Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24752990 | 2014 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Lentiviral shRNA transduction and proliferation assay and western blotting | Phosphorylation | - | TBK1 has therapeutic potential under certain contexts and phosphorylation of its downstream target IRF3 is a biomarker of TBK1 activity. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. | Chromosome | 12 |
| Location | 12q14.2 |
| Start | 64452060 |
| End | 64502119 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 50060 |
| OMIM ID | 604834 |
| HGNC ID | HGNC:11584 |
| Unigene ID | Hs.505874 |
| Ensembl ID | ENSG00000183735 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_013254.3 |
|---|---|
| Exon | join(1..128,3781..3898,8130..8270,12275..12404, 14842..15023,22171..22331,27953..28063,29783..29962, 32244..32440,33396..33454,33867..33958,36428..36529, 37982..38060,43424..43545,43640..43716,44308..44347, 44890..44991,45104..45200,45589..45695,45909..45980, 49271..50060) | mRNA Sequence | Download Select all |
| Length | 3098 |
CDS Information
| Location | join(3812..3898,8130..8270,12275..12404,14842..15023, 22171..22331,27953..28063,29783..29962,32244..32440, 33396..33454,33867..33958,36428..36529,37982..38060, 43424..43545,43640..43716,44308..44347,44890..44991, 45104..45200,45589..45695,45909..45980,49271..49322) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_037386.1 |
|---|---|
| Protein Name | TANK-binding kinase 1 |
| Molecular Wt. (Da) | 83511 |
| Protein Sequence | Download Select all |
| Length | 729 |
| Uniprot ID | P01116 |
| Ensembl Protein ID | ENSP00000256078 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 172 |
| S | Phosphorylation | 716 |
| T | Phosphorylation | 672 |
| S | Phosphorylation | 509 |
| K | Acetylation | 584 |
Enzyme Information
| EC | 2.7.11.10 |
|---|---|
| Name | IkappaB kinase CHUK IKBKA IKBKB IKK IKK-1 IKK-2 inhibitor of NFkappaB kinase inhibitor of NF-kappaB kinase STK12 TANK-binding kinase 1 TBK1 |
| Class | Transferases; Transferring phosphorus-containing groups; Protein-serine/threonine kinases |
| Sysname | ATP:[IkappaB protein] phosphotransferase |
| Substrate | ATP [CPD:C00002]; [IkappaB protein] |
| Product | ADP [CPD:C00008]; [IkappaB phosphoprotein] |
| Reaction (IUBMB) |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3326 | HSP90AB1 | 6763 | NP_031381.2 | in vitro | 14743216 |
| 4690 | NCK1 | 2740 | NP_006144.1 | in vitro;in vivo | 7706279 |
| 4792 | NFKBIA | 1235 | NP_065390.1 | in vitro;in vivo | 8 601 309 972 110 310 000 000 |
| 7186 | TRAF2 | 3538 | NP_066961.2 | in vitro | 10990461 |
