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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20126641 | 2010 | Cell line : - Source : African-American patients undergoing colonoscopy at Howard University Hospital. Sample Type : Fresh frozen CRC tissues No. of Sample : 15 Stage : - | Genome-wide array comparative genome hybridization | Deletion Mutation | - | Some CAN genes were altered at high frequencies in AAs with EXOC4, EPHB6, GNAS, MLL3 and TBX22 as the most frequently deleted genes and HAPLN1, ADAM29, SMAD2 and SMAD4 as the most frequently amplified genes. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | T-boxes |
| Description | This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene have been associated with the inherited X-linked disorder, Cleft palate with ankyloglossia, and it is believed to play a major role in human palatogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | Chromosome | X |
| Location | Xq21.1 |
| Start | 79270255 |
| End | 79287268 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 17014 |
| OMIM ID | 300307 |
| HGNC ID | HGNC:11600 |
| Unigene ID | Hs.374253 |
| Ensembl ID | ENSG00000122145 |
| PharmGKB ID | PA36363 |
Protein Information
| Protein ID | NP_001103348.1 |
|---|---|
| Protein Name | T-box 22 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 520 |
| Uniprot ID | Q9NRS4 |
| Ensembl Protein ID | ENSP00000416037 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00182 | 91-287 | TBOX |
| cl00145 | 91-287 | TBOX superfamily |
| pfam00907 | 93-283 | T-box |
| smart00425 | 92-288 | TBOX |
Ontology Information
| HPRD ID | 7286 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.