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General Information
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19711377 | 2009 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Mass spectrometry, Western blotting and immunohistochemistry | Down-regulation | - | Altered expression represents interactions between cancer epithelium and stroma, such that transgelin might be a potential marker for CRC genesis and progression. Clinical and pathological parameter analysis revealed that downregulation of transgelin was associated with poor differentiation, and subsequent Dukes Stage and lower survival rate. |
| 19329940 | 2009 | Cell line : RKO, SW 620 and CW2 Source : Xiaoshan District, Zhejiang Province, China. Sample Type : CRC tumor and normal tissue No. of Sample : 221 patients with colorectal carcinoma Stage : - | 2-D Gel electrophoresis, Mass spectrometry, Western Blottingreal time RT-PCR, Immunohistochemistry | Hypermethylation | - | Transgelin as a suppressor may serve as important biomarker of malignancy. Loss of transgelin involves gene promoter hypermethylation and is closely associated with poor overall survival in colorectal cancer patients. |
| 20089989 | 2010 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis | Up-regulation | - | - |
| 20977730 | 2010 | Cell line : - Source : Nanfang Hospital tumor tissue bank Sample Type : - No. of Sample : 138 CRC patients Stage : - | Immunohistochemistry , Affymetrix 133 plus 2.0 expression chip platform. | Up-regulation | - | TAGLN upregulates in the presence of IGFBP-rP1 in colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] | Chromosome | 11 |
| Location | 11q23.2 |
| Start | 117199324 |
| End | 117204792 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 5469 |
| OMIM ID | 600818 |
| HGNC ID | HGNC:11553 |
| Unigene ID | Hs.410977 |
| Ensembl ID | ENSG00000149591 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001001522.1 |
|---|---|
| Exon | join(1..506,3679..3870,3984..4161,4459..4561,4892..5469) | mRNA Sequence | Download Select all |
| Length | 1574 |
CDS Information
| Location | join(3691..3870,3984..4161,4459..4561,4892..5036) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS8381.1 |
Protein Information
| Protein ID | NP_001001522.1 |
|---|---|
| Protein Name | Transgelin |
| Molecular Wt. (Da) | 22480 |
| Protein Sequence | Download Select all |
| Length | 201 |
| Uniprot ID | Q04828 |
| Ensembl Protein ID | ENSP00000370254 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 181 |
| S | Phosphorylation | 181 |
| Y | Phosphorylation | 193;- |
| Y | Phosphorylation | 193;- |
| K | Acetylation | 17 |
| K | Acetylation | 17 |
| T | Phosphorylation | 164 |
| T | Phosphorylation | 164 |
| T | Phosphorylation | 139 |
| T | Phosphorylation | 139 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 58 | ACTA1 | 30 | NP_001091.1 | in vitro;in vivo | 11053353 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00014 | 25-137 | CH |
| cl00030 | 25-137 | CH superfamily |
| smart00033 | 28-133 | CH |
| pfam00307 | 27-133 | CH |
| pfam00402 | 175-200 | Calponin |
| cl02859 | 175-200 | Calponin superfamily |
| COG5199 | 14-189 | SCP1 |
| COG5261 | 46-136 | IQG1 |
Ontology Information
| HPRD ID | 514 |
|---|---|
| Molecular Class | Cytoskeletal associated protein |
| Molecular Function | Structural constituent of cytoskeleton (GO:0005200) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.