| 10010 | TANK | 4870 | NP_004171.2 | in vivo;yeast 2-hybrid | 10581243 |
| 11140 | CDC37 | 5456 | NP_008996.1 | in vitro | 14743216 |
| 57506 | MAVS | 13847 | NP_065797.2 | in vitro;in vivo | 16153868 |
| 64343 | AZI2 | 10577 | NP_071906.1 | in vitro;in vivo | 14560022 |
| 148022 | TICAM1 | 6350 | NP_891549.1 | in vivo | 14530355 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytosolic DNA-sensing pathway | hsa04623 |
| Epstein-Barr virus infection | hsa05169 |
| Hepatitis B | hsa05161 |
| Hepatitis C | hsa05160 |
| Herpes simplex infection | hsa05168 |
| Influenza A | hsa05164 |
| Measles | hsa05162 |
| Ras signaling pathway | hsa04014 |
| RIG-I-like receptor signaling pathway | hsa04622 |
| Toll-like receptor signaling pathway | hsa04620 |
Structure Information
| PDB ID | 4EFO |
|---|---|
| Resolution | 1.77 |
| Method | X-RAY DIFFRACTION |
| Chains | A,B |
| Molecule | Serine/threonine-protein kinase TBK1 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd13988 | 15-330 | STKc_TBK1 |
| cl21453 | 15-330 | PKc_like superfamily |
| cd12219 | 297-385 | UBL_TBK1_like |
| cl00155 | 297-385 | UBQ superfamily |
| cd00180 | 15-212 | PKc |
| cd05117 | 9-241 | STKc_CAMK |
| cd06606 | 9-241 | STKc_MAPKKK |
| cd14014 | 9-242 | STKc_PknB_like |
| cd14003 | 9-243 | STKc_AMPK-like |
| cd13989 | 15-223 | STKc_IKK |
| cd14008 | 15-221 | STKc_LKB1_CaMKK |
| cd05122 | 15-242 | PKc_STE |
| cd14120 | 15-221 | STKc_ULK1_2-like |
| cd14009 | 15-300 | STKc_ATG1_ULK_like |
| cd05123 | 15-242 | STKc_AGC |
| cd14039 | 15-224 | STKc_IKK_alpha |
| cd14007 | 15-243 | STKc_Aurora |
| cd14038 | 15-246 | STKc_IKK_beta |
| cd08215 | 15-243 | STKc_Nek |
| cd14202 | 13-222 | STKc_ULK1 |
| cd14098 | 11-221 | STKc_Rad53_Cds1 |
| cd06626 | 9-242 | STKc_MEKK4 |
| cd13994 | 15-222 | STKc_HAL4_like |
| cd14006 | 15-222 | STKc_MLCK-like |
| cd13999 | 15-222 | STKc_MAP3K-like |
| cd14002 | 11-221 | STKc_STK36 |
| cd06627 | 11-221 | STKc_Cdc7_like |
| cd05579 | 17-221 | STKc_MAST_like |
| cd14201 | 13-222 | STKc_ULK2 |
| cd14166 | 13-221 | STKc_CaMKI_gamma |
| cd06610 | 11-244 | STKc_OSR1_SPAK |
| cd14095 | 14-238 | STKc_DCKL |
| cd14121 | 15-300 | STKc_ULK3 |
| cd14093 | 13-221 | STKc_PhKG |
| cd14185 | 14-238 | STKc_DCKL3 |
| cd14083 | 11-221 | STKc_CaMKI |
| cd06623 | 13-227 | PKc_MAPKK_plant_like |
| cd14010 | 11-221 | STKc_ULK4 |
| cd06612 | 11-260 | STKc_MST1_2 |
| cd06632 | 9-237 | STKc_MEKK1_plant |
| cd07829 | 13-222 | STKc_CDK_like |
| cd14072 | 15-221 | STKc_MARK |
| cd06605 | 13-242 | PKc_MAPKK |
| cd14084 | 11-241 | STKc_Chk2 |
| cd14099 | 15-238 | STKc_PLK |
| cd14118 | 48-221 | STKc_CAMKK |
| cd14092 | 7-240 | STKc_MSK_C |
| cd14069 | 9-220 | STKc_Chk1 |
| cd13997 | 15-220 | PKc_Wee1_like |
| cd05581 | 13-222 | STKc_PDK1 |
| cd14103 | 15-221 | STKc_MLCK |
| cd05582 | 14-241 | STKc_RSK_N |
| cd07833 | 15-217 | STKc_CDKL |
| cd14070 | 9-224 | STKc_HUNK |
| cd06613 | 15-210 | STKc_MAP4K3_like |
| cd07832 | 15-211 | STKc_CCRK |
| cd05118 | 15-238 | STKc_CMGC |
| cd14086 | 15-221 | STKc_CaMKII |
| cd14181 | 13-221 | STKc_PhKG2 |
| cd06917 | 13-242 | STKc_NAK1_like |
| cd14059 | 15-222 | STKc_MAP3K12_13 |
| cd05612 | 15-241 | STKc_PRKX_like |
| cd14075 | 15-222 | STKc_NIM1 |
| cd06614 | 15-211 | STKc_PAK |
| cd14081 | 9-221 | STKc_BRSK1_2 |
| cd05574 | 15-243 | STKc_phototropin_like |
| cd14078 | 7-239 | STKc_MELK |
| cd05578 | 14-229 | STKc_Yank1 |
| cd14073 | 15-221 | STKc_NUAK |
| cd06608 | 8-243 | STKc_myosinIII_N_like |
| cd05584 | 14-241 | STKc_p70S6K |
| cd14194 | 15-221 | STKc_DAPK1 |
| cd14663 | 11-238 | STKc_SnRK3 |
| cd05572 | 15-221 | STKc_cGK |
| cd08217 | 13-222 | STKc_Nek2 |
| cd05580 | 13-241 | STKc_PKA_like |
| cd14196 | 11-221 | STKc_DAPK2 |
| cd06644 | 6-262 | STKc_STK10 |
| cd06621 | 14-229 | PKc_Pek1_like |
| cd06630 | 9-221 | STKc_MEKK1 |
| cd14080 | 15-237 | STKc_TSSK-like |
| cd14105 | 15-221 | STKc_DAPK |
| cd14119 | 15-273 | STKc_LKB1 |
| cd14137 | 14-208 | STKc_GSK3 |
| cd14191 | 11-221 | STKc_MLCK1 |
| cd07838 | 12-212 | STKc_CDK4_6_like |
| cd14200 | 46-221 | STKc_CaMKK1 |
| cd06643 | 9-262 | STKc_SLK |
| cd00192 | 13-245 | PTKc |
| cd06609 | 15-220 | STKc_MST3_like |
| cd06631 | 9-220 | STKc_YSK4 |
| cd07847 | 15-217 | STKc_CDKL1_4 |
| cd13996 | 14-211 | STKc_EIF2AK |
| cd06625 | 9-243 | STKc_MEKK3_like |
| cd05583 | 14-242 | STKc_MSK_N |
| cd14085 | 7-238 | STKc_CaMKIV |
| cd14182 | 13-221 | STKc_PhKG1 |
| cd14114 | 15-221 | STKc_Twitchin_like |
| cd06628 | 9-221 | STKc_Byr2_like |
| cd08529 | 15-221 | STKc_FA2-like |
| cd06611 | 6-242 | STKc_SLK_like |
| cd14106 | 15-221 | STKc_DRAK |
| cd14169 | 6-221 | STKc_CaMKI_beta |
| cd07866 | 15-211 | STKc_BUR1 |
| cd14179 | 10-243 | STKc_MSK1_C |
| cd06652 | 9-239 | STKc_MEKK2 |
| cd14082 | 13-221 | STKc_PKD |
| cd06620 | 15-221 | PKc_Byr1_like |
| cd13990 | 53-221 | STKc_TLK |
| cd14199 | 48-247 | STKc_CaMKK2 |
| cd14195 | 15-221 | STKc_DAPK3 |
| cd05573 | 13-221 | STKc_ROCK_NDR_like |
| cd13993 | 11-223 | STKc_Pat1_like |
| cd14089 | 10-221 | STKc_MAPKAPK |
| cd13979 | 15-221 | STKc_Mos |
| cd14180 | 15-243 | STKc_MSK2_C |
| cd14116 | 9-221 | STKc_Aurora-A |
| cd06647 | 13-242 | STKc_PAK_I |
| cd14087 | 14-243 | STKc_PSKH1 |
| cd07830 | 15-243 | STKc_MAK_like |
| cd07841 | 15-211 | STKc_CDK7 |
| cd13985 | 15-223 | STKc_GAK_like |
| cd05611 | 17-225 | STKc_Rim15_like |
| cd14190 | 13-221 | STKc_MLCK2 |
| cd14091 | 11-221 | STKc_RSK_C |
| cd05614 | 11-243 | STKc_MSK2_N |
| cd07840 | 13-208 | STKc_CDK9_like |
| cd07846 | 14-223 | STKc_CDKL2_3 |
| cd14107 | 15-221 | STKc_obscurin_rpt1 |
| cd08530 | 13-241 | STKc_CNK2-like |
| cd14096 | 7-221 | STKc_RCK1-like |
| cd14108 | 15-221 | STKc_SPEG_rpt1 |
| cd14167 | 13-221 | STKc_CaMKI_alpha |
| cd14193 | 12-221 | STKc_MLCK4 |
| cd05596 | 14-221 | STKc_ROCK |
| cd14079 | 9-221 | STKc_AMPK_alpha |
| cd06636 | 11-221 | STKc_MAP4K4_6_N |
| cd06624 | 14-221 | STKc_ASK |
| cd14168 | 11-221 | STKc_CaMKI_delta |
| cd14184 | 14-222 | STKc_DCKL2 |
| cd14071 | 15-221 | STKc_SIK |
| cd07831 | 15-212 | STKc_MOK |
| cd14050 | 13-216 | PKc_Myt1 |
| cd14004 | 15-221 | STKc_PASK |
| cd05609 | 14-221 | STKc_MAST |
| cd13987 | 15-220 | STKc_SBK1 |
| cd07848 | 14-225 | STKc_CDKL5 |
| cd07865 | 14-208 | STKc_CDK9 |
| cd07836 | 15-243 | STKc_Pho85 |
| cd05613 | 11-242 | STKc_MSK1_N |
| cd14046 | 15-212 | STKc_EIF2AK4_GCN2_rpt2 |
| cd14209 | 15-244 | STKc_PKA |
| cd14198 | 1-221 | STKc_DRAK2 |
| cd14052 | 15-216 | PTKc_Wee1_fungi |
| cd14162 | 9-221 | STKc_TSSK4-like |
| cd14192 | 13-221 | STKc_MLCK3 |
| cd08225 | 14-278 | STKc_Nek5 |
| cd05041 | 15-222 | PTKc_Fes_like |
| cd13986 | 15-221 | STKc_16 |
| cd05570 | 14-222 | STKc_PKC |
| cd14164 | 9-221 | STKc_TSSK6-like |
| cd06653 | 9-271 | STKc_MEKK3_like_u1 |
| cd14161 | 7-221 | STKc_NUAK2 |
| cd06639 | 9-221 | STKc_myosinIIIB_N |
| cd06637 | 11-221 | STKc_TNIK |
| cd14074 | 8-221 | STKc_SNRK |
| cd13983 | 11-250 | STKc_WNK |
| cd14066 | 15-209 | STKc_IRAK |
| cd05038 | 7-242 | PTKc_Jak_rpt2 |
| cd06629 | 9-241 | STKc_Bck1_like |
| cd14061 | 14-226 | STKc_MLK |
| cd05575 | 14-242 | STKc_SGK |
| cd13978 | 15-254 | STKc_RIP |
| cd08528 | 13-221 | STKc_Nek10 |
| cd14183 | 14-241 | STKc_DCKL1 |
| cd05602 | 14-242 | STKc_SGK1 |
| cd14097 | 14-221 | STKc_STK33 |
| cd06638 | 9-242 | STKc_myosinIIIA_N |
| cd07843 | 23-211 | STKc_CDC2L1 |
| cd06651 | 9-226 | STKc_MEKK3 |
| cd14090 | 10-221 | STKc_Mnk |
| cd05595 | 14-221 | STKc_PKB_beta |
| cd13982 | 12-221 | STKc_IRE1 |
| cd07834 | 14-211 | STKc_MAPK |
| cd14189 | 14-252 | STKc_PLK3 |
| cd08218 | 15-240 | STKc_Nek1 |
| cd14111 | 16-241 | STKc_SPEG_rpt2 |
| cd05601 | 11-221 | STKc_CRIK |
| cd05148 | 15-240 | PTKc_Srm_Brk |
| cd05577 | 15-233 | STKc_GRK |
| cd08224 | 15-239 | STKc_Nek6_7 |
| cd05608 | 14-238 | STKc_GRK1 |
| cd14064 | 15-221 | PKc_TNNI3K |
| cd05603 | 14-242 | STKc_SGK2 |
| cd05590 | 14-221 | STKc_nPKC_eta |
| cd13995 | 12-221 | STKc_MAP3K8 |
| cd14186 | 13-221 | STKc_PLK4 |
| cd07871 | 13-243 | STKc_PCTAIRE3 |
| cd05621 | 14-221 | STKc_ROCK2 |
| cd14012 | 54-234 | PK_eIF2AK_GCN2_rpt1 |
| cd05624 | 14-221 | STKc_MRCK_beta |
| cd05619 | 9-221 | STKc_nPKC_theta |
| cd05622 | 14-221 | STKc_ROCK1 |
| cd05059 | 15-240 | PTKc_Tec_like |
| cd14165 | 9-221 | STKc_TSSK1_2-like |
| cd05597 | 14-221 | STKc_DMPK_like |
| cd08219 | 14-222 | STKc_Nek3 |
| cd05079 | 15-216 | PTKc_Jak1_rpt2 |
| cd14665 | 27-239 | STKc_SnRK2-3 |
| cd06655 | 15-242 | STKc_PAK2 |
| cd05604 | 14-242 | STKc_SGK3 |
| cd05571 | 14-238 | STKc_PKB |
| cd05599 | 14-221 | STKc_NDR_like |
| cd14094 | 11-221 | STKc_CASK |
| cd14060 | 16-226 | STKc_MLTK |
| cd05607 | 14-238 | STKc_GRK7 |
| cd07873 | 13-243 | STKc_PCTAIRE1 |
| cd14174 | 10-221 | STKc_Mnk1 |
| cd14117 | 15-221 | STKc_Aurora-B_like |
| cd08220 | 14-241 | STKc_Nek8 |
| cd14173 | 10-221 | STKc_Mnk2 |
| cd06656 | 15-242 | STKc_PAK3 |
| cd14172 | 10-221 | STKc_MAPKAPK3 |
| cd06618 | 6-242 | PKc_MKK7 |
| cd06645 | 15-210 | STKc_MAP4K3 |
| cd14109 | 15-241 | PK_Unc-89_rpt1 |
| cd06607 | 15-210 | STKc_TAO |
| cd05598 | 15-221 | STKc_LATS |
| cd05623 | 14-221 | STKc_MRCK_alpha |
| cd14132 | 15-237 | STKc_CK2_alpha |
| cd05589 | 14-221 | STKc_PKN |
| cd14058 | 15-252 | STKc_TAK1 |
| cd14005 | 11-222 | STKc_PIM |
| cd14187 | 15-221 | STKc_PLK1 |
| cd08222 | 15-241 | STKc_Nek11 |
| cd08223 | 15-241 | STKc_Nek4 |
| cd14188 | 14-221 | STKc_PLK2 |
| cd06654 | 15-242 | STKc_PAK1 |
| cd05034 | 15-244 | PTKc_Src_like |
| cd06616 | 4-224 | PKc_MKK4 |
| cd06619 | 13-226 | PKc_MKK5 |
| cd06650 | 15-223 | PKc_MEK1 |
| cd14037 | 13-221 | STKc_NAK_like |
| cd06622 | 13-223 | PKc_PBS2_like |
| cd05600 | 15-226 | STKc_Sid2p_like |
| cd14163 | 11-228 | STKc_TSSK3-like |
| cd14178 | 9-241 | STKc_RSK3_C |
| cd05080 | 31-241 | PTKc_Tyk2_rpt2 |
| cd07863 | 15-211 | STKc_CDK4 |
| cd06615 | 15-223 | PKc_MEK |
| cd14205 | 7-218 | PTKc_Jak2_rpt2 |
| cd14076 | 53-242 | STKc_Kin4 |
| cd06641 | 15-220 | STKc_MST3 |
| cd06646 | 1-210 | STKc_MAP4K5 |
| cd14077 | 9-221 | STKc_Kin1_2 |
| cd14146 | 14-226 | STKc_MLK4 |
| cd07844 | 13-243 | STKc_PCTAIRE_like |
| cd05620 | 14-221 | STKc_nPKC_delta |
| cd14170 | 12-221 | STKc_MAPKAPK2 |
| cd14175 | 9-241 | STKc_RSK1_C |
| cd14662 | 27-239 | STKc_SnRK2 |
| cd05593 | 14-221 | STKc_PKB_gamma |
| cd05116 | 15-241 | PTKc_Syk |
| cd14047 | 15-209 | STKc_EIF2AK2_PKR |
| cd14171 | 15-241 | STKc_MAPKAPK5 |
| cd06648 | 15-229 | STKc_PAK_II |
| cd06633 | 15-210 | STKc_TAO3 |
| cd14176 | 15-243 | STKc_RSK2_C |
| cd14177 | 11-243 | STKc_RSK4_C |
| cd05586 | 15-247 | STKc_Sck1_like |
| cd14113 | 15-221 | STKc_Trio_C |
| cd05115 | 10-241 | PTKc_Zap-70 |
| cd05112 | 55-240 | PTKc_Itk |
| cd07880 | 15-243 | STKc_p38gamma |
| cd05592 | 14-221 | STKc_nPKC_theta_like |
| cd08221 | 53-216 | STKc_Nek9 |
| cd14041 | 4-221 | STKc_TLK2 |
| cd07862 | 15-211 | STKc_CDK6 |
| cd14040 | 4-221 | STKc_TLK1 |
| cd05057 | 14-226 | PTKc_EGFR_like |
| cd05032 | 11-241 | PTKc_InsR_like |
| cd05084 | 15-221 | PTKc_Fes |
| cd13991 | 15-227 | STKc_NIK |
| cd14145 | 11-226 | STKc_MLK1 |
| cd07864 | 13-208 | STKc_CDK12 |
| cd14104 | 9-221 | STKc_Titin |
| cd07845 | 14-211 | STKc_CDK10 |
| cd05113 | 7-240 | PTKc_Btk_Bmx |
| cd14135 | 15-221 | STKc_PRP4 |
| cd05060 | 15-241 | PTKc_Syk_like |
| cd14197 | 15-221 | STKc_DRAK1 |
| cd06640 | 13-220 | STKc_MST4 |
| cd14068 | 14-162 | STKc_LRRK2 |
| cd06642 | 13-221 | STKc_STK25 |
| cd07879 | 15-222 | STKc_p38delta |
| cd07839 | 15-223 | STKc_CDK5 |
| cd07870 | 15-259 | STKc_PFTAIRE2 |
| cd14063 | 11-222 | PK_KSR |
| cd14065 | 15-228 | PKc_LIMK_like |
| cd06635 | 10-210 | STKc_TAO1 |
| cd14151 | 15-221 | STKc_B-Raf |
| cd14150 | 15-221 | STKc_A-Raf |
| cd07872 | 13-243 | STKc_PCTAIRE2 |
| cd05632 | 14-238 | STKc_GRK5 |
| cd05594 | 14-221 | STKc_PKB_alpha |
| cd14147 | 11-226 | STKc_MLK3 |
| cd06649 | 15-223 | PKc_MEK2 |
| cd06659 | 15-221 | STKc_PAK6 |
| cd05618 | 11-241 | STKc_aPKC_iota |
| cd05039 | 5-169 | PTKc_Csk_like |
| cd06634 | 10-210 | STKc_TAO2 |
| cd05114 | 53-244 | PTKc_Tec_Rlk |
| cd07860 | 15-211 | STKc_CDK2_3 |
| cd05591 | 14-221 | STKc_nPKC_epsilon |
| cd05616 | 14-221 | STKc_cPKC_beta |
| cd14110 | 23-250 | STKc_obscurin_rpt2 |
| cd05068 | 15-240 | PTKc_Frk_like |
| cd05630 | 14-233 | STKc_GRK6 |
| cd05036 | 15-240 | PTKc_ALK_LTK |
| cd14156 | 15-231 | PKc_LIMK_like_unk |
| cd08228 | 15-221 | STKc_Nek6 |
| cd14048 | 14-212 | STKc_EIF2AK3_PERK |
| cd14148 | 54-222 | STKc_MLK2 |
| cd14000 | 14-226 | STKc_LRRK |
| cd14033 | 55-243 | STKc_WNK4 |
| cd08229 | 15-221 | STKc_Nek7 |
| cd05081 | 7-218 | PTKc_Jak3_rpt2 |
| cd05627 | 14-221 | STKc_NDR2 |
| cd05085 | 13-226 | PTKc_Fer |
| cd07869 | 15-243 | STKc_PFTAIRE1 |
| cd14101 | 8-221 | STKc_PIM2 |
| cd05083 | 11-212 | PTKc_Chk |
| cd05071 | 15-221 | PTKc_Src |
| cd05610 | 15-221 | STKc_MASTL |
| cd05063 | 14-240 | PTKc_EphR_A2 |
| cd05056 | 11-240 | PTKc_FAK |
| cd14158 | 15-221 | STKc_IRAK4 |
| cd14062 | 15-222 | STKc_Raf |
| cd14154 | 15-209 | STKc_LIMK |
| cd07842 | 16-211 | STKc_CDK8_like |
| cd14203 | 15-240 | PTKc_Src_Fyn_like |
| cd14088 | 23-221 | STKc_CaMK_like |
| cd14131 | 15-227 | PKc_Mps1 |
| cd14049 | 13-241 | STKc_EIF2AK1_HRI |
| cd14001 | 15-220 | PKc_TOPK |
| cd05585 | 14-242 | STKc_YPK1_like |
| cd05588 | 14-242 | STKc_aPKC |
| cd05617 | 14-242 | STKc_aPKC_zeta |
| cd05615 | 14-221 | STKc_cPKC_alpha |
| cd06658 | 15-232 | STKc_PAK5 |
| cd05069 | 15-240 | PTKc_Yes |
| cd05628 | 14-221 | STKc_NDR1 |
| cd14019 | 13-221 | STKc_Cdc7 |
| cd07861 | 15-216 | STKc_CDK1_euk |
| cd13968 | 15-159 | PKc_like |
| cd05110 | 14-229 | PTKc_HER4 |
| cd07877 | 15-221 | STKc_p38alpha |
| cd07851 | 15-222 | STKc_p38 |
| cd14016 | 9-159 | STKc_CK1 |
| cd13981 | 12-188 | STKc_Bub1_BubR1 |
| cd05082 | 11-296 | PTKc_Csk |
| cd14054 | 14-216 | STKc_BMPR2_AMHR2 |
| cd05048 | 15-237 | PTKc_Ror |
| cd05631 | 14-237 | STKc_GRK4 |
| cd05065 | 11-221 | PTKc_EphR_B |
| cd06617 | 107-225 | PKc_MKK3_6 |
| cd14221 | 15-209 | STKc_LIMK1 |
| cd14149 | 10-221 | STKc_C-Raf |
| cd06657 | 15-221 | STKc_PAK4 |
| cd08216 | 21-221 | PK_STRAD |
| cd07876 | 54-222 | STKc_JNK2 |
| cd05037 | 15-212 | PTK_Jak_rpt1 |
| cd07850 | 15-221 | STKc_JNK |
| cd07853 | 38-211 | STKc_NLK |
| cd07835 | 15-211 | STKc_CDK1_CdkB_like |
| cd05033 | 11-168 | PTKc_EphR |
| cd07878 | 15-208 | STKc_p38beta |
| cd14031 | 15-243 | STKc_WNK3 |
| cd07854 | 15-221 | STKc_MAPK4_6 |
| cd05066 | 14-221 | PTKc_EphR_A |
| cd07852 | 15-208 | STKc_MAPK15-like |
| cd14056 | 13-182 | STKc_TGFbR_I |
| cd14152 | 11-222 | STKc_KSR1 |
| cd05070 | 15-240 | PTKc_Fyn |
| cd13998 | 13-215 | STKc_TGFbR-like |
| cd05587 | 14-221 | STKc_cPKC |
| cd05047 | 13-221 | PTKc_Tie |
| cd05072 | 15-240 | PTKc_Lyn |
| cd14067 | 15-220 | STKc_LRRK1 |
| cd07849 | 13-208 | STKc_ERK1_2_like |
| cd14025 | 15-243 | STKc_RIP4_like |
| cd05040 | 15-180 | PTKc_Ack_like |
| cd05108 | 14-221 | PTKc_EGFR |
| cd07858 | 15-211 | STKc_TEY_MAPK |
| cd14664 | 15-234 | STK_BAK1_like |
| cd05046 | 14-251 | PTK_CCK4 |
| cd07856 | 15-239 | STKc_Sty1_Hog1 |
| cd05090 | 15-234 | PTKc_Ror1 |
| cd14030 | 55-253 | STKc_WNK1 |
| cd14032 | 55-221 | STKc_WNK2_like |
| cd07855 | 15-211 | STKc_ERK5 |
| cd07859 | 11-250 | STKc_TDY_MAPK |
| cd05045 | 11-238 | PTKc_RET |
| cd07837 | 15-211 | STKc_CdkB_plant |
| cd14112 | 54-222 | STKc_Unc-89_rpt2 |
| cd14210 | 13-159 | PKc_DYRK |
| cd14223 | 14-222 | STKc_GRK2 |
| cd05633 | 14-222 | STKc_GRK3 |
| cd05067 | 15-168 | PTKc_Lck_Blk |
| cd05109 | 14-226 | PTKc_HER2 |
| cd14017 | 15-222 | STKc_TTBK |
| cd14100 | 8-221 | STKc_PIM1 |
| cd05605 | 14-222 | STKc_GRK4_like |
| cd05074 | 11-240 | PTKc_Tyro3 |
| cd05089 | 11-221 | PTKc_Tie1 |
| cd14204 | 7-221 | PTKc_Mer |
| cd05049 | 10-241 | PTKc_Trk |
| cd13992 | 8-242 | PK_GC |
| cd14212 | 13-161 | PKc_YAK1 |
| cd05052 | 15-167 | PTKc_Abl |
| cd07874 | 54-208 | STKc_JNK3 |
| cd05626 | 15-221 | STKc_LATS2 |
| cd05061 | 15-240 | PTKc_InsR |
| cd14133 | 9-222 | PKc_DYRK_like |
| cd05111 | 14-227 | PTK_HER3 |
| cd14020 | 8-217 | STKc_KIS |
| cd14115 | 15-221 | STKc_Kalirin_C |
| cd05092 | 15-240 | PTKc_TrkA |
| cd05062 | 15-240 | PTKc_IGF-1R |
| cd14053 | 23-225 | STKc_ACVR2 |
| cd08226 | 23-237 | PK_STRAD_beta |
| cd05088 | 11-221 | PTKc_Tie2 |
| cd14134 | 13-222 | PKc_CLK |
| cd14155 | 15-209 | PKc_TESK |
| cd05058 | 36-222 | PTKc_Met_Ron |
| cd14027 | 53-240 | STKc_RIP1 |
| cd05073 | 15-227 | PTKc_Hck |
| cd14229 | 13-208 | STKc_HIPK3 |
| cd14102 | 116-221 | STKc_PIM3 |
| cd14142 | 11-215 | STKc_ACVR1_ALK1 |
| cd14144 | 15-215 | STKc_BMPR1 |
| cd07867 | 15-211 | STKc_CDC2L6 |
| cd14051 | 15-220 | PTKc_Wee1 |
| cd14220 | 15-215 | STKc_BMPR1a |
| cd05075 | 11-221 | PTKc_Axl |
| cd07857 | 9-208 | STKc_MPK1 |
| cd05087 | 53-224 | PTKc_Aatyk1 |
| cd05035 | 11-221 | PTKc_TAM |
| cd05606 | 14-222 | STKc_beta_ARK |
| cd05050 | 15-274 | PTKc_Musk |
| cd14013 | 108-188 | STKc_SNT7_plant |
| cd07875 | 54-221 | STKc_JNK1 |
| cd14055 | 14-189 | STKc_TGFbR2_like |
| cd13975 | 106-220 | PKc_Dusty |
| cd14139 | 15-245 | PTKc_Wee1b |
| cd05625 | 15-221 | STKc_LATS1 |
| cd05055 | 53-172 | PTKc_PDGFR |
| cd14222 | 15-209 | STKc_LIMK2 |
| cd14211 | 13-161 | STKc_HIPK |
| cd05629 | 14-221 | STKc_NDR_like_fungal |
| cd05099 | 15-221 | PTKc_FGFR4 |
| cd05053 | 11-166 | PTKc_FGFR |
| cd14136 | 102-232 | STKc_SRPK |
| cd05043 | 10-225 | PTK_Ryk |
| cd05078 | 15-159 | PTK_Jak2_rpt1 |
| cd05044 | 15-164 | PTKc_c-ros |
| cd05091 | 61-234 | PTKc_Ror2 |
| cd13974 | 107-221 | STKc_SHIK |
| cd07868 | 15-211 | STKc_CDK8 |
| cd05093 | 7-241 | PTKc_TrkB |
| cd14138 | 15-172 | PTKc_Wee1a |
| cd05051 | 53-164 | PTKc_DDR |
| cd14160 | 15-217 | PK_IRAK3 |
| cd05095 | 15-216 | PTKc_DDR2 |
| cd14153 | 11-159 | PK_KSR2 |
| cd13977 | 85-212 | STKc_PDIK1L |
| cd14206 | 53-222 | PTKc_Aatyk3 |
| cd14215 | 15-259 | PKc_CLK2 |
| smart00220 | 9-242 | S_TKc |
| pfam00069 | 9-243 | Pkinase |
| COG0515 | 9-260 | SPS1 |
| smart00219 | 11-241 | TyrKc |
| smart00221 | 11-241 | STYKc |
| pfam07714 | 11-172 | Pkinase_Tyr |
| PTZ00263 | 9-241 | PTZ00263 |
| PTZ00267 | 7-282 | PTZ00267 |
| PLN00034 | 14-221 | PLN00034 |
| PTZ00266 | 15-221 | PTZ00266 |
| PTZ00283 | 11-241 | PTZ00283 |
| PTZ00036 | 4-208 | PTZ00036 |
| PTZ00024 | 15-218 | PTZ00024 |
| PHA03209 | 55-212 | PHA03209 |
| PHA03390 | 22-226 | pk1 |
| PTZ00426 | 15-221 | PTZ00426 |
| PHA03207 | 54-221 | PHA03207 |
| PHA03212 | 55-217 | PHA03212 |
| TIGR03903 | 54-217 | TOMM_kin_cyc |
| PHA03211 | 55-229 | PHA03211 |
| PRK13184 | 53-236 | pknD |
| PLN03224 | 115-188 | PLN03224 |
| PLN00009 | 15-211 | PLN00009 |
| PLN03225 | 114-164 | PLN03225 |
| COG0478 | 54-219 | RIO2 |
| COG0661 | 75-204 | AarF |
Ontology Information
| HPRD ID | 1010 |
|---|---|
| Molecular Class | Serine/threonine kinase |
| Molecular Function | Structural molecule activity (GO:0005198) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.