12202484   
6993DYNLT115987NP_006510.1Y2H16880273   
7041TGFB1I13831NP_001035919.1in vivo11792840   
7126TNFAIP11856NP_066960.1 VV;Y2H20309963   
7205TRIP64242NP_003293.2Y2H16880273   
7431VIM1899NP_003371.2VV12202484   
8379MAD1L14065NP_003541.2Y2H16880273   
8409UXT2209NP_705582.1Y2H20309963   
9644SH3PXD2A10228NP_055446.2 VV;Y2H20309963   
9928KIF146605NP_055690.1 VT; VV;Y2H20309963   
10198MPHOSPH912022NP_073619.2Y2H20309963   
10211FLOT16105NP_005794.1VV12202484   
10456HAX112075NP_006109.2 VV;Y2H20309963   
10627MYL12A14735NP_006462.1VV12202484   
23421ITGB3BP9267NP_055103.3Y2H20309963   
24137KIF4A6606NP_036442.3Y2H16880273   
51421AMOTL216485NP_057285.3Y2H16880273   
51474LIMA19755NP_001107018.1 VT; VV;Y2H20309963   
51631LUC7L217456NP_057103.2yeast 2-hybrid16169070   
57409MIF4GD10629NP_065730.2 VV;Y2H20309963   
57496MKL217577NP_054767.3Y2H20309963   
63940GPSM313605NP_071390.1VV12202484   
64005MYO1G17622NP_149043.2VV12202484   
64386MMP257090NP_071913.1VV12202484   
84823LMNB21037NP_116126.2Y2H20309963   
152007GLIPR26187NP_071738.1VV12202484   
255967PAN317818NP_787050.4Y2H20309963   


Pathway Information


No matching records could be found.

Structure Information


PDB ID1S9J
Resolution2.4
MethodX-RAY DIFFRACTION
Chains A  
Molecule Dual specificity mitogen-activated protein kinase kinase 1  
Model View



Domain Information




ID Location Description
cd112931746-1859  gelsolin_S4_like
cl156971746-1859  ADF_gelsolin superfamily
cd112891442-1538  gelsolin_S2_like
cl156971442-1538  ADF_gelsolin superfamily
cd112881879-1984  gelsolin_S5_like
cl156971879-1984  ADF_gelsolin superfamily
cd112801563-1663  gelsolin_like
cl156971563-1663  ADF_gelsolin superfamily
smart002621445-1539  GEL
cd112881444-1542  gelsolin_S5_like
smart001532179-2214  VHP
cl024912179-2214  VHP superfamily
pfam022092179-2214  VHP
smart002621884-1980  GEL
cd112901754-1868  gelsolin_S1_like
cd112912001-2123  gelsolin_S6_like
cl156972001-2123  ADF_gelsolin superfamily
smart002621756-1862  GEL
cd112802000-2119  gelsolin_like
cd112921587-1679  gelsolin_S3_like
smart002622027-2122  GEL
pfam006261459-1522  Gelsolin
cd112921464-1535  gelsolin_S3_like
cd112801811-1859  gelsolin_like
smart002621584-1682  GEL
cd112801459-1537  gelsolin_like
cd112881584-1630  gelsolin_S5_like
pfam006261814-1856  Gelsolin
PRK1026399-411  PRK10263


Ontology Information


   
HPRD ID4386
Molecular ClassCytoskeletal associated protein
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO